The common γ-chain cytokine receptor: tricks-and-treats for T cells

Insights into Cytokine–Receptor Interactions from Cytokine Engineering

(2015) Jamie B. Spangler et al.   Annual Review of Immunology

IL-7 and TSLP receptors: twisted sisters

(2014) S. K. Durum   BLOOD

Therapeutic activity of multiple common  -chain cytokine inhibition in acute and chronic GVHD

(2014) A.-K. Hechinger et al.   BLOOD

Novel activating mutations lacking cysteine in type I cytokine receptors in acute lymphoblastic leukemia

(2014) C. Shochat et al.   BLOOD

Activated T Cells Secrete an Alternatively Spliced Form of Common γ-Chain that Inhibits Cytokine Signaling and Exacerbates Inflammation

(2014) Changwan Hong et al.   IMMUNITY

An Uncommon Tail about the Common γ-Chain

(2014) Stephen C. Jameson et al.   IMMUNITY

T cell receptor stimulation impairs IL-7 receptor signaling by inducing expression of the microRNA miR-17 to target Janus kinase 1

(2014) G. Katz et al.   Science Signaling

Pim1 permits generation and survival of CD4+T cells in the absence of γc cytokine receptor signaling

(2013) Brett A. Linowes et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Th17 family: flexibility follows function

(2013) Rajatava Basu et al.   IMMUNOLOGICAL REVIEWS

Using EAE to better understand principles of immune function and autoimmune pathology

(2013) Manu Rangachari et al.   JOURNAL OF AUTOIMMUNITY

Circulating IL-15 exists as heterodimeric complex with soluble IL-15R  in human and mouse serum

(2012) C. Bergamaschi et al.   BLOOD

Structural insights into the common γ-chain family of cytokines and receptors from the interleukin-7 pathway

(2012) Scott T. R. Walsh   IMMUNOLOGICAL REVIEWS

Conditional deletion of cytokine receptor chains reveals that IL-7 and IL-15 specify CD8 cytotoxic lineage fate in the thymus

(2012) Tom M. McCaughtry et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-7 signaling must be intermittent, not continuous, during CD8+ T cell homeostasis to promote cell survival instead of cell death

(2012) Motoko Y Kimura et al.   NATURE IMMUNOLOGY

Structural reorganization of the interleukin-7 signaling complex

(2012) C. A. McElroy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Jak1 Has a Dominant Role over Jak3 in Signal Transduction through γc-Containing Cytokine Receptors

(2011) Claude Haan et al.   CHEMISTRY & BIOLOGY

Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia

(2011) Priscila P Zenatti et al.   NATURE GENETICS

Prolonged Interleukin-2Rα Expression on Virus-Specific CD8+ T Cells Favors Terminal-Effector Differentiation In Vivo

(2010) Vandana Kalia et al.   IMMUNITY

Interleukin-7 Compartmentalizes Its Receptor Signaling Complex to Initiate CD4 T Lymphocyte Response

(2010) Thierry Rose et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Critical Requirement of GABPα for Normal T Cell Development

(2010) Shuyang Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Implications for Gene Therapy-Limiting Expression of IL-2R c Delineate Differences in Signaling Thresholds Required for Lymphocyte Development and Maintenance

(2010) S. J. Orr et al.   JOURNAL OF IMMUNOLOGY

IL-2 Induces Conformational Changes in Its Preassembled Receptor Core, Which Then Migrates in Lipid Raft and Binds to the Cytoskeleton Meshwork

(2010) Anne-Hélène Pillet et al.   JOURNAL OF MOLECULAR BIOLOGY

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

(2010) Jung-Hyun Park et al.   NATURE IMMUNOLOGY

T cells expressing the transcription factor PLZF regulate the development of memory-like CD8+ T cells

(2010) Michael A Weinreich et al.   NATURE IMMUNOLOGY

Interleukin-2 in the development and control of inflammatory disease

(2009) Katrina K. Hoyer et al.   IMMUNOLOGICAL REVIEWS

The Cellular Amount of the Common  -Chain Influences Spontaneous or Induced Cell Proliferation

(2009) S. Amorosi et al.   JOURNAL OF IMMUNOLOGY

A Fundamental Role for Interleukin-21 in the Generation of T Follicular Helper Cells

(2008) Alexis Vogelzang et al.   IMMUNITY

Generation of T Follicular Helper Cells Is Mediated by Interleukin-21 but Independent of T Helper 1, 2, or 17 Cell Lineages

(2008) Roza I. Nurieva et al.   IMMUNITY

The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation

(2008) Wenjun Ouyang et al.   IMMUNITY

Ligand-independent Homomeric and Heteromeric Complexes between Interleukin-2 or -9 Receptor Subunits and the γ Chain

(2008) Yaniv Malka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Biology of Shared Cytokine Receptors

(2007) Xinquan Wang et al.   Annual Review of Immunology