Article
Critical Care Medicine
Helen K. Reddel, Leonard B. Bacharier, Eric D. Bateman, Christopher E. Brightling, Guy G. Brusselle, Roland Buhl, Alvaro A. Cruz, Liesbeth Duijts, Jeffrey M. Drazen, J. Mark FitzGerald, Louise J. Fleming, Hiromasa Inoue, Fanny W. Ko, Jerry A. Krishnan, Mark L. Levy, Jiangtao Lin, Kevin Mortimer, Paulo M. Pitrez, Aziz Sheikh, Arzu A. Yorgancioglu, Louis-Philippe Boulet
Summary: The article summarizes key recommendations from GINA 2021 and the recent changes, highlighting the importance of not relying solely on short-acting beta(2)-agonists for asthma treatment and provides targeted treatment suggestions based on severity and age.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Respiratory System
Helen K. Reddel, Leonard B. Bacharier, Eric D. Bateman, Christopher E. Brightling, Guy G. Brusselle, Roland Buhl, Alvaro A. Cruz, Liesbeth Duijts, Jeffrey M. Drazen, J. Mark FitzGerald, Louise J. Fleming, Hiromasa Inoue, Fanny W. Ko, Jerry A. Krishnan, Mark L. Levy, Jiangtao Lin, Kevin Mortimer, Paulo M. Pitrez, Aziz Sheikh, Arzu A. Yorgancioglu, Louis-Philippe Boulet
Summary: The GINA 2021 Strategy Report provides updated evidence-based recommendations for managing and preventing asthma, including the use of ICS-formoterol as a reliever and additional recommendations for moderate-to-severe asthma. It also introduces new treatment options for children aged 6-11. Regular personalized assessment, modifiable risk factor treatment, self-management education, and appropriate medication adjustment are highlighted as essential for optimizing asthma outcomes.
Article
Allergy
Helen K. Reddel, Leonard B. Bacharier, Eric D. Bateman, Christopher E. Brightling, Guy G. Brusselle, Roland Buhl, Alvaro A. Cruz, Liesbeth Duijts, Jeffrey M. Drazen, J. Mark FitzGerald, Louise J. Fleming, Hiromasa Inoue, Fanny W. Ko, Jerry A. Krishnan, Mark L. Levy, Jiangtao Lin, Kevin Mortimer, Paulo M. Pitrez, Aziz Sheikh, Arzu A. Yorgancioglu, Louis-Philippe Boulet
Summary: The GINA 2021 report provides evidence-based recommendations for asthma management, emphasizing the benefits of inhaled corticosteroids (ICS) and recommending the use of combination ICS-formoterol in two different tracks. Additional recommendations are provided for adults with moderate-to-severe asthma, with options for add-on therapies such as long-acting muscarinic antagonists and azithromycin. Regular personalized assessment and treatment adjustments are essential across all age groups and severity levels to optimize asthma outcomes.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Computer Science, Artificial Intelligence
Zhibang Yang, Xu Zhou, Kenli Li, Yunjun Gao, Keqin Li
Summary: The GSky query aims to report optimal groups that are not dominated by any other group of the same size, making it more practical compared to traditional group skyline queries. However, the GSky query often returns too many results, making it difficult for users to pick their expected results. To address this, a flexible G-Skyline (FGSky) query is proposed to directly compute optimal groups and provide effective pruning strategies.
KNOWLEDGE AND INFORMATION SYSTEMS
(2021)
Article
Medicine, General & Internal
Philip C. M. Au, Kathryn C. B. Tan, David C. L. Lam, Bernard M. Y. Cheung, Ian C. K. Wong, Wang Chun Kwok, Chor-Wing Sing, Ching-Lung Cheung
Summary: This retrospective cohort study found that among patients with type 2 diabetes in Hong Kong, the use of sodium-glucose cotransporter 2 inhibitors (SGLT2Is) was associated with a reduced risk of incident obstructive airway disease (OAD) and a lower rate of exacerbations compared with the use of dipeptidyl peptidase-4 inhibitors (DPP4Is) in clinical practice.
Article
Engineering, Industrial
Ann Marie Dale, Marco Barrera, Ryan Colvin, Jaime Strickland, Bradley A. Evanoff
Summary: The study found that general contractors with exemplary safety programs have a positive impact on the safety climate and safety behaviors of workers. Smaller subcontractors typically have fewer safety elements, so many small subcontractors need to adopt more safety policies and practices to work for general contractors.
Article
Biochemistry & Molecular Biology
Ayazoddin Aunoddin Kazi, B. V. Subba Reddy, L. Ravithej Singh
Summary: Respiratory infections caused by pulmonary inflammation are a leading cause of death worldwide, yet only twenty-seven new drugs have been approved in the past fifty years. This review outlines synthetic approaches and mode of action for these FDA-approved medications used to treat asthma and COPD.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Vasile Valeriu Lupu, Elena Jechel, Silvia Fotea, Ionela Daniela Morariu, Iuliana Magdalena Starcea, Alice Azoicai, Adriana Mocanu, Elena Cristina Mitrofan, Ancuta Lupu, Dragos Munteanu, Minerva Codruta Badescu, Magdalena Cuciureanu, Ileana Ioniuc
Summary: This article discusses the challenges of managing asthma during adolescence, including individualized therapy, compliance control, social integration, and the importance of communication in monitoring the condition. Currently, there is an increasing morbidity and mortality among children with asthma, highlighting the need for better symptom control and maintenance of quality of life.
Review
Oncology
Evangelos Terpos, Elena Zamagni, Suzanne Lentzsch, Matthew T. Drake, Ramon Garcia-Sanz, Niels Abildgaard, Ioannis Ntanasis-Stathopoulos, Fredrik Schjesvold, Javier de la Rubia, Charalampia Kyriakou, Jens Hillengass, Sonja Zweegman, Michele Cavo, Philippe Moreau, Jesus San-Miguel, Meletios A. Dimopoulos, Nikhil Munshi, Brian G. M. Durie, Noopur Raje
Summary: The Bone Working Group of the International Myeloma Working Group recommends the use of zoledronic acid as the preferred bone-targeted agent for patients with newly diagnosed multiple myeloma. Denosumab can be considered for patients with renal impairment. Cement augmentation is effective for painful vertebral compression fractures.
Article
Environmental Studies
Amy Garbett, Natasha D. Phillips, Jonathan D. R. Houghton, Paulo Prodohl, James Thorburn, Sophie L. Loca, Lawrence E. Eagling, Gary Hannon, Daniel Wise, Liz Pothanikat, Cat Gordon, Maurice Clarke, Peter Williams, Rebecca Hunter, Ronan McShane, Aafke Brader, Jane Dodd, Chris McGonigle, Heidi McIlvenny, Olivia Daly, Ronald Surgenor, Sarah Varian, Peter Verhoog, Gijs Van Zonneveld, Lylian R. Burke, Ian Davies, Terri A. Souster, Paul A. Mayo, Tanja N. Schwanck, Catherine S. Jones, Patrick C. Collins
Summary: The flapper skate, a large European skate species, has been classified as Critically Endangered and efforts have been made to establish the Flapper Skate Working Group (SWG) to support conservation initiatives. Comprising government, NGOs, sport-fishing associates, and academics, the SWG aims to consolidate expertise for the conservation of the species. The first SWG workshop held in Belfast in 2019 focused on conservation efforts in the North-East Atlantic region and produced key recommendations for collaborative conservation in the future.
Editorial Material
Oncology
Sharon L. Manne, Cheryl L. Knott, Ann Berger, Victoria L. Champion, Elizabeth Chrischilles, Marian L. Fitzgibbon, Anita Y. Kinney, Eugene J. Lengerich, Sarah H. Nash, Melissa A. Simon, Amy Trentham-Dietz, Electra D. Paskett
Summary: In 2021, the NCI issued updated guidance clarifying the mission of cancer centers in addressing the cancer burden of the catchment area (CA) and partnering with the community to reduce the cancer burden. This paper discusses the approaches to implementing these guidelines and the impact of these efforts on the burden of cancer in respective CAs. The authors also highlight the challenge of implementing the new guidelines and hope to foster cross-center collaborations for effective reduction of the cancer burden in the US.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Respiratory System
Helen K. Reddel, Leonard B. Bacharier, Eric D. Bateman, Christopher E. Brightling, Guy G. Brusselle, Roland Buhl, Alvaro A. Cruz, Liesbeth Duijts, Jeffrey M. Drazen, J. Mark FitzGerald, Louise J. Fleming, Hiromasa Inoue, Fanny W. Ko, Jerry A. Krishnan, Mark L. Levy, Jiangtao Lin, Kevin Mortimer, Paulo M. Pitrez, Aziz Sheikh, Arzu A. Yorgancioglu, Louis-Philippe Boulet
Summary: The Global Initiative for Asthma (GINA) Strategy Report provides clinicians with an evidence-based strategy for asthma management and prevention, emphasizing the importance of regular personalized assessment, treatment of modifiable risk factors, self-management education, and appropriate medication adjustment for optimizing asthma outcomes.
ARCHIVOS DE BRONCONEUMOLOGIA
(2022)
Article
Cardiac & Cardiovascular Systems
Victor Aboyans, Rupert Bauersachs, Lucia Mazzolai, Marianne Brodmann, Jose F. Rodriguez Palomares, Sebastian Debus, Jean-Philippe Collet, Heinz Drexel, Christine Espinola-Klein, Basil S. Lewis, Marco Roffi, Dirk Sibbing, Henrik Sillesen, Eugenio Stabile, Oliver Schlager, Marco De Carlo
Summary: The collaborative document aims to update clinicians on optimal antithrombotic strategies for patients with aortic and/or peripheral arterial diseases. It highlights the importance of a regular reassessment of antithrombotic therapy based on individual patient's ischaemic and bleeding risks, as well as therapeutic paths.
EUROPEAN HEART JOURNAL
(2021)
Article
Health Care Sciences & Services
Ye Ye, Seemran Barapatre, Michael K. Davis, Keith O. Elliston, Christos Davatzikos, Andrey Fedorov, Jean-Christophe Fillion-Robin, Ian Foster, John R. Gilbertson, Andras Lasso, James Miller, Martin Morgan, Steve Pieper, Brigitte E. Raumann, Brion D. Sarachan, Guergana Savova, Jonathan C. Silverstein, Donald P. Taylor, Joyce B. Zelnis, Guo-Qiang Zhang, Jamie Cuticchia, Michael J. Becich
Summary: The SIP-WG was tasked with investigating options for enhancing the long-term sustainability of OSS developed by ITCR, including developing business models for sustainability. The working group reviewed existing sustainability models and reported on 10 OSS use cases, looking at aspects such as governance, documentation, code quality, and financial models. All 10 OSS were found to have effective governance, high code quality, and reliable support, with various licensing and financial models in place.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Review
Nutrition & Dietetics
Hanna Sikorska-Szaflik, Joanna Polomska, Barbara Sozanska
Summary: This article discusses the increasing prevalence of asthma and obesity in the pediatric population, and highlights the worse symptoms and treatment response in obese children with asthma. The shared genetic and immunologic origin of asthma and obesity is suggested. Diet plays a crucial role in controlling both diseases.
