Article
Chemistry, Physical
Bangyun Xiong, Jingjing Li, Chunqing He, Jiale Lai, Xiangjia Liu, Tao Huang
Summary: In this study, tunable mesoporous silica films were characterized using positron annihilation gamma-ray energy spectroscopy, positron annihilation lifetime spectroscopy, ellipsometric porosimetry, and heptane adsorption. The results showed that ellipsometric porosimetry combined with heptane adsorption is a highly sensitive method for calibrating mesopore size in interconnected films, while positron annihilation lifetime spectroscopy is a novel complementary tool for characterizing closed and open pores.
Article
Chemistry, Multidisciplinary
Hui Xie, Zhiguo He, Yanxing Liu, Changbo Zhao, Bing Guo, Caizhen Zhu, Jian Xu
Summary: This study demonstrates that mesoporous silica aerogels can serve as carriers for delivering slightly soluble antibacterial agents, forming uniform nanocrystals and enhancing antibacterial efficiency. The loaded aerogels exhibit high inhibition rates and good biocompatibility.
Article
Biochemistry & Molecular Biology
Min-Hsuan Tsou, Cheng-Chang Lee, Zhi-Yuan Wu, Zui-Harng Lee, Hsiu-Mei Lin
Summary: In this study, fucoidan was extracted from brown algae using a hot water extraction method, and synthesized into drug carrier-nanoparticles for drug delivery. Experimental results showed that rMSN-EuGd@Fucoidan exhibited higher cytotoxicity against A549 cancer cells compared to fucoidan itself.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Ophthalmology
Martin Hammer, Juliane Jakob-Girbig, Linda Schwanengel, Christine A. Curcio, Somar Hasan, Daniel Meller, Rowena Schultz
Summary: The study observed changes in the retinal pigment epithelium (RPE) during the transition from dysmorphia to atrophy in age-related macular degeneration (AMD) using fluorescence lifetime imaging ophthalmoscopy (FLIO). The findings showed that as hyperpigmented areas form and RPE migrates into the retina, fluorescence lifetimes lengthen and emission spectrum intensity ratio (ESRI) of RPE cells increase, suggesting potential early biomarkers for AMD progression.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Caixia Sun, Xiaofei Sun, Peng Pei, Haisheng He, Jiang Ming, Xuan Liu, Minchao Liu, Yuntong Zhang, Yan Xia, Dongyuan Zhao, Xiaomin Li, Yang Xie, Fan Zhang
Summary: A biocompatible NIR-II J-aggregates labelled mesoporous implant for imaging-guided osteosynthesis with minimal invasion is reported, which can effectively reduce the surgical wound and operational duration. NIR-II imaging can clearly display the location and outline of the implant both in vitro and in vivo.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Paul Joyce, Silver Joemetsa, Simon Isaksson, Shakhawath Hossain, Per Larsson, Christel Bergstrom, Fredrik Hook
Summary: This study established a new method to monitor membrane permeation kinetics using mesoporous silica substrate and total internal reflection fluorescence microscopy. By contrasting the permeation behavior of pure felodipine with felodipine coupled to the permeability enhancer caprylate (C8), evidence for C8-facilitated transport across lipid membranes was provided, validating the potential of this approach to quantify carrier system-induced changes to cellular membrane permeation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Cell Biology
Yifang Yuan, Ronghui Zhou, Ting Li, Shuang Qu, Hua Bai, Jiawu Liang, Xiaoxiao Cai, Bin Guo
Summary: AuNCs enriched with MSNs can achieve highly sensitive fluorescence/CT dual-modal imaging, indicating potential for disease diagnosis and treatment. The strategy of combining AuNCs with MSNs can provide enhanced imaging capabilities for acquiring more information about diseases.
