Article
Microbiology
Peng Li, Chaminda J. Seneviratne, Qingxian Luan, Lijian Jin
Summary: Candida albicans biofilms exhibit significantly increased antifungal resistance, with a higher survival rate and complex cellular pathways in response to caspofungin treatment. Key proteins involved in cell wall integrity, stress response, and metabolic activities play a crucial role in the antifungal resistance of C. albicans biofilms.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Nilesh R. Rarokar, Sunil S. Menghani, Deweshri R. Kerzare, Pramod B. Khedekar, Ashish P. Bharne, Abdulhakeem S. Alamri, Walaa F. Alsanie, Majid Alhomrani, Nagaraja Sreeharsha, Syed Mohammed Basheeruddin Asdaq
Summary: The present study developed a drug-loaded solid lipid nanoparticle hydrogel for improved antifungal efficacy. The hydrogel demonstrated sustained drug release over 24 hours and showed better physical stability at lower temperatures.
Article
Immunology
Yali Li, Sheng Li, Min Chen, Jialing Xiao, Hong Fang
Summary: The study showed that the combination of pyrvinium pamoate with azoles and amphotericin B has synergistic effects on Cryptococcus neoformans, leading to improved survival rates.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Infectious Diseases
Yuting Wang, Haiying Yan, Jinfeng Li, Yuan Zhang, Zhen Wang, Shujuan Sun
Summary: The number of invasive fungal infections has increased significantly, leading to high morbidity and mortality in immunocompromised patients. Caspofungin (CAS) resistance is a growing concern, limiting the treatment options for severe invasive Candida albicans infections. This study investigated the activity of CAS in combination with ribavirin (RBV) against C. albicans, and found that the combination had synergistic effects in inhibiting biofilm formation and reducing tissue damage. The findings provide insights into drug resistance and suggest potential applications for RBV in the treatment of C. albicans infections.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Immunology
Sana Jemel, Yannick Raveloarisaona, Anne-Laure Bidaud, Elie Djenontin, Aicha Kallel, Jacques Guillot, Kalthoum Kallel, Francoise Botterel, Eric Dannaoui
Summary: Azole resistance in Aspergillus fumigatus is a major concern for the optimal management of patients with invasive aspergillosis. This study evaluates the combination of caspofungin with voriconazole or posaconazole for the treatment of azole-resistant strains. In vitro and in vivo experiments were conducted, and the combination therapy showed promising results.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Microbiology
Sarah R. Beattie, Taiwo Esan, Robert Zarnowski, Emily Eix, Jeniel E. Nett, David R. Andes, Timothy Hagen, Damian J. Krysan
Summary: New antifungal therapies are needed for various fungal infections, including biofilms and drug-resistant strains. A novel keto-alkyl-pyridinium scaffold has been identified with broad spectrum activity against medically important fungi. This class of molecules shows potential for non-systemic applications.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Microbiology
Joseph Meletiadis, Maria-Ioanna Beredaki, Antigoni Elefanti, Spyros Pournaras, Anouk Muller
Summary: In order to evaluate the efficacy of combination therapy, it is necessary to study the correlation between in vitro and in vivo testing. This study attempted to correlate the in vitro chequerboard testing of posaconazole and amphotericin B with the in vivo outcome of combination therapy. The results showed consistency between the in vitro and in vivo testing.
Article
Biochemistry & Molecular Biology
Yue Zhang, Qiuhao Li, Wen Chao, Yulin Qin, Jiayan Chen, Yingwen Wang, Runhui Liu, Quanzhen Lv, Jinxin Wang
Summary: Nowadays, discovering new skeleton antifungal drugs is crucial for addressing clinical fungal infections. In this study, the structure-activity relationship of pyrylium salt SM21 was investigated, and a series of derivatives were synthesized. The synthesized compounds showed improved antifungal activities, with one compound, XY12, displaying stronger antifungal effects and decreased cytotoxicity compared to SM21. XY12 also had efficacy against fluconazole-resistant Candida species and improved the survival rate in mice with systemic Candida infection. These findings suggest the potential of structural modification of pyrylium salts in discovering new antifungal drugs.
Article
Biochemistry & Molecular Biology
Yi Gong, Haoyi Li, Fei Wu, Yishuai Li, Shicui Zhang
Summary: Derived from AP-2 complex subunit mu-A, the short peptide AP10W exhibits notable antifungal activities against Candida albicans and Aspergillus fumigatus. It inhibits fungal biofilm formation and reduces pre-established fungal biofilms. AP10W acts through various mechanisms including interaction with fungal cell walls, enhancement of cell wall permeability, membrane depolarization induction, and increase in intracellular ROS generation. It shows low toxicity towards mammalian cells and promotes wound healing in C. albicans-infected skin.
Article
Microbiology
Yu Zhang, Yan-Chao Liu, Si-Min Chen, Hui Zong, Wei-Tong Hou, Xi-Ran Qiu, Shi-Yu Guo, Yu-Fang Sun, Yuan-Ying Jiang, Mao-Mao An, Hui Shen
Summary: This study aimed to develop anidulafungin-loaded Human Serum Albumin nanoparticles to enhance its solubility and antifungal efficacy. The results showed that the nanoparticles improved water solubility of anidulafungin, exhibited stronger antifungal effects in vitro, and prolonged survival time in a murine model of invasive candidiasis compared to the free drug. The developed nanoparticles have the potential to improve drug administration and therapeutic outcomes for fungal diseases.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Giovanna Ginestra, Teresa Gervasi, Francesca Mancuso, Federica Bucolo, Laura De Luca, Rosaria Gitto, Davide Barreca, Giuseppina Mandalari
Summary: In this study, a series of arylsulfonamide compounds were screened and the structure-activity relationship was established based on a hit compound. The antifungal activity against various Candida species was tested, and cytotoxicity was evaluated. These findings could contribute to the development of novel topical therapeutics for fungal infections.
Article
Microbiology
Lulu An, Jingwen Tan, Yuanyuan Wang, Siyu Liu, Yongyong Li, Lianjuan Yang
Summary: This study found that the combination therapy of deferoxamine and fluconazole has a synergistic antifungal effect against drug-resistant Candida albicans. The combination inhibits the growth and hyphal formation of the fungus, reduces infectivity and resistance, and affects signaling pathways. This may offer a novel approach for the treatment of cutaneous candidiasis.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Immunology
Guillermo Quindos, Katherine Miranda-Cadena, Rosario San-Millan, Katyna Borroto-Esoda, Emilia Canton, Maria Jose Linares-Sicilia, Axel Hamprecht, Isabel Montesinos, Anna Maria Tortorano, Anna Prigitano, Matxalen Vidal-Garcia, Cristina Marcos-Arias, Andrea Guridi, Ferran Sanchez-Reus, Jesus Machuca-Barcena, Manuel Antonio Rodriguez-Iglesias, Estrella Martin-Mazuelos, Carmen Castro-Mendez, Leyre Lopez-Soria, Alba Ruiz-Gaitan, Marcelo Fernandez-Rivero, Damaris Lorenzo, Javier Capilla, Antonio Rezusta, Javier Peman, Josep Guarro, Joana Pereira, Celia Pais, Orazio Romeo, Guillermo Ezpeleta, Nerea Jauregizar, David Angulo, Elena Eraso
Summary: This study assessed the in vitro activity of Ibrexafungerp and other drugs against 434 blood isolates of Candida in Europe. The results showed that Ibrexafungerp exhibited potent activity against these isolates and also showed activity against fluconazole- and echinocandin-resistant isolates.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Infectious Diseases
Qianting Yang, Zhiyong Liu, Yan Wang, Jiao Xie, Kanghuai Zhang, Yalin Dong, Yun F. Wang
Summary: Combination antifungal therapies, specifically caspofungin with fluconazole or voriconazole, may be effective against infections caused by Candida species, especially Candida glabrata with FKS mutation.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Saeed Ullah Khattak, Zafar Iqbal, Ghosia Lutfullah, Sajjad Ahmad, Metab Alharbi, Abdullah F. Alasmari, Muhammad Irfan
Summary: The study focused on the isolation and characterization of an antifungal compound produced by Penicillium crysogenum. The purified compound showed potential for inhibiting the growth of Candida albicans and Candida glaberata, indicating its potential as a future antifungal candidate.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Biotechnology & Applied Microbiology
Shang-Jie Yu, Ya-Lin Chang, Ying-Lien Chen
FEMS YEAST RESEARCH
(2015)
Article
Chemistry, Applied
Daria Wieczorek, Daniela Gwiazdowska, Katarzyna Staszak, Ying-Lien Chen, Tang-Long Shen
JOURNAL OF SURFACTANTS AND DETERGENTS
(2016)
Article
Infectious Diseases
Li-Hang Hsu, Hsuan-Fu Wang, Pei-Lun Sun, Fung-Rong Hu, Ying-Lien Chen
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2017)
Article
Microbiology
Shang-Jie Yu, Ya-Lin Chang, Ying-Lien Chen
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2018)
Article
Immunology
Chi-Jan Lin, Chia-Yen Wu, Shang-Jie Yu, Ying-Lien Chen
Article
Infectious Diseases
Chi-Jan Lin, Yi-Hsuan Hou, Ying-Lien Chen
Article
Infectious Diseases
Hao-Tai Ko, Li-Hang Hsu, Sheng-Yung Yang, Ying-Lien Chen
Article
Multidisciplinary Sciences
Li-Hang Hsu, Dobrawa Kwasniewska, Shih-Cheng Wang, Tang-Long Shen, Daria Wieczorek, Ying-Lien Chen
SCIENTIFIC REPORTS
(2020)
Review
Microbiology
Dobrawa Kwasniewska, Ying-Lien Chen, Daria Wieczorek
Article
Infectious Diseases
Chi-Jan Lin, Ya-Lin Chang, Yu-Liang Yang, Ying-Lien Chen
Summary: The study demonstrates that tryptanthrin possesses novel antifungal activity against Cryptococcus species by interfering with the cell cycle and signaling pathways, indicating its potential as a drug or adjuvant for the treatment of cryptococcosis.
Article
Medicine, Research & Experimental
Li-Hang Hsu, Chen-Yi Su, Pei-Lun Sun, Ying-Lien Chen
Summary: This study reported a case of a rough-tail stingray infected by FSSC, diagnosed and successfully treated with voriconazole and terbinafine therapy.
MEDICAL MYCOLOGY CASE REPORTS
(2021)
Article
Infectious Diseases
Chi-Jan Lin, Sheng-Yung Yang, Li-Hang Hsu, Shang-Jie Yu, Ying-Lien Chen
Summary: This study characterizes the functions of the conserved histone acetyltransferase module in the pathogenesis of Candida glabrata. The findings reveal the diverse roles of this module in the pathogenesis of C. glabrata, which is important for understanding the regulation of its virulence traits.
Article
Microbiology
Yeseul Choi, Eunji Jeong, Dong-Gi Lee, Jae-Hyung Jin, Yee-Seul So, Seong-Ryong Yu, Kyung-Jo Lee, Yoonjie Ha, Chi-Jan Lin, Ying-Lien Chen, Jun Bae Park, Hyun-Soo Cho, Anna F. Averette, Joseph Heitman, Kyu-Ho Lee, Kangseok Lee, Yong-Sun Bahn
Summary: The pathobiological roles of the KEOPS complex in the fungal meningitis-causing pathogen C. neoformans were comprehensively analyzed in this study. The CnKEOPS complex not only played conserved roles in growth, sexual development, stress responses, and tRNA modification but also had unique roles in controlling virulence factor production and pathogenicity. The unique extended loop structure in CnBud32 was critical for the KEOPS complex in C. neoformans.
Article
Infectious Diseases
Yue-Han Huang, Yi-Hang Lee, Chi-Jan Lin, Li-Hang Hsu, Ying-Lien Chen
Summary: The DUB module of Candida glabrata plays important roles in gene regulation, drug tolerance, and biofilm formation.
Review
Microbiology
Chi-Jan Lin, Ying-Lien Chen