Protease-activated receptor 2, rather than protease-activated receptor 1, contributes to the aggressive properties of synovial fibroblasts in rheumatoid arthritis

PAR1- and PAR2-induced innate immune markers are negatively regulated by PI3K/Akt signaling pathway in oral keratinocytes

(2010) Maryam G Rohani et al.   BMC IMMUNOLOGY

Curcumin Inhibits the Proteinase-Activated Receptor-2–Triggered Prostaglandin E2 Production by Suppressing Cyclooxygenase-2 Upregulation and Akt-Dependent Activation of Nuclear Factor-κB in Human Lung Epithelial Cells

(2010) Kazumi Moriyuki et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

PAR1 and PAR2 Couple to Overlapping and Distinct Sets of G Proteins and Linked Signaling Pathways to Differentially Regulate Cell Physiology

(2010) K. L. McCoy et al.   MOLECULAR PHARMACOLOGY

Protease activated receptor-1 inhibits the Maspin tumor-suppressor gene to determine the melanoma metastatic phenotype

(2010) G. J. Villares et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rheumatoid arthritis progression mediated by activated synovial fibroblasts

(2010) Elena Neumann et al.   TRENDS IN MOLECULAR MEDICINE

Cell culture and passaging alters gene expression pattern and proliferation rate in rheumatoid arthritis synovial fibroblasts

(2010) Elena Neumann et al.   ARTHRITIS RESEARCH & THERAPY

Protease-activated receptor-1 (PAR-1) promotes the motility of human melanomas and is associated to their metastatic phenotype

(2009) Antonietta Silini et al.   CLINICAL & EXPERIMENTAL METASTASIS

Protease-activated receptor-1 regulates cytokine production and induces the suppressor of cytokine signaling-3 in microglia

(2009) Fabrizi   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Synovial fibroblasts spread rheumatoid arthritis to unaffected joints

(2009) Stephanie Lefèvre et al.   NATURE MEDICINE

Thrombin receptor: An endogenous inhibitor of inflammatory pain, activating opioid pathways

(2009) Laurence Martin et al.   PAIN

PAR2 triggers IL-8 release via MEK/ERK and PI3-kinase/Akt pathways in GI epithelial cells

(2008) Yusuke Tanaka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protease-Activated Receptor (PAR) 2, but not PAR1, Signaling Promotes the Development of Mammary Adenocarcinoma in Polyoma Middle T Mice

(2008) H. H. Versteeg et al.   CANCER RESEARCH

p38/NF‐kB‐dependent expression of COX‐2 during differentiation and inflammatory response of chondrocytes

(2008) Valentina Ulivi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Role of protease-activated receptors in inflammatory responses, innate and adaptive immunity

(2008) V. Shpacovitch et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Signalling, inflammation and arthritis: NF- B and its relevance to arthritis and inflammation

(2008) R. E. Simmonds et al.   RHEUMATOLOGY

Thrombin-induced IL-6 production in human synovial fibroblasts is mediated by PAR1, phospholipase C, protein kinase Cα, c-Src, NF-kappaB and p300 pathway

(2007) Yung-Cheng Chiu et al.   MOLECULAR IMMUNOLOGY