The Role of Proteinase-Activated Receptors 1 and 2 in the Regulation of Periodontal Tissue Metabolism and Disease

uPA Attenuated LPS-induced Inflammatory Osteoclastogenesis through the Plasmin/PAR-1/Ca2+/CaMKK/AMPK Axis

(2016) Yosuke Kanno et al.   International Journal of Biological Sciences

Thrombin Activates Latent TGFβ1 via Integrin αvβ1 in Gingival Fibroblasts

(2016) W.H. Yang et al.   JOURNAL OF DENTAL RESEARCH

Downregulation of Proteinase-Activated Receptor-2, Interleukin-17, and Other Proinflammatory Genes by Subantimicrobial Doxycycline Dose in a Rat Periodontitis Model

(2016) Myrella L. Castro et al.   JOURNAL OF PERIODONTOLOGY

Porphyromonas gingivalis Gingipain-Dependently Enhances IL-33 Production in Human Gingival Epithelial Cells

(2016) Hiroyuki Tada et al.   PLoS One

Protease-activated receptors expression in gingiva in periodontal health and disease

(2014) Diya Zhang et al.   ARCHIVES OF ORAL BIOLOGY

Expression of Protease Activated Receptor-1 in Chronic Periodontitis

(2014) Henrique Aparecido Bueno da Silva et al.   JOURNAL OF PERIODONTOLOGY

Influence of Parstatin on Experimental Periodontal Disease and Repair in Rats

(2014) Luís Carlos Spolidorio et al.   JOURNAL OF PERIODONTOLOGY

Biased Signaling of Protease-Activated Receptors

(2014) Peishen Zhao et al.   Frontiers in Endocrinology

Biased signalling and proteinase-activated receptors (PARs): targeting inflammatory disease

(2013) M D Hollenberg et al.   BRITISH JOURNAL OF PHARMACOLOGY

Periodontal Treatment Downregulates Protease-Activated Receptor 2 in Human Gingival Crevicular Fluid Cells

(2013) Vanessa Tubero Euzebio Alves et al.   INFECTION AND IMMUNITY

Human β-defensin 2 and protease activated receptor-2 expression in patients with chronic periodontitis

(2012) Alexandre Lustosa Pereira et al.   ARCHIVES OF ORAL BIOLOGY

Targeting proteinase-activated receptors: therapeutic potential and challenges

(2012) Rithwik Ramachandran et al.   NATURE REVIEWS DRUG DISCOVERY

Plasmin Is Essential in Preventing Periodontitis in Mice

(2011) Rima Sulniute et al.   AMERICAN JOURNAL OF PATHOLOGY

Protease-activated receptor 2, rather than protease-activated receptor 1, contributes to the aggressive properties of synovial fibroblasts in rheumatoid arthritis

(2011) Meilang Xue et al.   ARTHRITIS AND RHEUMATISM

Porphyromonas Gingivalisis Associated With Protease-Activated Receptor-2 Upregulation in Chronic Periodontitis

(2011) José Américo G. Fagundes et al.   JOURNAL OF PERIODONTOLOGY

Nafamostat mesilate, a potent tryptase inhibitor, modulates periodontitis in rats

(2010) Marinella Holzhausen et al.   Clinical Oral Investigations

Protease-activated Receptor-2 (par2) in Human Periodontitis

(2010) M. Holzhausen et al.   JOURNAL OF DENTAL RESEARCH

Thrombin-stimulated growth factor and cytokine expression in osteoblasts is mediated by protease-activated receptor-1 and prostanoids

(2009) Charles N. Pagel et al.   BONE

Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts

(2009) Nathalie Amiable et al.   BONE

Regulation of protease-activated receptor-2 expression in gingival fibroblasts and Jurkat T cells byPorphyromonas gingivalis

(2009) Georgios N Belibasakis et al.   CELL BIOLOGY INTERNATIONAL

Thrombin-stimulated proliferation is mediated by endothelin-1 in cultured rat gingival fibroblasts

(2009) Nozomi Ohuchi et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Protease-Activated Receptor 2 Has Pivotal Roles in Cellular Mechanisms Involved in Experimental Periodontitis

(2009) D. M. Wong et al.   INFECTION AND IMMUNITY

Modulation of expression of innate immunity markers CXCL5/ENA-78 and CCL20/MIP3α by protease-activated receptors (PARs) in human gingival epithelial cells

(2009) Maryam G. Rohani et al.   Innate Immunity

Cleavage of protease-activated receptors on an immortalized oral epithelial cell line by Porphyromonas gingivalis gingipains

(2009) R. A. Giacaman et al.   MICROBIOLOGY-SGM

Protease-activated receptors as drug targets in inflammation and pain

(2009) Nathalie Vergnolle   PHARMACOLOGY & THERAPEUTICS

Protease-activated receptor 2 mediates interleukin-8 and intercellular adhesion molecule-1 expression in response toAggregatibacter actinomycetemcomitans

(2009) T. Shimada et al.   Oral microbiology and immunology

Gingipains from Porphyromonas gingivalis synergistically induce the production of proinflammatory cytokines through protease-activated receptors with Toll-like receptor and NOD1/2 ligands in human monocytic cells

(2008) A. Uehara et al.   CELLULAR MICROBIOLOGY

Thrombin induces osteoprotegerin synthesis via phosphatidylinositol 3′-kinase/mammalian target of rapamycin pathway in human periodontal ligament cells

(2008) U. Arayatrakoollikit et al.   JOURNAL OF PERIODONTAL RESEARCH

Role of PAR2 in murine pulmonary pseudomonal infection

(2007) Theo J. Moraes et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY