ROCK as a therapeutic target for ischemic stroke

Clinical Effectiveness of Statin Therapy After Ischemic Stroke: Primary Results From the Statin Therapeutic Area of the Patient-Centered Research Into Outcomes Stroke Patients Prefer and Effectiveness Research (PROSPER) StudyClinical Perspective

(2015) Emily C. O’Brien et al.   CIRCULATION

B-Lymphocyte-Mediated Delayed Cognitive Impairment following Stroke

(2015) K. P. Doyle et al.   JOURNAL OF NEUROSCIENCE

The Role of Activated Microglia and Resident Macrophages in the Neurovascular Unit during Cerebral Ischemia: Is the Jury Still Out?

(2015) Rawan Barakat et al.   MEDICAL PRINCIPLES AND PRACTICE

ROCK-Isoform-Specific Polarization of Macrophages Associated with Age-Related Macular Degeneration

(2015) Souska Zandi et al.   Cell Reports

Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism

(2014) Alexandra Zanin-Zhorov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased rho kinase activity in temporal artery biopsies from patients with giant cell arteritis

(2014) L. Lally et al.   RHEUMATOLOGY

ROCK2 is a major regulator of axonal degeneration, neuronal death and axonal regeneration in the CNS

(2014) J C Koch et al.   Cell Death & Disease

Enhanced Rho-Associated Protein Kinase Activation in Patients With Systemic Lupus Erythematosus

(2013) Josephine Isgro et al.   ARTHRITIS AND RHEUMATISM

14-3-3 Proteins Interact with a Hybrid Prenyl-Phosphorylation Motif to Inhibit G Proteins

(2013) Philippe Riou et al.   CELL

Gene variations of ROCKs and risk of ischaemic stroke: the Women's Genome Health Study

(2013) Robert Y. L. Zee et al.   CLINICAL SCIENCE

Rho-associated coiled-coil kinase (ROCK) signaling and disease

(2013) Alice V. Schofield et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Physiological roles of Rho and Rho effectors in mammals

(2013) Dean Thumkeo et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Astrocyte-Derived Sonic Hedgehog Contributes to Angiogenesis in Brain Microvascular Endothelial Cells via RhoA/ROCK Pathway After Oxygen–Glucose Deprivation

(2013) Quan-Wei He et al.   MOLECULAR NEUROBIOLOGY

RhoA Is Essential for Maintaining Normal Megakaryocyte Ploidy and Platelet Generation

(2013) Aae Suzuki et al.   PLoS One

B Cells Use Mechanical Energy to Discriminate Antigen Affinities

(2013) E. Natkanski et al.   SCIENCE

Rho-ROCK Inhibition in the Treatment of Spinal Cord Injury

(2013) Nicole Forgione et al.   World Neurosurgery

Selective ROCK2 inhibition in focal cerebral ischemia

(2013) Jeong Hyun Lee et al.   Annals of Clinical and Translational Neurology

Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's disease

(2012) L. Tonges et al.   BRAIN

Immune mechanisms of stroke

(2012) Tim Magnus et al.   CURRENT OPINION IN NEUROLOGY

Inhibition of Rho-kinase attenuates endothelial–leukocyte interaction during ischemia–reperfusion injury

(2012) Qing Mei Wang et al.   VASCULAR MEDICINE

Ocular Hypotensive Effect of the Rho Kinase Inhibitor AR-12286 in Patients With Glaucoma and Ocular Hypertension

(2011) Robert D. Williams et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis

(2011) I. Pleines et al.   BLOOD

Bisphosphonates: The first 40years

(2011) R. Graham G. Russell   BONE

Long term incidence of dementia, predictors of mortality and pathological diagnosis in older stroke survivors

(2011) L. M. Allan et al.   BRAIN

Shroom2 regulates contractility to control endothelial morphogenesis

(2011) Matthew J. Farber et al.   MOLECULAR BIOLOGY OF THE CELL

Association of Rho-associated protein kinase 1 with E-cadherin complexes is mediated by p120-catenin

(2011) Andrew L. Smith et al.   MOLECULAR BIOLOGY OF THE CELL

Fasudil Decreases Lesion Burden in a Murine Model of Cerebral Cavernous Malformation Disease

(2011) David A. McDonald et al.   STROKE

ROCKing regeneration: Rho kinase inhibition as molecular target for neurorestoration

(2011) Lars Tönges   Frontiers in Molecular Neuroscience

Familial facioscapulohumeral muscular dystrophy: phenotypic diversity and genetic abnormality

(2010) M. Nakagawa et al.   ACTA NEUROLOGICA SCANDINAVICA

Fingolimod provides long-term protection in rodent models of cerebral ischemia

(2010) Ying Wei et al.   ANNALS OF NEUROLOGY

Rho-kinase mediates TNF-α-induced MCP-1 expression via p38 MAPK signaling pathway in mesangial cells

(2010) Keiichiro Matoba et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity

(2010) Mutsuki Amano et al.   Cytoskeleton

Rho Kinase-2 Activation in Human Endothelial Cells Drives Lysophosphatidic Acid-mediated Expression of Cell Adhesion Molecules via NF-κB p65

(2010) Hideaki Shimada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C3 peptide enhances recovery from spinal cord injury by improved regenerative growth of descending fiber tracts

(2010) F. Boato et al.   JOURNAL OF CELL SCIENCE

Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice

(2010) Partha S. Biswas et al.   JOURNAL OF CLINICAL INVESTIGATION

Calcium channel blocker and Rho-associated kinase activity in patients with hypertension

(2010) Takaki Hata et al.   JOURNAL OF HYPERTENSION

Inflammatory mechanisms in ischemic stroke: role of inflammatory cells

(2010) Rong Jin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Fasudil protects hippocampal neurons against hypoxia-reoxygenation injury by suppressing microglial inflammatory responses in mice

(2010) Jing Ding et al.   JOURNAL OF NEUROCHEMISTRY

Rho kinase inhibitor Fasudil induces neuroprotection and neurogenesis partially through astrocyte-derived G-CSF

(2009) Jing Ding et al.   BRAIN BEHAVIOR AND IMMUNITY

Pharmacological Characterization of SAR407899, a Novel Rho-Kinase Inhibitor

(2009) Matthias Löhn et al.   HYPERTENSION

TH17 cells and regulatory T cells in primary immunodeficiency diseases

(2009) Hans D. Ochs et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The neurovascular unit in the setting of stroke

(2009) G. J. del Zoppo   JOURNAL OF INTERNAL MEDICINE

N-terminus-mediated dimerization of ROCK-I is required for RhoE binding and actin reorganization

(2008) Ritu Garg et al.   BIOCHEMICAL JOURNAL

Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets for treatment

(2008) G. Stoll et al.   BLOOD

Increased leukocyte ROCK activity in patients after acute ischemic stroke

(2008) Steven K. Feske et al.   BRAIN RESEARCH

Deficiency of ROCK1 in bone marrow-derived cells protects against atherosclerosis in LDLR−/− mice

(2008) Hong-Wei Wang et al.   FASEB JOURNAL