Monopathogenic vs multipathogenic explanations of pemphigus pathophysiology

Antimelanogenic effects of luteolin 7-sulfate isolated fromPhyllospadix iwatensisMakino

(2016) J.Y. Kwak et al.   BRITISH JOURNAL OF DERMATOLOGY

Serum and salivary IgG and IgA antibodies to desmoglein 3 in mucosal pemphigus vulgaris

(2016) S. Ali et al.   BRITISH JOURNAL OF DERMATOLOGY

Multiplexed autoantigen microarrays identify HLA as a key driver of anti-desmoglein and -non-desmoglein reactivities in pemphigus

(2016) Thomas Sajda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pseudo Pemphigus Phenotypes in Mice with Inactivated Desmoglein 3

(2015) Sergei A. Grando et al.   AMERICAN JOURNAL OF PATHOLOGY

A Spontaneous Deletion within the Desmoglein 3 Extracellular Domain of Mice Results in Hypomorphic Protein Expression, Immunodeficiency, and a Wasting Disease Phenotype

(2015) Evgueni I. Kountikov et al.   AMERICAN JOURNAL OF PATHOLOGY

Epitope analysis of antidesmoglein 1 autoantibodies from patients with pemphigus foliaceus across different activity stages

(2015) K. Kamiya et al.   BRITISH JOURNAL OF DERMATOLOGY

Pemphigus vulgaris antibodies target the mitochondrial nicotinic acetylcholine receptors that protect keratinocytes from apoptolysis

(2015) Alex Chernyavsky et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Critical Role of the Neonatal Fc Receptor (FcRn) in the Pathogenic Action of Antimitochondrial Autoantibodies Synergizing with Anti-desmoglein Autoantibodies in Pemphigus Vulgaris

(2015) Yumay Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of Desmoglein Binding Is Not Sufficient for Keratinocyte Dissociation in Pemphigus

(2015) Franziska Vielmuth et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Preclinical Studies Identify Non-Apoptotic Low-Level Caspase-3 as Therapeutic Target in Pemphigus Vulgaris

(2015) Camille Luyet et al.   PLoS One

Detailed profiling of anti-desmoglein autoantibodies identifies anti-Dsg1 reactivity as a key driver of disease activity and clinical expression in pemphigus vulgaris

(2014) S. Y. Naseer et al.   AUTOIMMUNITY

Specific immunoadsorption of pathogenic autoantibodies in pemphigus requires the entire ectodomains of desmogleins

(2014) Jana Langenhan et al.   EXPERIMENTAL DERMATOLOGY

Pathogenic IgG Antibodies against Desmoglein 3 in Pemphigus Vulgaris Are Regulated by HLA-DRB1*04:02–Restricted T Cells

(2014) Rüdiger Eming et al.   JOURNAL OF IMMUNOLOGY

No Evidence of Apoptotic Cells in Pemphigus Acantholysis

(2014) Ineke C. Janse et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Pemphigus vulgaris autoimmune globulin induces Src-dependent tyrosine-phosphorylation of plakophilin 3 and its detachment from desmoglein 3

(2013) Nicola Cirillo et al.   AUTOIMMUNITY

Autoreactive T cells in the immune pathogenesis of pemphigus vulgaris

(2013) Kyle T. Amber et al.   EXPERIMENTAL DERMATOLOGY

Mechanisms of Mitochondrial Damage in Keratinocytes by Pemphigus Vulgaris Antibodies

(2013) Mina Kalantari-Dehaghi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A New Light on an Old Disease: Adhesion Signaling in Pemphigus Vulgaris

(2013) Arnaud Galichet et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Autoantibody depletion ameliorates disease in murine experimental autoimmune encephalomyelitis

(2013) Dilip K. Challa et al.   mAbs

Desmoglein 1 deficiency results in severe dermatitis, multiple allergies and metabolic wasting

(2013) Liat Samuelov et al.   NATURE GENETICS

Pemphigus Vulgaris Autoantibody Profiling by Proteomic Technique

(2013) Mina Kalantari-Dehaghi et al.   PLoS One

Desmoglein 2 Is Less Important than Desmoglein 3 for Keratinocyte Cohesion

(2013) Eva Hartlieb et al.   PLoS One

Detection of antibodies against the non-calcium-dependent epitopes of desmoglein 3 in pemphigus vulgaris and their pathogenic significance

(2012) K. Kamiya et al.   BRITISH JOURNAL OF DERMATOLOGY

Is there an emergent need to modify the desmoglein compensation theory in pemphigus on the basis of Dsg ELISA data and alternative pathogenic mechanisms?

(2012) K. Sardana et al.   BRITISH JOURNAL OF DERMATOLOGY

Apoptotic Pathways in the Pathogenesis of Pemphigus: Targets for New Therapies

(2012) Roberta Lotti et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Epitope Spreading Is Rarely Found in Pemphigus Vulgaris by Large-Scale Longitudinal Study Using Desmoglein 2–Based Swapped Molecules

(2012) Bungo Ohyama et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Population-Specific Association between a Polymorphic Variant in ST18, Encoding a Pro-Apoptotic Molecule, and Pemphigus Vulgaris

(2012) Ofer Sarig et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

IgG Autoantibodies Against Desmocollin 3 in Pemphigus Sera Induce Loss of Keratinocyte Adhesion

