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Title
The origins, function, and regulation of T follicular helper cells
Authors
Keywords
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Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 209, Issue 7, Pages 1241-1253
Publisher
Rockefeller University Press
Online
2012-07-03
DOI
10.1084/jem.20120994
References
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Note: Only part of the references are listed.- IL-21-Induced Isotype Switching to IgG and IgA by Human Naive B Cells Is Differentially Regulated by IL-4
- (2014) D. T. Avery et al. JOURNAL OF IMMUNOLOGY
- T cell-B cell interactions in primary immunodeficiencies
- (2012) Stuart G. Tangye et al. Annals of the New York Academy of Sciences
- Functional STAT3 deficiency compromises the generation of human T follicular helper cells
- (2012) C. S. Ma et al. BLOOD
- Interleukin-2 Inhibits Germinal Center Formation by Limiting T Follicular Helper Cell Differentiation
- (2012) André Ballesteros-Tato et al. IMMUNITY
- IL-6 Triggers IL-21 production by human CD4+ T cells to drive STAT3-dependent plasma cell differentiation in B cells
- (2012) Sean A Diehl et al. IMMUNOLOGY AND CELL BIOLOGY
- STAT5 is a potent negative regulator of TFHcell differentiation
- (2012) Robert J. Johnston et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Bcl6 and Maf Cooperate To Instruct Human Follicular Helper CD4 T Cell Differentiation
- (2012) M. A. Kroenke et al. JOURNAL OF IMMUNOLOGY
- Follicular Helper NKT Cells Induce Limited B Cell Responses and Germinal Center Formation in the Absence of CD4+ T Cell Help
- (2012) E. Tonti et al. JOURNAL OF IMMUNOLOGY
- The development and fate of follicular helper T cells defined by an IL-21 reporter mouse
- (2012) Katja Lüthje et al. NATURE IMMUNOLOGY
- Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile
- (2012) Kenneth J Oestreich et al. NATURE IMMUNOLOGY
- Follicular Helper CD4 T Cells (TFH)
- (2011) Shane Crotty Annual Review of Immunology
- Human Blood CXCR5+CD4+ T Cells Are Counterparts of T Follicular Cells and Contain Specific Subsets that Differentially Support Antibody Secretion
- (2011) Rimpei Morita et al. IMMUNITY
- Early Th1 Cell Differentiation Is Marked by a Tfh Cell-like Transition
- (2011) Shingo Nakayamada et al. IMMUNITY
- ICOS Receptor Instructs T Follicular Helper Cell versus Effector Cell Differentiation via Induction of the Transcriptional Repressor Bcl6
- (2011) Youn Soo Choi et al. IMMUNITY
- Germinal Center B Cell and T Follicular Helper Cell Development Initiates in the Interfollicular Zone
- (2011) Steven M. Kerfoot et al. IMMUNITY
- Functional and Epigenetic Studies Reveal Multistep Differentiation and Plasticity of In Vitro-Generated and In Vivo-Derived Follicular T Helper Cells
- (2011) Kristina T. Lu et al. IMMUNITY
- Bcl6 Protein Expression Shapes Pre-Germinal Center B Cell Dynamics and Follicular Helper T Cell Heterogeneity
- (2011) Masahiro Kitano et al. IMMUNITY
- B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells
- (2011) Sau K. Lee et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells
- (2011) Laura M. Fahey et al. JOURNAL OF EXPERIMENTAL MEDICINE
- B Cell-Specific Expression of B7-2 Is Required for Follicular Th Cell Function in Response to Vaccinia Virus
- (2011) S. Salek-Ardakani et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: Distinct Waves of BCL6 Expression during T Follicular Helper Cell Development
- (2011) D. Baumjohann et al. JOURNAL OF IMMUNOLOGY
- CXCR5 Expressing Human Central Memory CD4 T Cells and Their Relevance for Humoral Immune Responses
- (2011) N. Chevalier et al. JOURNAL OF IMMUNOLOGY
- Regulation of the Germinal Center Reaction by Foxp3+ Follicular Regulatory T Cells
- (2011) I. Wollenberg et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: Dendritic Cell-Restricted Antigen Presentation Initiates the Follicular Helper T Cell Program but Cannot Complete Ultimate Effector Differentiation
- (2011) R. Goenka et al. JOURNAL OF IMMUNOLOGY
- The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells
- (2011) Wataru Ise et al. NATURE IMMUNOLOGY
- Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses
- (2011) Pheh-Ping Chang et al. NATURE IMMUNOLOGY
- Invariant natural killer T cells direct B cell responses to cognate lipid antigen in an IL-21-dependent manner
- (2011) Irah L King et al. NATURE IMMUNOLOGY
- Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions
- (2011) Yeonseok Chung et al. NATURE MEDICINE
- Foxp3+ follicular regulatory T cells control the germinal center response
- (2011) Michelle A Linterman et al. NATURE MEDICINE
- IL-21 and IL-6 Are Critical for Different Aspects of B Cell Immunity and Redundantly Induce Optimal Follicular Helper CD4 T Cell (Tfh) Differentiation
- (2011) Danelle Eto et al. PLoS One
- Human tonsil B-cell lymphoma 6 (BCL6)-expressing CD4+ T-cell subset specialized for B-cell help outside germinal centers
- (2011) S.-E. Bentebibel et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Late Interleukin-6 Escalates T Follicular Helper Cell Responses and Controls a Chronic Viral Infection
- (2011) J. A. Harker et al. SCIENCE
- Optimal Germinal Center Responses Require a Multistage T Cell:B Cell Adhesion Process Involving Integrins, SLAM-Associated Protein, and CD84
- (2010) Jennifer L. Cannons et al. IMMUNITY
- Follicular Helper T Cell Differentiation Requires Continuous Antigen Presentation that Is Independent of Unique B Cell Signaling
- (2010) Elissa K. Deenick et al. IMMUNITY
- IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells
- (2010) Marcel Batten et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Batf coordinates multiple aspects of B and T cell function required for normal antibody responses
- (2010) Briana C. Betz et al. JOURNAL OF EXPERIMENTAL MEDICINE
- IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses
- (2010) Michelle A. Linterman et al. JOURNAL OF EXPERIMENTAL MEDICINE
- IL-21 regulates germinal center B cell differentiation and proliferation through a B cell–intrinsic mechanism
- (2010) Dimitra Zotos et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Germinal Center T Follicular Helper Cell IL-4 Production Is Dependent on Signaling Lymphocytic Activation Molecule Receptor (CD150)
- (2010) I. Yusuf et al. JOURNAL OF IMMUNOLOGY
- In Vivo Regulation of Bcl6 and T Follicular Helper Cell Development
- (2010) A. C. Poholek et al. JOURNAL OF IMMUNOLOGY
- Inhibition of follicular T-helper cells by CD8+ regulatory T cells is essential for self tolerance
- (2010) Hye-Jung Kim et al. NATURE
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- (2010) Nadége Pelletier et al. NATURE IMMUNOLOGY
- Control systems and decision making for antibody production
- (2010) Christopher C Goodnow et al. NATURE IMMUNOLOGY
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- (2010) M. Mitsdoerffer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4+ T Cells
- (2010) J. J. O'Shea et al. SCIENCE
- Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus
- (2009) Nicholas Simpson et al. ARTHRITIS AND RHEUMATISM
- Memory B cells: Effectors of long-lived immune responses
- (2009) Stuart G. Tangye et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Human Dendritic Cells Induce the Differentiation of Interleukin-21-Producing T Follicular Helper-like Cells through Interleukin-12
- (2009) Nathalie Schmitt et al. IMMUNITY
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- (2009) Di Yu et al. IMMUNITY
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- (2009) Hyokjoon Kwon et al. IMMUNITY
- Early commitment of naïve human CD4+ T cells to the T follicular helper (TFH ) cell lineage is induced by IL-12
- (2009) Cindy S Ma et al. IMMUNOLOGY AND CELL BIOLOGY
- The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+T cells
- (2009) Oliver Dienz et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Follicular helper T cells are required for systemic autoimmunity
- (2009) Michelle A. Linterman et al. JOURNAL OF EXPERIMENTAL MEDICINE
- T follicular helper cells differentiate from Th2 cells in response to helminth antigens
- (2009) Arielle Glatman Zaretsky et al. JOURNAL OF EXPERIMENTAL MEDICINE
- IL-4–producing CD4+T cells in reactive lymph nodes during helminth infection are T follicular helper cells
- (2009) Irah L. King et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Cutting Edge: IL-27 Induces the Transcription Factor c-Maf, Cytokine IL-21, and the Costimulatory Receptor ICOS that Coordinately Act Together to Promote Differentiation of IL-10-Producing Tr1 Cells
- (2009) C. Pot et al. JOURNAL OF IMMUNOLOGY
- c-Maf activates the promoter and enhancer of the IL-21 gene, and TGF-β inhibits c-Maf-induced IL-21 production in CD4+ T cells
- (2009) Yukiko Hiramatsu et al. JOURNAL OF LEUKOCYTE BIOLOGY
- The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding
- (2009) Nicolas Fazilleau et al. NATURE IMMUNOLOGY
- Cytokine-secreting follicular T cells shape the antibody repertoire
- (2009) R Lee Reinhardt et al. NATURE IMMUNOLOGY
- Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase
- (2009) M. Gigoux et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation
- (2009) R. J. Johnston et al. SCIENCE
- Bcl6 Mediates the Development of T Follicular Helper Cells
- (2009) R. I. Nurieva et al. SCIENCE
- T Follicular Helper (TFH) Cells in Normal and Dysregulated Immune Responses
- (2008) Cecile King et al. Annual Review of Immunology
- A Fundamental Role for Interleukin-21 in the Generation of T Follicular Helper Cells
- (2008) Alexis Vogelzang et al. IMMUNITY
- Generation of T Follicular Helper Cells Is Mediated by Interleukin-21 but Independent of T Helper 1, 2, or 17 Cell Lineages
- (2008) Roza I. Nurieva et al. IMMUNITY
- The role of IL-21 in regulating B-cell function in health and disease
- (2008) Rachel Ettinger et al. IMMUNOLOGICAL REVIEWS
- Development and characterization of IL-21–producing CD4+T cells
- (2008) Akira Suto et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Deficiency of Th17 cells in hyper IgE syndrome due to mutations inSTAT3
- (2008) Cindy S. Ma et al. JOURNAL OF EXPERIMENTAL MEDICINE
- SAP-controlled T–B cell interactions underlie germinal centre formation
- (2008) Hai Qi et al. NATURE
- The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells
- (2008) Aurelie T Bauquet et al. NATURE IMMUNOLOGY
- IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype
- (2008) M. Huber et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulatory T Cells: Mechanisms of Differentiation and Function
- (2007) Steven Z. Josefowicz et al. Annual Review of Immunology
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