Journal
MEDICINAL RESEARCH REVIEWS
Volume 34, Issue 3, Pages 596-643Publisher
WILEY
DOI: 10.1002/med.21299
Keywords
SPECT; HER2; EGFR; PET
Categories
Funding
- U.S. Department of Energy [DE-SC0001781]
- U.S. Department of Energy (DOE) [DE-SC0001781] Funding Source: U.S. Department of Energy (DOE)
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In an effort to discover a noninvasive method for predicting which cancer patients will benefit from therapy targeting the EGFR and HER2 proteins, a large body of the research has been conducted toward the development of PET and SPECT imaging agents, which selectively target these receptors. We provide a general overview of the advances made toward imaging EGFR and HER2, detailing the investigation of PET and SPECT imaging agents ranging in size from small molecules to monoclonal antibodies.
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