Review
Cell Biology
Laura Montani
Summary: This article discusses the important role of lipids in the formation and maintenance of myelin, as well as their association with neurodegenerative diseases. Lipids act not only as structural building blocks, but also as signaling molecules driving cell proliferation and differentiation.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Vanessa Naffaa, Romain Magny, Anne Regazzetti, Juliette Van Steenwinckel, Pierre Gressens, Olivier Laprevote, Nicolas Auzeil, Anne-Laure Schang
Summary: In this study, a comprehensive lipidomic analysis was performed on myelin-enriched fractions prepared from mouse brains at two developmental stages. The results showed profound remodeling in phospholipid subclasses during myelination, including a decrease in phosphatidylcholine content and an increase in phosphatidylethanolamine, phosphatidylserine, and phosphatidylinositol contents, accompanied by an increased proportion of monounsaturated fatty acids.
Article
Immunology
Allison Y. Louie, Justin S. Kim, Jenny Drnevich, Payam Dibaeinia, Hisami Koito, Saurabh Sinha, Daniel B. McKim, Katiria Soto-Diaz, Romana A. Nowak, Aditi Das, Andrew J. Steelman
Summary: Recent data suggest that myelin may be altered by physiological events occurring outside of the central nervous system, which may cause changes to cognition and behavior. Similarly, peripheral infection by non-neurotropic viruses is also known to evoke changes to cognition and behavior.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Neurosciences
Karlie N. Fedder-Semmes, Bruce Appel
Summary: Oligodendrocytes produce myelin to insulate and support axons in the vertebrate central nervous system. Akt-mTOR signaling pathway plays a crucial role in promoting myelin sheath growth and stability through regulating translation, highlighting the importance of local translation in controlling myelin sheath growth.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Kingston King-Shi Mok, Sunny Hoi-Sang Yeung, Gerald Wai-Yeung Cheng, Iris Wai-Ting Ma, Ralph Hon-Sun Lee, Karl Herrup, Kai-Hei Tse
Summary: Carriers of the APOE4 variant are more susceptible to Alzheimer's disease due to altered lipid and cholesterol transport capabilities. This study examines the impact of APOE4 on oligodendrocytes and finds a disruption in myelination, possibly contributing to the development of Alzheimer's disease.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Sunil Krishna, Bokun Cheng, Deep R. Sharma, Sunita Yadav, Erin S. Stempinski, Sahil Mamtani, Elisa Shah, Anjali Deo, Trishna Acherjee, Teena Thomas, Xusheng Zhang, Jinghang Zhang, Dumitru A. Iacobas, Praveen Ballabh
Summary: Activation of PPAR-γ enhances myelination and neurological function in preterm rabbits with IVH, but does not reduce hydrocephalus. Treatment with PPAR-γ agonist may enhance myelination and neurological recovery in premature infants with IVH.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Melanie Piller, Inge L. Werkman, Evan A. Brown, Andrew J. Latimer, Sarah Kucenas
Summary: The study found that the ionotropic glutamate receptor subunit GluR4A plays a crucial role in OPC migration and myelination, disruption of which leads to abnormal migration and distribution of OPCs in the spinal cord. Through genetic and pharmacological experiments, it was discovered that voltage-gated calcium channels are downstream of glutamate receptor signaling in OPCs and can rescue migration and myelination defects caused by disrupted glutamate signaling.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Tanya L. Brown, Hirokazu Hashimoto, Lisbet T. Finseth, Teresa L. Wood, Wendy B. Macklin
Summary: The actin regulator PAK1 promotes oligodendrocyte morphologic changes and myelin production, influencing communication within the CNS.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Cell Biology
Ana Palma, Juan Carlos Chara, Alejandro Montilla, Amaia Otxoa-de-Amezaga, Francisca Ruiz-Jaen, Anna M. Planas, Carlos Matute, Alberto Perez-Samartin, Maria Domercq
Summary: Abnormalities in myelination are associated with behavioral and cognitive dysfunction in neurodevelopmental psychiatric disorders. Clemastine, a drug that promotes myelination, has complex effects on myelin development during the developmental process. The study found that clemastine treatment increased oligodendrocyte differentiation but decreased conduction velocity and myelin thickness in the corpus callosum. Additionally, the population of microglia cells and insulin growth factor-1 levels decreased in clemastine-treated mice.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Tomohiro Torii, Tomohiro Miyasaka, Hiroaki Misonou
Summary: This review article discusses the presence of tau in oligodendrocytes and its potential impact on oligodendrocyte function. The study shows that the expression levels of tau significantly change in hypomyelination models and in demyelination regions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Neurosciences
Lauren Rose Hirschfeld, Shannon L. Risacher, Kwangsik Nho, Andrew J. Saykin
Summary: This literature review investigates the significant overlap between myelin-repair signaling pathways and pathways known to contribute to hallmark pathologies of Alzheimer's disease, and discusses therapeutic targets and potential research directions.
TRANSLATIONAL NEURODEGENERATION
(2022)
Article
Neurosciences
Carlie L. Cullen, Megan O'Rourke, Shannon J. Beasley, Loic Auderset, Yilan Zhen, Renee E. Pepper, Robert Gasperini, Kaylene M. Young
Summary: Primary cilia play a crucial role in the myelination process of oligodendrocyte progenitor cells, with their assembly regulated by the gene Kif3a. Deletion of Kif3a leads to decreased OPC proliferation and oligodendrogenesis, affecting fine motor coordination in specific brain regions.
Article
Anatomy & Morphology
M. P. Madrigal, B. Ballester-Lurbe, O. Gomez, J. A. Moreno-Bravo, E. Puelles, S. Jurado, J. M. Garcia-Verdugo, I. Perez-Roger, Jose Terrado
Summary: Rnd3 is a protein involved in oligodendrocyte maturation, with potential roles in the development of the central nervous system and demyelinating diseases. Its absence leads to hypomyelination, reduced oligodendrocyte numbers, and thinner myelin sheaths in mice, indicating its crucial role in myelination.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Biology
Sinisa Pajevic, Dietmar Plenz, Peter J. Basser, R. Douglas Fields, Inna Slutsky
Summary: This article discusses the role of myelin plasticity in neural signal synchronization and proposes a mathematical model that explains how oligodendrocytes use feedback mechanisms to achieve synchronization. The results show that the model can efficiently synchronize correlated signals within a specific time range and at low firing rates.
Review
Immunology
Meihui Xu, Chi Ma, Ming Dong, Chunjie Guo, Simin Yang, Yue Liu, Xu Wang
Summary: This study aims to characterize the clinical symptoms, MRI findings, and prognosis of adult cerebral cortical encephalitis (CCE) with anti-MOG antibody. Two adult cases of CCE with anti-MOG antibody were presented and a systematic review of the literature was conducted. The majority of patients had a favorable prognosis after treatment, highlighting the importance of early detection and immunotherapy in improving outcomes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Brigid K. Jensen, Hubert Monnerie, Maggie V. Mannell, Patrick J. Gannon, Cagla Akay Espinoza, Michelle A. Erickson, Annadora J. Bruce-Keller, Benjamin B. Gelman, Lisa A. Briand, R. Christopher Pierce, Kelly L. Jordan-Sciutto, Judith B. Grinspan
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2015)
Article
Cell Biology
Thomas Westergard, Brigid K. Jensen, Xinmei Wen, Jingli Cai, Elizabeth Kropf, Lorraine Iacovitti, Piera Pasinelli, Davide Trotti
Article
Neurosciences
Cagla Akay, Michael Cooper, Akinleye Odeleye, Brigid K. Jensen, Michael G. White, Fair Vassoler, Patrick J. Gannon, Joseph Mankowski, Jamie L. Dorsey, Alison M. Buch, Stephanie A. Cross, Denise R. Cook, Michelle-Marie Pena, Emily S. Andersen, Melpo Christofidou-Solomidou, Kathryn A. Lindl, M. Christine Zink, Janice Clements, R. Christopher Pierce, Dennis L. Kolson, Kelly L. Jordan-Sciutto
JOURNAL OF NEUROVIROLOGY
(2014)
Article
Neurosciences
Lindsay Festa, Lindsay M. Roth, Brigid K. Jensen, Jonathan D. Geiger, Kelly L. Jordan-Sciutto, Judith B. Grinspan
