Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action

Intraflagellar transport: mechanisms of motor action, cooperation, and cargo delivery

(2017) Bram Prevo et al.   FEBS Journal

Microtubule Motors Drive Hedgehog Signaling in Primary Cilia

(2017) Mu He et al.   TRENDS IN CELL BIOLOGY

Ensemble and single-molecule dynamics of IFT dynein in Caenorhabditis elegans cilia

(2017) Jona Mijalkovic et al.   Nature Communications

Mechanisms and functions of lysosome positioning

(2016) Jing Pu et al.   JOURNAL OF CELL SCIENCE

KymographClear and KymographDirect: two tools for the automated quantitative analysis of molecular and cellular dynamics using kymographs

(2016) Pierre Mangeol et al.   MOLECULAR BIOLOGY OF THE CELL

Cytoplasmic Dynein Antagonists with Improved Potency and Isoform Selectivity

(2015) Stephanie K. See et al.   ACS Chemical Biology

Dynein motors: How AAA+ ring opening and closing coordinates microtubule binding and linker movement

(2015) Helgo Schmidt   BIOESSAYS

Dynein and intraflagellar transport

(2015) Yuqing Hou et al.   EXPERIMENTAL CELL RESEARCH

Regulation of the oncoprotein Smoothened by small molecules

(2015) Hayley J Sharpe et al.   Nature Chemical Biology

Cytoplasmic dynein regulates its attachment to microtubules via nucleotide state-switched mechanosensing at multiple AAA domains

(2015) Matthew P. Nicholas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ciliobrevins as tools for studying dynein motor function

(2015) Douglas H. Roossien et al.   Frontiers in Cellular Neuroscience

Control of cytoplasmic dynein force production and processivity by its C-terminal domain

(2015) Matthew P. Nicholas et al.   Nature Communications

Superresolution Pattern Recognition Reveals the Architectural Map of the Ciliary Transition Zone

(2015) T. Tony Yang et al.   Scientific Reports

Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy

(2014) Raymond J Deshaies   BMC BIOLOGY

Allosteric Communication in the Dynein Motor Domain

(2014) Gira Bhabha et al.   CELL

The dynein inhibitor Ciliobrevin D inhibits the bidirectional transport of organelles along sensory axons and impairs NGF-mediated regulation of growth cones and axon branches

(2014) Rajiv Sainath et al.   Developmental Neurobiology

Structure of human cytoplasmic dynein-2 primed for its power stroke

(2014) Helgo Schmidt et al.   NATURE

The AAA3 domain of cytoplasmic dynein acts as a switch to facilitate microtubule release

(2014) Mark A DeWitt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Reactions of 2-(2-hetaryl)-2-(tetrahydrofuran-2-ylidene)acetonitriles with tertiary amines

(2013) D. S. Milokhov et al.   Chemistry of Heterocyclic Compounds

The journey of the organelle: teamwork and regulation in intracellular transport

(2013) Kari Barlan et al.   CURRENT OPINION IN CELL BIOLOGY

Centrosome repositioning in T cells is biphasic and driven by microtubule end-on capture-shrinkage

(2013) Jason Yi et al.   JOURNAL OF CELL BIOLOGY

Crystal clear insights into how the dynein motor moves

(2013) A. P. Carter   JOURNAL OF CELL SCIENCE

Diacylglycerol promotes centrosome polarization in T cells via reciprocal localization of dynein and myosin II

(2013) X. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single molecule imaging reveals a major role for diffusion in the exploration of ciliary space by signaling receptors

(2013) Fan Ye et al.   eLife

Cytoplasmic dynein

(2012) Victoria J. Allan   BIOCHEMICAL SOCIETY TRANSACTIONS

Design and evaluation of a series of pyrazolopyrimidines as p70S6K inhibitors

(2012) Joerg Bussenius et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The role of retrograde intraflagellar transport in flagellar assembly, maintenance, and function

(2012) Benjamin D. Engel et al.   JOURNAL OF CELL BIOLOGY

Parallel Reaction Monitoring for High Resolution and High Mass Accuracy Quantitative, Targeted Proteomics

(2012) Amelia C. Peterson et al.   MOLECULAR & CELLULAR PROTEOMICS

Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein

(2012) Ari J. Firestone et al.   NATURE

Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles

(2012) Iana M Serafimova et al.   Nature Chemical Biology

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

ClpXP, an ATP-powered unfolding and protein-degradation machine

(2011) Tania A. Baker et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Ciliogenesis: building the cell's antenna

(2011) Hiroaki Ishikawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Skyline: an open source document editor for creating and analyzing targeted proteomics experiments

(2010) Brendan MacLean et al.   BIOINFORMATICS

A Cell-Based High-Throughput Screen Validates the Plasmodial Surface Anion Channel As an Antimalarial Target

(2010) A. D. Pillai et al.   MOLECULAR PHARMACOLOGY

A cytoplasmic dynein tail mutation impairs motor processivity

(2010) Kassandra M. Ori-McKenney et al.   NATURE CELL BIOLOGY

The primary cilium: a signalling centre during vertebrate development

(2010) Sarah C. Goetz et al.   NATURE REVIEWS GENETICS

Structure validation in chemical crystallography

(2009) Anthony L. Spek   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Identification of substituted pyrazolo[1,5-a]quinazolin-5(4H)-one as potent poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors

(2009) Federica Orvieto et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Opposite-polarity motors activate one another to trigger cargo transport in live cells

(2009) Shabeen Ally et al.   JOURNAL OF CELL BIOLOGY

Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade

(2009) J. M. Hyman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LIS1 and NDEL1 coordinate the plus-end-directed transport of cytoplasmic dynein

(2008) Masami Yamada et al.   EMBO JOURNAL