The Multifunctional Role of the Chemokine System in Arthritogenic Processes

CXCR3/CXCL10 Axis Regulates Neutrophil–NK Cell Cross-Talk Determining the Severity of Experimental Osteoarthritis

(2017) Giorgia Benigni et al.   JOURNAL OF IMMUNOLOGY

CCL2 and CCR2 regulate pain-related behaviour and early gene expression in post-traumatic murine osteoarthritis but contribute little to chondropathy

(2017) J. Miotla Zarebska et al.   OSTEOARTHRITIS AND CARTILAGE

Upregulated expression of CCR3 in osteoarthritis and CCR3 mediated activation of fibroblast-like synoviocytes

(2016) Xin Chang et al.   CYTOKINE

Inflammatory Cells in Patients with Endstage Knee Osteoarthritis: A Comparison between the Synovium and the Infrapatellar Fat Pad

(2016) I. R. Klein-Wieringa et al.   JOURNAL OF RHEUMATOLOGY

Fractalkine/CX3CL1 in rheumatoid arthritis

(2016) Toshihiro Nanki et al.   Modern Rheumatology

Crosstalk between astrocytic CXCL12 and microglial CXCR4 contributes to the development of neuropathic pain

(2016) Xin Luo et al.   Molecular Pain

Osteoarthritis year in review 2015: soluble biomarkers and the BIPED criteria

(2016) A.C. Bay-Jensen et al.   OSTEOARTHRITIS AND CARTILAGE

Human neutrophils in auto-immunity

(2016) Nathalie Thieblemont et al.   SEMINARS IN IMMUNOLOGY

Brief Report: CXCL10 Is a Possible Biomarker for the Development of Psoriatic Arthritis Among Patients With Psoriasis

(2016) Fatima Abji et al.   Arthritis & Rheumatology

Dysregulation of Chemokine/Chemokine Receptor Axes and NK Cell Tissue Localization during Diseases

(2016) Giovanni Bernardini et al.   Frontiers in Immunology

K/BxN Serum-Transfer Arthritis as a Model for Human Inflammatory Arthritis

(2016) Anne D. Christensen et al.   Frontiers in Immunology

The pathogenic role of angiogenesis in rheumatoid arthritis

(2015) Hatem A. Elshabrawy et al.   ANGIOGENESIS

Autoantibodies to citrullinated proteins induce joint pain independent of inflammation via a chemokine-dependent mechanism

(2015) Gustaf Wigerblad et al.   ANNALS OF THE RHEUMATIC DISEASES

Expression of chemokines CXCL4 and CXCL7 by synovial macrophages defines an early stage of rheumatoid arthritis

(2015) L Yeo et al.   ANNALS OF THE RHEUMATIC DISEASES

Leukocyte Chemoattractant Receptors in Human Disease Pathogenesis

(2015) Brian A. Zabel et al.   Annual Review of Pathology-Mechanisms of Disease

Pain in systemic inflammatory rheumatic diseases

(2015) Fabiola Atzeni et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Induction of CXCL2 and CCL2 by pressure force requires IL-1β-MyD88 axis in osteoblasts

(2015) Aya Maeda et al.   BONE

The role and modulation of CCR6+ Th17 cell populations in rheumatoid arthritis

(2015) Sandra M.J. Paulissen et al.   CYTOKINE

CXCL16 upregulates RANKL expression in rheumatoid arthritis synovial fibroblasts through the JAK2/STAT3 and p38/MAPK signaling pathway

(2015) Chang-hong Li et al.   INFLAMMATION RESEARCH

Attenuation of cartilage pathogenesis in post-traumatic osteoarthritis (PTOA) in mice by blocking the stromal derived factor 1 receptor (CXCR4) with the specific inhibitor, AMD3100

(2015) Nathan P. Thomas et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Opioid and chemokine receptor crosstalk: a promising target for pain therapy?

(2015) Stéphane Mélik Parsadaniantz et al.   NATURE REVIEWS NEUROSCIENCE

Successes and failures of chemokine-pathway targeting in rheumatoid arthritis

(2015) Zoltán Szekanecz et al.   Nature Reviews Rheumatology

The chemokine receptor CCR5 plays a role in post-traumatic cartilage loss in mice, but does not affect synovium and bone

(2015) K. Takebe et al.   OSTEOARTHRITIS AND CARTILAGE

Inflammatory biomarkers in osteoarthritis

(2015) H.N. Daghestani et al.   OSTEOARTHRITIS AND CARTILAGE

Potential involvement of IL-9 and Th9 cells in the pathogenesis of rheumatoid arthritis

(2015) F. Ciccia et al.   RHEUMATOLOGY

HIF-2α-induced chemokines stimulate motility of fibroblast-like synoviocytes and chondrocytes into the cartilage-pannus interface in experimental rheumatoid arthritis mouse models

(2015) Yun Hyun Huh et al.   ARTHRITIS RESEARCH & THERAPY

Serum and synovial fluid chemokine ligand 2/monocyte chemoattractant protein 1 concentrations correlates with symptomatic severity in patients with knee osteoarthritis

(2015) Liang Li et al.   ANNALS OF CLINICAL BIOCHEMISTRY

A homeostatic function of CXCR2 signalling in articular cartilage

(2014) Joanna Sherwood et al.   ANNALS OF THE RHEUMATIC DISEASES

Discovery of the CCR1 Antagonist, BMS-817399, for the Treatment of Rheumatoid Arthritis

(2014) Joseph B. Santella et al.   JOURNAL OF MEDICINAL CHEMISTRY

CXCL13 predicts disease activity in early rheumatoid arthritis and could be an indicator of the therapeutic `window of opportunity'

(2014) Stinne Ravn Greisen et al.   ARTHRITIS RESEARCH & THERAPY

Neuronal CC chemokines: the distinct roles of CCL21 and CCL2 in neuropathic pain

(2014) Knut Biber et al.   Frontiers in Cellular Neuroscience

Citrullination of Epithelial Neutrophil-Activating Peptide 78/CXCL5 Results in Conversion From a Non-Monocyte-Recruiting Chemokine to a Monocyte-Recruiting Chemokine

(2014) Ken Yoshida et al.   Arthritis & Rheumatology

Antibodies from patients with rheumatoid arthritis target citrullinated histone 4 contained in neutrophils extracellular traps

(2013) Federico Pratesi et al.   ANNALS OF THE RHEUMATIC DISEASES

Proteomic Analysis of Synovial Fluid From the Osteoarthritic Knee: Comparison With Transcriptome Analyses of Joint Tissues

(2013) Susan Y. Ritter et al.   ARTHRITIS AND RHEUMATISM

The role of natural killer cells, gamma delta T-cells and other innate immune cells in spondyloarthritis

(2013) Mohammad H. Al-Mossawi et al.   CURRENT OPINION IN RHEUMATOLOGY

Chemokine and cytokine levels in osteoarthritis and rheumatoid arthritis synovial fluid

(2013) Ulrike Hampel et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Reciprocal Activation of CD4+ T Cells and Synovial Fibroblasts by Stromal Cell-Derived Factor 1 Promotes RANKL Expression and Osteoclastogenesis in Rheumatoid Arthritis

(2013) Hae-Rim Kim et al.   Arthritis & Rheumatology

Differential chemotactic receptor requirements for NK cell subset trafficking into bone marrow

(2013) Giovanni Bernardini et al.   Frontiers in Immunology

Chemokine receptor CCR1 antagonist CCX354-C treatment for rheumatoid arthritis: CARAT-2, a randomised, placebo controlled clinical trial

(2012) Paul P Tak et al.   ANNALS OF THE RHEUMATIC DISEASES

The Chemokine Superfamily Revisited

(2012) Albert Zlotnik et al.   IMMUNITY

CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis

(2012) R. E. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serum levels of CXCL13 are associated with ultrasonographic synovitis and predict power Doppler persistence in early rheumatoid arthritis treated with non-biological disease-modifying anti-rheumatic drugs

(2012) Serena Bugatti et al.   ARTHRITIS RESEARCH & THERAPY

Maraviroc, a chemokine receptor-5 antagonist, fails to demonstrate efficacy in the treatment of patients with rheumatoid arthritis in a randomized, double-blind placebo-controlled trial

(2012) Dona L Fleishaker et al.   ARTHRITIS RESEARCH & THERAPY

Proinflammatory Th17 cells are expanded and induced by dendritic cells in spondylarthritis-prone HLA-B27-transgenic rats

(2011) Simon Glatigny et al.   ARTHRITIS AND RHEUMATISM

Interleukin-17-positive mast cells contribute to synovial inflammation in spondylarthritis

