Activatable probes for diagnosis and biomarker detection by MRI

Surface Modification of Gd Nanoparticles with pH-Responsive Block Copolymers for Use As Smart MRI Contrast Agents

(2016) Liping Zhu et al.   ACS Applied Materials & Interfaces

19F Magnetic Resonance Imaging Signals from Peptide Amphiphile Nanostructures Are Strongly Affected by Their Shape

(2016) Adam T. Preslar et al.   ACS Nano

Mesoporous manganese silicate coated silica nanoparticles as multi-stimuli-responsive T 1 -MRI contrast agents and drug delivery carriers

(2016) Xiaowei Li et al.   Acta Biomaterialia

Using “On/Off” 19F NMR/Magnetic Resonance Imaging Signals to Sense Tyrosine Kinase/Phosphatase Activity in Vitro and in Cell Lysates

(2016) Zhen Zheng et al.   ANALYTICAL CHEMISTRY

Multimodal Detection of a Small Molecule Target Using Stimuli-Responsive Liposome Triggered by Aptamer–Enzyme Conjugate

(2016) Hang Xing et al.   ANALYTICAL CHEMISTRY

What We Can Really Do with Bioresponsive MRI Contrast Agents

(2016) Goran Angelovski   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cell-Permeable Esterase-Activated Ca(II)-Sensitive MRI Contrast Agent

(2016) Keith W. MacRenaris et al.   BIOCONJUGATE CHEMISTRY

Redoxable heteronanocrystals functioning magnetic relaxation switch for activatable T 1 and T 2 dual-mode magnetic resonance imaging

(2016) Myeong-Hoon Kim et al.   BIOMATERIALS

A CatalyCEST MRI Contrast Agent that Can Simultaneously Detect Two Enzyme Activities

(2016) Gabriela Fernández-Cuervo et al.   CHEMBIOCHEM

Nanoparticle-based highly sensitive MRI contrast agents with enhanced relaxivity in reductive milieu

(2016) Severin J. Sigg et al.   CHEMICAL COMMUNICATIONS

Gadolinium-Decorated Silica Microspheres as Redox-Responsive MRI Probes for Applications in Cell Therapy Follow-Up

(2016) Monica Muñoz Úbeda et al.   CHEMISTRY-A EUROPEAN JOURNAL

Prototypes of Lanthanide(III) Agents Responsive to Enzymatic Activities in Three Complementary Imaging Modalities: Visible/Near-Infrared Luminescence, PARACEST-, and T1-MRI

(2016) Jiefang He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Exploiting Copper Redox for 19F Magnetic Resonance-Based Detection of Cellular Hypoxia

(2016) Da Xie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Conjugating Prussian blue nanoparticles onto antigen-specific T cells as a combined nanoimmunotherapy

(2016) Rachel A Burga et al.   Nanomedicine

Nanoparticle-based probes to enable noninvasive imaging of proteolytic activity for cancer diagnosis

(2016) Tareq Anani et al.   Nanomedicine

pH-Responsive biodegradable polymeric micelles with anchors to interface magnetic nanoparticles for MR imaging in detection of cerebral ischemic area

(2016) Hong Yu Yang et al.   Nanoscale

A pH-activatable nanoparticle with signal-amplification capabilities for non-invasive imaging of tumour malignancy

(2016) Peng Mi et al.   Nature Nanotechnology

pH-Activatable MnO-Based Fluorescence and Magnetic Resonance Bimodal Nanoprobe for Cancer Imaging

(2016) Benedict You Wei Hsu et al.   Advanced Healthcare Materials

Fluorinated smart micelles as enzyme-responsive probes for 19F-magnetic resonance

(2016) Marina Buzhor et al.   Journal of Materials Chemistry B

Smart polymeric particle encapsulated gadolinium oxide and europium: theranostic probes for magnetic resonance/optical imaging and antitumor drug delivery

(2016) Ruiqing Liu et al.   Journal of Materials Chemistry B

Self-Assembly/Disassembly of Nanostructures Confers “Off/On” Signal for Molecular Imaging

(2016) Yusi Cui et al.   ChemNanoMat

Ratiometric Method for Rapid Monitoring of Biological Processes Using Bioresponsive MRI Contrast Agents

(2016) Serhat Gündüz et al.   ACS Sensors

Detection of Alkaline Phosphatase Enzyme Activity with a CatalyCEST MRI Biosensor

(2016) Iman Daryaei et al.   ACS Sensors

Ion-Responsive 19F MRI Contrast Agents for the Detection of Cancer Cells

(2016) Cheng Zhang et al.   ACS Sensors

Real-Time Monitoring of Arsenic Trioxide Release and Delivery by Activatable T1 Imaging

(2015) Zhenghuan Zhao et al.   ACS Nano

Magnetic Resonance Imaging of Stem Cell Apoptosis in Arthritic Joints with a Caspase Activatable Contrast Agent

(2015) Hossein Nejadnik et al.   ACS Nano

Intracellular Self-Assembly and Disassembly of 19F Nanoparticles Confer Respective “Off” and “On” 19F NMR/MRI Signals for Legumain Activity Detection in Zebrafish

(2015) Yue Yuan et al.   ACS Nano

A pH-Responsive MRI Agent that Can Be Activated Beyond the Tissue Magnetization Transfer Window

(2015) Xiaojing Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper complexes as a source of redox active MRI contrast agents

(2015) Lynsey Dunbar et al.   BIOMETALS

19F MRI Probes with Tunable Switches and Highly Sensitive 19F MRI Nanoprobes

(2015) Kazuya Kikuchi   BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN

Nanomaterial-based activatable imaging probes: from design to biological applications

(2015) Jingjing Li et al.   CHEMICAL SOCIETY REVIEWS

Concentration-independent MRI of pH with a dendrimer-based pH-responsive nanoprobe

(2015) Mohammed P. I. Bhuiyan et al.   Contrast Media & Molecular Imaging

Bioresponsive probes for molecular imaging: concepts andin vivoapplications

(2015) Sander M. J. van Duijnhoven et al.   Contrast Media & Molecular Imaging

Activatable Dendritic 19F Probes for Enzyme Detection

(2015) Hui Wang et al.   ACS Macro Letters

Investigation of a Calcium-Responsive Contrast Agent in Cellular Model Systems: Feasibility for Use as a Smart Molecular Probe in Functional MRI

(2014) Goran Angelovski et al.   ACS Chemical Neuroscience

Controlled Intracellular Self-Assembly and Disassembly of 19F Nanoparticles for MR Imaging of Caspase 3/7 in Zebrafish

(2014) Yue Yuan et al.   ACS Nano

Ratiometric MRI Sensors Based on Core-Shell Nanoparticles for Quantitative pH Imaging

(2014) Satoshi Okada et al.   ADVANCED MATERIALS

Activatable19F MRI Nanoparticle Probes for the Detection of Reducing Environments

(2014) Tatsuya Nakamura et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Redox-Triggered Self-Assembly of Gadolinium-Based MRI Probes for Sensing Reducing Environment

(2014) Deju Ye et al.   BIOCONJUGATE CHEMISTRY

MRI-Based Detection of Alkaline Phosphatase Gene Reporter Activity Using a Porphyrin Solubility Switch

(2014) Gil G. Westmeyer et al.   CHEMISTRY & BIOLOGY

Detecting Enzyme Activities with Exogenous MRI Contrast Agents

(2014) Dina V. Hingorani et al.   CHEMISTRY-A EUROPEAN JOURNAL

Redox- and Hypoxia-Responsive MRI Contrast Agents

(2014) Quyen N. Do et al.   ChemMedChem

A review of responsive MRI contrast agents: 2005-2014

(2014) Dina V. Hingorani et al.   Contrast Media & Molecular Imaging

Structure–Redox–Relaxivity Relationships for Redox Responsive Manganese-Based Magnetic Resonance Imaging Probes

(2014) Eric M. Gale et al.   INORGANIC CHEMISTRY

Redox-activated MRI contrast agents based on lanthanide and transition metal ions

(2014) Pavel B. Tsitovich et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Activatable Fluorescence/MRI Bimodal Platform for Tumor Cell Imaging via MnO2 Nanosheet–Aptamer Nanoprobe

(2014) Zilong Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Single 19F Probe for Simultaneous Detection of Multiple Metal Ions Using miCEST MRI

(2014) Amnon Bar-Shir et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Novel 19F Activatable Probe for the Detection of Matrix Metalloprotease-2 Activity by MRI/MRS

