LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs

Translational control by 5'-untranslated regions of eukaryotic mRNAs

(2016) A. G. Hinnebusch et al.   SCIENCE

The race to decipher the top secrets of TOP mRNAs

(2015) Oded Meyuhas et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1)

(2015) Bruno D. Fonseca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting the translation machinery in cancer

(2015) Mamatha Bhat et al.   NATURE REVIEWS DRUG DISCOVERY

The RNA-binding protein LARP1 is a post-transcriptional regulator of survival and tumorigenesis in ovarian cancer

(2015) Thomas G. Hopkins et al.   NUCLEIC ACIDS RESEARCH

The La-related protein 1-specific domain repurposes HEAT-like repeats to directly bind a 5′TOP sequence

(2015) Roni M. Lahr et al.   NUCLEIC ACIDS RESEARCH

An AXIN2 Mutant Allele Associated With Predisposition to Colorectal Neoplasia Has Context-Dependent Effects on AXIN2 Protein Function

(2015) Serina M. Mazzoni et al.   NEOPLASIA

Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translation

(2014) J. Tcherkezian et al.   GENES & DEVELOPMENT

Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner

(2014) Rachel Miloslavski et al.   Journal of Molecular Cell Biology

LARP1 specifically recognizes the 3′ terminus of poly(A) mRNA

(2013) Kazuma Aoki et al.   FEBS LETTERS

A compendium of RNA-binding motifs for decoding gene regulation

(2013) Debashish Ray et al.   NATURE

Signal integration by mTORC1 coordinates nutrient input with biosynthetic output

(2013) Christian C. Dibble et al.   NATURE CELL BIOLOGY

mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin

(2013) S. A. Kang et al.   SCIENCE

Pervasive and dynamic protein binding sites of the mRNA transcriptome in Saccharomyces cerevisiae

(2013) Mallory A Freeberg et al.   GENOME BIOLOGY

A unifying model for mTORC1-mediated regulation of mRNA translation

(2012) Carson C. Thoreen et al.   NATURE

The translational landscape of mTOR signalling steers cancer initiation and metastasis

(2012) Andrew C. Hsieh et al.   NATURE

REVIGO Summarizes and Visualizes Long Lists of Gene Ontology Terms

(2011) Fran Supek et al.   PLoS One

Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling

(2011) Y. Yu et al.   SCIENCE

The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

(2011) P. P. Hsu et al.   SCIENCE

Therapeutic Targeting of SPINK1-Positive Prostate Cancer

(2011) B. Ateeq et al.   Science Translational Medicine

Conserved and divergent features of the structure and function of La and La-related proteins (LARPs)

(2010) Mark A. Bayfield et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP

(2010) Markus Hafner et al.   CELL

The RNA binding protein Larp1 regulates cell division, apoptosis and cell migration

(2010) C. Burrows et al.   NUCLEIC ACIDS RESEARCH

TORC-Specific Phosphorylation of Mammalian Target of Rapamycin (mTOR): Phospho-Ser2481 Is a Marker for Intact mTOR Signaling Complex 2

(2009) J. Copp et al.   CANCER RESEARCH

Drosophila Larp associates with poly(A)-binding protein and is required for male fertility and syncytial embryo development

(2009) Sarah P. Blagden et al.   DEVELOPMENTAL BIOLOGY

MEME SUITE: tools for motif discovery and searching

(2009) T. L. Bailey et al.   NUCLEIC ACIDS RESEARCH

A comprehensive analysis of the La-motif protein superfamily

(2009) C. Bousquet-Antonelli et al.   RNA

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY

SM-164: A Novel, Bivalent Smac Mimetic That Induces Apoptosis and Tumor Regression by Concurrent Removal of the Blockade of cIAP-1/2 and XIAP

(2008) J. Lu et al.   CANCER RESEARCH

Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 Gene Fusions in Prostate Cancer

(2008) B. E. Helgeson et al.   CANCER RESEARCH