(2011) Troy Noordenbos et al.   ARTHRITIS AND RHEUMATISM

A phase II, randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of MDX-1100, a fully human anti-CXCL10 monoclonal antibody, in combination with methotrexate in patients with rheumatoid arthritis

(2011) Michael Yellin et al.   ARTHRITIS AND RHEUMATISM

Chronic widespread pain in the spectrum of rheumatological diseases

(2011) Fabiola Atzeni et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Central pain mechanisms in chronic pain states – Maybe it is all in their head

(2011) Kristine Phillips et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Pharmacokinetic and Pharmacodynamic Evaluation of the Novel CCR1 Antagonist CCX354 in Healthy Human Subjects: Implications for Selection of Clinical Dose

(2011) D J Dairaghi et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Inflammation in osteoarthritis

(2011) Mary B. Goldring et al.   CURRENT OPINION IN RHEUMATOLOGY

Fractalkine/CX3CR1 Signalling in Chronic Pain and Inflammation

(2011) Anna K. Clark et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

T helper cells promote disease progression of osteoarthritis by inducing macrophage inflammatory protein-1γ

(2011) P.-C. Shen et al.   OSTEOARTHRITIS AND CARTILAGE

Discovery of INCB8761/PF-4136309, a Potent, Selective, and Orally Bioavailable CCR2 Antagonist

(2011) Chu-Biao Xue et al.   ACS Medicinal Chemistry Letters

Preclinical and clinical investigation of a CCR5 antagonist, AZD5672, in patients with rheumatoid arthritis receiving methotrexate

(2010) Daniëlle M. Gerlag et al.   ARTHRITIS AND RHEUMATISM

Synovial tissue-infiltrating natural killer cells in osteoarthritis and periprosthetic inflammation

(2010) Ryan S. Huss et al.   ARTHRITIS AND RHEUMATISM

Evaluation of degranulation and cytokine production in natural killer cells from spondyloarthritis patients at single-cell level

(2010) Rossana Scrivo et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Lipid-Cytokine-Chemokine Cascade Drives Neutrophil Recruitment in a Murine Model of Inflammatory Arthritis

(2010) Richard C. Chou et al.   IMMUNITY

Reduced inflammatory and neuropathic pain and decreased spinal microglial response in fractalkine receptor (CX3CR1) knockout mice

(2010) Amelia A. Staniland et al.   JOURNAL OF NEUROCHEMISTRY

The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis

(2010) Jérémie Sellam et al.   Nature Reviews Rheumatology

Macrophage inflammatory protein-1α mediates the development of neuropathic pain following peripheral nerve injury through interleukin-1β up-regulation

(2010) Norikazu Kiguchi et al.   PAIN

Neutrophil function in inflammation and inflammatory diseases

(2010) H. L. Wright et al.   RHEUMATOLOGY

Systemic levels of IL-23 are strongly associated with disease activity in rheumatoid arthritis but not spondyloarthritis

(2009) L. Melis et al.   ANNALS OF THE RHEUMATIC DISEASES

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

Interleukin-17 and Type 17 Helper T Cells

(2009) Pierre Miossec et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rheumatoid Arthritis Synovium Contains Two Subsets of CD83−DC-LAMP− Dendritic Cells with Distinct Cytokine Profiles

(2008) M. Cristina Lebre et al.   AMERICAN JOURNAL OF PATHOLOGY

Rho kinase-dependent CCL20 induced by dynamic compression of human chondrocytes

(2008) Dominik R. Haudenschild et al.   ARTHRITIS AND RHEUMATISM

Modulation of CCR2 in rheumatoid arthritis: A double‐blind, randomized, placebo‐controlled clinical trial

(2008) Clarissa E. Vergunst et al.   ARTHRITIS AND RHEUMATISM

Reciprocal cross-talk between RANKL and interferon-γ–inducible protein 10 is responsible for bone-erosive experimental arthritis

(2008) Han Bok Kwak et al.   ARTHRITIS AND RHEUMATISM

Increased numbers of circulating polyfunctional Th17 memory cells in patients with seronegative spondylarthritides

(2008) Camilla Jandus et al.   ARTHRITIS AND RHEUMATISM

How chemokines invite leukocytes to dance

(2008) Marcus Thelen et al.   NATURE IMMUNOLOGY

Exuberant expression of chemokine genes by adult human articular chondrocytes in response to IL-1β

(2008) L.J. Sandell et al.   OSTEOARTHRITIS AND CARTILAGE