DLK1-DIO3 imprinted locus deregulation in development, respiratory disease, and cancer

MicroRNA-134-3p is a novel potential inhibitor of human ovarian cancer stem cells by targeting RAB27A

(2017) Cui Chang et al.   GENE

Severe damage to the placental fetal capillary network causes mid- to late fetal lethality and reduction in placental size inPeg11/Rtl1KO mice

(2017) Moe Kitazawa et al.   GENES TO CELLS

MiR-485 inhibits metastasis and EMT of lung adenocarcinoma by targeting Flot2

(2016) Xuri Mou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Value of miR-299-5p in Diagnosis and Prognosis of Intestinal-Type Gastric Adenocarcinoma

(2016) Shirin Azarbarzin et al.   BIOCHEMICAL GENETICS

Novel microdeletions on chromosome 14q32.2 suggest a potential role for non-coding RNAs in Kagami-Ogata syndrome

(2016) Ilse M van der Werf et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Regulation of the imprintedDlk1-Dio3locus by allele-specific enhancer activity

(2016) Zhuojuan Luo et al.   GENES & DEVELOPMENT

Integrative analysis of transcriptome and miRNome unveils the key regulatory connections involved in different stages of hepatocellular carcinoma

(2016) Vignesh Ramesh et al.   GENES TO CELLS

MEG3 Long Noncoding RNA Contributes to the Epigenetic Regulation of Epithelial-Mesenchymal Transition in Lung Cancer Cell Lines

(2016) Minoru Terashima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-134 inhibits non-small cell lung cancer growth by targeting the epidermal growth factor receptor

(2016) Qin Qin et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Developmental transcription factor NFIB is a putative target of oncofetal miRNAs and is associated with tumour aggressiveness in lung adenocarcinoma

(2016) Daiana D Becker-Santos et al.   JOURNAL OF PATHOLOGY

Fetus-derived DLK1 is required for maternal metabolic adaptations to pregnancy and is associated with fetal growth restriction

(2016) Mary A M Cleaton et al.   NATURE GENETICS

Expression of the lncRNA Maternally Expressed Gene 3 (MEG3) Contributes to the Control of Lung Cancer Cell Proliferation by the Rb Pathway

(2016) Traci L. Kruer et al.   PLoS One

Epithelial Notch signaling regulates lung alveolar morphogenesis and airway epithelial integrity

(2016) Po-Nien Tsao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasma miRNAs in predicting radiosensitivity in non-small cell lung cancer

(2016) Xu Chen et al.   TUMOR BIOLOGY

MiR-541-3p reverses cancer progression by directly targeting TGIF2 in non-small cell lung cancer

(2016) You-Jin Lu et al.   TUMOR BIOLOGY

Hsa-miR-134 suppresses non-small cell lung cancer (NSCLC) development through down-regulation of CCND1

(2016) Cheng-Cao Sun et al.   Oncotarget

Imprinting defects at human 14q32 locus alters gene expression and is associated with the pathobiology of osteosarcoma

(2016) Jingmin Shu et al.   Oncotarget

Hsa-miR-329 exerts tumor suppressor function through down-regulation of MET in non-small cell lung cancer

(2016) Cheng-Cao Sun et al.   Oncotarget

miRs-134 and -370 function as tumor suppressors in colorectal cancer by independently suppressing EGFR and PI3K signalling

(2016) Sherien M. El-Daly et al.   Scientific Reports

Small RNA Sequencing in Cells and Exosomes Identifies eQTLs and 14q32 as a Region of Active Export

(2016) Emily K. Tsang et al.   G3-Genes Genomes Genetics

Screening of long non-coding RNA and TUG1 inhibits proliferation with TGF-β induction in patients with COPD

(2016) Wenxiang Tang et al.   International Journal of Chronic Obstructive Pulmonary Disease

Inhibition of miR-154 Protects Against Cardiac Dysfunction and Fibrosis in a Mouse Model of Pressure Overload

(2016) Bianca C. Bernardo et al.   Scientific Reports

Identification of long non-coding RNAs involved in neuronal development and intellectual disability

(2016) Eva D’haene et al.   Scientific Reports

Temple syndrome as a result of isolated hypomethylation of the 14q32 imprinted DLK1/MEG3 region

(2015) Tracy A. Briggs et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

New patients with Temple syndrome caused by 14q32 deletion: Genotype-phenotype correlations and risk of thyroid cancer

(2015) Giulia Severi et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Multiple myeloma cells alter the senescence phenotype of bone marrow mesenchymal stromal cells under participation of the DLK1-DIO3 genomic region

(2015) Rimma Berenstein et al.   BMC CANCER

A trans-homologue interaction between reciprocally imprinted miR-127 and Rtl1 regulates placenta development

(2015) M. Ito et al.   DEVELOPMENT

Comprehensive clinical studies in 34 patients with molecularly defined UPD(14)pat and related conditions (Kagami–Ogata syndrome)

