Decreased microRNA levels lead to deleterious increases in neuronal M2 muscarinic receptors in Spinal Muscular Atrophy models

The Power of Human Protective Modifiers: PLS3 and CORO1C Unravel Impaired Endocytosis in Spinal Muscular Atrophy and Rescue SMA Phenotype

(2016) Seyyedmohsen Hosseinibarkooie et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Cell-type-specific miR-431 dysregulation in a motor neuron model of spinal muscular atrophy

(2016) Mary H. Wertz et al.   HUMAN MOLECULAR GENETICS

Decreased function of survival motor neuron protein impairs endocytic pathways

(2016) Maria Dimitriadi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Re-thinking miRNA-mRNA interactions: Intertwining issues confound target discovery

(2015) Nicole Cloonan   BIOESSAYS

Streamlined Genome Engineering with a Self-Excising Drug Selection Cassette

(2015) Daniel J. Dickinson et al.   GENETICS

Selective loss of alpha motor neurons with sparing of gamma motor neurons and spinal cord cholinergic neurons in a mouse model of spinal muscular atrophy

(2015) Rachael A. Powis et al.   JOURNAL OF ANATOMY

A Long Noncoding RNA on the Ribosome Is Required for Lifespan Extension

(2015) Paul B. Essers et al.   Cell Reports

Streamlined Genome Engineering with a Self-Excising Drug Selection Cassette

(2015) Daniel J. Dickinson et al.   GENETICS

Modeling the Early Phenotype at the Neuromuscular Junction of Spinal Muscular Atrophy Using Patient-Derived iPSCs

(2015) Michiko Yoshida et al.   Stem Cell Reports

Expression of Muscle-Specific MiRNA 206 in the Progression of Disease in a Murine SMA Model

(2015) Valeria Valsecchi et al.   PLoS One

Rapid and Precise Engineering of the Caenorhabditis elegans Genome with Lethal Mutation Co-Conversion and Inactivation of NHEJ Repair

(2014) Jordan D. Ward   GENETICS

SMN regulates axonal local translation via miR-183/mTOR pathway

(2014) Min Jeong Kye et al.   HUMAN MOLECULAR GENETICS

Mechanisms Involved in Spinal Cord Central Synapse Loss in a Mouse Model of Spinal Muscular Atrophy

(2014) Olga Tarabal et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Survival of motor neuron protein downregulates miR-9 expression in patients with spinal muscular atrophy

(2014) Li-Ting Wang et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

Exome-wide Rare Variant Analysis Identifies TUBA4A Mutations Associated with Familial ALS

(2014) Bradley N. Smith et al.   NEURON

Swimming against the tide: investigations of the C-bouton synapse

(2014) Adam S. Deardorff et al.   Frontiers in Neural Circuits

The Neuroprotective Drug Riluzole Acts via Small Conductance Ca2+-Activated K+ Channels to Ameliorate Defects in Spinal Muscular Atrophy Models

(2013) M. Dimitriadi et al.   JOURNAL OF NEUROSCIENCE

Biphasic Cholinergic Synaptic Transmission Controls Action Potential Activity in Thalamic Reticular Nucleus Neurons

(2013) Y.-G. Sun et al.   JOURNAL OF NEUROSCIENCE

Heritable genome editing in C. elegans via a CRISPR-Cas9 system

(2013) Ari E Friedland et al.   NATURE METHODS

DIANA-microT web server v5.0: service integration into miRNA functional analysis workflows

(2013) Maria D. Paraskevopoulou et al.   NUCLEIC ACIDS RESEARCH

MicroRNA-128 Governs Neuronal Excitability and Motor Behavior in Mice

(2013) C. L. Tan et al.   SCIENCE

Neuron-Specific Feeding RNAi in C. elegans and Its Use in a Screen for Essential Genes Required for GABA Neuron Function

(2013) Christopher Firnhaber et al.   PLoS Genetics

Functional microRNA targets in protein coding sequences

(2012) Martin Reczko et al.   BIOINFORMATICS

Evolution and function of the extended miR-2 microRNA family

(2012) Antonio Marco et al.   RNA Biology

The Survival of Motor Neuron (SMN) Protein Interacts with the mRNA-Binding Protein HuD and Regulates Localization of Poly(A) mRNA in Primary Motor Neuron Axons

(2011) C. Fallini et al.   JOURNAL OF NEUROSCIENCE

SMN and the Gemin proteins form sub-complexes that localise to both stationary and dynamic neurite granules

(2010) Adrian G. Todd et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SAHA ameliorates the SMA phenotype in two mouse models for spinal muscular atrophy

(2010) Markus Riessland et al.   HUMAN MOLECULAR GENETICS

A novel Caenorhabditis elegans allele, smn-1(cb131), mimicking a mild form of spinal muscular atrophy, provides a convenient drug screening platform highlighting new and pre-approved compounds

(2010) J. N. Sleigh et al.   HUMAN MOLECULAR GENETICS

SMN, Gemin2 and Gemin3 Associate with β-Actin mRNA in the Cytoplasm of Neuronal Cells In Vitro

(2010) Adrian G. Todd et al.   JOURNAL OF MOLECULAR BIOLOGY

Formation, regulation and evolution of Caenorhabditis elegans 3′UTRs

(2010) Calvin H. Jan et al.   NATURE

Enhanced neuronal RNAi in C. elegans using SID-1

(2010) Andrea Calixto et al.   NATURE METHODS

miRNA malfunction causes spinal motor neuron disease

(2010) S. Haramati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conserved Genes Act as Modifiers of Invertebrate SMN Loss of Function Defects

(2010) Maria Dimitriadi et al.   PLoS Genetics

The DEAD-box protein MEL-46 is required in the germ line of the nematode Caenorhabditis elegans

(2009) Ryuji Minasaki et al.   BMC DEVELOPMENTAL BIOLOGY

Impaired Synaptic Vesicle Release and Immaturity of Neuromuscular Junctions in Spinal Muscular Atrophy Mice

(2009) L. Kong et al.   JOURNAL OF NEUROSCIENCE

Differential requirements for clathrin in receptor-mediated endocytosis and maintenance of synaptic vesicle pools

(2009) K. Sato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-scale spatiotemporal analysis of Caenorhabditis elegans microRNA promoter activity

(2008) N. J. Martinez et al.   GENOME RESEARCH

Deletion of smn-1, the Caenorhabditis elegans ortholog of the spinal muscular atrophy gene, results in locomotor dysfunction and reduced lifespan

(2008) M. Briese et al.   HUMAN MOLECULAR GENETICS

Behavioral Impact of Neurotransmitter-Activated G-Protein-Coupled Receptors: Muscarinic and GABAB Receptors Regulate Caenorhabditis elegans Locomotion

(2008) J. S. Dittman et al.   JOURNAL OF NEUROSCIENCE

Differential Outgrowth of Axons and their Branches Is Regulated by Localized Calcium Transients

(2008) B. I. Hutchins et al.   JOURNAL OF NEUROSCIENCE

p75 Neurotrophin Receptor Mediates Neuronal Cell Death by Activating GIRK Channels through Phosphatidylinositol 4,5-Bisphosphate

(2008) E. J. Coulson et al.   JOURNAL OF NEUROSCIENCE

Widespread changes in protein synthesis induced by microRNAs

(2008) Matthias Selbach et al.   NATURE

Single-copy insertion of transgenes in Caenorhabditis elegans

(2008) Christian Frøkjær-Jensen et al.   NATURE GENETICS

A chemical-genetic strategy reveals distinct temporal requirements for SAD-1 kinase in neuronal polarization and synapse formation

(2008) Joanne SM Kim et al.   Neural Development

An RNAi Screen Identifies Genes that Regulate GABA Synapses

(2008) Amy B. Vashlishan et al.   NEURON

Sequence Relationships among C. elegans, D. melanogaster and Human microRNAs Highlight the Extensive Conservation of microRNAs in Biology

(2008) Carolina Ibáñez-Ventoso et al.   PLoS One

ITSN-1 Controls Vesicle Recycling at the Neuromuscular Junction and Functions in Parallel with DAB-1

(2008) Wei Wang et al.   TRAFFIC

Profiling Synaptic Proteins Identifies Regulators of Insulin Secretion and Lifespan

(2008) QueeLim Ch'ng et al.   PLoS Genetics

A Motor Function for the DEAD-Box RNA Helicase, Gemin3, in Drosophila

(2008) Ruben J. Cauchi et al.   PLoS Genetics