(2011) David Rafei et al.   AMERICAN JOURNAL OF PATHOLOGY

Pathogenic Relevance of IgG and IgM Antibodies against Desmoglein 3 in Blister Formation in Pemphigus Vulgaris

(2011) Kazuyuki Tsunoda et al.   AMERICAN JOURNAL OF PATHOLOGY

Constructing immunoprofiles to deconstruct disease complexity in pemphigus

(2011) Animesh A. Sinha   AUTOIMMUNITY

Pemphigus autoimmunity: Hypotheses and realities

(2011) Sergei A. Grando   AUTOIMMUNITY

Low-dose rituximab is effective in pemphigus

(2011) B. Horváth et al.   BRITISH JOURNAL OF DERMATOLOGY

Megalin/Cubilin-mediated Uptake of FITC-labeled IgG by OK Kidney Epithelial Cells

(2011) Junya Nagai et al.   Drug Metabolism and Pharmacokinetics

New targets of pemphigus vulgaris antibodies identified by protein array technology

(2011) Mina Kalantari-Dehaghi et al.   EXPERIMENTAL DERMATOLOGY

Neonatal Fc Receptor Blockade by Fc Engineering Ameliorates Arthritis in a Murine Model

(2011) D. A. Patel et al.   JOURNAL OF IMMUNOLOGY

An Adult Passive Transfer Mouse Model to Study Desmoglein 3 Signaling in Pemphigus Vulgaris

(2011) Katja Schulze et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Autoimmunity to Desmocollin 3 in Pemphigus Vulgaris

(2010) Xuming Mao et al.   AMERICAN JOURNAL OF PATHOLOGY

ACE inhibitors can induce circulating antibodies directed to antigens of the superficial epidermal cells

(2010) Emanuele Cozzani et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Novel ELISA systems for antibodies to desmoglein 1 and 3: correlation of disease activity with serum autoantibody levels in individual pemphigus patients

(2010) Enno Schmidt et al.   EXPERIMENTAL DERMATOLOGY

Comparison of enzyme-linked immunosorbent assay test with immunoblot assay in the diagnosis of pemphigus in Indian patients

(2010) Sujay Khandpur et al.   Indian Journal of Dermatology Venereology & Leprology

p38MAPK Signaling and Desmoglein-3 Internalization Are Linked Events in Pemphigus Acantholysis

(2010) Puneet S. Jolly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Homologous regions of autoantibody heavy chain complementarity-determining region 3 (H-CDR3) in patients with pemphigus cause pathogenicity

(2010) Jun Yamagami et al.   JOURNAL OF CLINICAL INVESTIGATION

What’s new in i.v. immunoglobulin therapy and pemphigus: High-dose i.v. immunoglobulin therapy and its mode of action for treatment of pemphigus

(2010) Yumi AOYAMA   JOURNAL OF DERMATOLOGY

ELISA Testing of Anti–Desmoglein 1 and 3 Antibodies in the Management of Pemphigus

(2009) Claire Abasq et al.   ARCHIVES OF DERMATOLOGY

Apoptosis in pemphigus

(2009) Enno Schmidt et al.   AUTOIMMUNITY REVIEWS

Detection of Autoantibodies against Recombinant Desmoglein 1 and 3 Molecules in Patients with Pemphigus vulgaris: Correlation with Disease Extent at the Time of Diagnosis and during Follow-Up

(2009) Anna Belloni-Fortina et al.   Clinical & Developmental Immunology

Clinical activity of pemphigus vulgaris relates to IgE autoantibodies against desmoglein 3

(2009) Angela Nagel et al.   CLINICAL IMMUNOLOGY

An imbalance in Akt/mTOR is involved in the apoptotic and acantholytic processes in a mouse model of pemphigus vulgaris

(2009) Maider Pretel et al.   EXPERIMENTAL DERMATOLOGY

Apoptolysis: a novel mechanism of skin blistering in pemphigus vulgaris linking the apoptotic pathways to basal cell shrinkage and suprabasal acantholysis

(2009) Sergei A. Grando et al.   EXPERIMENTAL DERMATOLOGY

Biphasic Activation of p38MAPK Suggests That Apoptosis Is a Downstream Event in Pemphigus Acantholysis

(2009) Hua En Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antimitochondrial Autoantibodies in Pemphigus Vulgaris

(2009) Steve Marchenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Desmosomes at a glance

(2009) Bhushan V. Desai et al.   JOURNAL OF CELL SCIENCE

Update on the cloning of monoclonal anti-desmoglein antibodies from human pemphigus patients: implications for targeted therapy

(2009) John R. Stanley et al.   VETERINARY DERMATOLOGY

Apoptosis is not required for acantholysis in pemphigus vulgaris

(2008) Enno Schmidt et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Loss of desmocollin 3 in mice leads to epidermal blistering

(2008) J. Chen et al.   JOURNAL OF CELL SCIENCE

Neonatal Fc receptor deficiency protects from tissue injury in experimental epidermolysis bullosa acquisita

(2008) Alina Sesarman et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Anti-desmoglein IgG autoantibodies in patients with pemphigus in remission

(2008) EJ Kwon et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Neonatal Fc Receptor Mediates Internalization of Fc in Transfected Human Endothelial Cells

(2008) Nancy A. Goebl et al.   MOLECULAR BIOLOGY OF THE CELL

The most widespread desmosomal cadherin, desmoglein 2, is a novel target of caspase 3-mediated apoptotic machinery

(2007) Nicola Cirillo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY