Article
Oncology
Hanqing Wang, Sidi Zhao, Yang Liu, Fengyuan Sun, Xiaoming Huang, Tong Wu
Summary: This study demonstrates that downregulation of SOST promotes the malignant progression of uveal melanoma by activating the Wnt/beta-catenin signaling pathway. Mechanistically, SOST may exert this function by interacting with LRP5/LRP6 membrane receptors.
FRONTIERS IN ONCOLOGY
(2022)
Article
Plant Sciences
Chuan Li, Liru Tian, Yihai Wang, Huan Luo, Jia Zeng, Peiqiang Su, Shulin Chen, Zhiheng Liao, Weimin Guo, Xiangjiu He, Shuqing Chen, Caixia Xu
Summary: The study showed that M13 promotes the proliferation and osteogenic differentiation of MSCs by activating the Wnt/β-catenin pathway. This finding provides new evidence to support the use of Morinda officinalis for the treatment of osteoporosis.
Article
Biochemistry & Molecular Biology
Cuidi Xu, Hongli Shi, Xin Jiang, Yongqian Fan, Donghui Huang, Xinming Qi, Qun Cheng
Summary: ZEB1 is a key transcription factor in BMSC differentiation, playing a crucial role in maintaining bone health. Silencing ZEB1 can enhance osteogenesis and inhibit bone loss.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ashish Kumar Tripathi, Divya Rai, Priyanka Kothari, Pragati Kushwaha, Koneni Sashidhara, Ritu Trivedi
Summary: A compound, 4e, has been identified to have osteogenic potential in glucocorticoid induced osteoporosis (GIOP). Compound 4e preserved osteoblast differentiation and increased the expression of osteogenic genes, resulting in the preservation of bone microarchitecture and cortical thickness. This study is important for the treatment of glucocorticoid-induced osteoporosis.
Article
Cell & Tissue Engineering
Ming Chen, Hui Han, Siqi Zhou, Yinxian Wen, Liaobin Chen
Summary: This study demonstrates the ability of Morusin to promote osteogenic differentiation of BMSCs through activation of the Wnt/β-catenin signaling pathway, and suggests the potential of Morusin as a treatment for osteoporosis.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Cell Biology
Qian Ren, Jiongcheng Chen, Youhua Liu
Summary: LRP5 and LRP6 are crucial in mediating Wnt signaling, with similar functions but also distinct characteristics, as they interact with different protein partners, each possessing its own unique functions. Understanding the precise roles of LRP5 and LRP6 may help in identifying and refining therapeutic targets for various human diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Plant Sciences
Fujiang Wang, Pengfei Tu, Kewu Zeng, Yong Jiang
Summary: The study found that the total glycosides and polysaccharides extracts of Cistanche deserticola can promote osteoblastogenic bone formation and improve bone microstructure damage in SAMP6 mice, and their therapeutic effect on osteoporosis is via activating the Wnt/beta-catenin signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuri Lee, Hai-long Piao, Jongchan Kim
Summary: The Wnt signaling pathway is crucial for regulating various cellular processes, and dysregulation of this pathway has been linked to human diseases, including cancer. In this study, researchers aimed to identify the deubiquitinases (DUBs) that regulate the pathway through the essential component LEF1. They discovered that OTUD7B interacts with LEF1 and activates Wnt signaling. Furthermore, OTUD7B promotes the nuclear localization of LEF1, leading to increased interaction with beta-catenin. This study suggests that OTUD7B may serve as a potential therapeutic target in diseases where Wnt signaling is dysregulated, such as cancer.
Article
Cell Biology
Changsheng Yang, Panpan Yang, Peilin Liu, Hong Wang, Ee Ke, Kai Li, Huibo Yan
Summary: This study revealed that FLNA plays a crucial role in osteoporosis by inhibiting osteogenesis and promoting osteoclastogenesis. Inhibiting FLNA and activating the WNT/β-catenin signaling pathway can protect against bone loss in postmenopausal osteoporosis.
CELLULAR SIGNALLING
(2022)
Article
Biochemistry & Molecular Biology
Min Gyu Lee, Hwamok Oh, Jong Woo Park, Jueng Soo You, Jeung-Whan Han
Summary: Nuclear S6K1 functions in the regulation of Wnt target gene expression and has an impact on cell proliferation and invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Zheng Qin, Yupei Li, Jiameng Li, Luojia Jiang, Zhuyun Zhang, Kaixi Chang, Qinbo Yang, Shanshan Chen, Ruoxi Liao, Baihai Su
Summary: This study found that exosomal STAT1 derived from HP-treated HUVECs can promote VSMC calcification. Activation of the Wnt/beta-catenin pathway may be a potential mechanism of exosome-promoted VSMC calcification.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Zeliha Guney, Sivge Kurgan, Canan Onder, Mahmure Ayse Tayman, Oemer Gunhan, Alpdogan Kantarci, Muhittin Abdulkadir Serdar, Meral Gunhan
Summary: This study aimed to evaluate the activity of the Wnt/beta-catenin signaling pathway in gingival samples obtained from patients with periodontitis. The results showed that periodontal inflammation disrupts the Wnt/beta-catenin signaling pathway, leading to tissue inflammation and changes in morphology. This finding may shed light on the pathogenesis of periodontal disease.
CLINICAL ORAL INVESTIGATIONS
(2023)
Review
Biochemistry & Molecular Biology
Michael Latour, Nam-Gu Her, Santosh Kesari, Elmar Nurmemmedov
Summary: The WNT signaling pathway plays a crucial role in glioblastoma genesis and therapy resistance, presenting a therapeutic challenge. Current targeted therapies under clinical investigation may offer new treatment options.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Dong Wu, Lei Li, Zhun Wen, Guangbin Wang
Summary: Osteoporosis is a global burden, especially among older individuals. While there are various medications available for treatment, they come with limitations and adverse events. Romosozumab, a novel drug, shows promising results in treating osteoporosis but is also accompanied by controversy.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Yang Zhou, Jiang Xu, Haichang Luo, Xiangjing Meng, Ming Chen, Di Zhu
Summary: Abnormal activation of the Wnt/beta-catenin signaling pathway is closely related to tumorigenesis and immune surveillance, leading to increased resistance to immunotherapy.