LRP1 regulates peroxisome biogenesis and cholesterol homeostasis in oligodendrocytes and is required for proper CNS myelin development and repair

The Peroxisome-Mitochondria Connection: How and Why?

(2017) Marc Fransen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Endothelial LRP1 regulates metabolic responses by acting as a co-activator of PPARγ

(2017) Hua Mao et al.   Nature Communications

Oligodendroglial myelination requires astrocyte-derived lipids

(2017) Nutabi Camargo et al.   PLOS BIOLOGY

Peroxisomal biogenesis is genetically and biochemically linked to carbohydrate metabolism in Drosophila and mouse

(2017) Michael F. Wangler et al.   PLoS Genetics

Peroxisomes in brain development and function

(2016) Johannes Berger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Human disorders of peroxisome metabolism and biogenesis

(2016) Hans R. Waterham et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Low-density lipoprotein receptor-related protein 1 is a novel modulator of radial glia stem cell proliferation, survival, and differentiation

(2016) Dina Safina et al.   GLIA

Reduced sterol regulatory element-binding protein (SREBP) processing through site-1 protease (S1P) inhibition alters oligodendrocyte differentiationin vitro

(2016) Hubert Monnerie et al.   JOURNAL OF NEUROCHEMISTRY

PPARgene: A Database of Experimentally Verified and Computationally Predicted PPAR Target Genes

(2016) Li Fang et al.   PPAR Research

PI(3,5)P2 biosynthesis regulates oligodendrocyte differentiation by intrinsic and extrinsic mechanisms

(2016) Yevgeniya A Mironova et al.   eLife

LRP1 expression in microglia is protective during CNS autoimmunity

(2016) Tzu-Ying Chuang et al.   Acta Neuropathologica Communications

Low Density Lipoprotein-Receptor Related Protein 1 Is Differentially Expressed by Neuronal and Glial Populations in the Developing and Mature Mouse Central Nervous System

(2016) Loic Auderset et al.   PLoS One

Cholesterol in myelin biogenesis and hypomyelinating disorders

(2015) Gesine Saher et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Interplay between transcriptional control and chromatin regulation in the oligodendrocyte lineage

(2015) Marylens Hernandez et al.   GLIA

Low-density Lipoprotein Receptor-related Proteins in a Novel Mechanism of Axon Guidance and Peripheral Nerve Regeneration

(2015) Lila M. Landowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Th Cell Diversity in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

(2015) Kevin S. Carbajal et al.   JOURNAL OF IMMUNOLOGY

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Stage-Specific Regulation of Oligodendrocyte Development by Wnt/ -Catenin Signaling

(2014) Z.-M. Dai et al.   JOURNAL OF NEUROSCIENCE

Mutation of 3-Hydroxy-3-Methylglutaryl CoA Synthase I Reveals Requirements for Isoprenoid and Cholesterol Synthesis in Oligodendrocyte Migration Arrest, Axon Wrapping, and Myelin Gene Expression

(2014) E. S. Mathews et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E in Synaptic Plasticity and Alzheimer’s Disease: Potential Cellular and Molecular Mechanisms

(2014) Jaekwang Kim et al.   MOLECULES AND CELLS

DLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injury

(2014) Kimberly A. Fernandes et al.   NEUROBIOLOGY OF DISEASE

Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Regulates the Stability and Function of GluA1 α-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionic Acid (AMPA) Receptor in Neurons

(2014) Ming Gan et al.   PLoS One

mTORC1 Controls PNS Myelination along the mTORC1-RXRγ-SREBP-Lipid Biosynthesis Axis in Schwann Cells

(2014) Camilla Norrmén et al.   Cell Reports

The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer’s disease

(2014) Takahisa Kanekiyo et al.   Frontiers in Aging Neuroscience

Cholesterol biosynthesis and ER stress in peroxisome deficiency

(2013) Phyllis L. Faust et al.   BIOCHIMIE

The nuclear receptor peroxisome proliferator-activated receptor-γ promotes oligodendrocyte differentiation through mechanisms involving mitochondria and oscillatory Ca2+ waves

(2013) Antonietta Bernardo et al.   BIOLOGICAL CHEMISTRY

Axonal selection and myelin sheath generation in the central nervous system

(2013) Mikael Simons et al.   CURRENT OPINION IN CELL BIOLOGY

Intrinsic and extrinsic control of oligodendrocyte development

(2013) J Bradley Zuchero et al.   CURRENT OPINION IN NEUROBIOLOGY

Peroxisome proliferator-activated receptor gamma-coactivator-1 alpha coordinates sphingolipid metabolism, lipid raft composition and myelin protein synthesis

(2013) Alberto Camacho et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Low-density Lipoprotein Receptor-related Protein 1 (LRP1)-dependent Cell Signaling Promotes Axonal Regeneration

(2013) Choya Yoon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A LewisX Glycoprotein Screen Identifies the Low Density Lipoprotein Receptor-related Protein 1 (LRP1) as a Modulator of Oligodendrogenesis in Mice