CELL PROLIFERATION
(2021)
Article
Nanoscience & Nanotechnology
Jan Grzelak, Jaume Gazquez, Alba Grayston, Mariana Teles, Fernando Herranz, Nerea Roher, Anna Rosell, Anna Roig, Marti Gich
Summary: Multifunctional magnetic nanocomposites based on mesoporous silica have a wide range of potential applications in various fields. By controlling the structure, nanoparticles with different shapes can be prepared to respond to external magnetic fields. The application of these nanoparticles in biomedicine is particularly promising, but research on nanorods is currently limited.
ACS APPLIED NANO MATERIALS
(2022)
Article
Engineering, Environmental
Adrian Monteleone, Folker Wenzel, Heinz Langhals, Daniel Dietrich
Summary: The FLIM method was tested for identification and characterization of six types of plastics, showing significant differentiation in 94.55% of the comparisons. Results suggest that FLIM has the potential for sub-micrometer plastic characterization and allows for visual 3D-sectioning of samples, which could be important for identifying and characterizing plastics in tissue and environmental samples.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Biochemical Research Methods
P. Wang, F. Hecht, G. Ossato, S. Tille, S. E. Fraser, J. A. Junge
Summary: Fluorescence lifetime imaging microscopy (FLIM) with phasor analysis allows for easy visualization and analysis of fluorophores' lifetimes, but typically suffers from low photon budgets leading to poor signal to noise ratios. Traditional median filters used in phasor analysis degrade high spatial frequency FLIM information, especially edges and puncta. A new filtering strategy using complex wavelet filtering and Anscombe transform preserves fine structures and accurate lifetimes in photon starved FLIM imaging, outperforming median filters and enabling FLIM imaging with lower laser power and faster imaging speed.
BIOMEDICAL OPTICS EXPRESS
(2021)
Article
Biochemistry & Molecular Biology
Zhongtao Li, Jing Guo, Guiqiang Qi, Meng Zhang, Liguo Hao
Summary: A pH-responsive and imaging nanocarriers system using mesoporous silica nanoparticles (MSNs) doped with gadolinium (Gd) was developed. The system showed pH-responsiveness and high biocompatibility, and the T1 contrast was significantly enhanced by Gd, making it a promising system for cancer diagnosis and treatment.
Article
Chemistry, Medicinal
Cesar Ivan Corpus-Mendoza, Denisse de Loera, Lluvia Itzel Lopez-Lopez, Brenda Acosta, Sarai Vega-Rodriguez, Gabriela Navarro-Tovar
Summary: This study evaluates the adsorption properties of 1,4-naftoquinone (NQ) molecules into SBA-15 microparticles and reveals the interaction mechanisms and the most stable forms of interaction between NQ and SBA-15 through theoretical simulations and experimental results.
Article
Medicine, General & Internal
Tomasz Wybranowski, Jerzy Pyskir, Maciej Bosek, Marta Napiorkowska, Michal Cyrankiewicz, Blanka Ziomkowska, Marta Pilaczynska-Cemel, Malgorzata Pyskir, Milena Roganska, Stefan Kruszewski, Grzegorz Przybylski
Summary: This study investigated the use of time-resolved fluorescence spectroscopy to assess pulmonary fibrosis in COVID-19 patients. The results showed that a decrease in the mean fluorescence lifetime of plasma was associated with mortality and may be a risk factor for pulmonary fibrosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Analytical
Hang He, Song Meng, Haimin Li, Qingyuan Yang, Ziqiang Xu, Xueqin Chen, Zhengguang Sun, Bingbing Jiang, Cao Li
Summary: The study developed a mitochondrial-targeted drug delivery system which can release drugs in a GSH-dependent manner and achieve near-infrared fluorescence imaging of mitochondria. This system shows promising activity in anti-tumor therapy.
