Peripherally Induced Regulatory T Cells: Recruited Protectors of the Central Nervous System against Autoimmune Neuroinflammation

The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets

(2017) Bertrand Allard et al.   IMMUNOLOGICAL REVIEWS

Dendritic cells tip the balance towards induction of regulatory T cells upon priming in experimental autoimmune encephalomyelitis

(2017) Magdalena Paterka et al.   JOURNAL OF AUTOIMMUNITY

Diversity of immune cell types in multiple sclerosis and its animal model: Pathological and therapeutic implications

(2017) Yun Cheng et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Selective depletion of CD11c+CD11b+dendritic cells partially abrogates tolerogenic effects of intravenous MOG in murine EAE

(2016) Limei Wang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Immunomodulatory Functions of BTLA and HVEM Govern Induction of Extrathymic Regulatory T Cells and Tolerance by Dendritic Cells

(2016) Andrew Jones et al.   IMMUNITY

Functions of Murine Dendritic Cells

(2016) Vivek Durai et al.   IMMUNITY

Regulatory B Cells Induce Formation of IL-10-Expressing T Cells in Mice with Autoimmune Neuroinflammation

(2016) Andrea Pennati et al.   JOURNAL OF NEUROSCIENCE

Targeting Non-classical Myelin Epitopes to Treat Experimental Autoimmune Encephalomyelitis

(2016) Xiaohua Wang et al.   Scientific Reports

Targeting Treg signaling for the treatment of autoimmune diseases

(2015) Allyson Spence et al.   CURRENT OPINION IN IMMUNOLOGY

Thymus-derived regulatory T cells restrain pro-inflammatory Th1 responses by downregulating CD70 on dendritic cells

(2015) M. Dhainaut et al.   EMBO JOURNAL

CD5 Instructs Extrathymic Regulatory T Cell Development in Response to Self and Tolerizing Antigens

(2015) Jacob G. Henderson et al.   IMMUNITY

TIGIT predominantly regulates the immune response via regulatory T cells

(2015) Sema Kurtulus et al.   JOURNAL OF CLINICAL INVESTIGATION

Peripherally Induced Tolerance Depends on Peripheral Regulatory T Cells That Require Hopx To Inhibit Intrinsic IL-2 Expression

(2015) Andrew Jones et al.   JOURNAL OF IMMUNOLOGY

Cell-Based Modulation of Autoimmune Responses in Multiple Sclerosis and Experimental Autoimmmune Encephalomyelitis: Therapeutic Implications

(2015) Vasileios Mastorodemos et al.   NEUROIMMUNOMODULATION

Multiple Sclerosis

(2014) Daniel M. Harrison   ANNALS OF INTERNAL MEDICINE

Fluorochrome-based definition of naturally occurring Foxp3+regulatory T cells of intra- and extrathymic origin

(2014) Cathleen Petzold et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Enhanced suppressor function of TIM-3+FoxP3+regulatory T cells

(2014) Anne-Sophie Gautron et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Treg Cells Expressing the Coinhibitory Molecule TIGIT Selectively Inhibit Proinflammatory Th1 and Th17 Cell Responses

(2014) Nicole Joller et al.   IMMUNITY

Continuous T Cell Receptor Signals Maintain a Functional Regulatory T Cell Pool

(2014) J. Christoph Vahl et al.   IMMUNITY

Regulatory T cells in autoimmune neuroinflammation

(2014) Markus Kleinewietfeld et al.   IMMUNOLOGICAL REVIEWS

tTregs, pTregs, and iTregs: similarities and differences

(2014) Ethan M. Shevach et al.   IMMUNOLOGICAL REVIEWS

Natural Naive CD4 + CD25 + CD127 low Regulatory T Cell (Treg) Development and Function Are Disturbed in Multiple Sclerosis Patients: Recovery of Memory Treg Homeostasis during Disease Progression

(2014) Koen Venken et al.   JOURNAL OF IMMUNOLOGY

CD8+CD205+ Splenic Dendritic Cells Are Specialized to Induce Foxp3+ Regulatory T Cells

(2014) S. Yamazaki et al.   JOURNAL OF IMMUNOLOGY

Regulatory T Cells Inhibit Dendritic Cells by Lymphocyte Activation Gene-3 Engagement of MHC Class II

(2014) Bitao Liang et al.   JOURNAL OF IMMUNOLOGY

Self-antigen-Driven Activation Induces Instability of Regulatory T Cells during an Inflammatory Autoimmune Response

(2013) Samantha L. Bailey-Bucktrout et al.   IMMUNITY

T Cell-Positive Selection Uses Self-Ligand Binding Strength to Optimize Repertoire Recognition of Foreign Antigens

(2013) Judith N. Mandl et al.   IMMUNITY

Promotion and prevention of autoimmune disease by CD8+ T cells

(2013) David M. Gravano et al.   JOURNAL OF AUTOIMMUNITY

Specialized role of migratory dendritic cells in peripheral tolerance induction

(2013) Juliana Idoyaga et al.   JOURNAL OF CLINICAL INVESTIGATION

Fine-Tuning of Regulatory T Cell Function: The Role of Calcium Signals and Naive Regulatory T Cells for Regulatory T Cell Deficiency in Multiple Sclerosis

(2013) A. Schwarz et al.   JOURNAL OF IMMUNOLOGY

Targeting of Autoantigens to DEC205+ Dendritic Cells In Vivo Suppresses Experimental Allergic Encephalomyelitis in Mice

(2013) S. Ring et al.   JOURNAL OF IMMUNOLOGY

IL-2/Anti-IL-2 Complex Attenuates Renal Ischemia-Reperfusion Injury through Expansion of Regulatory T Cells

(2013) M.-G. Kim et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

(2013) Ashley H Beecham et al.   NATURE GENETICS

IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39

(2013) Ivan D Mascanfroni et al.   NATURE IMMUNOLOGY

Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3+ regulatory T cells

(2013) Wim Pierson et al.   NATURE IMMUNOLOGY

Regulatory T cell proliferative potential is impaired in human autoimmune disease

(2013) Fortunata Carbone et al.   NATURE MEDICINE

Modeling the heterogeneity of multiple sclerosis in animals

(2013) Sarah B. Simmons et al.   TRENDS IN IMMUNOLOGY

Interleukin-2, Interleukin-7, T cell-mediated autoimmunity, and N-glycosylation

(2012) Ani Grigorian et al.   Annals of the New York Academy of Sciences

Decisions About Dendritic Cells: Past, Present, and Future

(2012) Ralph M. Steinman   Annual Review of Immunology

Pathogenic and regulatory roles for B cells in experimental autoimmune encephalomyelitis

(2012) Monica K. Mann et al.   AUTOIMMUNITY

Extrathymic Generation of Regulatory T Cells in Placental Mammals Mitigates Maternal-Fetal Conflict

(2012) Robert M. Samstein et al.   CELL

FOXP3,CBLBandITCHgene expression and cytotoxic T lymphocyte antigen 4 expression on CD4+CD25highT cells in multiple sclerosis

(2012) F. Sellebjerg et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

CD73 is a phenotypic marker of effector memory Th17 cells in inflammatory bowel disease

(2012) Glen A. Doherty et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Dendritic Cells Ameliorate Autoimmunity in the CNS by Controlling the Homeostasis of PD-1 Receptor+ Regulatory T Cells

(2012) Nir Yogev et al.   IMMUNITY

Regulatory T cells in the central nervous system

(2012) Daniel E. Lowther et al.   IMMUNOLOGICAL REVIEWS

Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs

(2012) Shipra Gupta et al.   JOURNAL OF CLINICAL INVESTIGATION

The TIGIT/CD226 Axis Regulates Human T Cell Function

(2012) E. Lozano et al.   JOURNAL OF IMMUNOLOGY

Extrathymically generated regulatory T cells control mucosal TH2 inflammation

(2012) Steven Z. Josefowicz et al.   NATURE

Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis

(2012) Daniel R Getts et al.   NATURE BIOTECHNOLOGY

The immunomodulatory properties of the CD5 lymphocyte receptor in health and disease

(2011) Gloria Soldevila et al.   CURRENT OPINION IN IMMUNOLOGY

A Requisite Role for Induced Regulatory T Cells in Tolerance Based on Expanding Antigen Receptor Diversity

(2011) Dipica Haribhai et al.   IMMUNITY

Increased Frequencies of Myelin Oligodendrocyte Glycoprotein/MHC Class II-Binding CD4 Cells in Patients with Multiple Sclerosis

(2011) K. Raddassi et al.   JOURNAL OF IMMUNOLOGY

Tolerance Induced by Apoptotic Antigen-Coupled Leukocytes Is Induced by PD-L1+ and IL-10-Producing Splenic Macrophages and Maintained by T Regulatory Cells

(2011) D. R. Getts et al.   JOURNAL OF IMMUNOLOGY

Peripheral education of the immune system by colonic commensal microbiota

(2011) Stephanie K. Lathrop et al.   NATURE

Identification of T helper type 1–like, Foxp3+ regulatory T cells in human autoimmune disease

(2011) Margarita Dominguez-Villar et al.   NATURE MEDICINE

Neuropilin-1 attenuates autoreactivity in experimental autoimmune encephalomyelitis

(2011) Benjamin D. Solomon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Regulatory T Cells Rapidly Suppress T Cell Receptor-Induced Ca2+, NF- B, and NFAT Signaling in Conventional T Cells

(2011) A. Schmidt et al.   Science Signaling

Type 1 regulatory T cells (Tr1) in autoimmunity

(2011) Caroline Pot et al.   SEMINARS IN IMMUNOLOGY

Expression of CD39 by Human Peripheral Blood CD4+CD25+ T Cells Denotes a Regulatory Memory Phenotype

(2010) K. M. Dwyer et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity

(2010) Thomas R. Malek et al.   IMMUNITY

TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo

(2010) Rachel A. Gottschalk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The transcription cofactor Hopx is required for regulatory T cell function in dendritic cell–mediated peripheral T cell unresponsiveness

(2010) Daniel Hawiger et al.   NATURE IMMUNOLOGY

Promoting tolerance to proteolipid protein-induced experimental autoimmune encephalomyelitis through targeting dendritic cells

(2010) J. N. H. Stern et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo expansion of T reg cells with IL-2–mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression

(2009) Kylie E. Webster et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Feedback control of regulatory T cell homeostasis by dendritic cells in vivo

(2009) Guillaume Darrasse-Jèze et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

(2009) Loise M. Francisco et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity

(2009) Caspar Ohnmacht et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD39+Foxp3+ Regulatory T Cells Suppress Pathogenic Th17 Cells and Are Impaired in Multiple Sclerosis

(2009) J. M. Fletcher et al.   JOURNAL OF IMMUNOLOGY

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

(2009) Xuyu Zhou et al.   NATURE IMMUNOLOGY

Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal

(2009) Brian T Fife et al.   NATURE IMMUNOLOGY

Toll-like receptor 2–dependent induction of vitamin A–metabolizing enzymes in dendritic cells promotes T regulatory responses and inhibits autoimmunity

(2009) Santhakumar Manicassamy et al.   NATURE MEDICINE

IFN-β regulates CD73 and adenosine expression at the blood-brain barrier

(2008) Jussi Niemelä et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Adaptive Foxp3+ Regulatory T Cell-Dependent and -Independent Control of Allergic Inflammation

(2008) Maria A. Curotto de Lafaille et al.   IMMUNITY

Contextual Regulation of Inflammation: A Duet by Transforming Growth Factor-β and Interleukin-10

(2008) Ming O. Li et al.   IMMUNITY

Neuropilin-1 Expression on Regulatory T Cells Enhances Their Interactions with Dendritic Cells during Antigen Recognition

(2008) Milka Sarris et al.   IMMUNITY

Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction

(2008) Qizhi Tang et al.   IMMUNITY

Human regulatory T cells: role in autoimmune disease and therapeutic opportunities

(2008) Todd M. Brusko et al.   IMMUNOLOGICAL REVIEWS

Regulatory T cells fail to suppress CD4+ T-bet+T cells in relapsing multiple sclerosis patients

(2008) Giovanni Frisullo et al.   IMMUNOLOGY

Foxp3+ regulatory T cells in the control of experimental CNS autoimmune disease

(2008) Richard A. O'Connor et al.   JOURNAL OF NEUROIMMUNOLOGY

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET

CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease

(2008) Husein Hadeiba et al.   NATURE IMMUNOLOGY

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

(2008) Xin Yu et al.   NATURE IMMUNOLOGY

Disease-modifying therapy in multiple sclerosis: Update and clinical implications

(2008) D. S. Goodin   NEUROLOGY

Programmed death 1 ligand signaling regulates the generation of adaptive Foxp3+CD4+ regulatory T cells

(2008) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CTLA-4 Control over Foxp3+ Regulatory T Cell Function

(2008) K. Wing et al.   SCIENCE

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology

Compromised CD4+ CD25highregulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 expression at the single-cell level

(2007) Koen Venken et al.   IMMUNOLOGY