Cancer-induced muscle wasting: latest findings in prevention and treatment

CCP score and risk stratification for prostate cancer patients at biopsy.

(2017) E. David Crawford et al.   JOURNAL OF CLINICAL ONCOLOGY

Molecular pathways leading to loss of skeletal muscle mass in cancer cachexia – can findings from animal models be translated to humans?

(2016) Tara C. Mueller et al.   BMC CANCER

PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer

(2016) Serkan Kir et al.   Cell Metabolism

Protein anabolic resistance in cancer

(2016) Mariëlle P.K.J. Engelen et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Exercise-induced skeletal muscle signaling pathways and human athletic performance

(2016) Donny M. Camera et al.   FREE RADICAL BIOLOGY AND MEDICINE

The regulation of autophagy during exercise in skeletal muscle

(2016) Anna Vainshtein et al.   JOURNAL OF APPLIED PHYSIOLOGY

Effects of skeletal muscle energy availability on protein turnover responses to exercise

(2016) William J. Smiles et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Targeting cancer cachexia: we're on the way

(2016) Maurizio Muscaritoli   LANCET ONCOLOGY

Anamorelin in patients with non-small-cell lung cancer and cachexia (ROMANA 1 and ROMANA 2): results from two randomised, double-blind, phase 3 trials

(2016) Jennifer S Temel et al.   LANCET ONCOLOGY

Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia

(2016) Tomoya Fukawa et al.   NATURE MEDICINE

Cancer-associated malnutrition, cachexia and sarcopenia: the skeleton in the hospital closet 40 years later

(2016) Aoife M. Ryan et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Experimental cancer cachexia: Evolving strategies for getting closer to the human scenario

(2016) Fabio Penna et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Study Design and Rationale for the Phase 3 Clinical Development Program of Enobosarm, a Selective Androgen Receptor Modulator, for the Prevention and Treatment of Muscle Wasting in Cancer Patients (POWER Trials)

(2016) Jeffrey Crawford et al.   Current Oncology Reports

Beneficial bacteria inhibit cachexia

(2016) Bernard J. Varian et al.   Oncotarget

Espindolol for the treatment and prevention of cachexia in patients with stage III/IV non-small cell lung cancer or colorectal cancer: a randomized, double-blind, placebo-controlled, international multicentre phase II study (the ACT-ONE trial)

(2016) Andrew J. Stewart Coats et al.   Journal of Cachexia Sarcopenia and Muscle

Aerobic Exercise and Pharmacological Treatments Counteract Cachexia by Modulating Autophagy in Colon Cancer

(2016) Eva Pigna et al.   Scientific Reports

High anabolic potential of essential amino acid mixtures in advanced nonsmall cell lung cancer

(2015) M. P. K. J. Engelen et al.   ANNALS OF ONCOLOGY

Mechanisms of anorexia–cachexia syndrome and rational for treatment with selective ghrelin receptor agonist

(2015) Angela Esposito et al.   CANCER TREATMENT REVIEWS

Targeting of Fn14 Prevents Cancer-Induced Cachexia and Prolongs Survival

(2015) Amelia J. Johnston et al.   CELL

Cachexia: A preventable comorbidity of cancer. A T.A.R.G.E.T. approach

(2015) Maurizio Muscaritoli et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Muscle wasting

(2015) Didier Attaix et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Novel investigational drugs mimicking exercise for the treatment of cachexia

(2015) F. Penna et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Advances in pharmacologic strategies for cancer cachexia

(2015) Clelia Madeddu et al.   EXPERT OPINION ON PHARMACOTHERAPY

Anamorelin hydrochloride for the treatment of cancer-anorexia-cachexia in NSCLC

(2015) Hongjie Zhang et al.   EXPERT OPINION ON PHARMACOTHERAPY

Complete reversal of muscle wasting in experimental cancer cachexia: Additive effects of activin type II receptor inhibition and β-2 agonist

(2015) Míriam Toledo et al.   INTERNATIONAL JOURNAL OF CANCER

Diagnostic Criteria for the Classification of Cancer-Associated Weight Loss

(2015) Lisa Martin et al.   JOURNAL OF CLINICAL ONCOLOGY

Cancer Cachexia: Emerging pre-clinical evidence and the pathway forward to clinical trials

