标题
Exploiting the WNT Signaling Pathway for Clinical Purposes
作者
关键词
Wnt, Wnt signaling, Lrp5, Osteoporosis, Mechanostat, β-catenin
出版物
Current Osteoporosis Reports
Volume 15, Issue 3, Pages 153-161
出版商
Springer Nature
发表日期
2017-04-21
DOI
10.1007/s11914-017-0357-0
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Targeted disruption of BMP signaling through type IA receptor (BMPR1A) in osteocyte suppresses SOST and RANKL, leading to dramatic increase in bone mass, bone mineral density and mechanical strength
- (2016) Nobuhiro Kamiya et al. BONE
- Postnatal β-catenin deletion from Dmp1-expressing osteocytes/osteoblasts reduces structural adaptation to loading, but not periosteal load-induced bone formation
- (2016) Kyung Shin Kang et al. BONE
- The role of the wnt/β-catenin signaling pathway in formation and maintenance of bone and teeth
- (2016) Peipei Duan et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- WNT5A and Its Receptors in the Bone-Cancer Dialogue
- (2016) Stefanie Thiele et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Activation of Wnt Signaling by Mechanical Loading Is Impaired in the Bone of Old Mice
- (2016) Nilsson Holguin et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Expression of Wnt3a, Wnt10b,β-catenin and DKK1 in periodontium during orthodontic tooth movement in rats
- (2015) Juan Lu et al. ACTA ODONTOLOGICA SCANDINAVICA
- In vivo mechanical loading rapidly activates β-catenin signaling in osteocytes through a prostaglandin mediated mechanism
- (2015) N. Lara-Castillo et al. BONE
- Administration of romosozumab improves vertebral trabecular and cortical bone as assessed with quantitative computed tomography and finite element analysis
- (2015) Christian Graeff et al. BONE
- Regulation of bone metabolism by Wnt signals
- (2015) Yasuhiro Kobayashi et al. JOURNAL OF BIOCHEMISTRY
- HDAC5 Controls MEF2C-Driven Sclerostin Expression in Osteocytes
- (2015) Marc N Wein et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Activation of the Canonical Wnt Signaling Pathway Induces Cementum Regeneration
- (2015) Pingping Han et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Wnt Acts as a Prosurvival Signal to Enhance Dentin Regeneration
- (2015) Daniel J Hunter et al. JOURNAL OF BONE AND MINERAL RESEARCH
- The Effect of Discontinuing Treatment With Blosozumab: Follow-up Results of a Phase 2 Randomized Clinical Trial in Postmenopausal Women With Low Bone Mineral Density
- (2015) Christopher P Recknor et al. JOURNAL OF BONE AND MINERAL RESEARCH
- A Randomized, Double-Blind Phase 2 Clinical Trial of Blosozumab, a Sclerostin Antibody, in Postmenopausal Women with Low Bone Mineral Density
- (2015) Robert R. Recker et al. JOURNAL OF BONE AND MINERAL RESEARCH
- LRP receptor family member associated bone disease
- (2015) N. Lara-Castillo et al. REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
- Effects of Age and Estrogen on Skeletal Gene Expression in Humans as Assessed by RNA Sequencing
- (2015) Joshua N. Farr et al. PLoS One
- HDAC4 integrates PTH and sympathetic signaling in osteoblasts
- (2014) Arnaud Obri et al. JOURNAL OF CELL BIOLOGY
- Sclerostin Inhibition for Osteoporosis — A New Approach
- (2014) Carolyn B. Becker NEW ENGLAND JOURNAL OF MEDICINE
- Romosozumab in Postmenopausal Women with Low Bone Mineral Density
- (2014) Michael R. McClung et al. NEW ENGLAND JOURNAL OF MEDICINE
- Wise Regulates Bone Deposition through Genetic Interactions with Lrp5
- (2014) Debra L. Ellies et al. PLoS One
- Effect of glucocorticoid treatment on Wnt signalling antagonists (sclerostin and Dkk-1) and their relationship with bone turnover
- (2013) L. Gifre et al. BONE
- Regulation of Wnt/β-catenin signaling within and from osteocytes
- (2013) Travis A. Burgers et al. BONE
- The relationship between inhibitors of the Wnt signalling pathway (Dickkopf-1(DKK1) and sclerostin), bone mineral density, vascular calcification and arterial stiffness in post-menopausal women
- (2013) Geeta Hampson et al. BONE
- Wnt Signaling Regulates Pulp Volume and Dentin Thickness
- (2013) Won Hee Lim et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Deletion of a Single β-Catenin Allele in Osteocytes Abolishes the Bone Anabolic Response to Loading
- (2013) Behzad Javaheri et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Single- and Multiple-Dose Randomized Studies of Blosozumab, a Monoclonal Antibody Against Sclerostin, in Healthy Postmenopausal Women
