Induction of Mkp-1 and Nuclear Translocation of Nrf2 by Limonoids from Khaya grandifoliola C.DC Protect L-02 Hepatocytes against Acetaminophen-Induced Hepatotoxicity

Active chemical fractions of stem bark extract of Khaya grandifoliola C.DC and Entada africana Guill. et Perr. synergistically protect primary rat hepatocytes against paracetamol-induced damage

(2016) Frédéric Nico Njayou et al.   BMC Complementary and Alternative Medicine

Caffeic acid prevents acetaminophen-induced liver injury by activating the Keap1-Nrf2 antioxidative defense system

(2016) Chun Pang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Antioxidant fractions of Khaya grandifoliola C.DC. and Entada africana Guill. et Perr. induce nuclear translocation of Nrf2 in HC-04 cells

(2015) Frédéric Nico Njayou et al.   CELL STRESS & CHAPERONES

Role of Mitochondrial Electron Transport Chain Dysfunction in Cr(VI)-Induced Cytotoxicity in L-02 Hepatocytes

(2014) Fang Xiao et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Mechanisms of acetaminophen-induced cell death in primary human hepatocytes

(2014) Yuchao Xie et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Review of natural products with hepatoprotective effects

(2014) Eduardo Madrigal-Santillán   WORLD JOURNAL OF GASTROENTEROLOGY

Models of drug-induced liver injury for evaluation of phytotherapeutics and other natural products

(2013) Hartmut Jaeschke et al.   FOOD AND CHEMICAL TOXICOLOGY

The Protective Effect of Glycyrrhetinic Acid on Carbon Tetrachloride-Induced Chronic Liver Fibrosis in Mice via Upregulation of Nrf2

(2013) Shaoru Chen et al.   PLoS One

An Overview on Chemical Aspects and Potential Health Benefits of Limonoids and Their Derivatives

(2012) Rosa Tundis et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity

(2012) Hartmut Jaeschke et al.   DRUG METABOLISM REVIEWS

Lupeol protects against acetaminophen-induced oxidative stress and cell death in rat primary hepatocytes

(2012) Archana Kumari et al.   FOOD AND CHEMICAL TOXICOLOGY

Lupeol prevents acetaminophen-induced in vivo hepatotoxicity by altering the Bax/Bcl-2 and oxidative stress-mediated mitochondrial signaling cascade

(2012) Archana Kumari et al.   LIFE SCIENCES

Andirolides H–P from the flower of andiroba (Carapa guianensis, Meliaceae)

(2012) Yuji Tanaka et al.   TETRAHEDRON

Mitogen-activated Protein Kinase Phosphatase (Mkp)-1 Protects Mice against Acetaminophen-induced Hepatic Injury

(2012) Lyn M. Wancket et al.   TOXICOLOGIC PATHOLOGY

Current issues with acetaminophen hepatotoxicity—A clinically relevant model to test the efficacy of natural products

(2011) Hartmut Jaeschke et al.   LIFE SCIENCES

Apoptosis-Inducing Factor Modulates Mitochondrial Oxidant Stress in Acetaminophen Hepatotoxicity

(2011) Mary Lynn Bajt et al.   TOXICOLOGICAL SCIENCES

Absolute stereostructure of Andirolides A–G from the flower of Carapa guianensis (Meliaceae)

(2010) Yuji Tanaka et al.   TETRAHEDRON

Temporal study of acetaminophen (APAP) and S-adenosyl-l-methionine (SAMe) effects on subcellular hepatic SAMe levels and methionine adenosyltransferase (MAT) expression and activity

(2010) J. Michael Brown et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity

(2010) Chieko Saito et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Hepatoprotective effects ofS-adenosyl-L-methionine against alcohol- and cytochrome P450 2E1-induced liver injury

(2010) Arthur I Cederbaum   WORLD JOURNAL OF GASTROENTEROLOGY

Protective mechanisms ofN-acetyl-cysteine against pyrrolizidine alkaloid clivorine-induced hepatotoxicity

(2009) Lili Ji et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Dietary Curcumin and Limonin Suppress CD4+ T-Cell Proliferation and Interleukin-2 Production in Mice

(2009) Wooki Kim et al.   JOURNAL OF NUTRITION

Structure Determination of Grandifotane A fromKhaya grandifoliolaby NMR, X-ray Diffraction, and ECD Calculation

(2009) Tao Yuan et al.   ORGANIC LETTERS

Nrf2 signaling and cell survival

(2009) Suryakant K. Niture et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The MAP Kinase Phosphatase-1 MKP-1/DUSP1 Is a Regulator of Human Liver Response to Transplantation

(2008) T. Boutros et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Deletion of Apoptosis Signal-Regulating Kinase 1 Attenuates Acetaminophen-Induced Liver Injury by Inhibiting c-Jun N-Terminal Kinase Activation

(2008) Hayato Nakagawa et al.   GASTROENTEROLOGY

Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance

(2008) Rajat Singh et al.   HEPATOLOGY

Role of JNK Translocation to Mitochondria Leading to Inhibition of Mitochondria Bioenergetics in Acetaminophen-induced Liver Injury

(2008) Naoko Hanawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Glucosidase Inhibitory Activity of Triterpenoids fromCichorium intybus

(2008) Atta-ur-Rahman et al.   JOURNAL OF NATURAL PRODUCTS

Evaluations of the trans-sulfuration pathway in multiple liver toxicity studies

(2008) Laura K. Schnackenberg et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY