Glycyrrhizic Acid Prevents Diabetic Nephropathy by Activating AMPK/SIRT1/PGC-1α Signaling in db/db Mice

Lipoxin A4 Attenuates Bronchopulmonary Dysplasia via Upregulation of Let-7c and Downregulation of TGF-β1 Signaling Pathway

(2017) Xiao-Qing Chen et al.   INFLAMMATION

Periodontitis changes renal structures by oxidative stress and lipid peroxidation

(2017) Luiz Felipe C. França et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Methane alleviates carbon tetrachloride induced liver injury in mice: anti-inflammatory action demonstrated by increased PI3K/Akt/GSK-3β-mediated IL-10 expression

(2017) Ying Yao et al.   JOURNAL OF MOLECULAR HISTOLOGY

Suppression of endothelial PGC-1α is associated with hypoxia-induced endothelial dysfunction and provides a new therapeutic target in pulmonary arterial hypertension

(2016) Jia-Xin Ye et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

A very-low-protein diet ameliorates advanced diabetic nephropathy through autophagy induction by suppression of the mTORC1 pathway in Wistar fatty rats, an animal model of type 2 diabetes and obesity

(2016) Munehiro Kitada et al.   DIABETOLOGIA

Glycyrrhizic Acid Attenuates Sepsis-Induced Acute Kidney Injury by Inhibiting NF-κB Signaling Pathway

(2016) Hongyu Zhao et al.   Evidence-based Complementary and Alternative Medicine

Inhibiting HMGB1 with Glycyrrhizic Acid Protects Brain Injury after DAI via Its Anti-Inflammatory Effect

(2016) Honggang Pang et al.   MEDIATORS OF INFLAMMATION

Role of ROS and RNS Sources in Physiological and Pathological Conditions

(2016) Sergio Di Meo et al.   Oxidative Medicine and Cellular Longevity

RAGE and TGF-β1 Cross-Talk Regulate Extracellular Matrix Turnover and Cytokine Synthesis in AGEs Exposed Fibroblast Cells

(2016) Andreea Iren Serban et al.   PLoS One

Acetyl-CoA carboxylase 2 suppression rescues human proximal tubular cells from palmitic acid induced lipotoxicity via autophagy

(2015) Wei Xin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Relaxin Inhibits High Glucose-Induced Matrix Accumulation in Human Mesangial Cells by Interfering with TGF-β1 Production and Mesangial Cells Phenotypic Transition

(2015) Xiangcheng Xie et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Serum Levels of Progranulin Are Closely Associated with Microvascular Complication in Type 2 Diabetes

(2015) Lin Xu et al.   DISEASE MARKERS

Polymorphic differences in the SOD-2 gene may affect the pathogenesis of nephropathy in patients with diabetes and diabetic complications

(2015) Annwyne Houldsworth et al.   GENE

Astaxanthin from shrimp by-products ameliorates nephropathy in diabetic rats

(2014) Assaâd Sila et al.   EUROPEAN JOURNAL OF NUTRITION

The Protective Effect of Glycyrrhizic Acid on Renal Tubular Epithelial Cell Injury Induced by High Glucose

(2014) Shaozhang Hou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Diabetic kidney disease: from physiology to therapeutics

(2014) Carmen Mora-Fernández et al.   JOURNAL OF PHYSIOLOGY-LONDON

Glycyrrhizic acid attenuated glycative stress in kidney of diabetic mice through enhancing glyoxalase pathway

(2014) Zhi-hong Wang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Glomerular structural-functional relationship models of diabetic nephropathy are robust in type 1 diabetic patients

(2014) M. Mauer et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Indole-3-carbinol inhibits nasopharyngeal carcinoma cell growth in vivo and in vitro through inhibition of the PI3K/Akt pathway

(2014) CHENG-GANG MAO et al.   Experimental and Therapeutic Medicine

A systematic review ofGymnema sylvestrein obesity and diabetes management

(2013) Ramesh Pothuraju et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Role of SIRT1 and FOXO factors in eNOS transcriptional activation by resveratrol

(2013) Ning Xia et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Advances in Murine Models of Diabetic Nephropathy

(2013) Li-li Kong et al.   Journal of Diabetes Research

Tubulointerstitial De Novo Expression of the α8 Integrin Chain in a Rodent Model of Renal Fibrosis – A Potential Target for Anti-Fibrotic Therapy?

(2012) Andrea Hartner et al.   PLoS One

18β-Glycyrrhetinic Acid Delivered Orally Induces Isolated Lymphoid Follicle Maturation at the Intestinal Mucosa and Attenuates Rotavirus Shedding

(2012) Jay M. Hendricks et al.   PLoS One

Chrysin suppresses renal carcinogenesis via amelioration of hyperproliferation, oxidative stress and inflammation: Plausible role of NF-κB

(2012) Muneeb U. Rehman et al.   TOXICOLOGY LETTERS

Resveratrol Improves Oxidative Stress and Protects Against Diabetic Nephropathy Through Normalization of Mn-SOD Dysfunction in AMPK/SIRT1-Independent Pathway

(2011) M. Kitada et al.   DIABETES

Royal Jelly Modulates Oxidative Stress and Apoptosis in Liver and Kidneys of Rats Treated with Cisplatin

(2011) Ali Karadeniz et al.   Oxidative Medicine and Cellular Longevity

Alleviation of lung injury by glycyrrhizic acid in benzo(a)pyrene exposed rats: Probable role of soluble epoxide hydrolase and thioredoxin reductase

(2011) Wajhul Qamar et al.   TOXICOLOGY

AMPK and SIRT1: a long-standing partnership?

(2010) Neil B. Ruderman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

AMP-activated Protein Kinase (AMPK) Negatively Regulates Nox4-dependent Activation of p53 and Epithelial Cell Apoptosis in Diabetes

(2010) Assaad A. Eid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Choosing the right mouse model for diabetic nephropathy

(2010) Detlef Schlöndorff   KIDNEY INTERNATIONAL

Oxidative stress in early diabetic nephropathy: fueling the fire

(2010) Dhruv K. Singh et al.   Nature Reviews Endocrinology

Glycyrrhizin, the main active compound in liquorice, attenuates pro-inflammatory responses by interfering with membrane-dependent receptor signalling

(2009) Bärbel Schröfelbauer et al.   BIOCHEMICAL JOURNAL

Oxidative Stress as a Major Culprit in Kidney Disease in Diabetes

(2008) J. M. Forbes et al.   DIABETES

Adiponectin regulates albuminuria and podocyte function in mice

(2008) Kumar Sharma et al.   JOURNAL OF CLINICAL INVESTIGATION

PPARα activators upregulate eNOS activity and inhibit cytokine-induced NF-κB activation through AMP-activated protein kinase activation

(2008) Toshie Okayasu et al.   LIFE SCIENCES