Are Follicular Regulatory T Cells Involved in Autoimmune Diseases?

Transcriptional repressor Blimp1 regulates follicular regulatory T-cell homeostasis and function

(2017) Guang Yang et al.   IMMUNOLOGY

Caspase-1 inhibitor regulates humoral responses in experimental autoimmune myasthenia gravis via IL-6- dependent inhibiton of STAT3

(2017) Cong-Cong Wang et al.   NEUROSCIENCE LETTERS

T follicular helper and T follicular regulatory cells have different TCR specificity

(2017) Ana Raquel Maceiras et al.   Nature Communications

IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2

(2017) Christoph Jandl et al.   Nature Communications

Follicular regulatory T cells repress cytokine production by follicular helper T cells and optimize IgG responses in mice

(2016) Hao Wu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Store-Operated Ca 2+ Entry in Follicular T Cells Controls Humoral Immune Responses and Autoimmunity

(2016) Martin Vaeth et al.   IMMUNITY

Biological effects of IL-21 on different immune cells and its role in autoimmune diseases

(2016) Tohid Gharibi et al.   IMMUNOBIOLOGY

T follicular regulatory cells

(2016) Peter T. Sage et al.   IMMUNOLOGICAL REVIEWS

Circulating T helper and T regulatory subsets in untreated early rheumatoid arthritis and healthy control subjects

(2016) Jayesh M. Pandya et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Suppression by TFR cells leads to durable and selective inhibition of B cell effector function

(2016) Peter T Sage et al.   NATURE IMMUNOLOGY

Imbalance of circulating CD4 + CXCR5 + FOXP3 + Tfr-like cells and CD4 + CXCR5 + FOXP3 − Tfh-like cells in myasthenia gravis

(2016) Yanbin Wen et al.   NEUROSCIENCE LETTERS

Block of both TGF-β and IL-2 signaling impedes Neurophilin-1+ regulatory T cell and follicular regulatory T cell development

(2016) Liang Li et al.   Cell Death & Disease

Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells

(2016) Meryem Aloulou et al.   Nature Communications

Critical roles of mTOR Complex 1 and 2 for T follicular helper cell differentiation and germinal center responses

(2016) Jialong Yang et al.   eLife

Regulators of Tfh Cell Differentiation

(2016) Gajendra M. Jogdand et al.   Frontiers in Immunology

Stat3 Is Important for Follicular Regulatory T Cell Differentiation

(2016) Hao Wu et al.   PLoS One

Humoral autoimmunity: A failure of regulatory T cells?

(2015) Tessa Dhaeze et al.   AUTOIMMUNITY REVIEWS

Higher frequency of peripheral blood follicular regulatory T cells in patients with new onset ankylosing spondylitis

(2015) Yuxing Shan et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

The FOXO1 Transcription Factor Instructs the Germinal Center Dark Zone Program

(2015) David Dominguez-Sola et al.   IMMUNITY

PI3 Kinase and FOXO1 Transcription Factor Activity Differentially Control B Cells in the Germinal Center Light and Dark Zones

(2015) Sandrine Sander et al.   IMMUNITY

T follicular helper cells, T follicular regulatory cells and autoimmunity

(2015) Yangyang Zhu et al.   INTERNATIONAL IMMUNOLOGY

Helios Controls a Limited Subset of Regulatory T Cell Functions

(2015) Mathew Sebastian et al.   JOURNAL OF IMMUNOLOGY

Circulating Follicular Regulatory T Cells Are Defective in Multiple Sclerosis

(2015) Tessa Dhaeze et al.   JOURNAL OF IMMUNOLOGY

T follicular regulatory cells in the regulation of B cell responses

(2015) Peter T. Sage et al.   TRENDS IN IMMUNOLOGY

The role of microRNA-1246 in the regulation of B cell activation and the pathogenesis of systemic lupus erythematosus

(2015) Shuangyan Luo et al.   Clinical Epigenetics

Regulation of Autoimmune Germinal Center Reactions in Lupus-Prone BXD2 Mice by Follicular Helper T Cells

(2015) Young Uk Kim et al.   PLoS One

Human T-follicular helper and T-follicular regulatory cell maintenance is independent of germinal centers

(2014) E. F. Wallin et al.   BLOOD

Regulatory T Cells Control Antigen-Specific Expansion of Tfh Cell Number and Humoral Immune Responses via the Coreceptor CTLA-4

(2014) James Badger Wing et al.   IMMUNITY

TGF-β prevents T follicular helper cell accumulation and B cell autoreactivity

(2014) Mark J. McCarron et al.   JOURNAL OF CLINICAL INVESTIGATION

Circulating T follicular regulatory and helper cells have memory-like properties

(2014) Peter T. Sage et al.   JOURNAL OF CLINICAL INVESTIGATION

Follicular regulatory T cells control humoral autoimmunity via NFAT2-regulated CXCR5 expression

(2014) Martin Vaeth et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Id2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease

(2014) Masaki Miyazaki et al.   NATURE IMMUNOLOGY

A p85α-osteopontin axis couples the receptor ICOS to sustained Bcl-6 expression by follicular helper and regulatory T cells