Article
Nanoscience & Nanotechnology
Emma Ortiz-Islas, Anahi Sosa-Arroniz, Ma Elena Manriquez-Ramirez, C. Ekaterina Rodriguez-Perez, Francisco Tzompantzi, Juan Manuel Padilla
Summary: This study reported the preparation, characterization, and drug release study of mesoporous silica nanoparticles functionalized with folic acid for targeted release of Cis-Pt to kill glioblastoma cancer cells. The MNPSiO2 showed high surface area, large pore size, and proper functionalization, with Higuchi model fitting better to the experimental results. The MNPSiO2-FA were highly biocompatible and enhanced the cytotoxic effect of Cis-Pt.
REVIEWS ON ADVANCED MATERIALS SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Jeemol James, Jonas Enger, Marica B. Ericson
Summary: The combination of MPM and FCS is considered a useful tool in biomedical research for studying diffusion and molecular interactions at a subcellular level. However, implementing MPM-FCS is not straightforward and requires attention to experimental conditions such as objective lens, fluorophore concentration, and laser power. The challenges and limitations observed in this study reduce the versatility of MPM-FCS in biomedicine, but systematic investigations and fundamental insights provided in this report could potentially overcome technical limitations and make MPM-FCS a highly useful tool in biomedical research.
APPLIED SCIENCES-BASEL
(2021)
Article
Nanoscience & Nanotechnology
Tiago Moreira, Francesca Di Maria, Mattia Zangoli, Eduardo Fabiano, Ilse Manet, Raffaello Mazzaro, Vittorio Morandi, Martina Marinelli, Giuseppe Gigli, Antonio Jorge Parola, Cesar A. T. Laia, Giovanna Barbarella
Summary: This study reports the expedient synthesis of a novel class of thiophene-based electrochromic polymers and their application in flexible solid-state electrochromic devices. The tuning of electro-optical properties through alkyl or alkoxy substituents and linker modulation is demonstrated, with improved device performance shown using NPs films spray-coated from water.
ADVANCED ELECTRONIC MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Seda Demirel Topel, Sevgi Balcioglu, Burhan Ates, Meltem Asilturk, Onder Topel, Marica B. Ericson
Summary: This study introduces a biocompatible theranostic platform by encapsulating UCNPs in cellulose acetate (CA), demonstrating stable luminescence properties of UCNPs post-encapsulation. The efficient loading and acid-induced release of the chemotherapeutic drug doxorubicin onto UCNP-CA nanocapsules were achieved. Encapsulation was shown to reduce toxicity of UCNPs in cellular assays, making the developed UCNP-CA nanocapsules a promising platform for further refinement and exploration.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Sabrina Valetti, Hanna Thomsen, Jitendra Wankar, Peter Falkman, Ilse Manet, Adam Feiler, Marica B. Ericson, Johan Engblom
Summary: Research has shown that porous particles of appropriate size and porosity can accumulate in hair follicles and furrows on the skin, providing a potential area for drug delivery. The combination of follicle orifices and furrows can cover up to 20% of the skin surface, making them valuable for optimizing bioavailability of topical formulations. This work highlights the potential of skin furrows for topical drug delivery.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Chemistry, Multidisciplinary
Niranjan G. Kotla, Srinivasa Reddy Bonam, Swetha Rasala, Jitendra Wankar, Raghvendra A. Bohara, Jagadeesh Bayry, Yury Rochev, Abhay Pandit
Summary: Hyaluronan, a naturally occurring biopolymer, has diverse biological effects and plays a crucial role in inflammation and cancer. This review discusses the sources, properties, and potential applications of hyaluronan in therapeutic systems and cancer targeting delivery.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Biochemistry & Molecular Biology
Marco Agnes, Elisabetta Pancani, Milo Malanga, Eva Fenyvesi, Ilse Manet
Summary: Cyclodextrin-based polymers can be prepared using green and low-cost methods, allowing for fine-tuning of functionality. They have superior solubility and solubilizing power, and enable combination therapy with multiple therapeutic agents. A significant amount of scientific data is available, indicating potential in biomedical applications.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Elisa Martella, Barbara Dozza, Claudia Ferroni, Clement Osuru Obeyok, Andrea Guerrini, Daniele Tedesco, Ilse Manet, Giovanna Sotgiu, Marta Columbaro, Marco Ballestri, Lucia Martini, Milena Fini, Enrico Lucarelli, Greta Varchi, Serena Duchi
Summary: Combination therapy utilizing nanoparticle formulations can overcome challenges in osteosarcoma treatment and improve therapeutic index. In a murine model, the combination of photodynamic therapy and chemotherapy demonstrated effective inhibition of osteosarcoma cell growth.
