Article
Chemistry, Multidisciplinary
Kathleen E. Prosser, Da Xie, Annica Chu, Gregory A. MacNeil, Bryton R. Varju, Rahul T. Kadakia, Emily L. Que, Charles J. Walsby
Summary: The development of Cu-II complexes with preferential activation in the reduction window provided by hypoxic tissues, particularly the NO2-substituted complex, shows enhanced cytotoxic selectivity and cellular accumulation under hypoxia. The localization in HeLa cell nuclei and DNA nuclease activity suggest potential therapeutic applications by redox activation. Selective detection by F-19 MRI indicates promising hypoxia-targeting theranostic applications.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Analytical
Lihua Xu, Biling Huang, Zhiying Hou, Shaohua Huang, Yufen Zhao
Summary: This study demonstrates the simultaneous analysis of a complex mixture using solvent effects by F-19 NMR spectroscopy, which enables the identification and quantification of multiple amino acids. This method has important implications for human health and disease diagnosis.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Chenlong Li, Huimin Zhou, Jingjiang Sun, Deshuo Wang, Jun Chang, Qingfu Wang, Yanan Li, Wei Zhao
Summary: F-19 MRI-assisted drug delivery allows for real-time monitoring and tracking of drug transportation. Amphiphilic block copolymers containing hydrophilic polyethylene glycol and F-19-containing hydrophobic segments were synthesized, with the photolysis behavior of the copolymers controlled using o-nitrobenzyl oxygen. Increasing the hydrophobic chain length enhanced drug loading capacity and photoresponsivity, while reducing chain mobility and FMRI-F-19 signal. Nanoparticles with a PTFEA polymerization degree of 10 exhibited detectable FMRI-F-19 signals and sufficient drug loading capacity (loading efficiency = 10%, cumulative release = 49%), providing a promising smart theranostic platform for F-19 MRI.
Article
Chemistry, Multidisciplinary
Bridget Tang, Katie Chong, Arthur J. Ragauskas, Robert Evans
Summary: This article introduces the collaboration between Aston University in the UK and the University of Tennessee and Oak Ridge National Laboratory in the USA, showcasing the accuracy and quantitativeness of low-field NMR spectrometers in the analysis of bio-oils. The research article is available at 10.1002/cssc.202300625.
Article
Engineering, Biomedical
Xianglong Zhu, Hehe Xiong, Sitian Wang, Yanyan Li, Jingxian Chi, Xuefei Wang, Tiantian Li, Qiuju Zhou, Jinhao Gao, Saige Shi
Summary: This study presents a versatile model of activatable probes for multicolor F-19 MRI based on fluorinated ionic liquids, loaded in nanocarriers and sealed by stimuli-sensitive copolymers. It allows non-invasive detection of tumor hallmarks by distinguishing individual colors in living organisms, offering a new realm in mechanistic understanding of complex pathophysiologic processes in vivo.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Inorganic & Nuclear
Mariusz Zalewski, Dawid Janasik, Adrianna Wierzbicka, Tomasz Krawczyk
Summary: 19F MRI is a promising tool in medical diagnostics that can improve sensitivity and develop responsive contrast agents. This study used relaxation theory to predict the properties of existing complexes and evaluate design strategies. The results were well aligned with experiments, indicating potential advantages of other metal ions in addition to Gd3+.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Alvja Mali, Margot Verbeelen, Paul B. White, Alexander H. J. Staal, N. Koen van Riessen, Cyril Cadiou, Francoise Chuburu, Olga Koshkina, Mangala Srinivas
Summary: F-19 magnetic resonance imaging (F-19 MRI) is a promising technique for quantitative imaging in novel therapies. By using biodegradable polymeric nanoparticles with a multicore structure, the F-19 signal can be modulated and the nanoparticles can be sensitive to different pH environments.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiudi Lu, Linglei Meng, Yongmin Zhou, Shaoshi Wang, Miller Fawaz, Meiyun Wang, E. Mark Haacke, Chao Chai, Meizhu Zheng, Jinxia Zhu, Yu Luo, Shuang Xia
Summary: SWIvolume-DWI mismatch showed higher diagnostic efficacy than SWIASPECTS-DWI mismatch in defining the ischemic penumbra and demonstrated good consistency with PWI-DWI mismatch in acute ischemic stroke. Quantitation of APCVs using SWIM provided an accurate method for determining hypoperfusion and reflected the hypoxia of penumbra reliably. Positive correlations were found between SWIvolume-DWI and PWI-DWI mismatch, as well as between SWI-volume and Tmax > 6 s volume. Negative correlations were found between SWIvolume-DWI mismatch and NIHSS, as well as between SWIASPECTS-DWI mismatch and NIHSS.
EUROPEAN RADIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Vyshakh M. Panakkal, Dominik Havlicek, Ewa Pavlova, Marcela Filipova, Semira Bener, Daniel Jirak, Ondrej Sedlacek
Summary: A straightforward synthetic route to highly fluorinated 19F MRI nanotracers was reported, using water-soluble fluorinated monomers and polymerization-induced self-assembly. The resulting nanoparticles exhibited strong 19F NMR/MRI signals in an aqueous environment and were confirmed to be non-toxic.
Article
Biophysics
Kexin Chen, Tingjuan Wu, Mou Jiang, Anfeng Li, Xingxing Peng, Shizhen Chen, Zhigang Yang, Xin Zhou, Xing Zheng, Zhong-Xing Jiang
Summary: This study introduces a novel dual imaging agent for cell tracking using partially fluorinated aromatic agents to formulate nanoemulsions for 19F MRI and fluorescence imaging. These agents have low density, high solubility, and short relaxation times, enabling the preparation of stable, biocompatible, and multifunctional nanoemulsions with high 19F MRI sensitivity. This approach may address issues associated with perfluorocarbons and provide a new strategy for high-performance 19F MRI agents.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Qiaoyun Wang, Ye Yu, Yixin Chang, Xin Xu, Min Wu, Gayathri R. Ediriweera, Hui Peng, Xu Zhen, Xiqun Jiang, Debra J. Searles, Changkui Fu, Andrew K. Whittaker
Summary: This study developed a tumor microenvironment-responsive hybrid theranostic agent by grafting water-soluble, low-fouling fluoropolymers to pH-responsive zeolitic imidazolate framework-8 (ZIF-8) nanoparticles. The nanoparticles showed sensitive in vivo visualization by 19F MRI, prolonged circulation time in the bloodstream, and improved delivery efficiency to tumor tissue. The particles also responded to the acidic tumor microenvironment, leading to degradation and release of zinc ions and encapsulated anticancer drugs.
Review
Biochemistry & Molecular Biology
Andrea Huwiler, Karl-Friedrich Beck, Josef Pfeilschifter
Summary: Redox-active mediators are powerful molecules regulating cellular dynamics and gene expression. Reactive oxygen species (ROS), and gasotransmitters such as NO, CO, and H2S, are key mediators, along with sphingolipid molecules. Cross-regulation between redox mediators and sphingolipids influences cell fate and organ function. This review highlights the effects of redox-active mediators on sphingolipid signaling, metabolism, and their impact on pathophysiological processes.
Article
Chemistry, Multidisciplinary
Alan J. R. Smith, Richard York, Dusan Uhrin, Nicholle G. A. Bell
Summary: This article introduces a new NMR analysis method centered on F-19, which utilizes a set of broadband, phase-sensitive NMR experiments to obtain a large number of NMR parameters and achieve structure elucidation of fluorinated compounds. The method performs well in the structure determination of fluorinated compounds embedded in complex mixtures.
Article
Chemistry, Multidisciplinary
Ran Xu, Fanqiang Meng, Yanyue Liu, Dida Duosiken, Kang Sun, Sijian Pan, Ke Tao
Summary: By controlling the size and lattice distortion of CaF2 nanocrystals, we accelerated their longitudinal relaxation, addressing the issue of unacceptable scanning time in MR imaging.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Hongyu Lin, Xiaoxue Tang, Ao Li, Jinhao Gao
Summary: F-19 MRI serves as an exceptional complement to H-1 MRI, offering high sensitivity, low biological background, and a wide range of chemical shifts. When combined with activatable nanoprobes, the specificity and sensitivity of F-19 MRI can be further enhanced, allowing for in vivo detection and imaging at cellular or even molecular level in deep tissues.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Inorganic & Nuclear
Sandip Mandal, Arnab Banerjee, Debasree Ghosh, Dipak Kumar Mandal, Damir A. Safin, Maria G. Babashkina, Koen Robeyns, Mariusz P. Mitoraj, Piotr Kubisiak, Yann Garcia, Debasis Das
DALTON TRANSACTIONS
(2015)
Article
Chemistry, Multidisciplinary
Sandip Mandal, Animesh Sahana, Arnab Banerjee, Damir A. Safin, Maria G. Babashkina, Koen Robeyns, Sjoerd Verkaart, Joost G. J. Hoenderop, Mariusz P. Mitoraj, Yann Garcia, Debasis Das
Article
Chemistry, Multidisciplinary
Sangita Adhikari, Arnab Banerjee, Sandip Nandi, Matilde Fondo, Jesus Sanmartin-Matalobos, Debasis Das
Article
Biochemistry & Molecular Biology
Sandip Nandi, Sangita Adhikari, Sandip Mandal, Arnab Banerjee, Debasis Das
JOURNAL OF MOLECULAR RECOGNITION
(2016)
Article
Chemistry, Inorganic & Nuclear
Da Xie, Seyong Kim, Vikraant Kohli, Arnab Banerjee, Meng Yu, Jose S. Enriquez, Jeffrey J. Luci, Emily L. Que
INORGANIC CHEMISTRY
(2017)
Article
Engineering, Chemical
Raja Saha, Animesh Sahana, Sisir Lohar, Arnab Banerjee, Sudipta Das, Debasis Das
DESALINATION AND WATER TREATMENT
(2014)
Article
Chemistry, Multidisciplinary
Sudipta Das, Arnab Banerjee, Sisir Lohar, Bidisha Sarkar, Subhra Kanti Mukhopadhyay, Jesus Sanmartin Matalobos, Animesh Sahana, Debasis Das
NEW JOURNAL OF CHEMISTRY
(2014)
Article
Chemistry, Organic
Sisir Lohar, Amab Banerjee, Animesh Sahana, Sukanya Panja, Ipsit Hauli, Subhra Kanti Mukhopadhyay, Debasis Das
TETRAHEDRON LETTERS
(2014)
Article
Chemistry, Multidisciplinary
Sudipta Das, Animesh Sahana, Sisir Lohar, Bidisha Sarkar, Subhra Kanti Mukhopadhya, Arnab Banerjee, Debasis Das
Article
Chemistry, Multidisciplinary
Arnab Banerjee, Animesh Sahana, Sisir Lohar, Sukanya Panja, Subhra Kanti Mukhopadhyay, Debasis Das
Article
Chemistry, Multidisciplinary
Miguel M. Lino, Tiago Rondao, Arnab Banerjee, Ines Aires, Magda Rodrigues, Tiago Reis, Antonio Santinha, Dominique Fernandes, Debora Serrenho, Tomas Sobrino, Joao Sargento-Freitas, Frederico C. Pereira, Ana Luisa Carvalho, Lino Ferreira
Summary: In this study, we investigated the local effect and bioactivity of small extracellular vesicles (sEVs) in the brain. sEVs derived from mononuclear cells (MNCs) showed superior effects in promoting neuroprotection and reducing microglia reactivity in a stroke mouse model compared to sEVs from mesenchymal stem cells (MSCs).
Article
Chemistry, Multidisciplinary
Arnab Banerjee, Vitor Alves, Tiago Rondao, Jose Sereno, Angela Neves, Miguel Lino, Andreia Ribeiro, Antero J. Abrunhosa, Lino S. Ferreira
Article
Chemistry, Multidisciplinary
Abhijit Ghosh, Somenath Banerjee, Arnab Banerjee, Debasis Das
JOURNAL OF THE INDIAN CHEMICAL SOCIETY
(2016)
Article
Chemistry, Multidisciplinary
Debasis Karak, Sisir Lohar, Animesh Sahana, Subarna Guha, Arnab Banerjee, Jesus Sanmartin Matalobos, Debasis Das
JOURNAL OF THE INDIAN CHEMICAL SOCIETY
(2014)
