The lack of BTK does not impair monocytes and polymorphonuclear cells functions in X-linked agammaglobulinemia under treatment with intravenous immunoglobulin replacement

Intravenous immunoglobulin replacement treatment does not alter polymorphonuclear leukocytes function and surface receptors expression in patients with common variable immunodeficiency

(2016) Alessandro Prezzo et al.   CELLULAR IMMUNOLOGY

Investigational Bruton’s tyrosine kinase inhibitors for the treatment of rheumatoid arthritis

(2016) Peter Norman   EXPERT OPINION ON INVESTIGATIONAL DRUGS

X-linked Agammaglobulinemia

(2016) Deepti Suri et al.   INDIAN JOURNAL OF PEDIATRICS

Second-generation inhibitors of Bruton tyrosine kinase

(2016) Jingjing Wu et al.   Journal of Hematology & Oncology

Mortality and morbidity in patients with X-linked agammaglobulinaemia

(2015) H. Abolhassani et al.   ALLERGOLOGIA ET IMMUNOPATHOLOGIA

Bruton's tyrosine kinase inhibitors in B-cell non-Hodgkin's lymphomas

(2015) L Alinari et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

A novel BTK gene mutation creates a de-novo splice site in an X-linked agammaglobulinemia patient

(2015) Chai Teng Chear et al.   GENE

Intravenous immunoglobulin replacement induces an in vivo reduction of inflammatory monocytes and retains the monocyte ability to respond to bacterial stimulation in patients with common variable immunodeficiencies

(2015) Filomena Monica Cavaliere et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Analysis of the Effects of the Bruton's tyrosine kinase (Btk) Inhibitor Ibrutinib on Monocyte Fcγ Receptor (FcγR) Function

(2015) Li Ren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Investigating CD11c expression as a potential genomic biomarker of response to TNF inhibitor biologics in whole blood rheumatoid arthritis samples

(2015) Samantha Louise Smith et al.   ARTHRITIS RESEARCH & THERAPY

A1.48 Enhanced expression of CD11c on non-classical CD16+peripheral blood monocytes in early rheumatoid arthritis

(2014) Olga Krystufkova et al.   ANNALS OF THE RHEUMATIC DISEASES

Ibrutinib: a first in class covalent inhibitor of Bruton's tyrosine kinase

(2014) Matthew S Davids et al.   Future Oncology

Bruton tyrosine kinase mediates TLR9-dependent human dendritic cell activation

(2014) Vassilios Lougaris et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Phosphoinositide 3-Kinase-Dependent Activation of Btk Is Required for Optimal Eicosanoid Production and Generation of Reactive Oxygen Species in Antigen-Stimulated Mast Cells

(2014) H. S. Kuehn et al.   JOURNAL OF IMMUNOLOGY

Is Dosing of Therapeutic Immunoglobulins Optimal? A Review of a Three-Decade Long Debate in Europe

(2014) Jacqueline Kerr et al.   Frontiers in Immunology

Persistent Immune Activation in CVID and the Role of IVIg in Its Suppression

(2014) Dominic Paquin-Proulx et al.   Frontiers in Immunology

Brutonˈs tyrosine kinase-an integral protein of B cell development that also has an essential role in the innate immune system

(2013) Gabriela López-Herrera et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The three human monocyte subsets: implications for health and disease

(2012) Kok Loon Wong et al.   IMMUNOLOGIC RESEARCH

Cell Signaling through Protein Kinase C Oxidation and Activation

(2012) Daniela Cosentino-Gomes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TREM-1: intracellular signaling pathways and interaction with pattern recognition receptors

(2012) R. J. W. Arts et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The kinase Btk negatively regulates the production of reactive oxygen species and stimulation-induced apoptosis in human neutrophils

(2012) Fumiko Honda et al.   NATURE IMMUNOLOGY

The CD14bright CD16+ monocyte subset is expanded in rheumatoid arthritis and promotes expansion of the Th17 cell population

(2011) Manuela Rossol et al.   ARTHRITIS AND RHEUMATISM

How does the oxidative burst of macrophages kill bacteria? Still an open question

(2011) James M. Slauch   MOLECULAR MICROBIOLOGY

A Differential Concentration-Dependent Effect of IVIg on Neutrophil Functions: Relevance for Anti-Microbial and Anti-Inflammatory Mechanisms

(2011) Sarah Casulli et al.   PLoS One

Redox Control of Protein Kinase C: Cell- and Disease-Specific Aspects

(2010) Carlotta Giorgi et al.   ANTIOXIDANTS & REDOX SIGNALING

Neutrophil development and function critically depend on Bruton tyrosine kinase in a mouse model of X-linked agammaglobulinemia

(2010) K. Fiedler et al.   BLOOD

TLR signaling and effector functions are intact in XLA neutrophils

(2010) Thomas U. Marron et al.   CLINICAL IMMUNOLOGY

The role of calcium signaling in phagocytosis

(2010) Paula Nunes et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response

(2009) A. F. Carlin et al.   BLOOD

Bruton’s tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain

(2009) Abdalla J. Mohamed et al.   IMMUNOLOGICAL REVIEWS

Primary immunodeficiencies

(2009) Luigi D. Notarangelo   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Structural Basis of Protein Kinase C Isoform Function

(2008) Susan F. Steinberg   PHYSIOLOGICAL REVIEWS

Toll-like receptor signaling is impaired in dendritic cells from patients with X-linked agammaglobulinemia

(2007) Hiromichi Taneichi et al.   CLINICAL IMMUNOLOGY