(2013) Eva Hennen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Low Density Lipoprotein Receptor-related Protein 1 (LRP1) ModulatesN-Methyl-d-aspartate (NMDA) Receptor-dependent Intracellular Signaling and NMDA-induced Regulation of Postsynaptic Protein Complexes

(2013) Chikako Nakajima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Schwann Cell LRP1 Regulates Remak Bundle Ultrastructure and Axonal Interactions to Prevent Neuropathic Pain

(2013) S. Orita et al.   JOURNAL OF NEUROSCIENCE

Identification of the Low Density Lipoprotein (LDL) Receptor-related Protein-1 Interactome in Central Nervous System Myelin Suggests a Role in the Clearance of Necrotic Cell Debris

(2012) Anthony Fernandez-Castaneda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LDL receptor-related protein-1 is a sialic-acid-independent receptor for myelin-associated glycoprotein that functions in neurite outgrowth inhibition by MAG and CNS myelin

(2012) Travis L. Stiles et al.   JOURNAL OF CELL SCIENCE

Myelin Regeneration: A Recapitulation of Development?

(2011) Stephen P.J. Fancy et al.   Annual Review of Neuroscience

Peroxisome Proliferator-Activated Receptor γ Agonists Accelerate Oligodendrocyte Maturation and Influence Mitochondrial Functions and Oscillatory Ca2+Waves

(2011) Chiara De Nuccio et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Congenital CNS Hypomyelination in the Fig4 Null Mouse Is Rescued by Neuronal Expression of the PI(3,5)P2 Phosphatase Fig4

(2011) J. J. Winters et al.   JOURNAL OF NEUROSCIENCE

Peroxisome-Proliferator-Activated Receptor Gamma Coactivator 1   Contributes to Dysmyelination in Experimental Models of Huntington's Disease

(2011) Z. Xiang et al.   JOURNAL OF NEUROSCIENCE

Signaling through LRP1: Protection from atherosclerosis and beyond

(2010) Philippe Boucher et al.   BIOCHEMICAL PHARMACOLOGY

Activation of PPAR-γ and PTEN cascade participates in lovastatin-mediated accelerated differentiation of oligodendrocyte progenitor cells

(2010) Ajaib S. Paintlia et al.   GLIA

Low Density Lipoprotein Receptor-related Protein (LRP1) Regulates Rac1 and RhoA Reciprocally to Control Schwann Cell Adhesion and Migration

(2010) Elisabetta Mantuano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Low Density Lipoprotein Receptor-related Protein 1 (LRP1) Forms a Signaling Complex with Platelet-derived Growth Factor Receptor-β in Endosomes and Regulates Activation of the MAPK Pathway

(2010) Selen Catania Muratoglu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer’s amyloid β-peptide elimination from the brain

(2010) Berislav V. Zlokovic et al.   JOURNAL OF NEUROCHEMISTRY

Neuronal LRP1 Knockout in Adult Mice Leads to Impaired Brain Lipid Metabolism and Progressive, Age-Dependent Synapse Loss and Neurodegeneration

(2010) Q. Liu et al.   JOURNAL OF NEUROSCIENCE

Simvastatin interferes with process outgrowth and branching of oligodendrocytes

(2010) Inge Smolders et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Developmental genetics of vertebrate glial–cell specification

(2010) David H. Rowitch et al.   NATURE

NG2+ CNS Glial Progenitors Remain Committed to the Oligodendrocyte Lineage in Postnatal Life and following Neurodegeneration

(2010) Shin H. Kang et al.   NEURON

Myelin Gene Regulatory Factor Is a Critical Transcriptional Regulator Required for CNS Myelination

(2009) Ben Emery et al.   CELL

Low Density Lipoprotein Receptor-related Protein 1 Promotes Anti-apoptotic Signaling in Neurons by Activating Akt Survival Pathway

(2009) Rodrigo A. Fuentealba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peroxisome Proliferator-Activated Receptor-γ Agonists Promote Differentiation and Antioxidant Defenses of Oligodendrocyte Progenitor Cells

(2009) Antonietta Bernardo et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Peroxisomes, Myelination, and Axonal Integrity in the CNS

(2009) Myriam Baes et al.   NEUROSCIENTIST

SCAP is required for timely and proper myelin membrane synthesis

(2009) Mark H. G. Verheijen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acquisition of Granule Neuron Precursor Identity Is a Critical Determinant of Progenitor Cell Competence to Form Shh-Induced Medulloblastoma

(2008) Ulrich Schüller et al.   CANCER CELL

Lovastatin induces the formation of abnormal myelin-like membrane sheets in primary oligodendrocytes

(2008) Olaf Maier et al.   GLIA

The Functional Role of the Second NPXY Motif of the LRP1 β-Chain in Tissue-type Plasminogen Activator-mediated Activation ofN-Methyl-D-aspartate Receptors

(2008) Anne M. Martin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Remyelination in the CNS: from biology to therapy

(2008) Robin J. M. Franklin et al.   NATURE REVIEWS NEUROSCIENCE

LDL Receptor-Related Protein 1: Unique Tissue-Specific Functions Revealed by Selective Gene Knockout Studies

(2008) Anna P. Lillis et al.   PHYSIOLOGICAL REVIEWS