(2015) Lisa Martin et al.   JNCI-Journal of the National Cancer Institute

Preclinical Investigation of the Novel Histone Deacetylase Inhibitor AR-42 in the Treatment of Cancer-Induced Cachexia

(2015) Yu-Chou Tseng et al.   JNCI-Journal of the National Cancer Institute

Anamorelin for patients with cancer cachexia: an integrated analysis of two phase 2, randomised, placebo-controlled, double-blind trials

(2015) José M Garcia et al.   LANCET ONCOLOGY

Muscle wasting in disease: molecular mechanisms and promising therapies

(2015) Shenhav Cohen et al.   NATURE REVIEWS DRUG DISCOVERY

Eicosapentaenoic acid in cancer improves body composition and modulates metabolism

(2015) Giulia Pappalardo et al.   NUTRITION

Preoperative Sarcopenia Negatively Impacts Postoperative Outcomes Following Major Hepatectomy with Extrahepatic Bile Duct Resection

(2015) Hidehiko Otsuji et al.   WORLD JOURNAL OF SURGERY

Combination of exercise training and erythropoietin prevents cancer-induced muscle alterations

(2015) Fabrizio Pin et al.   Oncotarget

Effects of oral meal feeding on whole body protein breakdown and protein synthesis in cachectic pancreatic cancer patients

(2015) David P.J. van Dijk et al.   Journal of Cachexia Sarcopenia and Muscle

Effect of the specific proteasome inhibitor bortezomib on cancer-related muscle wasting

(2015) Fabio Penna et al.   Journal of Cachexia Sarcopenia and Muscle

Request for regulatory guidance for cancer cachexia intervention trials

(2015) KCH Fearon et al.   Journal of Cachexia Sarcopenia and Muscle

A framework for prescription in exercise-oncology research

(2015) John P. Sasso et al.   Journal of Cachexia Sarcopenia and Muscle

Cancer Cachexia: Emerging pre-clinical evidence and the pathway forward to clinical trials

(2015) Lisa Martin et al.   JNCI-Journal of the National Cancer Institute

Preclinical Investigation of the Novel Histone Deacetylase Inhibitor AR-42 in the Treatment of Cancer-Induced Cachexia

(2015) Yu-Chou Tseng et al.   JNCI-Journal of the National Cancer Institute

The therapeutic potential of exercise to treat cachexia

(2015) Fábio S. Lira et al.   Current Opinion in Supportive and Palliative Care

Satellite cells in human skeletal muscle plasticity

(2015) Tim Snijders et al.   Frontiers in Physiology

Sunitinib prevents cachexia and prolongs survival of mice bearing renal cancer by restraining STAT3 and MuRF-1 activation in muscle

(2015) Francesca Pretto et al.   Oncotarget

A Switch from White to Brown Fat Increases Energy Expenditure in Cancer-Associated Cachexia

(2014) Michele Petruzzelli et al.   Cell Metabolism

Effects of an oral nutritional supplement containing eicosapentaenoic acid on nutritional and clinical outcomes in patients with advanced non-small cell lung cancer: Randomised trial

(2014) Karla Sánchez-Lara et al.   CLINICAL NUTRITION

Muscle contractile and metabolic dysfunction is a common feature of sarcopenia of aging and chronic diseases: From sarcopenic obesity to cachexia

(2014) Gianni Biolo et al.   CLINICAL NUTRITION

Ghrelin

(2014) Alessio Molfino et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Do patients with advanced cancer have any potential for protein anabolism in response to amino acid therapy?

