Autophagy: novel applications of nonsteroidal anti-inflammatory drugs for primary cancer

Mitigated NSAID-induced apoptotic and autophagic cell death with Smad7 overexpression

(2017) Ho-Jae Lee et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Autophagy activated by the c-Jun N-terminal kinase-mediated pathway protects human prostate cancer PC3 cells from celecoxib-induced apoptosis

(2017) Xin Zhu et al.   Experimental and Therapeutic Medicine

Aspirin Use for the Primary Prevention of Cardiovascular Disease and Colorectal Cancer: U.S. Preventive Services Task Force Recommendation Statement

(2016) Kirsten Bibbins-Domingo et al.   ANNALS OF INTERNAL MEDICINE

Celecoxib exerts antitumor effects in HL-60 acute leukemia cells and inhibits autophagy by affecting lysosome function

(2016) Ying Lu et al.   BIOMEDICINE & PHARMACOTHERAPY

Celecoxib suppresses autophagy and enhances cytotoxicity of imatinib in imatinib-resistant chronic myeloid leukemia cells

(2016) Ying Lu et al.   Journal of Translational Medicine

Which Aspirin Dose and Preparation Is Best for the Long-Term Prevention of Cardiovascular Disease and Cancer? Evidence From a Systematic Review and Network Meta-Analysis

(2016) Marzia Lotrionte et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Aspirin may inhibit angiogenesis and induce autophagy by inhibiting mTOR signaling pathway in murine hepatocarcinoma and sarcoma models

(2016) Qianqian Zhao et al.   Oncology Letters

Chemoprevention of colorectal cancer in individuals with previous colorectal neoplasia: systematic review and network meta-analysis

(2016) Parambir S Dulai et al.   BMJ-British Medical Journal

Chemoprevention of colorectal cancer in individuals with previous colorectal neoplasia: systematic review and network meta-analysis

(2016) Parambir S Dulai et al.   BMJ-British Medical Journal

Blocking autophagy enhances meloxicam lethality to hepatocellular carcinoma by promotion of endoplasmic reticulum stress

(2015) Jingtao Zhong et al.   CELL PROLIFERATION

PDE5 Inhibitors Enhance Celecoxib Killing in Multiple Tumor Types

(2015) Laurence Booth et al.   JOURNAL OF CELLULAR PHYSIOLOGY

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Obesity, Aspirin, and Risk of Colorectal Cancer in Carriers of Hereditary Colorectal Cancer: A Prospective Investigation in the CAPP2 Study

(2015) Mohammad Movahedi et al.   JOURNAL OF CLINICAL ONCOLOGY

p62 participates in the inhibition of NF-κB signaling and apoptosis induced by sulfasalazine in human glioma U251 cells

(2015) JING SU et al.   ONCOLOGY REPORTS

Sulfasalazine Induces Autophagic Cell Death in Oral Cancer Cells via Akt and ERK Pathways

(2014) Hye-Yeon Han et al.   Asian Pacific Journal of Cancer Prevention

The AMPK-PPARGC1A pathway is required for antimicrobial host defense through activation of autophagy

(2014) Chul-Su Yang et al.   Autophagy

Airway mesenchymal cell death by mevalonate cascade inhibition: Integration of autophagy, unfolded protein response and apoptosis focusing on Bcl2 family proteins

(2014) Saeid Ghavami et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Efficacy and Safety Profile of Celecoxib for Treating Advanced Cancers: A Meta-analysis of 11 Randomized Clinical Trials

(2014) Jian Chen et al.   CLINICAL THERAPEUTICS

Celecoxib regulates apoptosis and autophagy via the PI3K/Akt signaling pathway in SGC-7901 gastric cancer cells

(2014) MIN LIU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Role of p38 MAPK in enhanced human cancer cells killing by the combination of aspirin and ABT-737

(2014) Chong Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Gene of the month:BECN1

(2014) Sumit Sahni et al.   JOURNAL OF CLINICAL PATHOLOGY

Meloxicam Executes Its Antitumor Effects against Hepatocellular Carcinoma in COX-2- Dependent and -Independent Pathways

(2014) Xiaofeng Dong et al.   PLoS One

Celecoxib enhances radiosensitivity of hypoxic glioblastoma cells through endoplasmic reticulum stress

(2013) Kenshi Suzuki et al.   NEURO-ONCOLOGY

Protective Role of AMP-Activated Protein Kinase-Evoked Autophagy on an In Vitro Model of Ischemia/Reperfusion-Induced Renal Tubular Cell Injury

(2013) Li-Ting Wang et al.   PLoS One

Celecoxib-Induced Cytotoxic Effect Is Potentiated by Inhibition of Autophagy in Human Urothelial Carcinoma Cells

(2013) Kuo-How Huang et al.   PLoS One

The autophagy associated gene, ULK1, promotes tolerance to chronic and acute hypoxia

(2013) Marco B.E. Schaaf et al.   RADIOTHERAPY AND ONCOLOGY

Preferential killing of triple-negative breast cancer cells in vitro and in vivo when pharmacological aggravators of endoplasmic reticulum stress are combined with autophagy inhibitors

(2012) Simmy Thomas et al.   CANCER LETTERS

Aspirin Inhibits mTOR Signaling, Activates AMP-Activated Protein Kinase, and Induces Autophagy in Colorectal Cancer Cells

(2012) Farhat V.N. Din et al.   GASTROENTEROLOGY

eEF-2 Kinase Dictates Cross-Talk between Autophagy and Apoptosis Induced by Akt Inhibition, Thereby Modulating Cytotoxicity of Novel Akt Inhibitor MK-2206

(2011) Y. Cheng et al.   CANCER RESEARCH

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

p62/SQSTM1 involved in cisplatin resistance in human ovarian cancer cells by clearing ubiquitinated proteins

(2011) Huimei Yu et al.   EUROPEAN JOURNAL OF CANCER

Enhanced antitumor effect of lower-dose and longer-term CPT-11 treatment in combination with low-dose celecoxib against neuroblastoma xenografts

(2011) Setsuko Kaneko et al.   International Journal of Clinical Oncology

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

The expression of p33ING1, p53, and autophagy-related gene Beclin1 in patients with non-small cell lung cancer

(2011) Jun Liu et al.   TUMOR BIOLOGY

Celecoxib-induced apoptosis is enhanced by ABT-737 and by inhibition of autophagy in human colorectal cancer cells

(2010) Shengbing Huang et al.   Autophagy

Inhibition of Autophagy Enhances Anticancer Effects of Atorvastatin in Digestive Malignancies

(2010) P.-M. Yang et al.   CANCER RESEARCH

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Perspectives on inhibiting mTOR as a future treatment strategy for hematological malignancies

(2010) N Chapuis et al.   LEUKEMIA

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Cross talk between apoptosis and autophagy by caspase-mediated cleavage of Beclin 1

(2010) M Djavaheri-Mergny et al.   ONCOGENE

Down-regulation of the HGF/MET autocrine loop induced by celecoxib and mediated by P-gp in MDR-positive human hepatocellular carcinoma cell line

(2009) Roberto Mazzanti et al.   BIOCHEMICAL PHARMACOLOGY

AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with In vitro and In vivo Antitumor Activity

(2009) C. M. Chresta et al.   CANCER RESEARCH

p62 at the Crossroads of Autophagy, Apoptosis, and Cancer

(2009) Jorge Moscat et al.   CELL

Autophagy Suppresses Tumorigenesis through Elimination of p62

(2009) Robin Mathew et al.   CELL

The Double-Edged Sword of Autophagy Modulation in Cancer

(2009) E. White et al.   CLINICAL CANCER RESEARCH

Enhanced sensitivity of celecoxib in human glioblastoma cells: Induction of DNA damage leading to p53-dependent G1 cell cycle arrest and autophagy

(2009) Khong Kang et al.   Molecular Cancer

The autophagy effector Beclin 1: a novel BH3-only protein

(2009) S Sinha et al.   ONCOGENE

Anoikis: A necessary death program for anchorage-dependent cells

(2008) Paola Chiarugi et al.   BIOCHEMICAL PHARMACOLOGY

The Signaling Adaptor p62 Is an Important NF-κB Mediator in Tumorigenesis

(2008) Angeles Duran et al.   CANCER CELL

OSU-03012, a Novel Celecoxib Derivative, Induces Reactive Oxygen Species-Related Autophagy in Hepatocellular Carcinoma

(2008) M. Gao et al.   CANCER RESEARCH

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL