Article
Biochemistry & Molecular Biology
Sudath Hapuarachchige, Ge Si, Colin T. Huang, Wojciech G. Lesniak, Ronnie C. Mease, Xin Guo, Kathleen Gabrielson, Dmitri Artemov
Summary: Pretargeted drug delivery using a HER2 pretargeting component and a drug delivery component showed significant therapeutic efficacy in a HER2-positive breast cancer model, demonstrating a promising approach for cancer therapy.
Review
Oncology
Sankarsh Jetty, James Ryan Loftus, Abhinav Patel, Akshya Gupta, Savita Puri, Vikram Dogra
Summary: The imaging of prostate cancer has advanced with the use of molecular imaging, particularly Positron Emission Tomography (PET), replacing traditional CT and MRI for detecting prostate cancer recurrence. PET imaging provides better localization and characterization of disease recurrence, and also plays a role in assessing treatment response and determining patient prognosis and survival. This article reviews the commonly used molecular imaging agents for prostate cancer, focusing on Fluorine-18 fluciclovine (Axumin) and PSMA-ligand agents, including their imaging protocols, interpretation, and potential pitfalls.
Review
Oncology
Johannes Schwenck, Dominik Sonanini, Jonathan M. Cotton, Hans-Georg Rammensee, Christian la Fougere, Lars Zender, Bernd J. Pichler
Summary: PET imaging of cancer has advanced through its combination with CT and MRI and the development of imaging probes. However, in clinical practice, only a few parameters are used for image evaluation. Multiparametric in vivo imaging data can provide quantitative and invaluable information about tumor biology, receptor expression, metabolism, morphology, and function, as well as drug pharmacodynamics, which should be fully utilized for personalized medicine in cancer care.
NATURE REVIEWS CANCER
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Qian Zhao, Aisheng Dong, Tianlin He, Changjing Zuo
Summary: Somatostatin receptor PET imaging findings in 3 cases of diffuse pancreatic neuroendocrine tumor are presented. One case showed diffuse swelling and diffusely intense activity of the pancreas with multiple metastases. The other 2 cases showed diffusely intense activity of the pancreas without metastasis. The pancreatic tumor extended into the duodenum in all 3 cases. Familiarity with this rare pattern of radiotracer uptake may aid in diagnosis of pancreatic neuroendocrine tumor.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Oncology
Floris A. Vuijk, Fleur Kleiburg, Wyanne A. Noortman, Linda Heijmen, Shirin Feshtali Shahbazi, Floris H. P. van Velden, Victor M. Baart, Shadhvi S. Bhairosingh, Bert D. Windhorst, Lukas J. A. C. Hawinkels, Petra Dibbets-Schneider, Neanke Bouwman, Stijn A. L. P. Crobach, Arantza Farina-Sarasqueta, Andreas W. K. S. Marinelli, Daniela E. Oprea-Lager, Rutger-Jan Swijnenburg, Frits Smit, Alexander L. Vahrmeijer, Lioe-Fee De Geus-Oei, Denise E. Hilling, Marije Slingerland
Summary: PSMA-targeted PET/CT imaging shows potential in detecting gastrointestinal cancers, but challenges include low tumor expression and high physiological uptake in surrounding organs/tissues. Additionally, [F-18]FDG PET/CT may be more effective in detecting colon, gastric, and pancreatic cancers compared to [F-18]DCFPyL PET/CT.
Review
Oncology
Ioannis Tsechelidis, Alexis Vrachimis
Summary: PSMA PET, the latest nuclear medicine development, is regarded as the most promising tool for the diagnosis and treatment of prostate malignancy. However, there is still debate and ongoing research regarding its utility and position in guidelines, requiring further studies and trials for clarification.
FRONTIERS IN ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Iris J. M. C. Levink, Sanne Jaarsma, Brechtje D. M. A. Koopmann, Priscilla A. van Riet, Kasper Overbeek, Jihane Meziani, Marloes L. J. A. Sprij, Riccardo Casadei, Carlo Ingaldi, Marcin Polkowski, Megan M. L. A. Engels, Laurens van der Waaij, Silvia Carrara, Elizabeth Pando, Marlies Vornhuelz, Pieter J. Honkoop, Erik Schoon, Johanna F. Laukkarinen, Jilling Bergmann, Gemma Rossi, Frederike G. I. van Vilsteren, Anne-Marie van Berkel, Trevor P. Tabone, Matthijs Schwartz, Adriaan C. I. T. L. E. Tan, Jeanin van Hooft, Rutger Quispel, Ellert van Soest, Laszlo J. Czacko, Marco L. Bruno, Djuna Cahen, PACYFIC-Registry Work Grp
Summary: This study evaluated the role of CA19.9 monitoring in early detection and management of pancreatic cysts. Results showed that CA19.9 monitoring caused harm by shortening surveillance intervals and unnecessary surgeries. The current CA19.9 cutoff was not predictive of high-grade dysplasia and pancreatic cancer, while a higher cutoff may decrease false-positive results. The role of CA19.9 monitoring should be critically appraised before implementation in surveillance programs and guidelines.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Review
Medicine, Research & Experimental
Luman Liu, Prakash G. Kshirsagar, Shailendra K. Gautam, Mansi Gulati, Emad Wafa, John C. Christiansen, Brianna M. White, Surya K. Mallapragada, Michael J. Wannemuehler, Sushil Kumar, Joyce C. Solheim, Surinder K. Batra, Aliasger K. Salem, Balaji Narasimhan, Maneesh Jain
Summary: Pancreatic tumors are difficult to treat due to their highly fibrotic and immunosuppressive nature. Nanotechnology offers promising solutions by providing improved drug delivery and immunotherapy-based approaches. This review highlights the potential of nanoscale strategies for treating pancreatic tumors and discusses future research directions.
Article
Chemistry, Medicinal
Sara Lopes van den Broek, Vladimir Shalgunov, Rocio Garcia Vazquez, Natalie Beschorner, Natasha S. R. Bidesi, Maiken Nedergaard, Gitte M. Knudsen, Dag Sehlin, Stina Syvanen, Matthias M. Herth
Summary: Pretargeting is a nuclear imaging technique that utilizes bioorthogonal chemistry to achieve efficient imaging with antibodies, particularly in the field of neurodegenerative diseases. Research suggests that uptake of large molecule antibodies in the brain can be enhanced through ligand-mediated transport, potentially enabling pretargeted imaging beyond the BBB.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Zeyu Zhang, Shiwei Guo, Changjing Zuo, Chao Cheng
Summary: A 46-year-old man who had undergone radical resection of pancreatic cancer 6 years ago underwent PET/CT for metastatic survey. In addition to increased uptake in the operative area, increased FDG uptake was also observed in the left external abdominal oblique muscle and the left frontal scalp. Both intramuscular and subcutaneous lesions were surgically excised and diagnosed as metastases from pancreatic cancer.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Laura Gilardi, Lighea Simona Airo Farulla, Emre Demirci, Ilaria Clerici, Emanuela Omodeo Sale, Francesco Ceci
Summary: The tumor microenvironment (TME) is a complex system that promotes tumorigenesis, with cancer-associated fibroblasts (CAFs) playing a key role. Inhibitors targeting the fibroblast activation protein (FAP) have shown promise for molecular imaging and radio-ligand therapy, particularly in low FDG-avid tumors and unfavorable regions. However, more research is needed to determine the efficacy of this pan-tumoral approach.
Article
Medicine, Research & Experimental
Charles A. Maitz, Samantha Delaney, Brendon E. Cook, Afaf R. Genady, Rebecca Hoerres, Marina Kuchuk, Georgios Makris, John F. Valliant, Saman Sadeghi, Jason S. Lewis, Heather M. Hennkens, Jeffrey N. Bryan, Brian M. Zeglis
Summary: This study demonstrates the feasibility of in vivo pretargeting based on inverse electron demand Diels-Alder (IEDDA) click chemistry in large animals. Using a Cu-64-labeled tetrazine radioligand and a trans-cyclooctene-bearing bisphosphonate, the researchers achieved effective PET imaging of osteodestructive lesions in companion dogs.
MOLECULAR PHARMACEUTICS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Neil Gerard Quigley, Katja Steiger, Sebastian Hoberueck, Norbert Czech, Maximilian Alexander Zierke, Susanne Kossatz, Marc Pretze, Frauke Richter, Wilko Weichert, Christian Pox, Joerg Kotzerke, Johannes Notni
Summary: Ga-68-Trivehexin is a valuable probe for imaging of alpha v beta 6-integrin expression in human cancers. It shows high target-specific uptake in tumors and low non-specific uptake in other organs and tissues except for the excretory organs. Preclinical and in-human PET imaging results confirm its potential for PET imaging of carcinomas.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Maoxue Deng, Yue Chen, Liang Cai
Summary: In a 65-year-old man with suspected pancreatic cancer, Ga-68-FAPI PET/CT showed intense FAPI uptake in the pancreas, 10th rib, and multiple liver lesions, while F-18-FDG PET/CT only showed mild FDG uptake in the pancreas and bone destruction in the rib. Biopsy confirmed carcinoma in the head of the pancreas with liver metastasis, highlighting the potential of Ga-68-FAPI in identifying micrometastases of bones and hidden liver metastases.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ruohua Chen, Xinlan Yang, Yee Ling Ng, Xiaofeng Yu, Yanmiao Huo, Xiuying Xiao, Chenpeng Zhang, Yumei Chen, Chaojie Zheng, Lianghua Li, Gang Huang, Yun Zhou, Jianjun Liu
Summary: The study aimed to explore the pharmacokinetics of 68Ga-FAPI-04 PET/CT in pancreatic cancer and gastric cancer, and compare the parametric imaging of dynamic total-body data with SUV imaging. The results showed that parametric imaging using the 2T4K model improved tumor conspicuity and image quality, which may be helpful for early diagnosis, better characterization of tumors, or evaluation of treatment response.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Oncology
Veronica L. Nagle, Charli Ann J. Hertz, Kelly E. Henry, Maya S. Graham, Carl Campos, Nagavarakishore Pillarsetty, Andrea Schietinger, Ingo K. Mellinghoff, Jason S. Lewis
Summary: This study explores the use of anti-human-CD4 minibody for antibody-based PET to visualize human CD4(+) T cells. Through in vitro and in vivo experiments, it is found that this method can accurately detect CD4(+) T cells without impacting their abundance, proliferation, and activation state. In humanized mice, this method can also visualize the distribution of CD4(+) T cells in peripheral tissues and brain tumors.
MOLECULAR CANCER THERAPEUTICS
(2022)
Article
Medicine, Research & Experimental
Charles A. Maitz, Samantha Delaney, Brendon E. Cook, Afaf R. Genady, Rebecca Hoerres, Marina Kuchuk, Georgios Makris, John F. Valliant, Saman Sadeghi, Jason S. Lewis, Heather M. Hennkens, Jeffrey N. Bryan, Brian M. Zeglis
Summary: This study demonstrates the feasibility of in vivo pretargeting based on inverse electron demand Diels-Alder (IEDDA) click chemistry in large animals. Using a Cu-64-labeled tetrazine radioligand and a trans-cyclooctene-bearing bisphosphonate, the researchers achieved effective PET imaging of osteodestructive lesions in companion dogs.
MOLECULAR PHARMACEUTICS
(2022)
Article
Medicine, Research & Experimental
Vilma I. J. Jallinoja, Brandon D. Carney, Kavita Bhatt, Courtney H. Abbriano, David J. Schlyer, Paul J. Yazaki, Jacob L. Houghton
Summary: This study explores a host-guest chemistry-driven pretargeting approach by radiolabeling macromolecules in vivo using a radioligand. The results showed that this method achieves good tumor localization with a lag time of up to 9 days.
MOLECULAR PHARMACEUTICS
(2022)
Review
Oncology
Lisa Bodei, Ken Herrmann, Heiko Schoeder, Andrew M. Scott, Jason S. Lewis
Summary: Radiotheranostics, combining molecular imaging with targeted radionuclide therapy, has great potential and faces various challenges. It offers a huge opportunity in oncology to improve treatment outcomes and minimize side effects.
NATURE REVIEWS CLINICAL ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Javier Hernandez-Gil, Chun Yuen Chow, Hugo Chatras, Paula Demetrio de Souza Franca, Zachary V. Samuels, Mike Cornejo, Glenn F. King, Jason S. Lewis, Thomas Reiner, Junior Gonzales
Summary: In this study, an innovative method was reported to produce bacteriochlorins (bacs) by subjecting a porphyrin to a trimolecular reaction. Bacs are near-infrared probes with the ability to serve in multimodal imaging. The study demonstrated the precise and controlled appending of clickable linkers to bacs, which greatly improved their chemical stability, clickability, and solubility, making them more suitable for preclinical investigation.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Biochemical Research Methods
David Bauer, Samantha M. Sarrett, Jason S. Lewis, Brian M. Zeglis
Summary: The 2022 Nobel Prize in Chemistry was awarded to Professors K. Barry Sharpless, Morten Meldal and Carolyn Bertozzi for their pioneering roles in the advent of click chemistry. The development of click reactions has revolutionized chemical and biological science, providing unprecedented methods for manipulating living systems. Click chemistry has had a significant impact on radiopharmaceutical chemistry, improving efficiency and potentially advancing nuclear medicine.
Article
Multidisciplinary Sciences
Yi Rao, Zachary Samuels, Lukas M. Carter, Sebastien Monette, Sandeep Surendra Panikar, Patricia M. R. Pereira, Jason S. Lewis
Summary: HER2 is overexpressed in various cancers. Combining trastuzumab with lutetium-177 can deliver radiation to gastric tumors with minimal toxicity. Lovastatin can enhance cell surface HER2 levels and improve the therapeutic efficacy of [177Lu]Lu-DOTA-trastuzumab.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Chemistry, Multidisciplinary
Xiaona Wen, Luping Ou, Gabriel Cutshaw, Saji Uthaman, Yu-Chuan Ou, Tian Zhu, Sarah Szakas, Brandon Carney, Jacob Houghton, Alexander Gundlach-Graham, Marjan Rafat, Kai Yang, Rizia Bardhan
Summary: This study demonstrates the unexpected breakdown of functionalized gold nanostars (F-AuNSs) conjugated with antibodies and Cu-64 radiolabels in vivo and in artificial lysosomal fluid ex vivo. The short-term biodistribution of F-AuNSs is influenced by the route of systemic delivery, while the long-term fate is controlled by the tissue type in vivo. In vitro and in vivo studies show that F-AuNSs dynamics are governed by their physicochemical properties and route of delivery.
Article
Chemistry, Multidisciplinary
Natalia Herrero Alvarez, Alexa L. Michel, Tara D. Viray, Marius E. Mayerhoefer, Jason S. Lewis
Summary: Multiple myeloma (MM) and lymphomas are hematological malignancies with high unmet clinical needs. In this study, a novel immunoPET tracer, 89Zr-DFO-isatuximab, was developed for targeted imaging of CD38, an excellent biomarker for MM and certain lymphomas. In vitro validation demonstrated its high binding affinity and specificity. PET imaging further confirmed its effectiveness in delineating tumor burden in MM and Burkitt's lymphoma models. The potential of 89Zr-DFO-isatuximab as an alternative to 89Zr-DFO-daratumumab holds great clinical relevance.
Review
Biochemical Research Methods
David Bauer, Mike A. Cornejo, Tran T. Hoang, Jason S. Lewis, Brian M. Zeglis
Summary: The term click chemistry refers to a class of organic transformations aimed at simplifying and streamlining chemical synthesis. It has had a significant impact on various fields of chemical and biological science and has shown particular promise in radiopharmaceutical chemistry.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Oncology
Steven B. Maron, Walid Chatila, Henry Walch, Joanne F. Chou, Nicholas Ceglia, Ryan Ptashkin, Richard Kinh Gian Do, Viktoriya Paroder, Neeta Pandit-Taskar, Jason S. Lewis, Tiago Biachi De Castria, Shalom Sabwa, Fiona Socolow, Lara Feder, Jasmine Thomas, Isabell Schulze, Kwanghee Kim, Arijh Elzein, Viktoria Bojilova, Matthew Zatzman, Umesh Bhanot, Rebecca J. Nagy, Jeeyun Lee, Marc Simmons, Michal Segal, Geoffrey Yuyat Ku, David H. Ilson, Marinela Capanu, Jaclyn F. Hechtman, Taha Merghoub, Sohrab Shah, Nikolaus Schultz, David B. Solit, Yelena Y. Janjigian
Summary: The study highlights the clinical significance of identifying baseline intrapatient heterogeneity and serial ctDNA monitoring in HER2-positive esophagogastric cancer patients. These factors can be used to identify early evidence of treatment resistance, guiding proactive therapy escalation or deescalation.
CLINICAL CANCER RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Sandeep Surendra Panikar, Shayla Shmuel, Jason S. Lewis, Patricia M. R. Pereira
Summary: In this study, radiolabeled and fluorescently labeled anti-CAV1 antibodies were developed and tested as imaging agents for detecting CAV1 in HER2-positive/CAV1-high gastric tumors. The results showed that these imaging agents could effectively localize and detect CAV1 expression in gastric tumors.
Article
Chemistry, Medicinal
Afruja Ahad, Hiwa K. Saeed, Virginia del Solar, Javier E. Lopez-Hernandez, Alexa Michel, Joshua Mathew, Jason S. Lewis, Maria Contel
Summary: Antibody-drug conjugates (ADCs) combine the selectivity of monoclonal antibodies (mAbs) with the efficacy of chemotherapeutics to target cancers without toxicity to normal tissue. In this study, gold-based ADCs were developed and demonstrated significant anticancer potency in vitro assays. A specific ADC containing the [Au-(PEt3)] fragment showed impressive antitumor effects in a mouse xenograft model.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Afruja Ahad, Fatima Aftab, Alexa Michel, Jason S. Lewis, Maria Contel
Summary: Overexpression of HER2 is associated with aggressive breast cancer. Gold compounds are emerging as potential anticancer agents. This study developed immunoliposomes with trastuzumab and pertuzumab and encapsulated gold compounds for treating HER2-positive breast cancer.
RSC MEDICINAL CHEMISTRY
(2023)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Vilma Jallinoja, Brandon Carney, Kavita Bhatt, Courtney Abbriano, Jacob Houghton
NUCLEAR MEDICINE AND BIOLOGY
(2022)