Blockade of P2X4 Receptors Inhibits Neuropathic Pain-Related Behavior by Preventing MMP-9 Activation and, Consequently, Pronociceptive Interleukin Release in a Rat Model

Neuropathic pain prevalence following spinal cord injury: A systematic review and meta-analysis

(2016) D. Burke et al.   EUROPEAN JOURNAL OF PAIN

Participation of pro- and anti-nociceptive interleukins in botulinum toxin A-induced analgesia in a rat model of neuropathic pain

(2016) Magdalena Zychowska et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Celecoxib reverts oxaliplatin-induced neuropathic pain through inhibiting PI3K/Akt2 pathway in the mouse dorsal root ganglion

(2016) Shu-Ping Jiang et al.   EXPERIMENTAL NEUROLOGY

CORM-2 inhibits TXNIP/NLRP3 inflammasome pathway in LPS-induced acute lung injury

(2016) Lei Jiang et al.   INFLAMMATION RESEARCH

Animal models of chronic pain: Advances and challenges for clinical translation

(2016) Nicole E. Burma et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Blockade of IL-18 signaling diminished neuropathic pain and enhanced the efficacy of morphine and buprenorphine

(2016) Dominika Pilat et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Early P2X7R-related astrogliosis in autoimmune encephalomyelitis

(2016) Tomasz Grygorowicz et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Crosstalk between astrocytic CXCL12 and microglial CXCR4 contributes to the development of neuropathic pain

(2016) Xin Luo et al.   Molecular Pain

Pharmacological kynurenine 3-monooxygenase enzyme inhibition significantly reduces neuropathic pain in a rat model

(2016) Ewelina Rojewska et al.   NEUROPHARMACOLOGY

Maraviroc reduces neuropathic pain through polarization of microglia and astroglia – Evidence from in vivo and in vitro studies

(2016) Anna Piotrowska et al.   NEUROPHARMACOLOGY

Treatment with a carbon monoxide-releasing molecule (CORM-2) inhibits neuropathic pain and enhances opioid effectiveness in rats

(2016) Agnieszka M. Jurga et al.   Pharmacological Reports

Beneficial properties of maraviroc on neuropathic pain development and opioid effectiveness in rats

(2016) Klaudia Kwiatkowski et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Upregulation of Chemokine CXCL12 in the Dorsal Root Ganglia and Spinal Cord Contributes to the Development and Maintenance of Neuropathic Pain Following Spared Nerve Injury in Rats

(2016) Liying Bai et al.   Neuroscience Bulletin

Blockade of Toll-Like Receptors (TLR2, TLR4) Attenuates Pain and Potentiates Buprenorphine Analgesia in a Rat Neuropathic Pain Model

(2016) Agnieszka M. Jurga et al.   NEURAL PLASTICITY

MCP-1 stimulates spinal microglia via PI3K/Akt pathway in bone cancer pain

(2015) Di Jin et al.   BRAIN RESEARCH

Electroacupuncture inhibits excessive interferon-γ evoked up-regulation of P2X4 receptor in spinal microglia in a CCI rat model for neuropathic pain

(2015) X.-M. Chen et al.   BRITISH JOURNAL OF ANAESTHESIA

IL-1 receptor antagonist improves morphine and buprenorphine efficacy in a rat neuropathic pain model

(2015) Dominika Pilat et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

H2Treatment Attenuated Pain Behavior and Cytokine Release Through the HO-1/CO Pathway in a Rat Model of Neuropathic Pain

(2015) Yajun Chen et al.   INFLAMMATION

Retracted: CXCL12/CXCR4 chemokine signaling in spinal glia induces pain hypersensitivity through MAPKs-mediated neuroinflammation in bone cancer rats

(2015) Xue-Ming Hu et al.   JOURNAL OF NEUROCHEMISTRY

mTOR, a New Potential Target for Chronic Pain and Opioid-Induced Tolerance and Hyperalgesia

(2015) Brianna Marie Lutz et al.   Molecular Pain

Spinal Heme Oxygenase-1 (HO-1) Exerts Antinociceptive Effects Against Neuropathic Pain in a Mouse Model of L5 Spinal Nerve Ligation

(2015) Xiaoming Liu et al.   PAIN MEDICINE

Repetitive Treatment with Diluted Bee Venom Attenuates the Induction of Below-Level Neuropathic Pain Behaviors in a Rat Spinal Cord Injury Model

(2015) Suk-Yun Kang et al.   Toxins

Parthenolide Relieves Pain and Promotes M2 Microglia/Macrophage Polarization in Rat Model of Neuropathy

(2015) Katarzyna Popiolek-Barczyk et al.   NEURAL PLASTICITY

Neuropathic Pain Phenotype Does Not Involve the NLRP3 Inflammasome and Its End Product Interleukin-1β in the Mice Spared Nerve Injury Model

(2015) Verdad Curto-Reyes et al.   PLoS One

PD98059 Influences Immune Factors and Enhances Opioid Analgesia in Model of Neuropathy

(2015) Ewelina Rojewska et al.   PLoS One

Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice

(2014) Gang Chen et al.   BRAIN

Activation of spinal phosphatidylinositol 3-kinase/protein kinase B mediates pain behavior induced by plantar incision in mice

(2014) Bing Xu et al.   EXPERIMENTAL NEUROLOGY

Involvement of pro- and antinociceptive factors in minocycline analgesia in rat neuropathic pain model

(2014) Ewelina Rojewska et al.   JOURNAL OF NEUROIMMUNOLOGY

Histamine Induces Upregulated Expression of Histamine Receptors and Increases Release of Inflammatory Mediators from Microglia

(2014) Hongquan Dong et al.   MOLECULAR NEUROBIOLOGY

Delta-Opioid Receptor Analgesia Is Independent of Microglial Activation in a Rat Model of Neuropathic Pain

(2014) Joanna Mika et al.   PLoS One

Minocycline Enhances the Effectiveness of Nociceptin/Orphanin FQ during Neuropathic Pain

(2014) Katarzyna Popiolek-Barczyk et al.   Biomed Research International

Glucuronic acid and the ethanol metabolite ethyl-glucuronide cause toll-like receptor 4 activation and enhanced pain

(2013) Susannah S. Lewis et al.   BRAIN BEHAVIOR AND IMMUNITY

Importance of glial activation in neuropathic pain

(2013) Joanna Mika et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Effects of selective and non-selective inhibitors of nitric oxide synthase on morphine- and endomorphin-1-induced analgesia in acute and neuropathic pain in rats

(2013) Wioletta Makuch et al.   NEUROPHARMACOLOGY

The known knowns of microglia–neuronal signalling in neuropathic pain

(2013) Simon Beggs et al.   NEUROSCIENCE LETTERS

Treatment with a carbon monoxide-releasing molecule inhibits chronic inflammatory pain in mice: nitric oxide contribution

(2013) Roger Negrete et al.   PSYCHOPHARMACOLOGY

P2X4 Receptors Influence Inflammasome Activation after Spinal Cord Injury

(2012) J. P. de Rivero Vaccari et al.   JOURNAL OF NEUROSCIENCE

Painful Nerve Injury Increases Plasma Membrane Ca2+-ATPase Activity in Axotomized Sensory Neurons

(2012) Geza Gemes et al.   Molecular Pain

Regulation of inflammasome signaling

(2012) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

P2X4 purinoceptor signaling in chronic pain

(2012) Tuan Trang et al.   Purinergic Signalling

Inhibition of phosphatidylinositol-3 kinase γ reduces pruriceptive, inflammatory, and nociceptive responses induced by trypsin in mice

(2011) Paula Juliana Seadi Pereira et al.   PAIN

The carbon monoxide donor, CORM-2, is an antagonist of ATP-gated, human P2X4 receptors

(2011) William James Wilkinson et al.   Purinergic Signalling

An IL-1 receptor antagonist blocks a morphine-induced attenuation of locomotor recovery after spinal cord injury

(2010) Michelle A. Hook et al.   BRAIN BEHAVIOR AND IMMUNITY

Antinociceptive effects of histamine H3 receptor antagonist in the preclinical models of pain in rats and the involvement of central noradrenergic systems

(2010) Gin C. Hsieh et al.   BRAIN RESEARCH

Amitriptyline does not block the action of ATP at human P2X4 receptor

(2010) JA Sim et al.   BRITISH JOURNAL OF PHARMACOLOGY

R-Flurbiprofen Reduces Neuropathic Pain in Rodents by Restoring Endogenous Cannabinoids

(2010) Philipp Bishay et al.   PLoS One

Mechanisms underlying fibronectin-induced up-regulation of P2X4R expression in microglia: distinct roles of PI3K-Akt and MEK-ERK signalling pathways

(2009) Makoto Tsuda et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

(2009) Luigi Franchi et al.   NATURE IMMUNOLOGY

Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia

(2008) Mark R. Hutchinson et al.   BRAIN BEHAVIOR AND IMMUNITY

Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia

(2008) Mark R. Hutchinson et al.   BRAIN BEHAVIOR AND IMMUNITY

Interleukin-18-Mediated Microglia/Astrocyte Interaction in the Spinal Cord Enhances Neuropathic Pain Processing after Nerve Injury

(2008) K. Miyoshi et al.   JOURNAL OF NEUROSCIENCE

Up-Regulation of P2X4 Receptors in Spinal Microglia after Peripheral Nerve Injury Mediates BDNF Release and Neuropathic Pain

(2008) L. Ulmann et al.   JOURNAL OF NEUROSCIENCE

Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain

(2008) Yasuhiko Kawasaki et al.   NATURE MEDICINE

Interleukin-1alpha has antiallodynic and antihyperalgesic activities in a rat neuropathic pain model

(2008) Joanna Mika et al.   PAIN

Novel histamine H3 receptor antagonists GSK189254 and GSK334429 are efficacious in surgically-induced and virally-induced rat models of neuropathic pain

(2008) Stephen J. Medhurst et al.   PAIN

A novel role of minocycline: Attenuating morphine antinociceptive tolerance by inhibition of p38 MAPK in the activated spinal microglia

(2007) Yu Cui et al.   BRAIN BEHAVIOR AND IMMUNITY