Interaction of the amyloid precursor protein-like protein 1 (APLP1) E2 domain with heparan sulfate involves two distinct binding modes

The structural biology of the amyloid precursor protein APP – a complex puzzle reveals its multi-domain architecture

(2014) Ina Coburger et al.   BIOLOGICAL CHEMISTRY

Novel Zinc-binding Site in the E2 Domain Regulates Amyloid Precursor-like Protein 1 (APLP1) Oligomerization

(2014) Magnus C. Mayer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease

(2014) Edgar Dawkins et al.   JOURNAL OF NEUROCHEMISTRY

Heparin induced dimerization of APP is primarily mediated by E1 and regulated by its acidic domain

(2014) Sandra Hoefgen et al.   JOURNAL OF STRUCTURAL BIOLOGY

MAINsoftware for density averaging, model building, structure refinement and validation

(2013) Dušan Turk   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

ConSurf: Using Evolutionary Data to Raise Testable Hypotheses about Protein Function

(2013) Gershon Celniker et al.   ISRAEL JOURNAL OF CHEMISTRY

Sorting receptor SORLA - a trafficking path to avoid Alzheimer disease

(2013) T. E. Willnow et al.   JOURNAL OF CELL SCIENCE

Soluble amyloid-  precursor protein binds its cell surface receptor in a cooperative fashion with glypican and syndecan proteoglycans

(2013) C. Reinhard et al.   JOURNAL OF CELL SCIENCE

Heparan sulfate proteoglycan as a cell-surface endocytosis receptor

(2013) Helena C. Christianson et al.   MATRIX BIOLOGY

Analysis of the Overall Structure of the Multi-Domain Amyloid Precursor Protein (APP)

(2013) Ina Coburger et al.   PLoS One

Chondroitin sulphate N-acetylgalactosaminyl-transferase-1 inhibits recovery from neural injury

(2013) Kosei Takeuchi et al.   Nature Communications

Physiological Functions of APP Family Proteins

(2013) U. C. Muller et al.   Cold Spring Harbor Perspectives in Medicine

Metal Binding Dictates Conformation and Function of the Amyloid Precursor Protein (APP) E2 Domain

(2012) Sven O. Dahms et al.   JOURNAL OF MOLECULAR BIOLOGY

Facilities for macromolecular crystallography at the Helmholtz-Zentrum Berlin

(2012) Uwe Mueller et al.   JOURNAL OF SYNCHROTRON RADIATION

The lac Repressor Displays Facilitated Diffusion in Living Cells

(2012) P. Hammar et al.   SCIENCE

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The E2 Domains of APP and APLP1 Share a Conserved Mode of Dimerization

(2011) Sangwon Lee et al.   BIOCHEMISTRY

Regulated intramembrane proteolysis - lessons from amyloid precursor protein processing

(2011) Stefan F. Lichtenthaler et al.   JOURNAL OF NEUROCHEMISTRY

Crystal structure of amyloid precursor-like protein 1 and heparin complex suggests a dual role of heparin in E2 dimerization

(2011) Y. Xue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acids

(2010) H. Ashkenazy et al.   NUCLEIC ACIDS RESEARCH

Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein

(2010) S. O. Dahms et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular replacement withMOLREP

(2009) Alexei Vagin et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Amyloid precursor protein and its homologues: a family of proteolysis-dependent receptors

(2009) Kristin T. Jacobsen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Structural Characterization of the E2 Domain of APL-1, a Caenorhabditis elegans Homolog of Human Amyloid Precursor Protein, and Its Heparin Binding Site

(2009) James T. Hoopes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparanase: busy at the cell surface

(2009) Liat Fux et al.   TRENDS IN BIOCHEMICAL SCIENCES

Homophilic Interactions of the Amyloid Precursor Protein (APP) Ectodomain Are Regulated by the Loop Region and Affect β-Secretase Cleavage of APP

(2008) Daniela Kaden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY