LZAP is a novel Wip1 binding partner and positive regulator of its phosphatase activity in vitro

Noncanonical NF-κB Signaling in Health and Disease

(2016) Gökhan Cildir et al.   TRENDS IN MOLECULAR MEDICINE

Truncating mutations of PPM1D are found in blood DNA samples of lung cancer patients

(2015) A Zajkowicz et al.   BRITISH JOURNAL OF CANCER

Negative regulation of RelA phosphorylation: Emerging players and their roles in cancer

(2015) Xinyuan Lu et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Rho protein GTPases and their interactions with NFκB: crossroads of inflammation and matrix biology

(2014) Louis Tong et al.   BIOSCIENCE REPORTS

Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas

(2014) Liwei Zhang et al.   NATURE GENETICS

The WIP1 oncogene promotes progression and invasion of aggressive medulloblastoma variants

(2014) M C Buss et al.   ONCOGENE

Downregulation of Wip1 phosphatase modulates the cellular threshold of DNA damage signaling in mitosis

(2013) Libor Macurek et al.   CELL CYCLE

Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint

(2013) Petra Kleiblova et al.   JOURNAL OF CELL BIOLOGY

WIP1, a Homeostatic Regulator of the DNA Damage Response, Is Targeted by HIPK2 for Phosphorylation and Degradation

(2013) Dong Wook Choi et al.   MOLECULAR CELL

PPM1A is a RelA phosphatase with tumor suppressor-like activity

(2013) X Lu et al.   ONCOGENE

Activation of WIP1 Phosphatase by HTLV-1 Tax Mitigates the Cellular Response to DNA Damage

(2013) Tajhal Dayaram et al.   PLoS One

Wip1 suppresses apoptotic cell death through direct dephosphorylation of BAX in response to γ-radiation

(2013) J-Y Song et al.   Cell Death & Disease

Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer

(2012) Elise Ruark et al.   NATURE

Overexpression of a Novel Activator of PAK4, the CDK5 Kinase-Associated Protein CDK5RAP3, Promotes Hepatocellular Carcinoma Metastasis

(2011) G. W.-Y. Mak et al.   CANCER RESEARCH

Tumor suppressor Lzap regulates cell cycle progression, doming, and zebrafish epiboly

(2011) Dan Liu et al.   DEVELOPMENTAL DYNAMICS

Regulation of the Wip1 phosphatase and its effects on the stress response Julie Lowe, Hyukjin Cha, Mi-Ok Lee, Sharlyn J. Mazur, Ettore Appella, Albert J. Fornace Jr.

(2011) Julie Lowe   Frontiers in Bioscience-Landmark

LZAP Inhibits p38 MAPK (p38) Phosphorylation and Activity by Facilitating p38 Association with the Wild-Type p53 Induced Phosphatase 1 (WIP1)

(2011) Hanbing An et al.   PLoS One

Identification of LZAP as a New Candidate Tumor Suppressor in Hepatocellular Carcinoma

(2011) Jing-jing Zhao et al.   PLoS One

Wip1 Directly Dephosphorylates  -H2AX and Attenuates the DNA Damage Response

(2010) H. Cha et al.   CANCER RESEARCH

Hexamethylene Bisacetamide (HMBA) simultaneously targets AKT and MAPK pathway and represses NF-κB activity: Implications for cancer therapy

(2010) Anwesha Dey et al.   CELL CYCLE

A Novel C53/LZAP-interacting Protein Regulates Stability of C53/LZAP and DDRGK Domain-containing Protein 1 (DDRGK1) and Modulates NF-κB Signaling

(2010) Jianchun Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wild-type p53-induced Phosphatase 1 Dephosphorylates Histone Variant γ-H2AX and Suppresses DNA Double Strand Break Repair

(2010) Sung-Hwan Moon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel LZAP-binding Protein, NLBP, Inhibits Cell Invasion

(2010) Junhye Kwon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Telomere-independent Rap1 is an IKK adaptor and regulates NF-κB-dependent gene expression

(2010) Hsiangling Teo et al.   NATURE CELL BIOLOGY

Phosphorylation and Degradation of MdmX Is Inhibited by Wip1 Phosphatase in the DNA Damage Response

(2009) X. Zhang et al.   CANCER RESEARCH

p53 and NFκB: fresh breath in the cross talk

(2009) Vinay Tergaonkar   CELL RESEARCH

Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation

(2009) Hai Jiang et al.   CELL RESEARCH

WIP1 phosphatase is a negative regulator of NF-κB signalling

(2009) Joanne Chew et al.   NATURE CELL BIOLOGY

The type 2C phosphatase Wip1: An oncogenic regulator of tumor suppressor and DNA damage response pathways

(2008) Xiongbin Lu et al.   CANCER AND METASTASIS REVIEWS

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL