Human Endogenous Retrovirus-K and TDP-43 Expression Bridges ALS and HIV Neuropathology

Repetitive element transcripts are elevated in the brain of C9orf72 ALS/FTLD patients

(2017) Mercedes Prudencio et al.   HUMAN MOLECULAR GENETICS

TDP-43 expression influences amyloidβ plaque deposition and tau aggregation

(2017) Stephani A. Davis et al.   NEUROBIOLOGY OF DISEASE

Anti-HERV-K (HML-2) capsid antibody responses in HIV elite controllers

(2017) Miguel de Mulder et al.   Retrovirology

Molecular mechanisms by which HERV-K Gag interferes with HIV-1 Gag assembly and particle infectivity

(2017) Kazuaki Monde et al.   Retrovirology

Inhibition of human endogenous retrovirus-K by antiretroviral drugs

(2017) Richa Tyagi et al.   Retrovirology

Expression of HERV-K108 envelope interferes with HIV-1 production

(2017) Sandra N. Terry et al.   VIROLOGY

TRIM28 Controls a Gene Regulatory Network Based on Endogenous Retroviruses in Human Neural Progenitor Cells

(2017) Per Ludvik Brattås et al.   Cell Reports

Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALS

(2017) Lisa Krug et al.   PLoS Genetics

Cooccurrences of Putative Endogenous Retrovirus-Associated Diseases

(2017) Christine Brütting et al.   Biomed Research International

Endogenous Retroviruses: With Us and against Us

(2017) Thomas J. Meyer et al.   Frontiers in Chemistry

Human endogenous retroviruses in neurologic disease

(2016) Tove Christensen   APMIS

Stress granules at the intersection of autophagy and ALS

(2016) Zachary Monahan et al.   BRAIN RESEARCH

Physiological functions and pathobiology of TDP-43 and FUS/TLS proteins

(2016) Antonia Ratti et al.   JOURNAL OF NEUROCHEMISTRY

NF-κB and IRF1 Induce Endogenous Retrovirus K Expression via Interferon-Stimulated Response Elements in Its 5′ Long Terminal Repeat

(2016) Mamneet Manghera et al.   JOURNAL OF VIROLOGY

HIV-associated neurocognitive disorder — pathogenesis and prospects for treatment

(2016) Deanna Saylor et al.   Nature Reviews Neurology

TDP-43 regulates endogenous retrovirus-K viral protein accumulation

(2016) Mamneet Manghera et al.   NEUROBIOLOGY OF DISEASE

HIV-associated motor neuron disease

(2016) Lauren N. Bowen et al.   NEUROLOGY

Regulatory evolution of innate immunity through co-option of endogenous retroviruses

(2016) E. B. Chuong et al.   SCIENCE

Low molecular weight species of TDP-43 generated by abnormal splicing form inclusions in amyotrophic lateral sclerosis and result in motor neuron death

(2015) Shangxi Xiao et al.   ACTA NEUROPATHOLOGICA

Neuropsychological Impairment in Acute HIV and the Effect of Immediate Antiretroviral Therapy

(2015) Idil Kore et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Activation of the innate immune response by endogenous retroviruses

(2015) Tara P. Hurst et al.   JOURNAL OF GENERAL VIROLOGY

Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells

(2015) Edward J. Grow et al.   NATURE

TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets

(2015) Emma L. Scotter et al.   Neurotherapeutics

Human endogenous retrovirus-K contributes to motor neuron disease

(2015) Wenxue Li et al.   Science Translational Medicine

Frontotemporal lobar degeneration: defining phenotypic diversity through personalized medicine

(2014) David J. Irwin et al.   ACTA NEUROPATHOLOGICA

Endogenous Retrovirus-K and Nervous System Diseases

(2014) Mamneet Manghera et al.   Current Neurology and Neuroscience Reports

Syncytin proteins incorporated in placenta exosomes are important for cell uptake and show variation in abundance in serum exosomes from patients with preeclampsia

(2014) Amandine Vargas et al.   FASEB JOURNAL

Metabolism and mis-metabolism of the neuropathological signature protein TDP-43

(2014) C.-C. Huang et al.   JOURNAL OF CELL SCIENCE

Endogenous Retroviruses and the Development of Cancer

(2014) G. Kassiotis   JOURNAL OF IMMUNOLOGY

Regulation of the Human Endogenous Retrovirus K (HML-2) Transcriptome by the HIV-1 Tat Protein

(2014) M. J. Gonzalez-Hernandez et al.   JOURNAL OF VIROLOGY

Human Endogenous Retrovirus-K(II) Envelope Induction Protects Neurons during HIV/AIDS

(2014) Rakesh K. Bhat et al.   PLoS One

HIV-1 Replication in Human Immune Cells Is Independent of TAR DNA Binding Protein 43 (TDP-43) Expression

(2014) Julia Nehls et al.   PLoS One

Retroviruses and amyotrophic lateral sclerosis

(2013) Tariq Alfahad et al.   ANTIVIRAL RESEARCH

Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis

(2013) Shuo-Chien Ling et al.   NEURON

Endogenous retrovirus-K promoter: a landing strip for inflammatory transcription factors?

(2013) Mamneet Manghera et al.   Retrovirology

Nucleic Acid-Sensing Toll-like Receptors Are Essential for the Control of Endogenous Retrovirus Viremia and ERV-Induced Tumors

(2012) Philipp Yu et al.   IMMUNITY

Expression of Human Endogenous Retrovirus Type K (HML-2) Is Activated by the Tat Protein of HIV-1

(2012) M. J. Gonzalez-Hernandez et al.   JOURNAL OF VIROLOGY

Neurodevelopment in Children Born to HIV-Infected Mothers by Infection and Treatment Status

(2012) K. Le Doare et al.   PEDIATRICS

Aggregation of the 35-kDa fragment of TDP-43 causes formation of cytoplasmic inclusions and alteration of RNA processing

(2011) Mei-Xia Che et al.   FASEB JOURNAL

Neurologic and Neurobehavioral Sequelae in Children With Human Immunodeficiency Virus (HIV-1) Infection

(2011) Rajeshree Govender et al.   JOURNAL OF CHILD NEUROLOGY

The C-Terminal TDP-43 Fragments Have a High Aggregation Propensity and Harm Neurons by a Dominant-Negative Mechanism

(2011) Chunxing Yang et al.   PLoS One

Identification, characterization, and comparative genomic distribution of the HERV-K (HML-2) group of human endogenous retroviruses

(2011) Ravi P Subramanian et al.   Retrovirology

Cognitive and behavioral challenges in caring for patients with frontotemporal dementia and amyotrophic lateral sclerosis

(2010) Jennifer Merrilees et al.   Amyotrophic Lateral Sclerosis

HIV-associated neurocognitive disorders: ‘mind the gap’

(2010) Justin C McArthur et al.   ANNALS OF NEUROLOGY

Identification of active loci of a human endogenous retrovirus in neurons of patients with amyotrophic lateral sclerosis

(2010) Renée Douville et al.   ANNALS OF NEUROLOGY

Regulation of TDP-43 aggregation by phosphorylation andp62/SQSTM1

(2010) Owen A. Brady et al.   JOURNAL OF NEUROCHEMISTRY

HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors

(2010) Robert K. Heaton et al.   JOURNAL OF NEUROVIROLOGY

HIV-1 neuroimmunity in the era of antiretroviral therapy

(2010) Stephanie D. Kraft-Terry et al.   NEUROBIOLOGY OF DISEASE

Role of Tat Protein in HIV Neuropathogenesis

(2009) Wenxue Li et al.   NEUROTOXICITY RESEARCH

Molecular mechanisms mediated by human endogenous retroviruses (HERVs) in autoimmunity

(2009) Eva Balada et al.   REVIEWS IN MEDICAL VIROLOGY

The prevalence of motor delay among HIV infected children living in Cape Town, South Africa

(2009) Gillian Ferguson et al.   INTERNATIONAL JOURNAL OF REHABILITATION RESEARCH

Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity

(2008) Daniel B. Stetson et al.   CELL

Endogenous retroviruses

(2008) K. Ruprecht et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Endogenous retroviruses

(2008) V. Blikstad et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Multiple roles of TDP-43 in gene expression, splicing regulation, and human disease

(2007) Emanuele Buratti   Frontiers in Bioscience-Landmark