Article
Plant Sciences
Zhichao Zhang, Shuai Yu, Jing Li, Yanbin Zhu, Siqi Jiang, Haoran Xia, Yue Zhou, Daqiu Sun, Meiling Liu, Cong Li, Yanshu Zhu, Yanye Ruan, Xiaomei Dong
Summary: A total of 691 possible imprinted genes were identified in the sunflower endosperm, showing conservation and intraspecific variation, with limited imprinted loci found in other species. The study suggests that demethylation in the maternal CG context may induce genomic imprinting in the endosperm.
Article
Cell Biology
Teruhito Ishihara, Oliver W. Griffith, Shunsuke Suzuki, Marilyn B. Renfree
Summary: This study reveals that the active histone-3 lysine-4 trimethylation (H3K4me3) marks in the paternal genome remain present in sperm and embryos, playing a role in the regulation of parent-of-origin-specific gene expression from early zygotic stages to implantation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Qiong Wu, Anders E. Berglund, Arnold B. Etame
Summary: Glioblastoma is highly resistant to standard therapies and the durability of response to the best chemotherapy agent, Temozolomide, is often short-lived due to tumor resistance. The need for therapies that can provide synergy to chemoradiation is urgent, as adaptive resistance evolution in GBM is facilitated through treatment-induced epigenetic modifications. Understanding and targeting these epigenetic modifications associated with GBM resistance is a top priority.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Plant Sciences
Jun-Li Wang, Dong-Wei Di, Pan Luo, Li Zhang, Xiao-Feng Li, Guang-Qin Guo, Lei Wu
Summary: This review focuses on the molecular mechanisms through which epigenetic modifications regulate auxin biosynthesis, demonstrating that complex signaling pathways affect gene expression and subsequently protein production.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Oncology
Francisco Gimeno-Valiente, Gerardo Lopez-Rodas, Josefa Castillo, Luis Franco
Summary: This review focuses on the interconnections between epigenetics and alternative splicing in the development of cancer. It discusses the mechanisms involved in these interconnections and the potential diagnostic and therapeutic tools that can be derived from them. The reversible nature of epigenetic alterations and the possibility of correcting aberrant alternative splicing offer promising therapeutic possibilities for cancer treatment.
Review
Environmental Sciences
Arijit Chakraborty, Soma Ghosh, Bratisha Biswas, Sreemanta Pramanik, Jerome Nriagu, Subhamoy Bhowmick
Summary: Arsenic exposure can cause harmful epigenetic alterations, leading to various health complications. This review summarizes the mechanisms underlying arsenic-induced epigenetic changes and proposes therapeutic strategies to alleviate the global burden of arsenic poisoning.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Plant Sciences
Kajal Samantara, Aalok Shiv, Lorenna Lopes de Sousa, Karansher Singh Sandhu, Parichita Priyadarshini, Sourav Ranjan Mohapatra
Summary: Epigenetics is an important mechanism that can help plants cope with various stressors by altering gene expression without involving changes in DNA sequences. It provides diversity to aid plants in responding to the impacts of climate change.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2021)
Review
Plant Sciences
Hikaru Sato, Claudia Koehler
Summary: Seed dormancy is an important adaptive trait that allows plant seeds to germinate at the right environmental conditions for survival. The endosperm, a reproductive tissue formed after fertilization, plays a crucial role in establishing seed dormancy. Recent studies have shown that imprinted genes are involved in this process, revealing a new mechanism of parental control over this adaptive trait.
CURRENT OPINION IN PLANT BIOLOGY
(2022)
Review
Oncology
Junyuan Xie, Li Gan, Bingjian Xue, Xinxing Wang, Xinhong Pei
Summary: Breast cancer remains the leading cause of cancer-related death in women worldwide. Non-coding RNAs, especially lncRNAs, have been found to play important roles in breast cancer. The study of epigenetic modifications has also contributed to the understanding of the role of ncRNAs in breast cancer.
FRONTIERS IN ONCOLOGY
(2023)
Review
Cell Biology
Luke Twenhafel, DiAnna Moreno, Trista Punt, Madeline Kinney, Rebecca Ryznar
Summary: Osteosarcoma is a common malignant bone tumor in children and adolescents. Despite improvements in clinical outcomes, early detection is crucial for better survival rates and reducing the need for debilitating treatments like amputations. Research in the field of epigenetics, focusing on changes in genetic expression above the genome, shows potential for understanding and improving the treatment of osteosarcoma.
Review
Dermatology
Chang Zeng, Lam C. Tsoi, Johann E. Gudjonsson
Summary: The incidence of psoriasis is increasing over time, with recent studies pointing towards the importance of epigenetic modifications in its pathogenesis. Aberrant epigenetic patterns, including changes in DNA methylation, histone modifications and non-coding RNA expression, are observed in psoriatic skin. Reversing these epigenetic mechanisms has shown promise in improving psoriatic phenotypes, making epigenetic therapy a potential avenue for treating psoriasis.
EXPERIMENTAL DERMATOLOGY
(2021)
Review
Immunology
Liangjie Xu, Cuicui Zhou, Yi Liang, Tinpan Fan, Fen Zhang, Xinxin Chen, Wei Yuan
Summary: This article reviews the interaction between epigenetic modifications and the functions of myeloid-derived suppressor cells (MDSCs), and briefly introduces how the accumulation and function of MDSCs caused by epigenetic modifications impact disease development, providing a promising therapeutic strategy for related disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Roberta Giordo, Anna Maria Posadino, Arduino Aleksander Mangoni, Gianfranco Pintus
Summary: An intricate interplay between genetic and environmental factors contributes to the development of type 2 diabetes (T2D) and its complications. Metformin, a derivative of biguanide, exerts pleiotropic effects through multiple epigenetic modifications, which are reported in various organs, tissues, and cellular compartments. This review discusses the emerging evidence regarding metformin-mediated epigenetic modifications, their significance, potential applications, and future research directions.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ashby J. Morrison
Summary: Cellular adaptation to nutrient environment is crucial for survival, failure to adapt can result in cell death and diseases. Metabolism alterations, particularly in cancer cells, play a significant role in the pathogenesis of diseases. Recent studies have shown the interplay between metabolic pathways, epigenetic modifications, and transcriptional regulation in cancer cells.
Review
Cell Biology
Liang Zhang, Chenhai Xia, Yongjun Yang, Fangfang Sun, Yu Zhang, Huan Wang, Rui Liu, Ming Yuan
Summary: Atherosclerosis is a vascular pathology characterized by inflammation and plaque build-up in arterial vessel walls, acting as a major cause of cardiovascular diseases. Epigenetic modifications are increasingly associated with atherosclerosis and have implications for therapy and biomarker research.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Endocrinology & Metabolism
Lauren J. Mills, Milcah C. Scott, Pankti Shah, Anne R. Cunanan, Archana Deshpande, Benjamin Auch, Bridget Curtin, Kenneth B. Beckman, Logan G. Spector, Aaron L. Sarver, Subbaya Subramanian, Todd A. Richmond, Jaime F. Modiano
Summary: This study compares the DNA methylation patterns in osteosarcoma between humans and dogs, revealing the establishment of conserved transcriptional programs through DNA methylation in varied mutational landscapes. It provides insights into the epigenetic regulation of osteosarcoma.
Article
Oncology
Austin L. Brown, Pagna Sok, Michael E. Scheurer, Karen R. Rabin, Erin L. Marcotte, Douglas S. Hawkins, Logan G. Spector, Philip J. Lupo
Summary: This study evaluated the representativeness of the Childhood Cancer Research Network (CCRN) and identified factors associated with enrollment. Despite enrolling only 36% of newly diagnosed cases, CCRN remains a valuable resource for investigators conducting childhood cancer etiology and survivorship research.
Article
Oncology
Jeremy M. Schraw, Helen D. Bailey, Audrey Bonaventure, Ana M. Mora, Eve Roman, Beth A. Mueller, Jacqueline Clavel, Eleni T. Petridou, Maria Karalexi, Evangelia Ntzani, Sameera Ezzat, Wafaa M. Rashed, Erin L. Marcotte, Logan G. Spector, Catherine Metayer, Alice Y. Kang, Corrado Magnani, Lucia Miligi, John D. Dockerty, Juan Manuel Mejia-Arangure, Juan Carlos Nunez-Enriquez, Claire Infante-Rivard, Elizabeth Milne, Michael E. Scheurer
Summary: Growing evidence suggests that breastfeeding may have a protective effect against childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). This study analyzed data from multiple studies and found that longer breastfeeding duration is associated with decreased odds of ALL and AML.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Virology
Jennifer M. Geris, Logan G. Spector, Michelle Roesler, Nelmary Hernandez-Alvarado, Mark Blackstad, Heather H. Nelson, Mark R. Schleiss
Summary: Young children in the household are a known risk factor for maternal CMV infection and little is known about viral shedding in pre-school aged children. This study aimed to estimate the prevalence of CMV DNA shedding and antibodies among healthy children and their mothers. The results showed that the prevalence of CMV saliva shedding among children was approximately 11.0%, while the overall maternal seroprevalence was less than 50%. This suggests that these women are at risk for acquiring a primary CMV infection in subsequent pregnancies.
JOURNAL OF CLINICAL VIROLOGY
(2022)
Review
Genetics & Heredity
Kelsie L. Becklin, Garrett M. Draper, Rebecca A. Madden, Mitchell G. Kluesner, Tomoyuki Koga, Miller Huang, William A. Weiss, Logan G. Spector, David A. Largaespada, Branden S. Moriarity, Beau R. Webber
Summary: Advances in genome and tissue engineering have opened up new possibilities for cancer modeling. Human induced pluripotent stem cells (iPSCs) have shown potential in studying cellular processes in the context of disease-specific genetic backgrounds. However, their application in cancer research has faced challenges. This review focuses on the use of genetic engineering in iPSC-based cancer models, which allows for precise investigation of the genetic mechanisms underlying transformation, progression, and metastasis.
Article
Oncology
Jennifer M. Geris, Logan G. Spector, Ruth M. Pfeiffer, Ajit P. Limaye, Kelly J. Yu, Eric A. Engels
Summary: The study found that CMV status was not associated with the risk of most cancers among SOT recipients, but the inverse association with DLBCL may reflect the protective effects of CMV prophylaxis or treatment against EBV infection.
Article
Oncology
Freddy A. Barragan, Lauren J. Mills, Andrew R. Raduski, Erin L. Marcotte, Kelsey E. Grinde, Logan G. Spector, Lindsay A. Williams
Summary: Black children have lower incidence yet worse survival in B-cell acute lymphoblastic leukemia (B-ALL). Genetic ancestry and differentially expressed genes associated with ancestry play a role in death risk. The impact of reported race/ethnicity on death risk varies after adjusting for genetic ancestry genes. Other factors also contribute to B-ALL survival.
Article
Economics
Martha J. Bailey, Susan H. Leonard, Joseph Price, Evan Roberts, Logan Spector, Mengying Zhang
Summary: This paper describes the digitization of almost 185,000 causes of death for Ohio by combining handwriting recognition, data cleaning algorithms, and semi-automated classification of causes. The methods used in this research can be applied to other collections of handwritten data.
EXPLORATIONS IN ECONOMIC HISTORY
(2023)
Article
Medicine, General & Internal
Jennifer M. Geris, Mark R. Schleiss, Anthony J. Hooten, Erica Langer, Nelmary Hernandez-Alvarado, Michelle A. Roesler, Jeannette Sample, Lindsay A. Williams, David S. Dickens, Rajen J. Mody, Yaddanapudi Ravindranath, Kate L. Gowans, Matthew G. Pridgeon, Logan G. Spector, Heather H. Nelson
Summary: Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer and a leading cause of death in children. Congenital cytomegalovirus (cCMV) has been identified as a potential risk factor for ALL. This study compared the prevalence of cCMV infection between ALL cases and matched controls, and found that cCMV was associated with increased risk of hyperdiploid ALL.