Article
Biochemistry & Molecular Biology
Massimiliano Cavallini, Marco Brucale, Denis Gentili, Fabiola Liscio, Lucia Maini, Laura Favaretto, Ilse Manet, Massimo Zambianchi, Manuela Melucci
Summary: In this study, we address the issue of polymorph selection by introducing a general concept based on ordering. We demonstrate the concept by patterning four compounds on surfaces, which are capable of forming different polymorphs. Our approach takes advantage of the confinement of crystalline material growth within small cavities to generate only one polymorph. We verify our method by fabricating micrometric logic patterns using model compounds, where each printed pixel comprises only one polymorph and can be accessed individually.
Article
Biochemistry & Molecular Biology
Maria Gunnarsson, Sandra Larsson, Monika Malak, Marica B. Ericson, Daniel Topgaard, Emma Sparr
Summary: The study investigates the molecular mobilities and structures of keratin-rich materials in the human body, such as skin, nails, and hair. The research reveals that different materials have different responses to hydration and addition of urea, which contributes to a better understanding of skin diseases and the development of new materials.
Article
Chemistry, Multidisciplinary
Marco Agnes, Arianna Mazza, Eszter Kalydi, Szabolcs Beni, Milo Malanga, Ilse Manet
Summary: By selectively irradiating Methylene Blue, a low-cost photocatalyst, four aromatic substrates were optimized to produce their corresponding endoperoxides in organic solvent. By combining hydrophobic substrates with a hydrophilic cyclodextrin (CyD) polymer, their photooxygenation in homogeneous aqueous environment was achieved. These results have potential applications in green homogeneous photocatalysis and delivery of oxygen releasing agents to tissues.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Azra Riaz, Sanna Gidvall, Zdenka Prgomet, Aura Rocio Hernandez, Tautgirdas Ruzgas, Emelie J. J. Nilsson, Julia Davies, Sabrina Valetti
Summary: Oral mucosal equivalents (OME) are valuable membrane materials for drug permeation studies, as they can simulate in vivo conditions and provide better research results.
Article
Pharmacology & Pharmacy
Elisa Martella, Barbara Dozza, Claudia Ferroni, Chiara Bellotti, Clement Osuru Obeyok, Matilde Tubertini, Andrea Guerrini, Marco Ballestri, Marta Columbaro, Ilse Manet, Marco Gambarotti, Lucia Martini, Milena Fini, Luca Cevolani, Davide Maria Donati, Enrico Lucarelli, Greta Varchi, Serena Duchi
Summary: This study evaluates the efficacy of chemo-releasing and photoactive bimodal nanoparticles, kPCe6 NPs, delivered via mesenchymal stromal cells (MSCs). In vitro analyses demonstrated that cells internalize and retain kPCe6 NPs in a dose-dependent manner, and kPCe6-loaded cells induce massive tumor cell death in a tridimensional tumor model. However, when peritumoral administration of two doses containing 10(6) loaded cells was performed in an in vivo OS murine model, there was negligible tumor cell death.
ADVANCED THERAPEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Rania E. Morsi, Denis Gentili, Franco Corticelli, Vittorio Morandi, Alberto Figoli, Francesca Russo, Francesco Galiano, Giovanna Angela Gentilomi, Francesca Bonvicini, Ilse Manet, Barbara Ventura
Summary: The development of polymeric fabrics with photoinduced antibacterial activity is crucial for various applications. In this study, cellulose acetate membranes were prepared with the addition of additives, including a photosensitizer (TPP), a surfactant (Pluronic F-127), and graphene oxide (GO). The combination of these three additives exhibited excellent antibacterial properties.
Article
Chemistry, Multidisciplinary
Elisabetta Pancani, Daniele Veclani, Marco Agnes, Arianna Mazza, Alessandro Venturini, Milo Malanga, Ilse Manet
Summary: This study explored a series of cyclodextrin (CyD) polymers for the simultaneous encapsulation of different compounds with potential therapeutic interest for multimodal prostate cancer treatment. The co-encapsulation of three compounds, cabazitaxel, bicalutamide, and chlorin e6, was successfully achieved in certain CyD polymers. The p beta CyD performed best in drug solubilization ability, and Ce6 was able to efficiently produce singlet oxygen when encapsulated.
Article
Materials Science, Multidisciplinary
Massimiliano Cavallini, Ilse Manet, Marco Brucale, Laura Favaretto, Manuela Melucci, Lucia Maini, Fabiola Liscio, Michele della Ciana, Denis Gentili
Summary: Rubbing was used on thiophene-based organic semiconductor thin films to induce reversible mechanical amorphisation, which is associated with fluorescence switching regulated by the film's polymorphic nature. Thermal annealing of the films produced an opposite effect, inducing film crystallization starting at a low temperature and generating a stable polymorph at high temperatures in the bulk. The mechanism of mechanical transformation was explained considering the material's mechanical properties and demonstrated through X-ray diffraction, atomic force microscopy, and photoluminescence at confocal microscopy.
JOURNAL OF MATERIALS CHEMISTRY C
(2021)
Article
Materials Science, Biomaterials
Izabela Stupka, Artur P. Biela, Bernard Piette, Agnieszka Kowalczyk, Karolina Majsterkiewicz, Kinga Borzecka-Solarz, Antonina Naskalska, Jonathan G. Heddle
Summary: Artificial protein cages, such as TRAP-cages, have potential applications in vaccines and drug delivery. TRAP-cages have the ability to control the disassembly conditions by modifying the interface between their building blocks. By using TRAP rings with different numbers of monomers, it is possible to predict the formation of other cages.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Guo Zhang, Yu Wang, Hua Qiu, Lei Lu
Summary: This study presents a one-pot synthesis method for flower-like AMPs@EAMP particles by combining antimicrobial peptides with ellagic acid, offering enlarged surface area, excellent biocompatibility, and broad-spectrum antibacterial activity. In vivo studies indicate their potential for tissue repair and immune barrier reconstruction.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Jiamei Zhang, Lingshuang Wang, Cheng Xu, Yingui Cao, Shengsheng Liu, Rui L. Reis, Subhas C. Kundu, Xiao Yang, Bo Xiao, Lian Duan
Summary: Pluronic F127 modified silk fibroin film with different types of antibacterial agents could accelerate wound recovery by promoting fibroblast adhesion, eradicating bacteria, and facilitating angiogenesis and re-epithelialization.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Yinsheng Liu, Mingyue Wang, Yinfei Hui, Lei Sun, Yanrui Hao, Henlong Ren, Hao Guo, Wu Yang
Summary: In this study, a rare-earth hybrid luminescent material was developed for the detection of a biomarker for anthrax. The material showed excellent selectivity and high sensitivity, allowing for the determination of the biomarker in saliva and urine. Additionally, a convenient point-of-care testing method using fluorescent test paper and a smartphone was established for the initial diagnosis of anthrax.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Review
Materials Science, Biomaterials
Wenshuai Yang, Jingsi Chen, Ziqian Zhao, Meng Wu, Lu Gong, Yimei Sun, Charley Huang, Bin Yan, Hongbo Zeng
Summary: Injectable hydrogels with shear-thinning and/or in situ formation properties offer distinct advantages in bioengineering applications, as they can be directly delivered to target sites, possess self-healing abilities, and simplify the implantation process.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)