(2015) Masayo Kagami et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Down-Regulated Long Non-Coding RNA MEG3 and its Effect on Promoting Apoptosis and Suppressing Migration of Trophoblast Cells

(2015) Yuanyuan Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Kagami–Ogata syndrome: a clinically recognizable upd(14)pat and related disorder affecting the chromosome 14q32.2 imprinted region

(2015) Tsutomu Ogata et al.   JOURNAL OF HUMAN GENETICS

miR-377-dependent BCL-xL regulation drives chemotherapeutic resistance in B-cell lymphoid malignancies

(2015) Sayer Al-harbi et al.   Molecular Cancer

Skp2 regulates non-small cell lung cancer cell growth by Meg3 and miR-3163

(2015) Lin Su et al.   TUMOR BIOLOGY

The differentially methylated region ofMEG8is hypermethylated in patients with Temple syndrome

(2015) Susanne Bens et al.   Epigenomics

miR-134 in extracellular vesicles reduces triple-negative breast cancer aggression and increases drug sensitivity

(2015) Keith O’Brien et al.   Oncotarget

Loss of non-coding RNA expression from the DLK1-DIO3 imprinted locus correlates with reduced neural differentiation potential in human embryonic stem cell lines

(2015) Chu-Fan Mo et al.   Stem Cell Research & Therapy

PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells

(2015) Partha Pratim Das et al.   Cell Reports

The Long Noncoding RNA MEG3 Contributes to Cisplatin Resistance of Human Lung Adenocarcinoma

(2015) Jing Liu et al.   PLoS One

Clinical features associated with copy number variations of the 14q32 imprinted gene cluster

(2014) Jill A. Rosenfeld et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Epigenetic silencing of genes and microRNAs within the imprinted Dlk1-Dio3 region at human chromosome 14.32 in giant cell tumor of bone

(2014) Burkhard Lehner et al.   BMC CANCER

A MicroRNA Cluster at 14q32 Drives Aggressive Lung Adenocarcinoma

(2014) E. Nadal et al.   CLINICAL CANCER RESEARCH

ICR Noncoding RNA Expression Controls Imprinting and DNA Replication at the Dlk1-Dio3 Domain

(2014) Satya K. Kota et al.   DEVELOPMENTAL CELL

miR379-410 cluster miRNAs regulate neurogenesis and neuronal migration by fine-tuning N-cadherin

(2014) L. Rago et al.   EMBO JOURNAL

The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation

(2014) S. Labialle et al.   EMBO JOURNAL

Novel deletions affecting the MEG3-DMR provide further evidence for a hierarchical regulation of imprinting in 14q32

(2014) Jasmin Beygo et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Epimutations of the IG-DMR and the MEG3-DMR at the 14q32.2 imprinted region in two patients with Silver–Russell Syndrome-compatible phenotype

(2014) Masayo Kagami et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

MicroRNA-134 suppresses endometrial cancer stem cells by targeting POGLUT1 and Notch pathway proteins

(2014) Yongtao Gao et al.   FEBS LETTERS

Temple syndrome: improving the recognition of an underdiagnosed chromosome 14 imprinting disorder: an analysis of 51 published cases

(2014) Yiannis Ioannides et al.   JOURNAL OF MEDICAL GENETICS

Thyroid Hormone Inactivation in Gastrointestinal Stromal Tumors

(2014) Michelle A. Maynard et al.   NEW ENGLAND JOURNAL OF MEDICINE

DLK1 Promotes Lung Cancer Cell Invasion through Upregulation of MMP9 Expression Depending on Notch Signaling

(2014) Lin Li et al.   PLoS One

Genomic Imprinting in Mammals

(2014) D. P. Barlow et al.   Cold Spring Harbor Perspectives in Biology

Genome-wide analysis reveals downregulation of miR-379/miR-656 cluster in human cancers

(2013) Saurabh V Laddha et al.   Biology Direct

Long non-coding RNA MEG3 inhibits NSCLC cells proliferation and induces apoptosis by affecting p53 expression

(2013) Kai-hua Lu et al.   BMC CANCER

Genetic and epigenetic mutations of tumor suppressive genes in sporadic pituitary adenoma

(2013) Yunli Zhou et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

MiR-134/487b/655 Cluster Regulates TGF- -Induced Epithelial-Mesenchymal Transition and Drug Resistance to Gefitinib by Targeting MAGI2 in Lung Adenocarcinoma Cells

(2013) K. Kitamura et al.   MOLECULAR CANCER THERAPEUTICS

Upregulation of the microRNA cluster at the Dlk1-Dio3 locus in lung adenocarcinoma

(2013) P N Valdmanis et al.   ONCOGENE

Downregulation of 14q32 microRNAs in Primary Human Desmoplastic Medulloblastoma

(2013) Danielle Ribeiro Lucon et al.   Frontiers in Oncology

Profibrotic Role of miR-154 in Pulmonary Fibrosis

(2012) Jadranka Milosevic et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Cerebellar Abnormalities in Mice Lacking Type 3 Deiodinase and Partial Reversal of Phenotype by Deletion of Thyroid Hormone Receptor α1

(2012) Robin P. Peeters et al.   ENDOCRINOLOGY

miR-134 inhibits epithelial to mesenchymal transition by targeting FOXM1 in non-small cell lung cancer cells

(2012) Jipeng Li et al.   FEBS LETTERS

MiR-134 functions as a regulator of cell proliferation, apoptosis, and migration involving lung septation

(2012) Xiaoying Zhang et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

MicroRNAs in the ImprintedDLK1-DIO3Region Repress the Epithelial-to-Mesenchymal Transition by Targeting the TWIST1 Protein Signaling Network

(2012) Christopher L. Haga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specific small nucleolar RNA expression profiles in acute leukemia

(2012) W Valleron et al.   LEUKEMIA

Dihydropyrimidine dehydrogenase (DPD) expression is negatively regulated by certain microRNAs in human lung tissues

(2012) Takeshi Hirota et al.   LUNG CANCER

DLK1 as a Potential Target against Cancer Stem/Progenitor Cells of Hepatocellular Carcinoma

(2012) X. Xu et al.   MOLECULAR CANCER THERAPEUTICS

Loss of Imprinting and Allelic Switching at the DLK1-MEG3 Locus in Human Hepatocellular Carcinoma

(2012) Sumadi Lukman Anwar et al.   PLoS One

Identification of Dlk1-Dio3 Imprinted Gene Cluster Noncoding RNAs as Novel Candidate Biomarkers for Liver Tumor Promotion

(2012) Harri Lempiäinen et al.   TOXICOLOGICAL SCIENCES

Methylation dynamics of IG-DMR and Gtl2-DMR during murine embryonic and placental development

(2011) Shun Sato et al.   GENOMICS

Spatiotemporal expression pattern of Mirg, an imprinted non-coding gene, during mouse embryogenesis

(2011) Zhengbin Han et al.   JOURNAL OF MOLECULAR HISTOLOGY

Postnatal loss of Dlk1 imprinting in stem cells and niche astrocytes regulates neurogenesis

(2011) Sacri R. Ferrón et al.   NATURE

Prenatal findings of paternal uniparental disomy 14: Report of four patients

(2010) Michiko Yamanaka et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Molecular mechanisms regulating phenotypic outcome in paternal and maternal uniparental disomy for chromosome 14

(2010) Tsutomu Ogata et al.   Epigenetics

Delta-like 1 contributes to cell growth by increasing the interferon-inducible protein 16 expression in hepatocellular carcinoma

(2010) Feng Yu et al.   LIVER INTERNATIONAL

Dlk1 Is Necessary for Proper Skeletal Muscle Development and Regeneration

(2010) Jolena N. Waddell et al.   PLoS One

The IG-DMR and the MEG3-DMR at Human Chromosome 14q32.2: Hierarchical Interaction and Distinct Functional Properties as Imprinting Control Centers

(2010) Masayo Kagami et al.   PLoS Genetics

Deletion of Gtl2 , imprinted non-coding RNA, with its differentially methylated region induces lethal parent-origin-dependent defects in mice

(2009) Nozomi Takahashi et al.   HUMAN MOLECULAR GENETICS

Pleiotrophin Regulates Lung Epithelial Cell Proliferation and Differentiation during Fetal Lung Development via β-Catenin and Dlk1

(2009) Tingting Weng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-127 modulates fetal lung development

(2009) Manoj Bhaskaran et al.   PHYSIOLOGICAL GENOMICS

At Least Ten Genes Define the Imprinted Dlk1-Dio3 Cluster on Mouse Chromosome 12qF1

(2009) John P. Hagan et al.   PLoS One

Gene Dosage Effects of the Imprinted Delta-Like Homologue 1 (Dlk1/Pref1) in Development: Implications for the Evolution of Imprinting

(2009) Simao Teixeira da Rocha et al.   PLoS Genetics

Delta-Like 1 (Dlk-1), a Novel Marker of Prostate Basal and Candidate Epithelial Stem Cells, Is Downregulated by Notch Signalling in Intermediate/Transit Amplifying Cells of the Human Prostate

(2008) Jens A. Ceder et al.   EUROPEAN UROLOGY

Role of retrotransposon-derived imprinted gene, Rtl1, in the feto-maternal interface of mouse placenta

(2008) Yoichi Sekita et al.   NATURE GENETICS

Deletions and epimutations affecting the human 14q32.2 imprinted region in individuals with paternal and maternal upd(14)-like phenotypes

(2008) Masayo Kagami et al.   NATURE GENETICS