(2014) Stéphanie Chevalier et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Acylated and unacylated ghrelin administration to blunt muscle wasting

(2014) Simone Reano et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Novel investigational biologics for the treatment of cancer cachexia

(2014) Joseph D Ma et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Cancer cachexia: towards integrated therapeutic interventions

(2014) Alessio Molfino et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Phase II drugs that are currently in development for the treatment of cachexia

(2014) Anne-Marie C Dingemans et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Pharmacological Strategies in Lung Cancer-Induced Cachexia: Effects on Muscle Proteolysis, Autophagy, Structure, and Weakness

(2014) Alba Chacon-Cabrera et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Efficacy of Methylprednisolone on Pain, Fatigue, and Appetite Loss in Patients With Advanced Cancer Using Opioids: A Randomized, Placebo-Controlled, Double-Blind Trial

(2014) Ørnulf Paulsen et al.   JOURNAL OF CLINICAL ONCOLOGY

MABp1, a first-in-class true human antibody targeting interleukin-1α in refractory cancers: an open-label, phase 1 dose-escalation and expansion study

(2014) David S Hong et al.   LANCET ONCOLOGY

Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia

(2014) Serkan Kir et al.   NATURE

Voluntary Exercise Prevents Cisplatin-Induced Muscle Wasting during Chemotherapy in Mice

(2014) Pernille Hojman et al.   PLoS One

Distinct Behaviour of Sorafenib in Experimental Cachexia-Inducing Tumours: The Role of STAT3

(2014) Míriam Toledo et al.   PLoS One

Phase I/II trial of formoterol fumarate combined with megestrol acetate in cachectic patients with advanced malignancy

(2014) C. A. Greig et al.   SUPPORTIVE CARE IN CANCER

Formoterol in the treatment of experimental cancer cachexia: effects on heart function

(2014) Míriam Toledo et al.   Journal of Cachexia Sarcopenia and Muscle

Central tenet of cancer cachexia therapy: do patients with advanced cancer have exploitable anabolic potential?

(2013) Carla M Prado et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Beta-hydroxy-beta-methylbutyrate supplementation in health and disease: a systematic review of randomized trials

(2013) Alessio Molfino et al.   AMINO ACIDS

Physical activity and physical fitness in lymphoma patients before, during, and after chemotherapy: a prospective longitudinal study

(2013) Nele Vermaete et al.   ANNALS OF HEMATOLOGY

Sarcopenia as a predictor of prognosis in patients following hepatectomy for hepatocellular carcinoma

(2013) N. Harimoto et al.   BRITISH JOURNAL OF SURGERY

A new look at an old drug for the treatment of cancer cachexia: Megestrol acetate

(2013) Josep M. Argilés et al.   CLINICAL NUTRITION

Effect of physical exercise on muscle mass and strength in cancer patients during treatment—A systematic review

(2013) G.B. Stene et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Changes in insulin sensitivity in response to different modalities of exercise: a review of the evidence

(2013) S. Mann et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Muscle wasting in cancer

(2013) N. Johns et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

MG132-mediated inhibition of the ubiquitin–proteasome pathway ameliorates cancer cachexia

(2013) Liuping Zhang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Reduction of Cancer-Related Fatigue With Dexamethasone: A Double-Blind, Randomized, Placebo-Controlled Trial in Patients With Advanced Cancer

(2013) Sriram Yennurajalingam et al.   JOURNAL OF CLINICAL ONCOLOGY

Cancer Cachexia in the Age of Obesity: Skeletal Muscle Depletion Is a Powerful Prognostic Factor, Independent of Body Mass Index

(2013) Lisa Martin et al.   JOURNAL OF CLINICAL ONCOLOGY

Skeletal muscle, autophagy, and physical activity: the ménage à trois of metabolic regulation in health and disease

(2013) Anna Vainshtein et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Effects of enobosarm on muscle wasting and physical function in patients with cancer: a double-blind, randomised controlled phase 2 trial

(2013) Adrian S Dobs et al.   LANCET ONCOLOGY

Comparison of the anticatabolic effects of leucine and Ca-β-hydroxy-β-methylbutyrate in experimental models of cancer cachexia

(2013) Kamran A. Mirza et al.   NUTRITION

Relationship between muscle mass and muscle strength, and the impact of comorbidities: a population-based, cross-sectional study of older adults in the United States

(2013) Lei Chen et al.   BMC Geriatrics

Abstracts of the 7th Cachexia Conference, Kobe/Osaka, Japan, December 9-11, 2013

(2013)   Journal of Cachexia Sarcopenia and Muscle

Non-steroidal anti-inflammatory treatment in cancer cachexia: A systematic literature review

(2012) Tora S. Solheim et al.   ACTA ONCOLOGICA

JAK/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia

(2012) Andrea Bonetto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Differential Effects of Exercise on Cancer-Related Fatigue During and Following Treatment

(2012) Timothy W. Puetz et al.   AMERICAN JOURNAL OF PREVENTIVE MEDICINE

Skeletal muscle anabolism is a side effect of therapy with the MEK inhibitor: selumetinib in patients with cholangiocarcinoma

(2012) C M M Prado et al.   BRITISH JOURNAL OF CANCER

Sarcopenia is associated with postoperative infection and delayed recovery from colorectal cancer resection surgery

(2012) J R Lieffers et al.   BRITISH JOURNAL OF CANCER

Cancer Cachexia: Mediators, Signaling, and Metabolic Pathways

(2012) Kenneth C.H. Fearon et al.   Cell Metabolism

l-Carnitine: An adequate supplement for a multi-targeted anti-wasting therapy in cancer

(2012) Sílvia Busquets et al.   CLINICAL NUTRITION

Normal protein anabolic response to hyperaminoacidemia in insulin-resistant patients with lung cancer cachexia

(2012) Aaron Winter et al.   CLINICAL NUTRITION

Is the intravenous supplementation of amino acid to cancer patients adequate? A critical appraisal of literature

(2012) Federico Bozzetti et al.   CLINICAL NUTRITION

Resistance exercise modulates lipid plasma profile and cytokine content in the adipose tissue of tumour-bearing rats

(2012) F.F. Donatto et al.   CYTOKINE

The Role of Thalidomide and Placebo for the Treatment of Cancer-Related Anorexia-Cachexia Symptoms: Results of a Double-Blind Placebo-Controlled Randomized Study

(2012) Sriram Yennurajalingam et al.   JOURNAL OF PALLIATIVE MEDICINE

Understanding the mechanisms and treatment options in cancer cachexia

(2012) Kenneth Fearon et al.   Nature Reviews Clinical Oncology

JAK Inhibition with Ruxolitinib versus Best Available Therapy for Myelofibrosis

(2012) Claire Harrison et al.   NEW ENGLAND JOURNAL OF MEDICINE

L-Carnitine-supplementation in advanced pancreatic cancer (CARPAN) - a randomized multicentre trial

(2012) Matthias Kraft et al.   Nutrition Journal

Therapeutic potential of anamorelin, a novel, oral ghrelin mimetic, in patients with cancer-related cachexia: a multicenter, randomized, double-blind, crossover, pilot study

(2012) José M. Garcia et al.   SUPPORTIVE CARE IN CANCER

Prevalence and prognostic effect of sarcopenia in breast cancer survivors: the HEAL Study

(2012) Adriana Villaseñor et al.   Journal of Cancer Survivorship

Are there any benefits of exercise training in cancer cachexia?

(2012) Josep M. Argilés et al.   Journal of Cachexia Sarcopenia and Muscle

Cancer cachexia prevention via physical exercise: molecular mechanisms

(2012) Douglas W. Gould et al.   Journal of Cachexia Sarcopenia and Muscle

Sarcopenia, Dynapenia, and the Impact of Advancing Age on Human Skeletal Muscle Size and Strength; a Quantitative Review

(2012) W. Kyle Mitchell et al.   Frontiers in Physiology

l-Carnitine induces recovery of liver lipid metabolism in cancer cachexia

(2011) Renata Silvério et al.   AMINO ACIDS

Delta-9-tetrahydrocannabinol may palliate altered chemosensory perception in cancer patients: results of a randomized, double-blind, placebo-controlled pilot trial

(2011) T. D. Brisbois et al.   ANNALS OF ONCOLOGY

Changes in Myostatin Signaling in Non-Weight-Losing Cancer Patients

(2011) Zaira Aversa et al.   ANNALS OF SURGICAL ONCOLOGY

Chemotherapy-Induced Weakness and Fatigue in Skeletal Muscle: The Role of Oxidative Stress

(2011) Laura A.A. Gilliam et al.   ANTIOXIDANTS & REDOX SIGNALING

Carnitine Administration Reduces Cytokine Levels, Improves Food Intake, and Ameliorates Body Composition in Tumor-Bearing Rats

(2011) Alessandro Laviano et al.   CANCER INVESTIGATION

Muscle protein synthesis in cancer patients can be stimulated with a specially formulated medical food

(2011) Nicolaas E.P. Deutz et al.   CLINICAL NUTRITION

Randomized phase III clinical trial of a combined treatment with carnitine + celecoxib ± megestrol acetate for patients with cancer-related anorexia/cachexia syndrome

(2011) Clelia Madeddu et al.   CLINICAL NUTRITION

Beyond anorexia -cachexia. Nutrition and modulation of cancer patients' metabolism: Supplementary, complementary or alternative anti-neoplastic therapy?

(2011) Alessandro Laviano et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A Phase II Dose Titration Study of Thalidomide for Cancer-Associated Anorexia

(2011) Mellar Davis et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

Definition and classification of cancer cachexia: an international consensus

(2011) Kenneth Fearon et al.   LANCET ONCOLOGY

Pre-cachexia in patients with stages I–III non-small cell lung cancer: Systemic inflammation and functional impairment without activation of skeletal muscle ubiquitin proteasome system

(2011) C.M. Op den Kamp et al.   LUNG CANCER

Formoterol and cancer muscle wasting in rats: Effects on muscle force and total physical activity

(2011) SÍLVIA BUSQUETS et al.   Experimental and Therapeutic Medicine

Combined approach to counteract experimental cancer cachexia: eicosapentaenoic acid and training exercise

(2011) Fabio Penna et al.   Journal of Cachexia Sarcopenia and Muscle

The effect of exercise on IL-6-induced cachexia in theApcMin/+mouse

(2011) Melissa J. Puppa et al.   Journal of Cachexia Sarcopenia and Muscle

Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival

(2010) Xiaolan Zhou et al.   CELL

Resistance exercise and appropriate nutrition to counteract muscle wasting and promote muscle hypertrophy

(2010) Elisa I Glover et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Corticosteroids and muscle wasting: role of transcription factors, nuclear cofactors, and hyperacetylation

(2010) Per-Olof Hasselgren et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

The “parallel pathway”: a novel nutritional and metabolic approach to cancer patients

(2010) Maurizio Muscaritoli et al.   Internal and Emergency Medicine

Association of Skeletal Muscle Wasting With Treatment With Sorafenib in Patients With Advanced Renal Cell Carcinoma: Results From a Placebo-Controlled Study

(2010) Sami Antoun et al.   JOURNAL OF CLINICAL ONCOLOGY

Muscle Wasting and Impaired Myogenesis in Tumor Bearing Mice Are Prevented by ERK Inhibition

(2010) Fabio Penna et al.   PLoS One

An update of controlled physical activity trials in cancer survivors: a systematic review and meta-analysis

(2010) Rebecca M. Speck et al.   Journal of Cancer Survivorship

Acute inhibition of myostatin-family proteins preserves skeletal muscle in mouse models of cancer cachexia

(2009) Margaret E. Benny Klimek et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sarcopenia in an Overweight or Obese Patient Is an Adverse Prognostic Factor in Pancreatic Cancer

(2009) B. H.L. Tan et al.   CLINICAL CANCER RESEARCH

Sarcopenia as a Determinant of Chemotherapy Toxicity and Time to Tumor Progression in Metastatic Breast Cancer Patients Receiving Capecitabine Treatment

(2009) C. M.M. Prado et al.   CLINICAL CANCER RESEARCH

Deacetylase Inhibitors Modulate the Myostatin/Follistatin Axis without Improving Cachexia in Tumor-Bearing Mice

(2009) A. Bonetto et al.   CURRENT CANCER DRUG TARGETS

Muscle myostatin signalling is enhanced in experimental cancer cachexia

(2008) P. Costelli et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study

(2008) Carla MM Prado et al.   LANCET ONCOLOGY