Summary: Treatment of primary rat oligodendrocyte precursor cells with therapeutically relevant concentrations of either antiretroviral compound of the protease inhibitor class, darunavir or saquinavir, results in a concentration-dependent inhibition of oligodendrocyte maturation in vitro. Acidifying endolysosomal pH provides protection against darunavir- or saquinavir-induced inhibition of oligodendrocyte maturation, suggesting a critical role of proper endolysosomal pH in regulating OL differentiation and potential therapeutic targeting against antiretroviral-induced oligodendrocyte dysregulation.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2021)
Review
Neurosciences
Brigid K. Jensen, Lindsay M. Roth, Judith B. Grinspan, Kelly L. Jordan-Sciutto
Article
Medicine, Research & Experimental
Brigid K. Jensen, Martin H. Schuldi, Kevin McAvoy, Katelyn A. Russell, Ashley Boehringer, Bridget M. Curran, Karthik Krishnamurthy, Xinmei Wen, Thomas Westergard, Le Ma, Aaron R. Haeusler, Dieter Edbauer, Piera Pasinelli, Davide Trotti
EMBO MOLECULAR MEDICINE
(2020)
Article
Multidisciplinary Sciences
Karthik Krishnamurthy, Davide Trotti, Piera Pasinelli, Brigid Jensen
Summary: This study introduces a fluorescence-based live-imaging method to observe synaptic vesicle release and calcium influx dynamics in neurons, for studying the neuronal communication dysfunction underlying motor and cognitive deficits in ALS and FTLD patients. The use of styryl dye and Gcamp6m allows for clear elucidation of synaptic vesicle exocytosis and calcium entry processes.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Neurosciences
Brigid K. Jensen, Kevin J. McAvoy, Nicolette M. Heinsinger, Angelo C. Lepore, Hristelina Ilieva, Aaron R. Haeusler, Davide Trotti, Piera Pasinelli
Summary: Mutations in ubiquitously expressed genes are common in ALS, a motor neuron disease, and dysfunction of non-neuronal cells also contributes to the disease. This study demonstrates that a specific mutation in astrocytes induces neurotoxicity and death of spinal motor neurons through upregulation of TNF alpha. Targeting TNF alpha shows therapeutic success in preventing neurodegeneration and motor dysfunction.
Article
Multidisciplinary Sciences
Brandie Morris Verdone, Maria Elena Cicardi, Xinmei Wen, Sindhu Sriramoji, Katelyn Russell, Shashirekha S. Markandaiah, Brigid K. Jensen, Karthik Krishnamurthy, Aaron R. Haeusler, Piera Pasinelli, Davide Trotti
Summary: This study found that the short repeat sequence poly-GR is sufficient to cause toxicity in the nervous system, which has important implications for the understanding of the pathogenesis of amyotrophic lateral sclerosis and frontotemporal dementia.
SCIENTIFIC REPORTS
(2022)
Review
Neurosciences
Layla T. Ghaffari, Davide Trotti, Aaron R. Haeusler, Brigid K. Jensen
Summary: ALS is a progressive neurodegenerative disease with heterogeneous clinical manifestations and lack of effective treatment. Cortical hyper-excitability is observed early in the disease and is associated with nucleotide repeat expansion in the C9ORF72 gene. ALS and FTD are part of a disease spectrum, both characterized by synaptic dysfunction.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Pathology
Patrick J. Gannon, Cagla Akay-Espinoza, Alan C. Yee, Lisa A. Briand, Michelle A. Erickson, Benjamin B. Gelman, Yan Gao, Norman J. Haughey, M. Christine Zink, Janice E. Clements, Nicholas S. Kim, Gabriel Van De Wallet, Brigid K. Jensen, Robert Vassar, R. Christopher Pierce, Alexander J. Gill, Dennis L. Kolson, J. Alan Diehl, Joseph L. Mankowski, Kelly L. Jordan-Sciutto
AMERICAN JOURNAL OF PATHOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)