Article
Cardiac & Cardiovascular Systems
Rachel Zmora, Logan Spector, John Bass, Amanda Thomas, Jessica Knight, Kamakshi Lakshminarayan, James St Louis, Lazaros Kochilas
Summary: The study found that procedure-specific center volume is inversely associated with early postoperative mortality for infantile congenital heart surgery (CHS) but has no measurable effect on later mortality.
ANNALS OF THORACIC SURGERY
(2023)
Article
Biochemistry & Molecular Biology
Babatunde Bello, Yogesh N. Bundey, Roshan Bhave, Maksim Khotimchenko, Szczepan W. Baran, Kaushik Chakravarty, Jyotika Varshney
Summary: The COVID-19 pandemic has posed a significant challenge to healthcare, and identifying genomics and clinical biomarkers is crucial for patient management. AI and ML algorithms have been utilized to analyze omics and clinical datasets for patient stratification, showcasing their predictive accuracies. Our ML model identifies clinical features that indicate COVID-19 severity and survival, offering insights for clinicians to prioritize therapeutics. Furthermore, we use gene network analysis to explore associations between genes and COVID-19 severity, and demonstrate the importance of clinical biomarkers in identifying high-risk patients and predicting disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Travis J. Gates, Ce Yuan, Mihir Shetty, Thomas Kaiser, Andrew C. Nelson, Aastha Chauhan, Timothy K. Starr, Christopher Staley, Subbaya Subramanian
Summary: Inflammation of the colon (colitis) increases the risk of colorectal cancers, and gut microbiota may be involved in cancer development. Manipulating the bacteria community in the colon could be a potential way to prevent cancer. A study using mice found that transferring bacteria from healthy mice to those with colitis increased the presence of Akkermansia, which may alleviate colon inflammation, while untreated mice had an increase in other bacteria types, such as Anaeroplasma and Alistipes, which could contribute to inflammation. These findings suggest that specific bacteria types may help reduce colon inflammation and prevent cancer.
Article
Oncology
Philip J. Lupo, Tiffany M. Chambers, Beth A. Mueller, Jacqueline Clavel, John D. Dockerty, David R. Doody, Friederike Erdmann, Sameera Ezzat, Tommaso Filippini, Johnni Hansen, Julia E. Heck, Claire Infante-Rivard, Alice Y. Kang, Corrado Magnani, Carlotta Malagoli, Catherine Metayer, Helen D. Bailey, Ana M. Mora, Evangelia Ntzani, Eleni Th Petridou, Maria S. Pombo-de-Oliveira, Wafaa M. Rashed, Eve Roman, Joachim Schuz, Catharina Wesseling, Logan G. Spector, Michael E. Scheurer
Summary: The study explores the associations between nonchromosomal birth defects and childhood leukemia using data from the Childhood Cancer and Leukemia International Consortium. The results suggest possible novel genetic and environmental factors associated with birth defects that may also increase leukemia susceptibility.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Cindy Im, Noha Sharafeldin, Yan Yuan, Zhaoming Wang, Yadav Sapkota, Zhanni Lu, Logan G. Spector, Rebecca M. Howell, Michael A. Arnold, Melissa M. Hudson, Kirsten K. Ness, Leslie L. Robison, Smita Bhatia, Gregory T. Armstrong, Joseph P. Neglia, Yutaka Yasui, Lucie M. Turcotte
Summary: This study evaluated SMNs among long-term childhood cancer survivors of European and African genetic ancestry, finding that a polygenic risk score (PRS) could significantly impact SMN risk in survivors who did not receive radiation therapy and were treated with specific chemotherapies.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Xianda Zhao, Timothy Starr, Subbaya Subramanian