- (2013) Juliet McColm et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Mutations in WNT1 are a cause of osteogenesis imperfecta
- (2013) Somayyeh Fahiminiya et al. JOURNAL OF MEDICAL GENETICS
- WNT1 Mutations in Early-Onset Osteoporosis and Osteogenesis Imperfecta
- (2013) Christine M. Laine et al. NEW ENGLAND JOURNAL OF MEDICINE
- Serum extracellular secreted antagonists of the canonical Wnt/β-catenin signaling pathway in patients with Cushing’s syndrome
- (2013) Z. E. Belaya et al. OSTEOPOROSIS INTERNATIONAL
- Load Regulates Bone Formation and Sclerostin Expression through a TGFβ-Dependent Mechanism
- (2013) Jacqueline Nguyen et al. PLoS One
- Mechanotransduction in bone tissue: The A214V and G171V mutations in Lrp5 enhance load-induced osteogenesis in a surface-selective manner
- (2012) Paul J. Niziolek et al. BONE
- Sclerostin antibody improves skeletal parameters in a Brtl/+ mouse model of osteogenesis imperfecta
- (2012) Benjamin P Sinder et al. JOURNAL OF BONE AND MINERAL RESEARCH
- High-bone-mass-producing mutations in the Wnt signaling pathway result in distinct skeletal phenotypes
- (2011) Paul J. Niziolek et al. BONE
- Effects of estrogen on osteoprogenitor cells and cytokines/bone-regulatory factors in postmenopausal women
- (2011) Ulrike I. Mödder et al. BONE
- Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading
- (2011) Xiaolin Tu et al. BONE
- Sostdown-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4
- (2011) Gabriel L. Galea et al. FEBS LETTERS
- Dickkopf-1 regulates bone formation in young growing rodents and upon traumatic injury
- (2011) Xiaodong Li et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Mef2cdeletion in osteocytes results in increased bone mass
- (2011) Ina Kramer et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Long-term treatment with raloxifene, but not bisphosphonates, reduces circulating sclerostin levels in postmenopausal women
- (2011) Y. E. Chung et al. OSTEOPOROSIS INTERNATIONAL
- Mechanical loading-related changes in osteocyte sclerostin expression in mice are more closely associated with the subsequent osteogenic response than the peak strains engendered
- (2011) A. Moustafa et al. OSTEOPOROSIS INTERNATIONAL
- Calcitonin impairs the anabolic effect of PTH in young rats and stimulates expression of sclerostin by osteocytes
- (2010) J.H. Gooi et al. BONE
- Alterations of the Wnt/β-catenin pathway and its target genes for the N- and C-terminal domains of parathyroid hormone-related protein in bone from diabetic mice
- (2010) S. Portal-Núñez et al. FEBS LETTERS
- Sclerostin antibody treatment enhances metaphyseal bone healing in rats
- (2010) Fredrik Agholme et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Regulation of circulating sclerostin levels by sex steroids in women and in men
- (2010) Ulrike IL Mödder et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Inhibition of sclerostin by monoclonal antibody enhances bone healing and improves bone density and strength of nonfractured bones
- (2010) Michael S Ominsky et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Serum Sclerostin Levels Negatively Correlate with Parathyroid Hormone Levels and Free Estrogen Index in Postmenopausal Women
- (2010) Faryal S. Mirza et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Altered skeletal expression of sclerostin and its link to radiographic progression in ankylosing spondylitis
- (2009) Heiner Appel et al. ARTHRITIS AND RHEUMATISM
- Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma
- (2009) M. Fulciniti et al. BLOOD
- Mechano-transduction in Osteoblastic Cells Involves Strain-regulated Estrogen Receptor α-mediated Control of Insulin-like Growth Factor (IGF) I Receptor Sensitivity to Ambient IGF, Leading to Phosphatidylinositol 3-Kinase/AKT-dependent Wnt/LRP5 Receptor-independent Activation of β-Catenin Signaling
- (2009) Andrew Sunters et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the type IA receptor (BMPRIA) in osteoblasts
- (2009) Nobuhiro Kamiya et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Osteocytes, mechanosensing and Wnt signaling
- (2008) Lynda F. Bonewald et al. BONE
- BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway
- (2008) N. Kamiya et al. DEVELOPMENT
- Inhibiting Dickkopf-1 (Dkk1) Removes Suppression of Bone Formation and Prevents the Development of Osteolytic Bone Disease in Multiple Myeloma
- (2008) Deborah J Heath et al. JOURNAL OF BONE AND MINERAL RESEARCH
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