Article
Microbiology
Hongchao Zhou, Yuting Zhang, Jingjing Wang, Yuchao Yan, Yi Liu, Xiaojie Shi, Qi Zhang, Xingang Xu
Summary: PEDV infection enhances CCN1 expression by activating CREB and AP-1. Overexpression of CCN1 inhibits PEDV replication and promotes apoptosis, while knockdown of CCN1 promotes PEDV replication and inhibits apoptosis.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Wun-Hao Cheng, Kang-Yun Lee, Ming-Chih Yu, Jing-Yun Chen, Chien-Huang Lin, Bing-Chang Chen
Summary: Pref-1 plays a critical role in airway fibrosis in chronic obstructive asthma, participating in fibrosis and hypoxia-induced CTGF expression through the integrin receptor alpha 5 beta 1/ERK/AP-1 pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wun-Hao Cheng, Chia-Ling Chen, Jing-Yun Chen, Chien-Huang Lin, Bing-Chang Chen
Summary: The study suggested that ERK, PEA3, and AP1 are involved in hypoxia-induced Pref1 expression in human lung fibroblasts. Experimental results confirmed this mechanism through various methods.
MOLECULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Mariya I. Petrova, Gregor Reid, Jessica A. ter Haar
Summary: Lacticaseibacillus rhamnosus GR-1 is the most researched probiotic strain for women's health, showing significant effects on urogenital health and being extensively studied for its properties. Research demonstrates its safety and efficacy even for HIV-positive subjects.
TRENDS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xin Wen, Geng Hu, Xue Xiao, Xinzhi Zhang, Qiang Zhang, Hengjun Guo, Xianyao Li, Qingxin Liu, Haifang Li
Summary: FGF2 inhibits mineralization of bone marrow stromal cells by up-regulating osteoclastogenesis gene expression, while enhancing osteoclast development through the ERK-CREB pathway. This highlights the potential of FGF2/ERK/CREB inhibitors in treating bone-related disorders like osteoporosis.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Neurosciences
Jorge Chavez, Viridiana Alcantara-Alonso, Cinthia Garcia-Luna, Paulina Soberanes-Chavez, Dimitris Grammatopoulos, Patricia de Gortari
Summary: Among the modulatory functions of thyrotropin-releasing hormone (TRH), an anorectic behavior in rodents is observed when centrally injected. Hypothalamic paraventricular nucleus (PVN) neurons receive serotonergic inputs from dorsal raphe nucleus and express serotonin (5HT) receptors such as 5HT1A, 5HT2A/2C, 5HT6, which are involved in 5HT-induced feeding regulation.
Article
Cell Biology
Shanjun Huang, Weiqi Wang, Li Li, Ting Wang, Yihan Zhao, Ya Lin, Weijian Huang, Yonghua Wang, Zhouqing Huang
Summary: The study showed that P2X7R plays an important role in the pathogenesis of STZ-induced diabetic cardiac damage and remodeling through the PKC beta/ERK axis. These findings suggest that P2X7R might be a potential target in the treatment of diabetic cardiomyopathy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Shanjun Huang, Weiqi Wang, Li Li, Ting Wang, Yihan Zhao, Ya Lin, Weijian Huang, Yonghua Wang, Zhouqing Huang
Summary: The study indicates that P2X7R plays an important role in STZ-induced diabetic cardiac damage and remodeling, and may be a potential target for the treatment of diabetic cardiomyopathy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kyu-Ree In, Mi Ae Kang, Su Dong Kim, Jinho Shin, Sung Un Kang, Tae Jun Park, Seung-Joo Kim, Jong-Soo Lee
Summary: This study demonstrates that anhydrous alum can inhibit melanin synthesis by downregulating the expression of MITF. The mechanism of action of anhydrous alum involves attenuating phosphorylation of the co-activator of MITF gene transcription, cAMP response element-binding protein, and promoting phosphorylation of extracellular signal-regulated kinase to impair the nuclear localization of MITF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Tomomitsu Doi, Hironori Hojo, Shinsuke Ohba, Kunie Obayashi, Motoyoshi Endo, Toshimasa Ishizaki, Akira Katoh, Hiroyuki Kouji
Summary: This study investigates the regulatory mechanisms underlying β-catenin coactivator usage in human pancreatic carcinoma cells. The results suggest that AP-1 may coordinate the usage of β-catenin coactivators in these cells.
Article
Cell Biology
Jelena Ostojic, Young-Sil Yoon, Tim Sonntag, Billy Nguyen, Joan M. Vaughan, Maxim Shokhirev, Marc Montminy
Summary: The cyclic AMP pathway promotes melanocyte differentiation by activating CREB and CRTC1-3. In melanoma cells, CRTC3 deficiency leads to impaired differentiation and melanosome maturation. CRTC3 interacts with CREB to stimulate OCA2 expression, affecting pigmentation and melanoma risk, and is activated by ERK1/2 signaling.
Article
Chemistry, Medicinal
Sang-Hyun Ahn, Jung-Soo Suh, Yoon-Kwan Jang, Heon-Su Kim, Gyu-Ho Choi, Eunhye Kim, Tae-Jin Kim
Summary: This study demonstrates that the ethanol extract from Rhynchosia volubilis can protect cells against apoptosis by activating the cAMP-PKA/ERK-CREB pathway.
Article
Multidisciplinary Sciences
Tian Wang, Ezra Wiater, Xinmin Zhang, John B. Thomas, Marc Montminy
Summary: Fasting in mammals and Drosophila leads to metabolic changes, with Crtc gene involved in regulating glucagon and cAMP in fasting metabolism, promoting the expression of genes related to starvation response while inhibiting insulin secretion and signaling pathways, and enhancing activity in the one-carbon metabolism pathway.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Pharmacology & Pharmacy
Gerald Thiel, Lara Wagner, Myriam Ulrich, Oliver G. Roessler
Summary: Insulin binding to the insulin receptor triggers intracellular signaling cascades leading to changes in multiple cellular functions. The activation of Elk-1 by insulin induces the expression of the transcription factor Egr-1, and controls the transcriptional activity of AP-1 and serum response element. Additionally, insulin receptor activation stimulates CRE-controlled transcription involving the transcription factor CREB and is regulated by negative feedback loops involving MAP kinase phosphatase-1 and calcineurin A.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Plant Sciences
Susu Lin, Qiaoqiao Li, Shanshan Jiang, Zijin Xu, Yu Jiang, Ling Liu, Jinyan Jiang, Yingpeng Tong, Ping Wang
Summary: The study shows that saffron can alleviate depressive-like behaviors induced by chronic stress, regulate biochemical markers, protect neuronal cells, modulate signaling pathways in the hippocampus, and partially restore damaged intestinal microbiota.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Marco Antonio Parra-Montes de Oca, Mariana Gutierrez-Mariscal, Ma Felix Salmeron-Jimenez, Lorraine Jaimes-Hoy, Jean-Louis Charli, Patricia Joseph-Bravo
FRONTIERS IN ENDOCRINOLOGY
(2019)
Review
Endocrinology & Metabolism
Adair Rodriguez-Rodriguez, Ivan Lazcano, Edith Sanchez-Jaramillo, Rosa Maria Uribe, Lorraine Jaimes-Hoy, Patricia Joseph-Bravo, Jean-Louis Charli
FRONTIERS IN ENDOCRINOLOGY
(2019)
Article
Endocrinology & Metabolism
Lorraine Jaimes-Hoy, Fidelia Romero, Jean-Louis Charli, Patricia Joseph-Bravo
FRONTIERS IN ENDOCRINOLOGY
(2019)
Article
Chemistry, Applied
Yarini Arrebola, Laura Rivera, Alejandro Pedroso, Rory McGuire, Mario E. Valdes Tresanco, Gretchen Bergado, Jean-Louis Charli, Belinda Sanchez, Isel Pascual Alonso
Summary: The study found that bacitracin is a non-competitive inhibitor of porcine kidney APN and APA, with cytotoxic effects on murine melanoma cells and inhibitive effects on APN-like activity. Further experiments are needed to fully understand the mechanisms of action of bacitracin on melanoma cells and its potential therapeutic use.