(2014) Jianmei W Leavenworth et al.   NATURE IMMUNOLOGY

Regulatory T cells and control of the germinal centre response

(2014) Ine Vanderleyden et al.   ARTHRITIS RESEARCH & THERAPY

T cell-intrinsic role of IL-6 signaling in primary and memory responses

(2014) Simone A Nish et al.   eLife

Interleukin-21 Promotes Germinal Center Reaction by Skewing the Follicular Regulatory T Cell to Follicular Helper T Cell Balance in Autoimmune BXD2 Mice

(2014) Yanna Ding et al.   Arthritis & Rheumatology

Critical role of PD-1/PD-L1 pathway in generation and function of follicular regulatory T cells

(2013) Zhi-Qing Hu et al.   Cellular & Molecular Immunology

ATRA alters humoral responses associated with amelioration of EAMG symptoms by balancing Tfh/Tfr helper cell profiles

(2013) Xiaoli Xie et al.   CLINICAL IMMUNOLOGY

Germinal Center Centroblasts Transition to a Centrocyte Phenotype According to a Timed Program and Depend on the Dark Zone for Effective Selection

(2013) Oliver Bannard et al.   IMMUNITY

T-cell subsets in the germinal center

(2013) Roybel R. Ramiscal et al.   IMMUNOLOGICAL REVIEWS

TRAF3 regulates the effector function of regulatory T cells and humoral immune responses

(2013) Jae-Hoon Chang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The darker side of follicular helper T cells: from autoimmunity to immunodeficiency

(2012) Sudhanshu Shekhar et al.   Cellular & Molecular Immunology

Increased Frequency of Circulating Follicular Helper T Cells in Patients with Rheumatoid Arthritis

(2012) Jie Ma et al.   Clinical & Developmental Immunology

AP-1 is involved in ICOS gene expression downstream of TCR/CD28 and cytokine receptor signaling

(2012) Masashi Watanabe et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Interleukin-2 Inhibits Germinal Center Formation by Limiting T Follicular Helper Cell Differentiation

(2012) André Ballesteros-Tato et al.   IMMUNITY

The origins, function, and regulation of T follicular helper cells

(2012) Cindy S. Ma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bcl6 and Maf Cooperate To Instruct Human Follicular Helper CD4 T Cell Differentiation

(2012) M. A. Kroenke et al.   JOURNAL OF IMMUNOLOGY

The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood

(2012) Peter T Sage et al.   NATURE IMMUNOLOGY

Inhibition of Aberrant Circulating Tfh Cell Proportions by Corticosteroids in Patients with Systemic Lupus Erythematosus

(2012) Xuebing Feng et al.   PLoS One

Akt and mTOR in B Cell Activation and Differentiation

(2012) Jose J. Limon et al.   Frontiers in Immunology

Follicular Helper CD4 T Cells (TFH)

(2011) Shane Crotty   Annual Review of Immunology

Therapeutic Targeting of the Interleukin-6 Receptor

(2011) Toshio Tanaka et al.   Annual Review of Pharmacology and Toxicology

Germinal Center B Cell and T Follicular Helper Cell Development Initiates in the Interfollicular Zone

(2011) Steven M. Kerfoot et al.   IMMUNITY

Increased Frequency of Follicular Helper T Cells in Patients with Autoimmune Thyroid Disease

(2011) Chenlu Zhu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Regulation of the Germinal Center Reaction by Foxp3+ Follicular Regulatory T Cells

(2011) I. Wollenberg et al.   JOURNAL OF IMMUNOLOGY

Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions

(2011) Yeonseok Chung et al.   NATURE MEDICINE

Foxp3+ follicular regulatory T cells control the germinal center response

(2011) Michelle A Linterman et al.   NATURE MEDICINE

IL-21 and IL-6 Are Critical for Different Aspects of B Cell Immunity and Redundantly Induce Optimal Follicular Helper CD4 T Cell (Tfh) Differentiation

(2011) Danelle Eto et al.   PLoS One

B-cell targeted therapies in human autoimmune diseases: an updated perspective

(2010) Michael J. Townsend et al.   IMMUNOLOGICAL REVIEWS

IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses

(2010) Michelle A. Linterman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TNF Receptor-Associated Factor 3 Is Required for T Cell-Mediated Immunity and TCR/CD28 Signaling

(2010) P. Xie et al.   JOURNAL OF IMMUNOLOGY

Synergistic Effect of IL-6 and IL-4 in Driving Fate Revision of Natural Foxp3+ Regulatory T Cells

(2010) L. Kastner et al.   JOURNAL OF IMMUNOLOGY

The Influence of Excessive IL-6 Production In Vivo on the Development and Function of Foxp3+ Regulatory T Cells

(2010) M. Fujimoto et al.   JOURNAL OF IMMUNOLOGY

Germinal Center T Follicular Helper Cell IL-4 Production Is Dependent on Signaling Lymphocytic Activation Molecule Receptor (CD150)

(2010) I. Yusuf et al.   JOURNAL OF IMMUNOLOGY

Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal

(2009) Brian T Fife et al.   NATURE IMMUNOLOGY

Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation

(2009) R. J. Johnston et al.   SCIENCE

Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities

(2008) F. Eddahri et al.   BLOOD