Journal
JOURNAL OF NEUROSCIENCE RESEARCH
Volume 95, Issue 10, Pages 1973-1983Publisher
WILEY
DOI: 10.1002/jnr.24023
Keywords
multiple sclerosis; EAE; T cells; B cells; macrophage; tolerogenic dendritic cells; stem cells
Categories
Funding
- General Program of the National Natural Science Foundation of China [81671177, 81471216]
- China Scholarship Council [201600160072]
- International Science and Technology Cooperation Program of Jilin Provincial Science and Technology Development of China [20150414011GH]
- Technology Innovation Program of Jilin Provincial Health and Family Planning Commission of China [2010040]
- Norman Bethune Cultivation Plan of pin University [2015320]
- Science and Technology Program of Jilin Provincial Education Department of China [2016-462]
- Swedish Research Council [K2013-66X-22337-01-3, 2015-03005]
- First hospital, Jilin University of China
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Multiple sclerosis (MS) is an inflammatory, dennyelinating disease of the central nervous system with an autoimmune attack on the components of the myelin sheath and axons. The etiology of the disease remains largely unknown, but it is commonly acknowledged that the development of MS probably results from the interaction of environmental factors in conjunction with a genetic predisposition. Current therapeutic approaches can only ameliorate the clinical symptoms or reduce the frequency of relapse in MS. Most drugs used in this disease broadly suppress the functions of immune effector cells, which can result in serious side effects. Thus, new therapeutic methods resulting in greater efficacy and lower toxicity are needed. Toward this end, cell based therapies are of increasing interest in the treatment of MS. Several innmunoregulatory cell types, including regulatory T cells, regulatory B cells, M2 macrophages, tolerogenic dendritic cells, and stem cells, have been developed as novel therapeutic tools for the treatment of MS. In this Review, we summarize studies on the application of these cell populations for the treatment of MS and its animal model, experimental autoimmune encephalomyelitis, and call for further research on applications and mechanisms by which these cells act in the treatment of MS. (C) 2017 The Authors Journal of Neuroscience Research Published by Wiley Periodicals, Inc.
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