Article
Developmental Biology
Jing-Cong Dai, Jia-Yan Yang, Rui-Qi Chang, Yan Liang, Xiao-Yu Hu, Hu Li, Shuang You, Fan He, Li-Na Hu
Summary: GAS6 regulates the phenotype and function of decidual macrophages in the early maternal-foetal interface, playing a crucial role in maternal immunotolerance towards the foetus. Decreased GAS6 secretion by decidual stromal cells may contribute to miscarriage in the first trimester.
MOLECULAR HUMAN REPRODUCTION
(2022)
Article
Cell Biology
Mengdie Li, Fengrun Sun, Yuanyuan Xu, Lanting Chen, Chunqin Chen, Liyuan Cui, Jinfeng Qian, Dajin Li, Songcun Wang, Meirong Du
Summary: This study reveals the significant roles of Tim-3 in regulating macrophage function during pregnancy and its importance in maintaining normal pregnancy. The expression of Tim-3 on decidual macrophages is closely related to immune regulation between decidual cells and promotes pregnancy stability.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Hao Chai, Zilun Lei, Yanyao Liu, Junhua Gong, Zhenrui Cao, Zuotian Huang, Hang Yang, Zhongjun Wu
Summary: miR-505-5p alleviates acute rejection after liver transplantation by inducing M2 polarization of macrophages via the Myd88/TRAF6 axis.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Oncology
Yu Tao, Yan-Hong Li, Di Zhang, Ling Xu, Jia-Jia Chen, Yi-Fei Sang, Hai-Lan Piao, Xue-Ling Jing, Min Yu, Qiang Fu, Sheng-Tao Zhou, Da-Jin Li, Mei-Rong Du
Summary: The CXCR4(+)CD56(bright)dNK subset plays an important immunomodulatory role during early pregnancy, promoting Th2 shift and assisting in the establishment of immune-tolerance. This new dNK cell subset may provide important insights into NK cell mechanisms in early pregnancy, and offer potential prognostic factors for the diagnosis and therapy of recurrent miscarriage.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Tatiana Llorca, Maria Jose Ruiz-Magana, Rocio Martinez-Aguilar, Olga Maria Garcia-Valdeavero, Lucia Rodriguez-Dona, Ana Clara Abadia-Molina, Carmen Ruiz-Ruiz, Enrique G. Olivares
Summary: Decidual stromal cells (DSCs) are important in maternal-fetal immune tolerance, and the process of decidualization inhibits the expression of chemokines that attract T cells in humans.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Evolutionary Biology
Katelyn Mika, Vincent J. Lynch
Summary: This study reveals the important role of transposable elements in the development, evolution, and function of primate DSCs, highlighting their crucial regulatory function in progesterone responsiveness and proposing a two-step model in which latent enhancer functions of TEs are unmasked after they lose primary repressor functions.
GENOME BIOLOGY AND EVOLUTION
(2022)
Article
Multidisciplinary Sciences
Ashley L. Severance, Jeremy M. Kinder, Lijun Xin, Ashley R. Burg, Tzu-Yu Shao, Giang Pham, Tamara Tilburgs, Wendy A. Goodman, Sam Mesiano, Sing Sing Way
Summary: During pregnancy, progesterone stimulates the expansion of regulatory T cells to promote immune tolerance, ensuring fetal growth and preventing rejection from the mother's immune system. This study reveals the role of progesterone in promoting fetal tolerance and establishes a molecular link between immune and other physiological adaptations during pregnancy.
Article
Biochemistry & Molecular Biology
Yu Zhang, Hsun-Ming Chang, Hua Zhu, Peter C. K. Leung
Summary: BMP2 suppresses PTX3 production through a canonical ALK2/3-mediated SMAD1/5-SMAD4-dependent signaling pathway, potentially regulating the process of endometrial decidualization in humans.
Article
Cell Biology
Jiajia Chen, Yanhong Li, Ling Xu, Yifei Sang, Dajin Li, Meirong Du
Summary: The aim of this study was to investigate the balancing mechanisms between decidualization-associated inflammation and pregnancy-related immunotolerance. By collecting samples and isolating cells, the researchers identified NRP1 as a multifunctional controller that balances the inflammatory states of decidual stromal cells (DSCs) and decidual immune cells (DICs) in the gravid uterus. Abnormal expression of NRP1 was found to be implicated in miscarriage.
INFLAMMATION RESEARCH
(2023)
Article
Cell & Tissue Engineering
Chenyang Liu, Yan Xu, Yichi Lu, Pan Du, Xiaoxiao Li, Chengchun Wang, Peng Guo, Ling Diao, Guozhong Lu
Summary: The study demonstrates that S-IT MSCs can effectively induce M2 polarization of macrophages via IL-6 dependent signaling pathways and accelerate wound healing. Results show that S-IT MSCs significantly enhance the ability of M2 phenotype to promote vascularization and collagen deposition, ultimately improving wound healing quality.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Immunology
Hong-xia Ye, Guang-neng Liao, Ya-jun Dong, Lan Li, Xue-mei Wang, Jin Shu, Qu Zheng, Yan Jia
Summary: The down-regulation of miR-146a-5p in decidual macrophages is associated with M1/M2 polarization disorder in URSA. miR-146a-5p inhibits M1 polarization, promotes M2 polarization, and generates an anti-inflammatory microenvironment in vitro. In a murine model of URSA, intravenous injection of miR-146a-5p reduces embryo resorption rate and promotes M2 polarization of decidual macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Materials Science, Biomaterials
Runlian Lin, Kun Ge, Dehui Fan, Jing Li, Guoqiang Zhou, Kaihan Zhang, Yuanyu Huang, Lili Ma, Jinchao Zhang
Summary: This study investigated the effects of multi-walled carbon nanotubes (MWCNTs) on different types of cells in the bone microenvironment. The results showed that MWCNTs promoted osteogenesis in osteoblasts and inhibited osteogenic differentiation in bone marrow stromal cells (BMSCs). In addition, MWCNTs increased bone formation and angiogenesis in the osteolysis model.
REGENERATIVE BIOMATERIALS
(2023)
Review
Immunology
Ping Jiang, Xiaopeng Li
Summary: Precise expression and regulation of genes in the immune system are crucial for generating strong immune responses and preventing autoimmune diseases. Recent studies have shown that long noncoding RNAs play a significant role in immune function by regulating immune cell differentiation, development, and function. These RNAs can control the polarization of immune cells, promote pro-inflammatory or anti-inflammatory effects, and contribute to the pathogenesis of various diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Plant Sciences
Yuanyuan Wen, Shijie Zhang, Xinyu Meng, Chenyang Zhao, Bao Hou, Xuexue Zhu, Weiwei Cai, Yuetao Zhou, Liying Qiu, Haijian Sun
Summary: In this study, the main chemical compositions of WGLWE were identified using UPLC-Q-TOF-MS, which were found to directly target inflammatory pathway proteins in the treatment of rheumatoid arthritis. Both in vitro and in vivo experiments demonstrated that WGLWE can promote the transformation of M1 macrophages into M2 macrophages, suppress the release of proinflammatory cytokines, reduce ankle swelling, improve bone density, and alleviate synovial inflammation. These findings suggest that WGLWE may serve as a potential herbal preparation for RA treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Manuel Lasch, Kritika Sudan, Corinna Paul, Christian Schulz, Thomas Kolben, Julia van Dorp, Sibel Eren, Susanne Beyer, Lorenzo Siniscalchi, Sven Mahner, Udo Jeschke, Sarah Meister
Summary: This study established a new isolation method for investigating decidual macrophages and Hofbauer cells in the placenta. It provides a promising approach to understand the functional subsets of placental macrophages and identify therapeutic targets for pregnancy-associated diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Sanzhima Garmaeva, Anastasia Gulyaeva, Trishla Sinha, Andrey N. Shkoporov, Adam G. Clooney, Stephen R. Stockdale, Johanne E. Spreckels, Thomas D. S. Sutton, Lorraine A. Draper, Bas E. Dutilh, Cisca Wijmenga, Alexander Kurilshikov, Jingyuan Fu, Colin Hill, Alexandra Zhernakova
Summary: The study found that there is a high diversity of gut virome composition in healthy adults, with individual viromes stable at the family level but varying significantly at the genera and species levels. Lower initial diversity of the human gut virome leads to a more pronounced effect of dietary intervention on its composition.
Article
Microbiology
Johanne E. Spreckels, Erik Wejryd, Giovanna Marchini, Baldvin Jonsson, Dylan H. de Vries, Maria C. Jenmalm, Eva Landberg, Eva Sverremark-Ekstrom, Magali Marti, Thomas Abrahamsson
Summary: The study showed that Lactobacillus reuteri DSM 17938 supplementation leads to successful colonisation in extremely low birth weight infants, with a potential improvement in head growth for preterm ELBW infants.
Editorial Material
Immunology
Johanne E. Spreckels, Alexandra Zhernakova
Summary: The study found that Bifidobacteria can produce immunoregulatory compounds using milk sugars, aiding in immune tolerance and reducing intestinal inflammation in infants.
Article
Biology
Elisabeth Gludovacz, Kornelia Schuetzenberger, Marlene Resch, Katharina Tillmann, Karin Petroczi, Markus Schosserer, Sigrid Vondra, Serhii Vakal, Gerald Klanert, Jurgen Pollheimer, Tiina A. Salminen, Bernd Jilma, Nicole Borth, Thomas Boehm
Summary: By mutating the heparin-binding motif of hDAO, the plasma clearance rate was successfully reduced in rodents, showing potential for treating diseases characterized by high plasma histamine concentrations.
Correction
Radiology, Nuclear Medicine & Medical Imaging
Ida Friberger, Emma Jussing, Jinming Han, Jeroen A. C. M. Goos, Jonathan Siikanen, Helen Kaipe, Melanie Lambert, Robert A. Harris, Erik Samen, Mattias Carlsten, Staffan Holmin, Thuy A. Tran
MOLECULAR IMAGING AND BIOLOGY
(2022)
Review
Oncology
Elena Rangelova, Helen Kaipe
Summary: Although most trials reported limited clinical effectiveness, the immunological effects observed in almost all trials demonstrate the potential of immunotherapy. Check point inhibitors trials did not show survival advantage. Horizontal comparison indicates that careful re-evaluation of clinical premises and focus on combination and cell therapy may improve survival rates for pancreatic cancer patients through immunotherapy.
CHINESE CLINICAL ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Christoph Nowak, Marcus Lind, Zdenek Sumnik, Terezie Pelikanova, Lia Nattero Chavez, Elena Lundberg, Itxaso Rica, Maria A. Martinez-Brocca, Mari Sol Ruiz de Adana, Jeanette Wahlberg, Ragnar Hanas, Cristina Hernandez, Maria Clemente-Leon, Ana Gomez-Gila, Marta Ferrer Lozano, Theo Sas, Stepanka Pruhova, Fabricia Dietrich, Sara Puente Marin, Ulf Hannelius, Rosaura Casas, Johnny Ludvigsson
Summary: Intralymphatic GAD-alum improves glycemic control in recently diagnosed T1D patients carrying HLA DR3-DQ2.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Oncology
Laia Gorchs, Marlies Oosthoek, Tulay Yucel-Lindberg, Carlos Fernandez Moro, Helen Kaipe
Summary: The infiltration of T cells in pancreatic tumors is associated with better overall survival. However, cancer-associated fibroblasts (CAFs) in the tumor microenvironment can prevent T cells from reaching the tumor nests. This study investigated how CAFs modulate chemokine receptors on T cells and the spatial distribution of T cells within tumors. It was found that CXCR3 ligands were associated with increased T cell numbers in tumor-rich areas, and CAFs downregulated the expression of CXCR3 on T cells. Understanding these mechanisms is crucial for developing targeted therapies.
Article
Cell Biology
Sigrid Vondra, Anna-Lena Hobler, Andreas Ian Lackner, Johanna Raffetseder, Zala Nikita Mihalic, Andrea Vogel, Leila Saleh, Victoria Kunihs, Peter Haslinger, Markus Wahrmann, Heinrich Husslein, Raimund Oberle, Julia Kargl, Sandra Haider, Paulina Latos, Gernot Schabbauer, Martin Knofler, Jan Ernerudh, Jurgen Pollheimer
Summary: During pregnancy, different macrophage populations are found in the decidua basalis (decB) and decidua parietalis (decP), with decBAMs being CD11chi and efficient inducers of Tregs, while decPAMs exhibit a dendritic cell-like phenotype, enhanced phagocytosis, and the ability to activate T cells. Strikingly, EVT-conditioned media can convert decPAMs into a decBAM phenotype, highlighting the critical role of extravillous trophoblasts (EVTs) in the induction of decB-associated macrophage polarization.
Article
Developmental Biology
Bianca Dietrich, Victoria Kunihs, Andreas I. Lackner, Gudrun Meinhardt, Bon-Kyoung Koo, Jurgen Pollheimer, Sandra Haider, Martin Knoefler
Summary: This study reveals that autocrine NOTCH3 signaling controls human placental development by promoting self-renewal of cytotrophoblast progenitors.
Article
Multidisciplinary Sciences
Sukanta Jash, Sayani Banerjee, Shibin Cheng, Bin Wang, Chenxi Qiu, Asami Kondo, Jan Ernerudh, Xiao Zhen Zhou, Kun Ping Lu, Surendra Sharma
Summary: Preeclampsia (PE) is a major cause of maternal and fetal mortality worldwide, and may lead to dementia later in life. The etiological drivers of PE are still unknown. Cis P-tau is a potential biomarker and etiological driver in pre-clinical Alzheimer's and after brain injury, and can be targeted by a specific antibody. Research has found significant levels of cis P-tau in the placenta and serum of PE patients, indicating its potential role in the development of the disease. The depletion of cis P-tau by the antibody prevents the disruption of trophoblast invasion and endovascular activity, providing valuable insights for early diagnosis and treatment of PE.
NATURE COMMUNICATIONS
(2023)
Article
Ecology
Johanne E. Spreckels, Asier Fernandez-Pato, Marloes Kruk, Alexander Kurilshikov, Sanzhima Garmaeva, Trishla Sinha, Hiren Ghosh, Hermie Harmsen, Jingyuan Fu, Ranko Gacesa, Alexandra Zhernakova
Summary: This study aims to find a method to study milk bacteria and assess bacterial sharing between maternal and infant microbiota. The results show that DNA isolation using the PS or MX kits followed by 16S rRNA gene sequencing reliably characterizes human milk microbiota. Additionally, the use of 16S-ITS-23S rRNA gene sequencing enables the study of bacterial transmission in low-biomass samples.
ISME COMMUNICATIONS
(2023)