Mild chronic obstructive pulmonary disease: why spirometry is not sufficient!

Ventilation Heterogeneity in Never-smokers and COPD:

(2016) Christopher Davis et al.   ACADEMIC RADIOLOGY

Association between Functional Small Airway Disease and FEV1Decline in Chronic Obstructive Pulmonary Disease

(2016) Surya P. Bhatt et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A Novel Spirometric Measure Identifies Mild COPD Unidentified by Standard Criteria

(2016) Asli Gorek Dilektasli et al.   CHEST

Measuring Airway Remodeling in Patients With Different COPD Staging Using Endobronchial Optical Coherence Tomography

(2016) Ming Ding et al.   CHEST

Mechanisms of exertional dyspnoea in symptomatic smokers without COPD

(2016) Amany F. Elbehairy et al.   EUROPEAN RESPIRATORY JOURNAL

Muscular Dysfunction in COPD: Systemic Effect or Deconditioning?

(2016) Eulogio Pleguezuelos et al.   LUNG

Clinical Significance of Symptoms in Smokers with Preserved Pulmonary Function

(2016) Prescott G. Woodruff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Asymptomatic subjects with airway obstruction have significant impairment at exercise

(2016) Thibaud Soumagne et al.   THORAX

Persistence of circulating endothelial microparticles in COPD despite smoking cessation

(2016) Yael Strulovici-Barel et al.   THORAX

Roflumilast: a review of its use in the treatment of COPD

(2016) Jadwiga Wedzicha et al.   International Journal of Chronic Obstructive Pulmonary Disease

Asthma Worsenings: Approaches to Prevention and Management from the Asthma Worsenings Working Group

(2016) Meyer Balter et al.   Canadian Respiratory Journal

Pulmonary Gas Exchange Abnormalities in Mild Chronic Obstructive Pulmonary Disease. Implications for Dyspnea and Exercise Intolerance

(2015) Amany F. Elbehairy et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Exercise Limitation in Chronic Obstructive Pulmonary Disease. The O’Donnell Threshold

(2015) Richard Casaburi et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pulmonary Microvascular Blood Flow in Mild Chronic Obstructive Pulmonary Disease and Emphysema. The MESA COPD Study

(2015) Katja Hueper et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Clinical Relevance of Fixed Ratio vs Lower Limit of Normal of FEV1/FVC in COPD: Patient-Reported Outcomes From the CanCOLD Cohort

(2015) W. van Dijk et al.   ANNALS OF FAMILY MEDICINE

Physiologic Characterization of the Chronic Bronchitis Phenotype in GOLD Grade IB COPD

(2015) Amany F. Elbehairy et al.   CHEST

Risk of COPD with obstruction in active smokers with normal spirometry and reduced diffusion capacity

(2015) Ben-Gary Harvey et al.   EUROPEAN RESPIRATORY JOURNAL

COPD: Do Imaging Measurements of Emphysema and Airway Disease Explain Symptoms and Exercise Capacity?

(2015) Miranda Kirby et al.   RADIOLOGY

Clinical and Radiologic Disease in Smokers With Normal Spirometry

(2015) Elizabeth A. Regan et al.   JAMA Internal Medicine

Prevalence of quadriceps muscle weakness in patients with COPD and its association with disease severity

(2015) Kharbanda et al.   International Journal of Chronic Obstructive Pulmonary Disease

Pulmonary hemodynamic profile in chronic obstructive pulmonary disease

(2015) Karina Portillo et al.   International Journal of Chronic Obstructive Pulmonary Disease

Global and regional estimates of COPD prevalence: Systematic review and meta–analysis

(2015) Davies Adeloye et al.   Journal of Global Health

Impulse Oscillometry

(2014) Scott Bickel et al.   CHEST

Dynamic Contrast Enhanced Magnetic Resonance Perfusion Imaging in High-Risk Smokers and Smoking-Related COPD: Correlations with Pulmonary Function Tests and Quantitative Computed Tomography

(2014) Yi Xia et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Mechanisms of exercise intolerance in Global Initiative for Chronic Obstructive Lung Disease grade 1 COPD

(2014) J. A. Guenette et al.   EUROPEAN RESPIRATORY JOURNAL

Exercise ventilatory inefficiency in mild to end-stage COPD

(2014) J. Alberto Neder et al.   EUROPEAN RESPIRATORY JOURNAL

The Continuum of Physiological Impairment during Treadmill Walking in Patients with Mild-to-Moderate COPD: Patient Characterization Phase of a Randomized Clinical Trial

(2014) Denis E. O’Donnell et al.   PLoS One

Estimating population prevalence of potential airflow obstruction using different spirometric criteria: a pooled cross-sectional analysis of persons aged 40-95 years in England and Wales

(2014) S. Scholes et al.   BMJ Open

Computed Tomographic Measures of Pulmonary Vascular Morphology in Smokers and Their Clinical Implications

(2013) Raúl San José Estépar et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Does the Respiratory System Limit Exercise in Mild Chronic Obstructive Pulmonary Disease?

(2013) Roberto C. Chin et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Endothelial Microparticles in Mild Chronic Obstructive Pulmonary Disease and Emphysema. The Multi-Ethnic Study of Atherosclerosis Chronic Obstructive Pulmonary Disease Study

(2013) Michael A. Thomashow et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Percent Emphysema and Right Ventricular Structure and Function

(2013) Maria Grau et al.   CHEST

High-Dose N-Acetylcysteine in Stable COPD

(2013) Hoi Nam Tse et al.   CHEST

Pulmonary Hyperinflation and Left Ventricular Mass

(2013) Benjamin M. Smith et al.   CIRCULATION

Pulmonary Rehabilitation for Mild COPD: A Systematic Review

(2013) C. Jacome et al.   Respiratory Care

Impact of emphysema and airway wall thickness on quality of life in smoking-related COPD

(2013) Hester A. Gietema et al.   RESPIRATORY MEDICINE

CT and physiologic determinants of dyspnea and exercise capacity during the six-minute walk test in mild COPD

(2013) Alejandro A. Díaz et al.   RESPIRATORY MEDICINE

Fixed ratio or lower limit of normal as cut-off value for FEV1/VC: An outcome study

(2013) Per Wollmer et al.   RESPIRATORY MEDICINE

Estimating the U.S. prevalence of chronic obstructive pulmonary disease using pre- and post-bronchodilator spirometry: the National Health and Nutrition Examination Survey (NHANES) 2007–2010

(2013) Timothy Tilert et al.   RESPIRATORY RESEARCH

On the role of abnormal DLCOin ex-smokers without airflow limitation: symptoms, exercise capacity and hyperpolarised helium-3 MRI

(2013) Miranda Kirby et al.   THORAX

Capability of differentiating smokers with normal pulmonary function from COPD patients: a comparison of CT pulmonary volume analysis and MR perfusion imaging

(2012) Li Fan et al.   EUROPEAN RADIOLOGY

Haemodynamic responses to exercise in patients with COPD

(2012) Janne Mykland Hilde et al.   EUROPEAN RESPIRATORY JOURNAL

Multi-ethnic reference values for spirometry for the 3–95-yr age range: the global lung function 2012 equations

(2012) Philip H. Quanjer et al.   EUROPEAN RESPIRATORY JOURNAL

Pathogenesis of chronic obstructive pulmonary disease

(2012) Rubin M. Tuder et al.   JOURNAL OF CLINICAL INVESTIGATION

Walking exercise response to bronchodilation in mild COPD: A randomized trial

(2012) Philippe Gagnon et al.   RESPIRATORY MEDICINE

"GOLD or lower limit of normal definition? a comparison with expert-based diagnosis of chronic obstructive pulmonary disease in a prospective cohort-study"

(2012) Gülmisal Güder et al.   RESPIRATORY RESEARCH

Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease

(2012) Carlos H Martinez et al.   THORAX

New Models of Pulmonary Hypertension Based on VEGF Receptor Blockade-Induced Endothelial Cell Apoptosis

(2012) Mark R. Nicolls et al.   Pulmonary Circulation

Assessment of the right ventricular function in patients with chronic obstructive pulmonary disease using MRI

(2011) Yan Gao et al.   ACTA RADIOLOGICA

Evolution of Dyspnea during Exercise in Chronic Obstructive Pulmonary Disease

(2011) Pierantonio Laveneziana et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Circulating Endothelial Microparticles as a Measure of Early Lung Destruction in Cigarette Smokers

(2011) Cynthia Gordon et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Inducible NOS Inhibition Reverses Tobacco-Smoke-Induced Emphysema and Pulmonary Hypertension in Mice

(2011) Michael Seimetz et al.   CELL

Six-Minute Walk Distance Predictors, Including CT Scan Measures, in the COPDGene Cohort

(2011) Mehdi Rambod et al.   CHEST

Co-morbidity in Mild-to-Moderate COPD: Comparison to Normal and Restrictive Lung Function

(2011) Anne Lindberg et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Effects of cigarette smoke and hypoxia on pulmonary circulation in the guinea pig

(2011) E. Ferrer et al.   EUROPEAN RESPIRATORY JOURNAL

Determinants of Spirometry Use and Accuracy of COPD Diagnosis in Primary Care

(2011) Min J Joo et al.   JOURNAL OF GENERAL INTERNAL MEDICINE

Small-Airway Obstruction and Emphysema in Chronic Obstructive Pulmonary Disease

(2011) John E. McDonough et al.   NEW ENGLAND JOURNAL OF MEDICINE

Changes in Forced Expiratory Volume in 1 Second over Time in COPD

(2011) Jørgen Vestbo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Respiratory system impedance with impulse oscillometry in healthy and COPD subjects: ECLIPSE baseline results

(2011) Courtney Crim et al.   RESPIRATORY MEDICINE

Sex differences in exertional dyspnea in patients with mild COPD: Physiological mechanisms

(2011) Jordan A. Guenette et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Abdominal fat mass contributes to the systemic inflammation in chronic obstructive pulmonary disease

(2010) Erica P.A. Rutten et al.   CLINICAL NUTRITION

Lung Hyperinflation and Its Reversibility in Patients with Airway Obstruction of Varying Severity

(2010) Athavudh Deesomchok et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

CT Emphysema Predicts Thoracic Aortic Calcification in Smokers with and Without COPD

(2010) Mark T. Dransfield et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Prevalence of airflow obstruction in smokers and never-smokers in Switzerland

(2010) P.-O. Bridevaux et al.   EUROPEAN RESPIRATORY JOURNAL

Prioritised research agenda for prevention and control of chronic respiratory diseases

(2010) J. Bousquet et al.   EUROPEAN RESPIRATORY JOURNAL

Percent Emphysema, Airflow Obstruction, and Impaired Left Ventricular Filling

(2010) R. Graham Barr et al.   NEW ENGLAND JOURNAL OF MEDICINE

Quantitative CT Assessment of Chronic Obstructive Pulmonary Disease

(2010) Shin Matsuoka et al.   RADIOGRAPHICS

Sub-clinical left and right ventricular dysfunction in patients with COPD

(2010) Ramsey Sabit et al.   RESPIRATORY MEDICINE

Relationship of emphysema and airway disease assessed by CT to exercise capacity in COPD

(2010) Alejandro A. Diaz et al.   RESPIRATORY MEDICINE

Quantitative Computed Tomography Measures of Emphysema and Airway Wall Thickness Are Related to Respiratory Symptoms

(2009) Thomas B. Grydeland et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Hyperpolarized 3He magnetic resonance imaging: Preliminary evaluation of phenotyping potential in chronic obstructive pulmonary disease

(2009) Lindsay Mathew et al.   EUROPEAN JOURNAL OF RADIOLOGY

The prevalence of quadriceps weakness in COPD and the relationship with disease severity

(2009) J. M. Seymour et al.   EUROPEAN RESPIRATORY JOURNAL

Ventilation-perfusion imbalance and chronic obstructive pulmonary disease staging severity

(2009) Roberto Rodríguez-Roisin et al.   JOURNAL OF APPLIED PHYSIOLOGY

Effect of tiotropium on outcomes in patients with moderate chronic obstructive pulmonary disease (UPLIFT): a prespecified subgroup analysis of a randomised controlled trial

(2009) Marc Decramer et al.   LANCET

Prediction of the rate of decline in FEV1 in smokers using quantitative computed tomography

(2009) R Yuan et al.   THORAX

Airflow Limitation in Smokers Is Associated with Subclinical Atherosclerosis

(2008) Hiroshi Iwamoto et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Skeletal muscle capillarization and oxidative metabolism in healthy smokers

(2008) Rob C.I. Wüst et al.   Applied Physiology Nutrition and Metabolism

Peripheral Muscle Alterations in Non-COPD Smokers

(2008) Maria Montes de Oca et al.   CHEST

Pulmonary Vascular Involvement in COPD

(2008) Víctor I. Peinado et al.   CHEST

Diaphragm electromyography using an oesophageal catheter: current concepts

(2008) Yuan Ming Luo et al.   CLINICAL SCIENCE

COPD as a Systemic Disease

(2008) Àlvar Agusti et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Validity of apparent diffusion coefficient hyperpolarized 3He-MRI using MSCT and pulmonary function tests as references

(2008) Sandra Diaz et al.   EUROPEAN JOURNAL OF RADIOLOGY

Current clinical guideline definitions of airflow obstruction and COPD overdiagnosis in primary care

(2008) T. R. J. Schermer et al.   EUROPEAN RESPIRATORY JOURNAL

Autonomic and cerebrovascular abnormalities in mild COPD are worsened by chronic smoking

(2008) L. Bernardi et al.   EUROPEAN RESPIRATORY JOURNAL

Physical activity in patients with COPD

(2008) H. Watz et al.   EUROPEAN RESPIRATORY JOURNAL

Pulmonary hypertension in COPD

(2008) A. Chaouat et al.   EUROPEAN RESPIRATORY JOURNAL

Under-diagnosis of chronic obstructive pulmonary disease: A qualitative study in primary care

(2008) Julia A. Walters et al.   RESPIRATORY MEDICINE

Long-term decline in lung function, utilisation of care and quality of life in modified GOLD stage 1 COPD

(2008) P-O Bridevaux et al.   THORAX

Using the lower limit of normal for the FEV1/FVC ratio reduces the misclassification of airway obstruction

(2008) M P Swanney et al.   THORAX

Evaluation of acute bronchodilator reversibility in patients with symptoms of GOLD stage I COPD

(2008) D E O'Donnell et al.   THORAX

Extrapulmonary Effects of Chronic Obstructive Pulmonary Disease on Physical Activity

(2007) Henrik Watz et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mechanisms of Dyspnea during Cycle Exercise in Symptomatic Patients with GOLD Stage I Chronic Obstructive Pulmonary Disease

(2007) Dror Ofir et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE