Deciphering the BRCA1 Tumor Suppressor Network

MERIT40 deficiency expands hematopoietic stem cell pools by regulating thrombopoietin receptor signaling

(2015) K. Rozenova et al.   BLOOD

Repair versus Checkpoint Functions of BRCA1 Are Differentially Regulated by Site of Chromatin Binding

(2015) M. Goldstein et al.   CANCER RESEARCH

Interaction of BARD1 and HP1 Is Required for BRCA1 Retention at Sites of DNA Damage

(2015) W. Wu et al.   CANCER RESEARCH

BRCA1 Recruitment to Transcriptional Pause Sites Is Required for R-Loop-Driven DNA Damage Repair

(2015) Elodie Hatchi et al.   MOLECULAR CELL

MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5′ end resection

(2015) Vera Boersma et al.   NATURE

Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

(2015) Raphael Ceccaldi et al.   NATURE

Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination

(2015) Pedro A. Mateos-Gomez et al.   NATURE

REV7 counteracts DNA double-strand break resection and affects PARP inhibition

(2015) Guotai Xu et al.   NATURE

Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ

(2015) Tatiana Kent et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ

(2015) Tatiana Kent et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNF168 Promotes Noncanonical K27 Ubiquitination to Signal DNA Damage

(2015) Marco Gatti et al.   Cell Reports

Genome-wide analysis reveals a role for BRCA1 and PALB2 in transcriptional co-activation

(2014) A. Gardini et al.   EMBO JOURNAL

Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage

(2014) Sarah J. Hill et al.   GENES & DEVELOPMENT

PTIP associates with Artemis to dictate DNA repair pathway choice

(2014) Jiadong Wang et al.   GENES & DEVELOPMENT

Male Fertility Defect Associated with Disrupted BRCA1-PALB2 Interaction in Mice

(2014) Srilatha Simhadri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CtIP-mediated resection is essential for viability and can operate independently of BRCA1

(2014) Federica Polato et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of a BRCA1-mRNA Splicing Complex Required for Efficient DNA Repair and Maintenance of Genomic Stability

(2014) Kienan I. Savage et al.   MOLECULAR CELL

BRCA1 Promotes Unloading of the CMG Helicase from a Stalled DNA Replication Fork

(2014) David T. Long et al.   MOLECULAR CELL

BRCA1 controls homologous recombination at Tus/Ter-stalled mammalian replication forks

(2014) Nicholas A. Willis et al.   NATURE

Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome

(2014) Robert K. McGinty et al.   NATURE

BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2

(2014) Vaibhav Bhatia et al.   NATURE

Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks

(2014) François Aymard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Breast-Cancer Risk in Families with Mutations in PALB2

(2014) Antonis C. Antoniou et al.   NEW ENGLAND JOURNAL OF MEDICINE

BRCA1 haploinsufficiency for replication stress suppression in primary cells

(2014) Shailja Pathania et al.   Nature Communications

Synthetic Lethality in ATM-Deficient RAD50-Mutant Tumors Underlies Outlier Response to Cancer Therapy

(2014) H. Al-Ahmadie et al.   Cancer Discovery

Biallelic Mutations in BRCA1 Cause a New Fanconi Anemia Subtype

(2014) Sarah L. Sawyer et al.   Cancer Discovery

BRCA1 Is a Histone-H2A-Specific Ubiquitin Ligase

(2014) Reinhard Kalb et al.   Cell Reports

The BRCA1-Interacting Protein Abraxas Is Required for Genomic Stability and Tumor Suppression

(2014) Andy Castillo et al.   Cell Reports

BRCA1 Accelerates CtIP-Mediated DNA-End Resection

(2014) Andrés Cruz-García et al.   Cell Reports

Mechanism of Suppression of Chromosomal Instability by DNA Polymerase POLQ

(2014) Matthew J. Yousefzadeh et al.   PLoS Genetics

Transformation of the Fallopian Tube Secretory Epithelium Leads to High-Grade Serous Ovarian Cancer in Brca;Tp53;Pten Models

(2013) Ruth Perets et al.   CANCER CELL

Function of BRCA1 in the DNA Damage Response Is Mediated by ADP-Ribosylation

(2013) Mo Li et al.   CANCER CELL

ATR Inhibition Broadly Sensitizes Ovarian Cancer Cells to Chemotherapy Independent of BRCA Status

(2013) C. J. Huntoon et al.   CANCER RESEARCH

The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression

(2013) Colleen R. Reczek et al.   JOURNAL OF CELL BIOLOGY

53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark

(2013) Amélie Fradet-Turcotte et al.   NATURE

Fanconi anaemia and the repair of Watson and Crick DNA crosslinks

(2013) Molly C. Kottemann et al.   NATURE

Double-strand break repair: 53BP1 comes into focus

(2013) Stephanie Panier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination

(2013) Jiangbo Tang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Histone H4 deacetylation facilitates 53BP1 DNA damage signaling and double-strand break repair

(2013) K.-Y. Hsiao et al.   Journal of Molecular Cell Biology

Heterozygous mutations in PALB2 cause DNA replication and damage response defects

(2013) Jenni Nikkilä et al.   Nature Communications

A Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2

(2012) Katharina Schlacher et al.   CANCER CELL

Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

(2012) J. Murai et al.   CANCER RESEARCH

Mre11-Dependent Degradation of Stalled DNA Replication Forks Is Prevented by BRCA2 and PARP1

(2012) S. Ying et al.   CANCER RESEARCH

RAP80 Is Critical in Maintaining Genomic Stability and Suppressing Tumor Development

(2012) Z. Yin et al.   CANCER RESEARCH

RNF168 Ubiquitinates K13-15 on H2A/H2AX to Drive DNA Damage Signaling

(2012) Francesca Mattiroli et al.   CELL

Molecular Pathways: Understanding the Role of Rad52 in Homologous Recombination for Therapeutic Advancement

(2012) B. H. Lok et al.   CLINICAL CANCER RESEARCH

RAP80 Protein Is Important for Genomic Stability and Is Required for Stabilizing BRCA1-A Complex at DNA Damage Sitesin Vivo

(2012) Jiaxue Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RAD52 inactivation is synthetically lethal with deficiencies in BRCA1 and PALB2 in addition to BRCA2 through RAD51-mediated homologous recombination

(2012) B H Lok et al.   ONCOGENE

RNF4-Dependent Hybrid SUMO-Ubiquitin Chains Are Signals for RAP80 and Thereby Mediate the Recruitment of BRCA1 to Sites of DNA Damage

(2012) C. M. Guzzo et al.   Science Signaling

Breast Cancer-Associated Abraxas Mutation Disrupts Nuclear Localization and DNA Damage Response Functions

(2012) S. Solyom et al.   Science Translational Medicine

Loss of 53BP1 Causes PARP Inhibitor Resistance in Brca1 -Mutated Mouse Mammary Tumors

(2012) Janneke E. Jaspers et al.   Cancer Discovery

Biallelic Deleterious BRCA1 Mutations in a Woman with Early-Onset Ovarian Cancer

(2012) Susan M. Domchek et al.   Cancer Discovery

BRCA1 RING Function Is Essential for Tumor Suppression but Dispensable for Therapy Resistance

(2011) Rinske Drost et al.   CANCER CELL

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci

(2011) Y. Hu et al.   GENES & DEVELOPMENT

The BRCA1-RAP80 Complex Regulates DNA Repair Mechanism Utilization by Restricting End Resection

(2011) Kara A. Coleman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Secondary Somatic Mutations Restoring BRCA1/2 Predict Chemotherapy Resistance in Hereditary Ovarian Carcinomas

(2011) Barbara Norquist et al.   JOURNAL OF CLINICAL ONCOLOGY

Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study

(2011) Karen A Gelmon et al.   LANCET ONCOLOGY

BRCA1 Tumor Suppression Depends on BRCT Phosphoprotein Binding, But Not Its E3 Ligase Activity

(2011) R. Shakya et al.   SCIENCE

Germline Brca2 Heterozygosity Promotes KrasG12D -Driven Carcinogenesis in a Murine Model of Familial Pancreatic Cancer

(2010) Ferdinandos Skoulidis et al.   CANCER CELL

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

(2010) Samuel F. Bunting et al.   CELL

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

(2010) Andrew Tutt et al.   LANCET

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

(2010) M William Audeh et al.   LANCET

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

(2010) Peter Bouwman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate

(2010) C. E. Strom et al.   NUCLEIC ACIDS RESEARCH

Rad52 inactivation is synthetically lethal with BRCA2 deficiency

(2010) Z. Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle

(2009) Maximina H. Yun et al.   NATURE

Inhibition of Poly(ADP-Ribose) Polymerase in Tumors fromBRCAMutation Carriers

(2009) Peter C. Fong et al.   NEW ENGLAND JOURNAL OF MEDICINE

Familial breast cancer screening reveals an alteration in the RAP80 UIM domain that impairs DNA damage response function

(2009) J Nikkilä et al.   ONCOGENE

FANCJ Is a Structure-specific DNA Helicase Associated with the Maintenance of Genomic G/C Tracts

(2008) Timothy B. C. London et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers

(2008) Wataru Sakai et al.   NATURE

Resistance to therapy caused by intragenic deletion in BRCA2

(2008) Stacey L. Edwards et al.   NATURE

The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression

(2008) R. Shakya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA