Loss of LZAP inactivates p53 and regulates sensitivity of cells to DNA damage in a p53-dependent manner

LZAP is a novel Wip1 binding partner and positive regulator of its phosphatase activity in vitro

(2016) J. Jacob Wamsley et al.   CELL CYCLE

Mutant p53 determines pancreatic cancer poor prognosis to pancreatectomy through upregulation of cavin-1 in patients with preoperative serum CA19-9 ≥ 1,000 U/mL

(2016) Jin-Feng Xiang et al.   Scientific Reports

TP53: an oncogene in disguise

(2015) T Soussi et al.   CELL DEATH AND DIFFERENTIATION

Small-Molecule Reactivation of Mutant p53 to Wild-Type-like p53 through the p53-Hsp40 Regulatory Axis

(2015) Masatsugu Hiraki et al.   CHEMISTRY & BIOLOGY

Mutant p53: One, No One, and One Hundred Thousand

(2015) Dawid Walerych et al.   Frontiers in Oncology

Targeting Oncogenic Mutant p53 for Cancer Therapy

(2015) Alejandro Parrales et al.   Frontiers in Oncology

Radioprotection of normal tissue cells

(2014) Patrick Maier et al.   STRAHLENTHERAPIE UND ONKOLOGIE

Small molecule induced reactivation of mutant p53 in cancer cells

(2013) Xiangrui Liu et al.   NUCLEIC ACIDS RESEARCH

Cell-type, Dose, and Mutation-type Specificity Dictate Mutant p53 Functions In Vivo

(2012) Ming Kei Lee et al.   CANCER CELL

Mutant p53: one name, many proteins

(2012) W. A. Freed-Pastor et al.   GENES & DEVELOPMENT

Mutant p53 protein, master regulator of human malignancies: a report on the fifth Mutant p53 Workshop

(2011) G Blandino et al.   CELL DEATH AND DIFFERENTIATION

Tumor suppressor Lzap regulates cell cycle progression, doming, and zebrafish epiboly

(2011) Dan Liu et al.   DEVELOPMENTAL DYNAMICS

LZAP Inhibits p38 MAPK (p38) Phosphorylation and Activity by Facilitating p38 Association with the Wild-Type p53 Induced Phosphatase 1 (WIP1)

(2011) Hanbing An et al.   PLoS One

Wip1 promotes RUNX2-dependent apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agents

(2011) A. R. Goloudina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding wild-type and mutant p53 activities in human cancer: new landmarks on the way to targeted therapies

(2010) I Goldstein et al.   CANCER GENE THERAPY

A Novel C53/LZAP-interacting Protein Regulates Stability of C53/LZAP and DDRGK Domain-containing Protein 1 (DDRGK1) and Modulates NF-κB Signaling

(2010) Jianchun Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Radioprotection: smart games with death

(2010) Andrei V. Gudkov et al.   JOURNAL OF CLINICAL INVESTIGATION

Pathologies Associated with the p53 Response

(2010) A. V. Gudkov et al.   Cold Spring Harbor Perspectives in Biology

Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation

(2009) Hai Jiang et al.   CELL RESEARCH

Wrap53, a Natural p53 Antisense Transcript Required for p53 Induction upon DNA Damage

(2009) Salah Mahmoudi et al.   MOLECULAR CELL

The p53 target Wig-1 regulates p53 mRNA stability through an AU-rich element

(2009) A. Vilborg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutant p53 Gain-of-Function in Cancer

(2009) M. Oren et al.   Cold Spring Harbor Perspectives in Biology