Hyperactivity of Hypothalamic-Pituitary-Adrenal Axis Due to Dysfunction of the Hypothalamic Glucocorticoid Receptor in Sigma-1 Receptor Knockout Mice

Disruption of Glucagon-Like Peptide 1 Signaling in Sim1 Neurons Reduces Physiological and Behavioral Reactivity to Acute and Chronic Stress

(2017) Sriparna Ghosal et al.   JOURNAL OF NEUROSCIENCE

Retinoic acid increases glucocorticoid receptor phosphorylation via cyclin-dependent kinase 5

(2017) Julie Brossaud et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Sigma-1 receptor deficiency reduces GABAergic inhibition in the basolateral amygdala leading to LTD impairment and depressive-like behaviors

(2017) Baofeng Zhang et al.   NEUROPHARMACOLOGY

Sex differences in the effect of chronic mild stress on mouse prefrontal cortical BDNF levels: A role of major ovarian hormones

(2017) Bhanu Chandra Karisetty et al.   NEUROSCIENCE

The antidepressant effect of musk in an animal model of depression: a histopathological study

(2016) Nasra Naeim Ayuob et al.   CELL AND TISSUE RESEARCH

Regulation of the expression of corticotropin-releasing factor gene by pyroglutamylated RFamide peptide in rat hypothalamic 4B cells

(2016) Noriko Ishigame et al.   ENDOCRINE JOURNAL

Activation of Sigma-1 Receptor Alleviates Postpartum Estrogen Withdrawal-Induced “Depression” Through Restoring Hippocampal nNOS-NO-CREB Activities in Mice

(2016) Suyun Zhang et al.   MOLECULAR NEUROBIOLOGY

The HPA axis in bipolar disorder: Systematic review and meta-analysis

(2016) Martino Belvederi Murri et al.   PSYCHONEUROENDOCRINOLOGY

Signal transduction in the hypothalamic corticotropin-releasing factor system and its clinical implications

(2016) Kazunori Kageyama et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Mechanisms of rapid glucocorticoid feedback inhibition of the hypothalamic–pituitary–adrenal axis

(2016) Jeffrey G. Tasker et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Sex-related neurogenesis decrease in hippocampal dentate gyrus with depressive-like behaviors in sigma-1 receptor knockout mice

(2015) Sha Sha et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Simvastatin prevents β-amyloid25–35-impaired neurogenesis in hippocampal dentate gyrus through α7nAChR-dependent cascading PI3K-Akt and increasing BDNF via reduction of farnesyl pyrophosphate

(2015) Conghui Wang et al.   NEUROPHARMACOLOGY

Effect of a novel 5-HT 3 receptor antagonist 4i, in corticosterone-induced depression-like behavior and oxidative stress in mice

(2015) Deepali Gupta et al.   STEROIDS

The Role of Ketamine in Treatment-Resistant Depression: A Systematic Review

(2014) Gianluca Serafini et al.   Current Neuropharmacology

Glucocorticoid receptor deletion from the dorsal raphé nucleus of mice reduces dysphoria-like behavior and impairs hypothalamic-pituitary-adrenocortical axis feedback inhibition

(2014) Melanie Y. Vincent et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Lack of seipin in neurons results in anxiety- and depression-like behaviors via down regulation of PPARγ

(2014) Libin Zhou et al.   HUMAN MOLECULAR GENETICS

Relative adrenal insufficiency in mice deficient in 5α-reductase 1

(2014) Dawn E W Livingstone et al.   JOURNAL OF ENDOCRINOLOGY

NMDA Receptors Are Upregulated and Trafficked to the Plasma Membrane after Sigma-1 Receptor Activation in the Rat Hippocampus

(2014) M. Pabba et al.   JOURNAL OF NEUROSCIENCE

Effects of PB190 and PB212, new σ receptor ligands, on glucocorticoid receptor-mediated gene transcription in LMCAT cells

(2014) Grażyna Skuza et al.   Pharmacological Reports

Morning cortisol levels in schizophrenia and bipolar disorder: A meta-analysis

(2014) Leah Girshkin et al.   PSYCHONEUROENDOCRINOLOGY

Sigma-1 Receptor Knockout Impairs Neurogenesis in Dentate Gyrus of Adult HippocampusViaDown-Regulation of NMDA Receptors

(2013) Sha Sha et al.   CNS Neuroscience & Therapeutics

HPA axis changes during the initial phase of psychosocial stressor exposure in male mice

(2013) Nicole Uschold-Schmidt et al.   JOURNAL OF ENDOCRINOLOGY

Disrupting Hypothalamic Glucocorticoid Receptors Causes HPA Axis Hyperactivity and Excess Adiposity

(2013) Gloria Laryea et al.   MOLECULAR ENDOCRINOLOGY

Increased Prevalence of Anxiety-Associated Personality Traits in Patients with Cushing's Disease: A Cross-Sectional Study

(2012) C. Dimopoulou et al.   NEUROENDOCRINOLOGY

Involvement of PKA, CaMKII, PKC, MAPK/ERK and PI3K in the acute antidepressant-like effect of ferulic acid in the tail suspension test

(2012) Ana Lúcia Bertarello Zeni et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Protein kinase C phosphorylates the cAMP response element binding protein in the hypothalamic paraventricular nucleus during morphine withdrawal

(2011) F Martín et al.   BRITISH JOURNAL OF PHARMACOLOGY

Investigation of the role of sigma1-receptors in inositol 1,4,5-trisphosphate dependent calcium signaling in hepatocytes

(2011) A. Abou-lovergne et al.   CELL CALCIUM

Behavioural phenotyping of knockout mice for the sigma-1 (σ1) chaperone protein revealed gender-related anxiety, depressive-like and memory alterations

(2011) Nathalie Chevallier et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Psychiatric complications of treatment with corticosteroids: Review with case report

(2011) Heather A. Kenna et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

Neurosteroids as neuromodulators in the treatment of anxiety disorders

(2011) Patrizia Longone   Frontiers in Endocrinology

Sigma-1 receptors amplify dopamine D1 receptor signaling at presynaptic sites in the prelimbic cortex

(2010) Yingmei Fu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Corticotrophin-Releasing Factor Gene Transcription is Directly Activated After Deprivation of Glucocorticoids in Hypothalamic Cells

(2010) K. Kageyama et al.   JOURNAL OF NEUROENDOCRINOLOGY

Behavioral insights from mouse models of forebrain- and amygdala-specific glucocorticoid receptor genetic disruption

(2010) Melinda G. Arnett et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Pregnenolone sulfate enhances survival of adult-generated hippocampal granule cells via sustained presynaptic potentiation

(2010) Rong Yang et al.   NEUROPHARMACOLOGY

Behavioral and neurobiological consequences of prolonged glucocorticoid exposure in rats: Relevance to depression

(2010) Erin Y. Sterner et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Pharmacology and Therapeutic Potential of Sigma1 Receptor Ligands

(2009) E. Cobos et al.   Current Neuropharmacology

Regulatory Mechanisms Underlying Corticotropin-Releasing Factor Gene Expression in the Hypothalam

(2009) Kazunori KAGEYAMA et al.   ENDOCRINE JOURNAL

Postnatal Glucocorticoid Excess Due to Pituitary Glucocorticoid Receptor Deficiency: Differential Short- and Long-Term Consequences

(2009) Mathias V. Schmidt et al.   ENDOCRINOLOGY

The role of phosphorylated glucocorticoid receptor in mitochondrial functions and apoptotic signalling in brain tissue of stressed Wistar rats

(2009) Miroslav Adzic et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Genomic and Nongenomic Cross Talk between the Gonadotropin-Releasing Hormone Receptor and Glucocorticoid Receptor Signaling Pathways

(2009) Andrea Kotitschke et al.   MOLECULAR ENDOCRINOLOGY

Transient forebrain over-expression of CRF induces plasma corticosterone and mild behavioural changes in adult conditional CRF transgenic mice

(2009) Elena Vicentini et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Sigma-1 receptor knockout mice display a depressive-like phenotype

(2008) Valentina Sabino et al.   BEHAVIOURAL BRAIN RESEARCH

Chromatin immunoprecipitation scanning identifies glucocorticoid receptor binding regions in the proximal promoter of a ubiquitously expressed glucocorticoid target gene in brain

(2008) Siem van der Laan et al.   JOURNAL OF NEUROCHEMISTRY

The PKC and ERK/MAPK Pathways Regulate Glucocorticoid Action on TRH Transcription

(2008) Antonieta Cote-Vélez et al.   NEUROCHEMICAL RESEARCH

Two different molecular mechanisms underlying progesterone neuroprotection against ischemic brain damage

(2008) Weiyan Cai et al.   NEUROPHARMACOLOGY