Candida albicans Heat Shock Proteins and Hsps-Associated Signaling Pathways as Potential Antifungal Targets

Heat shock protein 90 localizes to the surface and augments virulence factors of Cryptococcus neoformans

(2017) Sharanya Chatterjee et al.   PLoS Neglected Tropical Diseases

The Hog1 MAP Kinase Promotes the Recovery from Cell Cycle Arrest Induced by Hydrogen Peroxide in Candida albicans

(2017) Inês Correia et al.   Frontiers in Microbiology

Staurosporine Induces Filamentation in the Human Fungal Pathogen Candida albicans via Signaling through Cyr1 and Protein Kinase A

(2017) Jinglin L. Xie et al.   mSphere

Involvement of Heat Shock Proteins in Candida albicans Biofilm Formation

(2017) Marco Becherelli et al.   JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY

Synergistic Effects and Mechanisms of Budesonide in Combination with Fluconazole against Resistant Candida albicans

(2017) Xiuyun Li et al.   PLoS One

Targeting the fungal calcium–calcineurin signaling network in overcoming drug resistance

(2016) Xiuyun Li et al.   Future Medicinal Chemistry

Inhibition of heat-shock protein 90 enhances the susceptibility to antifungals and reduces the virulence of Cryptococcus neoformans/Cryptococcus gattii species complex

(2016) Rossana de Aguiar Cordeiro et al.   MICROBIOLOGY-SGM

Signalling mucin Msb2 Regulates adaptation to thermal stress inCandida albicans

(2016) Darpan Saraswat et al.   MOLECULAR MICROBIOLOGY

Extensive functional redundancy in the regulation ofCandida albicansdrug resistance and morphogenesis by lysine deacetylases Hos2, Hda1, Rpd3 and Rpd31

(2016) Xinliu Li et al.   MOLECULAR MICROBIOLOGY

Virulence-specific cell cycle and morphogenesis connections in pathogenic fungi

(2016) José Pérez-Martín et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicans

(2016) Michelle D. Leach et al.   Nature Communications

Unmasking fungal pathogens by studying MAPK-dependent cell wall regulation inCandida albicans

(2016) Paul J. Cullen et al.   Virulence

Components of the Calcium-Calcineurin Signaling Pathway in Fungal Cells and Their Potential as Antifungal Targets

(2015) Shuyuan Liu et al.   EUKARYOTIC CELL

Cell Wall Remodeling Enzymes Modulate Fungal Cell Wall Elasticity and Osmotic Stress Resistance

(2015) Iuliana V. Ene et al.   mBio

The Mkk2 MAPKK Regulates Cell Wall Biogenesis in Cooperation with the Cek1-Pathway in Candida albicans

(2015) Elvira Román et al.   PLoS One

Hsp90-dependent regulatory circuitry controlling temperature-dependent fungal development and virulence

(2014) Teresa R. O'Meara et al.   CELLULAR MICROBIOLOGY

Heat shock protein 90 (Hsp90): A novel antifungal target againstAspergillus fumigatus

(2014) Frédéric Lamoth et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Differential Response of Candida albicans and Candida glabrata to Oxidative and Nitrosative Stresses

(2014) Mayra Cuéllar-Cruz et al.   CURRENT MICROBIOLOGY

Membrane Fluidity and Temperature Sensing Are Coupled via Circuitry Comprised of Ole1, Rsp5, and Hsf1 in Candida albicans

(2014) Michelle D. Leach et al.   EUKARYOTIC CELL

Inhibitory effect of verapamil onCandida albicanshyphal development, adhesion and gastrointestinal colonization

(2014) Qilin Yu et al.   FEMS YEAST RESEARCH

The Metacaspase (Mca1p) has a Dual Role in Farnesol-induced Apoptosis inCandida albicans

(2014) Thibaut Léger et al.   MOLECULAR & CELLULAR PROTEOMICS

The Calcium Channel Blocker Verapamil Inhibits Oxidative Stress Response in Candida albicans

(2014) Qilin Yu et al.   MYCOPATHOLOGIA

Progress and prospects for targeting Hsp90 to treat fungal infections

(2014) AMANDA VERI et al.   PARASITOLOGY

Calcineurin as a multifunctional regulator: Unraveling novel functions in fungal stress responses, hyphal growth, drug resistance, and pathogenesis

(2014) Praveen R. Juvvadi et al.   Fungal Biology Reviews

Human Monoclonal Antibody-Based Therapy in the Treatment of Invasive Candidiasis

(2013) Francesca Bugli et al.   Clinical & Developmental Immunology

Antifungal drug resistance mechanisms in pathogenic fungi: from bench to bedside

(2013) M. Cuenca-Estrella   CLINICAL MICROBIOLOGY AND INFECTION

Ras Signaling Gets Fine-Tuned: Regulation of Multiple Pathogenic Traits of Candida albicans

(2013) Diane O. Inglis et al.   EUKARYOTIC CELL

Heat Shock Proteins Regulate Activation-induced Proteasomal Degradation of the Mature Phosphorylated Form of Protein Kinase C

(2013) Michelle A. Lum et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ras Protein/cAMP-dependent Protein Kinase Signaling Is Negatively Regulated by a Deubiquitinating Enzyme, Ubp3, in Yeast

(2013) Yang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stress adaptation in a pathogenic fungus

(2013) A. J. P. Brown et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Hsp21 Potentiates Antifungal Drug Tolerance in Candida albicans

(2013) François L. Mayer et al.   PLoS One

Posaconazole Exhibits In Vitro and In Vivo Synergistic Antifungal Activity with Caspofungin or FK506 against Candida albicans

(2013) Ying-Lien Chen et al.   PLoS One

Hsp90 Orchestrates Transcriptional Regulation by Hsf1 and Cell Wall Remodelling by MAPK Signalling during Thermal Adaptation in a Pathogenic Yeast

(2013) Michelle D. Leach et al.   PLoS Pathogens

Phosphorylation of Calcineurin at a Novel Serine-Proline Rich Region Orchestrates Hyphal Growth and Virulence in Aspergillus fumigatus

(2013) Praveen R. Juvvadi et al.   PLoS Pathogens

Nonspecific Effect of Mycograb on Amphotericin B MIC

(2012) D. L. Richie et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pho85, Pcl1, and Hms1 Signaling Governs Candida albicans Morphogenesis Induced by High Temperature or Hsp90 Compromise

(2012) Rebecca S. Shapiro et al.   CURRENT BIOLOGY

The Heat-Induced Molecular Disaggregase Hsp104 of Candida albicans Plays a Role in Biofilm Formation and Pathogenicity in a Worm Infection Model

(2012) Alessandro Fiori et al.   EUKARYOTIC CELL

Candida albicans Msi3p, a homolog of the Saccharomyces cerevisiae Sse1p of the Hsp70 family, is involved in cell growth and fluconazole tolerance

(2012) Jun-ichi Nagao et al.   FEMS YEAST RESEARCH

Tight Control of Trehalose Content Is Required for Efficient Heat-induced Cell Elongation inCandida albicans

(2012) Joke Serneels et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformational Switching of the Molecular Chaperone Hsp90 via Regulated Phosphorylation

(2012) Joanna Soroka et al.   MOLECULAR CELL

Fungal Hsp90: a biological transistor that tunes cellular outputs to thermal inputs

(2012) Michelle D. Leach et al.   NATURE REVIEWS MICROBIOLOGY

Small but Crucial: The Novel Small Heat Shock Protein Hsp21 Mediates Stress Adaptation and Virulence in Candida albicans

(2012) François L. Mayer et al.   PLoS One

Functional Characterization of the Small Heat Shock Protein Hsp12p from Candida albicans

(2012) Man-Shun Fu et al.   PLoS One

Hsp90 Is Involved in Apoptosis of Candida albicans by Regulating the Calcineurin-Caspase Apoptotic Pathway

(2012) BaoDi Dai et al.   PLoS One

Retigeric Acid B Attenuates the Virulence of Candida albicans via Inhibiting Adenylyl Cyclase Activity Targeted by Enhanced Farnesol Production

(2012) Wenqiang Chang et al.   PLoS One

The Hsp90 Co-Chaperone Sgt1 Governs Candida albicans Morphogenesis and Drug Resistance

(2012) Rebecca S. Shapiro et al.   PLoS One

Lysine Deacetylases Hda1 and Rpd3 Regulate Hsp90 Function thereby Governing Fungal Drug Resistance

(2012) Nicole Robbins et al.   Cell Reports

Dose Range Evaluation of Mycograb C28Y Variant, a Human Recombinant Antibody Fragment to Heat Shock Protein 90, in Combination with Amphotericin B-Desoxycholate for Treatment of Murine Systemic Candidiasis

(2011) Arnold Louie et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Roles of Ras1 Membrane Localization during Candida albicans Hyphal Growth and Farnesol Response

(2011) Amy E. Piispanen et al.   EUKARYOTIC CELL

Cdc28 provides a molecular link between Hsp90, morphogenesis, and cell cycle progression in Candida albicans

(2011) Heather Senn et al.   MOLECULAR BIOLOGY OF THE CELL

Lack of Trehalose Accelerates H2O2-Induced Candida albicans Apoptosis through Regulating Ca2+ Signaling Pathway and Caspase Activity

(2011) Hui Lu et al.   PLoS One

Hsp90 Governs Dispersion and Drug Resistance of Fungal Biofilms

(2011) Nicole Robbins et al.   PLoS Pathogens

Epidemiology and treatment approaches in management of invasive fungal infections

(2011) James Ito et al.   Clinical Epidemiology

Molecular detection and characterisation of fungal heat shock protein 60

(2010) Reinhard B. Raggam et al.   MYCOSES

PKC Signaling Regulates Drug Resistance of the Fungal Pathogen Candida albicans via Circuitry Comprised of Mkc1, Calcineurin, and Hsp90

(2010) Shantelle L. LaFayette et al.   PLoS Pathogens

Host Cell Invasion and Virulence Mediated by Candida albicans Ssa1

(2010) Jianing N. Sun et al.   PLoS Pathogens

Efungumab: A Novel Agent in the Treatment of Invasive Candidiasis

(2009) Rakhi Karwa et al.   ANNALS OF PHARMACOTHERAPY

Heat-shock proteins can promote as well as regulate autoimmunity

(2009) Rajesh Rajaiah et al.   AUTOIMMUNITY REVIEWS

Hsp90 Orchestrates Temperature-Dependent Candida albicans Morphogenesis via Ras1-PKA Signaling

(2009) Rebecca S. Shapiro et al.   CURRENT BIOLOGY

Update on Hsp90 Inhibitors in Clinical Trial

(2009) Y. Kim et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Hsp90 is regulated by a switch point in the C-terminal domain

(2009) Marco Retzlaff et al.   EMBO REPORTS

The Ras/cAMP/PKA signaling pathway and virulence inCandida albicans

(2009) Deborah A Hogan et al.   Future Microbiology

Activity of MGCD290, a Hos2 Histone Deacetylase Inhibitor, in Combination with Azole Antifungals against Opportunistic Fungal Pathogens

(2009) M. A. Pfaller et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Role of the heat shock transcription factor, Hsf1, in a major fungal pathogen that is obligately associated with warm-blooded animals

(2009) Susan Nicholls et al.   MOLECULAR MICROBIOLOGY

Substrate binding site flexibility of the small heat shock protein molecular chaperones

(2009) N. Jaya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease

(2009) Leah E. Cowen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hsp90 Orchestrates Stress Response Signaling Governing Fungal Drug Resistance

(2009) Leah E. Cowen   PLoS Pathogens

Hsp90 Governs Echinocandin Resistance in the Pathogenic Yeast Candida albicans via Calcineurin

(2009) Sheena D. Singh et al.   PLoS Pathogens

Synergistic Effect of Calcineurin Inhibitors and Fluconazole against Candida albicans Biofilms

(2008) P. Uppuluri et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Efungumab and caspofungin: pre-clinical data supporting synergy

(2008) S. Hodgetts et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Ras links cellular morphogenesis to virulence by regulation of the MAP kinase and cAMP signalling pathways in the pathogenic fungus Candida albicans

(2003) Ekkehard Leberer et al.   MOLECULAR MICROBIOLOGY