NATURAL PRODUCT RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Jean-Louis Charli, Adair Rodriguez-Rodriguez, Karina Hernandez-Ortega, Antonieta Cote-Velez, Rosa Maria Uribe, Lorraine Jaimes-Hoy, Patricia Joseph-Bravo
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Isel Pascual Alonso, Laura Rivera Mendez, Mario E. Valdes-Tresanco, Lotfi Bounaadja, Marjorie Schmitt, Yarini Arrebola Sanchez, Luis Alvarez Lajonchere, Jean-Louis Charli, Isabelle Florent
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
(2020)
Article
Endocrinology & Metabolism
A. Castillo-Campos, A. Gutierrez-Mata, J-L Charli, P. Joseph-Bravo
Summary: Chronic stress was found to blunt the responses of the thyroid axis and brown adipose tissue to cold exposure. The long-term effects of stress on noradrenergic and hormonal signaling may be responsible for thyroid dysfunction.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Review
Endocrinology & Metabolism
Ivan Lazcano, Adair Rodriguez Rodriguez, Rosa Maria Uribe, Aurea Orozco, Patricia Joseph-Bravo, Jean-Louis Charli
Summary: Thyroid hormones are ancient signaling molecules that regulate metabolism and growth in vertebrates through the hypothalamus-pituitary-thyroid axis. The hypothalamic factors that induce TSH secretion vary among vertebrates, but all play a role in activating TH synthesis in the thyroid gland.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Laura Rivera Mendez, Yarini Arrebola, Mario E. Valdes-Tresanco, Lisset Diaz-Guevara, Gretchen Bergado, Belinda Sanchez, Jean-Louis Charli, Isel Pascual Alonso
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Endocrinology & Metabolism
Lorraine Jaimes-Hoy, Adrian Perez-Maldonado, Elian Narvaez Bahena, Natalia de la Cruz Guarneros, Adair Rodriguez-Rodriguez, Jean-Louis Charli, Xavier Soberon, Patricia Joseph-Bravo
Summary: In adult animals, chronic stress can inhibit the basal activity of the HPT axis and its response to cold or voluntary exercise. Maternal separation alters the basal activity of the HPT axis, reducing its response to energy demands and potentially causing epigenetic changes on the Trh promoter.
Article
Plant Sciences
Mario E. Valdes-Tresanco, Yarini Arrebola Sanchez, Laura Rivera Mendez, Fabiola Almeida, Belinda Sanchez, Jean-Louis Charli, Isel Pascual Alonso
Summary: The research findings demonstrate that bestatin is a non-competitive inhibitor of porcine APA, binding to it similarly to porcine aminopeptidase N. Additionally, analogs of bestatin such as probestin and phebestin may interact with the same residues.
INDIAN JOURNAL OF NATURAL PRODUCTS AND RESOURCES
(2021)
Article
Biochemistry & Molecular Biology
Patricia Joseph-Bravo, Ivan Lazcano, Lorraine Jaimes-Hoy, Mariana Gutierrez-Mariscal, Edith Sanchez-Jaramillo, Rosa Maria Uribe, Jean-Louis Charli
FRONTIERS IN BIOSCIENCE-LANDMARK
(2020)
Article
Multidisciplinary Sciences
Erzsebet Farkas, Edina Varga, Balazs Kovacs, Anett Szilvasy-Szabo, Antonieta Cote-Velez, Zoltan Peterfi, Magdalini Matziari, Monika Toth, Dora Zelena, Zsolt Mezriczky, Andrea Kadar, Dora Kovari, Masahiko Watanabe, Masanobu Kano, Ken Mackie, Balazs Rozsa, Yvette Ruska, Blanka Toth, Zoltan Mate, Ferenc Erdelyi, Gabor Szabo, Balazs Gereben, Ronald M. Lechan, Jean-Louis Charli, Patricia Joseph-Bravo, Csaba Fekete
Article
Biochemistry & Molecular Biology
Isel Pascual, Pedro A. Valiente, Gabriela Garcia, Mario E. Valdes-Tresanco, Yarini Arrebola, Lisset Diaz, Lotfi Bounaadja, Rosa Maria Uribe, Mae Chappe Pacheco, Isabelle Florent, Jean-Louis Charli
Article
Endocrinology & Metabolism
Israim Sotelo-Rivera, Antonieta Cote-Velez, Rosa-Maria Uribe, Jean-Louis Charli, Patricia Joseph-Bravo