(2014) Xuyi Yue et al.   MOLECULAR PHARMACEUTICS

Caspase-responsive smart gadolinium-based contrast agent for magnetic resonance imaging of drug-induced apoptosis

(2014) Deju Ye et al.   Chemical Science

In vivo Magnetic Resonance Imaging of Tumor Protease Activity

(2014) Mohammad Haris et al.   Scientific Reports

Monitoring Phospholipase A2 Activity with Gd-encapsulated Phospholipid Liposomes

(2014) Zhiliang Cheng et al.   Scientific Reports

Activation and Retention: A Magnetic Resonance Probe for the Detection of Acute Thrombosis

(2013) Galen S. Loving et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multi-Chromatic pH-Activatable19F-MRI Nanoprobes with Binary ON/OFF pH Transitions and Chemical-Shift Barcodes

(2013) Xiaonan Huang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Environmentally responsive MRI contrast agents

(2013) Gemma-Louise Davies et al.   CHEMICAL COMMUNICATIONS

pH-Triggered Au-fluorescent mesoporous silica nanoparticles for19F MR/fluorescent multimodal cancer cellular imaging

(2013) Shizhen Chen et al.   CHEMICAL COMMUNICATIONS

New Calcium-Selective Smart Contrast Agents for Magnetic Resonance Imaging

(2013) Kirti Dhingra Verma et al.   CHEMISTRY-A EUROPEAN JOURNAL

Specific Detection and Imaging of Enzyme Activity by Signal-Amplifiable Self-Assembling19F MRI Probes

(2013) Kazuya Matsuo et al.   CHEMISTRY-A EUROPEAN JOURNAL

Collective Activation of MRI Agents via Encapsulation and Disease-Triggered Release

(2013) Mathieu L. Viger et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Redox-Activated Manganese-Based MR Contrast Agent

(2013) Galen S. Loving et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Detection of in vivo enzyme activity with CatalyCEST MRI

(2013) Byunghee Yoo et al.   MAGNETIC RESONANCE IN MEDICINE

MRI-detectable pH nanosensors incorporated into hydrogels for in vivo sensing of transplanted-cell viability

(2013) Kannie W. Y. Chan et al.   NATURE MATERIALS

Role of Glutathione in Cancer Progression and Chemoresistance

(2013) Nicola Traverso et al.   Oxidative Medicine and Cellular Longevity

Development of Novel Tumor-Targeted Theranostic Nanoparticles Activated by Membrane-Type Matrix Metalloproteinases for Combined Cancer Magnetic Resonance Imaging and Therapy

(2013) Celina Ansari et al.   Small

A smart 19F and 1H MRI probe with self-immolative linker as a versatile tool for detection of enzymes

(2012) Aneta Keliris et al.   Contrast Media & Molecular Imaging

Promising strategies for Gd-based responsive magnetic resonance imaging contrast agents

(2012) Clara Shen et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Strategies for the development of gadolinium-based ‘q’-activatable MRI contrast agents

(2012) Chuqiao Tu et al.   NMR IN BIOMEDICINE

A cell-permeable gadolinium contrast agent for magnetic resonance imaging of copper in a Menkes disease model

(2012) Emily L. Que et al.   Chemical Science

Bimodal Quantitative Monitoring for Enzymatic Activity with Simultaneous Signal Increases in19F NMR and Fluorescence Using Silica Nanoparticle-Based Molecular Probes

(2011) Kazuo Tanaka et al.   BIOCONJUGATE CHEMISTRY

Chemical exchange saturation transfer (CEST): What is in a name and what isn't?

(2011) Peter C. M. van Zijl et al.   MAGNETIC RESONANCE IN MEDICINE

Reversible signal regulation system of 19F NMR by redox reactions using a metal complex as a switching module

(2009) Kazuo Tanaka et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Self-assembling nanoprobes that display off/on 19F nuclear magnetic resonance signals for protein detection and imaging

(2009) Yousuke Takaoka et al.   Nature Chemistry

A19F-NMR approach using reporter molecule pairs to assessβ-galactosidase in human xenograft tumorsin vivo

(2008) Jian-Xin Yu et al.   NMR IN BIOMEDICINE

Paramagnetic Relaxation-Based19F MRI Probe To Detect Protease Activity

(2007) Shin Mizukami et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY