Interaction between prenatal pesticide exposure and a common polymorphism in the PON1 gene on DNA methylation in genes associated with cardio-metabolic disease risk—an exploratory study

Methylation profiling identified novel differentially methylated markers includingOPCMLandFLRT2in prostate cancer

(2016) Yu Wu et al.   Epigenetics

Epigenome-wide profiling of DNA methylation in paired samples of adipose tissue and blood

(2016) Yen-Tsung Huang et al.   Epigenetics

FABP4-mediated homocysteine-induced cholesterol accumulation in THP-1 monocyte-derived macrophages and the potential epigenetic mechanism

(2016) YIDENG JIANG et al.   Molecular Medicine Reports

Integrative mutation, haplotype and G × G interaction evidence connects ABGL4, LRP8 and PCSK9 genes to cardiometabolic risk

(2016) Tao Guo et al.   Scientific Reports

Q192R Polymorphism of Paraoxonase 1 Gene Associated with Insulin Resistance in Mexican Children

(2015) Jorge Alejandro Alegría-Torres et al.   ARCHIVES OF MEDICAL RESEARCH

Leptin and adiponectin DNA methylation levels in adipose tissues and blood cells are associated with BMI, waist girth and LDL-cholesterol levels in severely obese men and women

(2015) Andrée-Anne Houde et al.   BMC Medical Genetics

Neuregulin 1 affects leptin levels, food intake and weight gain in normal-weight, but not obese, db/db mice

(2015) G. Ennequin et al.   DIABETES & METABOLISM

Investigation of GRIN2A in common epilepsy phenotypes

(2015) Dennis Lal et al.   EPILEPSY RESEARCH

High-methionine diets accelerate atherosclerosis by HHcy-mediated FABP4 gene demethylation pathway via DNMT1 in ApoE−/−mice

(2015) An-Ning Yang et al.   FEBS LETTERS

Correlation of functional GRIN2A gene promoter polymorphisms with schizophrenia and serum d-serine levels

(2015) Rui Liu et al.   GENE

Metabolic functions of FABPs—mechanisms and therapeutic implications

(2015) Gökhan S. Hotamisligil et al.   Nature Reviews Endocrinology

Occupational pesticide exposure in early pregnancy associated with sex-specific neurobehavioral deficits in the children at school age

(2015) Helle R. Andersen et al.   NEUROTOXICOLOGY AND TERATOLOGY

Interaction between paraoxonase 1 polymorphism and prenatal pesticide exposure on metabolic markers in children using a multiplex approach

(2015) Anne Jørgensen et al.   REPRODUCTIVE TOXICOLOGY

DisGeNET: a discovery platform for the dynamical exploration of human diseases and their genes

(2015) J. Pinero et al.   Database-The Journal of Biological Databases and Curation

mediation:RPackage for Causal Mediation Analysis

(2015) Dustin Tingley et al.   Journal of Statistical Software

Epigenetics as the mediator of fetal programming of adult onset disease: what is the evidence?

(2014) Richard Saffery et al.   ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA

Enhanced expression of hypothalamic nitric oxide synthase in rats developmentally exposed to organophosphates

(2014) Maryam Naseh et al.   BRAIN RESEARCH

A Novel Molecular Diagnostic Marker for Familial and Early-Onset Coronary Artery Disease and Myocardial Infarction in the LRP8 Gene

(2014) G.-Q. Shen et al.   Circulation-Cardiovascular Genetics

Regulation of obesity and insulin resistance by nitric oxide

(2014) Brian E. Sansbury et al.   FREE RADICAL BIOLOGY AND MEDICINE

Neuroendocrine targets of endocrine disruptors

(2014) Andrea Gore   Hormones-International Journal of Endocrinology and Metabolism

DNA methylation of leptin and adiponectin promoters in children is reduced by the combined presence of obesity and insulin resistance

(2014) M C García-Cardona et al.   INTERNATIONAL JOURNAL OF OBESITY

Control of Food Intake and Energy Expenditure by Nos1 Neurons of the Paraventricular Hypothalamus

(2014) A. K. Sutton et al.   JOURNAL OF NEUROSCIENCE

Neurobehavioural effects of developmental toxicity

(2014) Philippe Grandjean et al.   LANCET NEUROLOGY

Comprehensive analysis of DNA methylation data with RnBeads

(2014) Yassen Assenov et al.   NATURE METHODS

Hormonal and neural mechanisms of food reward, eating behaviour and obesity

(2014) Susan Murray et al.   Nature Reviews Endocrinology

Human paraoxonase 1 hydrolysis of nanomolar chlorpyrifos-oxon concentrations is unaffected by phenotype or Q192R genotype

(2014) R. Hunter Coombes et al.   TOXICOLOGY LETTERS

Genetic Control of Obesity and Gut Microbiota Composition in Response to High-Fat, High-Sucrose Diet in Mice

(2013) Brian W. Parks et al.   Cell Metabolism

What is the evidence in humans that DNA methylation changes link events in utero and later life disease?

(2013) Rebecca M. Reynolds et al.   CLINICAL ENDOCRINOLOGY

Mechanism and clinical evidence of lipocalin-2 and adipocyte fatty acid-binding protein linking obesity and atherosclerosis

(2013) Guangyu Wu et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Multi-allelic haplotype association identifies novel information different from single-SNP analysis: A new protective haplotype in the LRP8 gene is against familial and early-onset CAD and MI

(2013) Gong-Qing Shen et al.   GENE

Environmental Epigenetics and Its Implication on Disease Risk and Health Outcomes

(2013) S.-M. Ho et al.   ILAR JOURNAL

Tissue-specific Leptin promoter DNA methylation is associated with maternal and infant perinatal factors

(2013) Corina Lesseur et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Minireview: Toward the Establishment of a Link between Melatonin and Glucose Homeostasis: Association of Melatonin MT2Receptor Variants with Type 2 Diabetes

(2013) Angeliki Karamitri et al.   MOLECULAR ENDOCRINOLOGY

GRIN2A mutations cause epilepsy-aphasia spectrum disorders

(2013) Gemma L Carvill et al.   NATURE GENETICS

Alterations in nitric oxide synthase-expressing neurons in the forebrain regions of rats after developmental exposure to organophosphates

(2013) Maryam Naseh et al.   NEUROTOXICOLOGY AND TERATOLOGY

Duration of breastfeeding and gender are associated with methylation of the LEPTIN gene in very young children

(2013) Sylvia A. Obermann-Borst et al.   PEDIATRIC RESEARCH

Associations of PON1 and Genetic Ancestry with Obesity in Early Childhood

(2013) Karen Huen et al.   PLoS One

Genetic Variant R952Q in LRP8 is Associated with Increased Plasma Triglyceride Levels in Patients with Early-Onset CAD and MI

(2012) Gong-Qing Shen et al.   ANNALS OF HUMAN GENETICS

The sva package for removing batch effects and other unwanted variation in high-throughput experiments

(2012) Jeffrey T. Leek et al.   BIOINFORMATICS

A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data

(2012) Andrew E. Teschendorff et al.   BIOINFORMATICS

DNA methylation arrays as surrogate measures of cell mixture distribution

(2012) Eugene Houseman et al.   BMC BIOINFORMATICS

Admixture Mapping of Coronary Artery Calcified Plaque in African Americans With Type 2 Diabetes Mellitus

(2012) Jasmin Divers et al.   Circulation-Cardiovascular Genetics

Tired of Diabetes Genetics? Circadian Rhythms and Diabetes: The MTNR1B Story?

(2012) Cecilia Nagorny et al.   Current Diabetes Reports

Early breast development in girls after prenatal exposure to non-persistent pesticides

(2012) C. Wohlfahrt-Veje et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

Smaller genitals at school age in boys whose mothers were exposed to non-persistent pesticides in early pregnancy

(2012) C. Wohlfahrt-Veje et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

Corticotropin releasing factor (CRF) and obesity

(2012) Rajeev Sharma et al.   MATURITAS

Leptin action through hypothalamic nitric oxide synthase-1–expressing neurons controls energy balance

(2012) Rebecca L Leshan et al.   NATURE MEDICINE

Transcriptomic and Epigenetic Changes in the Hypothalamus Are Involved in an Increased Susceptibility to a High-Fat-Sucrose Diet in Prenatally Stressed Female Rats

(2012) L. Paternain et al.   NEUROENDOCRINOLOGY

Family based association of GRIN2A and GRIN2B with Korean autism spectrum disorders

(2012) Hee Jeong Yoo et al.   NEUROSCIENCE LETTERS

Neurobehavioral and neurodevelopmental effects of pesticide exposures

(2012) Leslie London et al.   NEUROTOXICOLOGY

DNA Methylation Patterns in Cord Blood DNA and Body Size in Childhood

(2012) Caroline L. Relton et al.   PLoS One

Paraoxonase 1 Polymorphism and Prenatal Pesticide Exposure Associated with Adverse Cardiovascular Risk Profiles at School Age

(2012) Helle R. Andersen et al.   PLoS One

Differential DNA Methylation in Purified Human Blood Cells: Implications for Cell Lineage and Studies on Disease Susceptibility

(2012) Lovisa E. Reinius et al.   PLoS One

Paraoxonase 1 (PON1) as a genetic determinant of susceptibility to organophosphate toxicity

(2012) Lucio G. Costa et al.   TOXICOLOGY

A mechanistic overview of health associated effects of low levels of organochlorine and organophosphorous pesticides

(2012) Vasilis P. Androutsopoulos et al.   TOXICOLOGY

PPARs in Regulation of Paraoxonases: Control of Oxidative Stress and Inflammation Pathways

(2012) Jordi Camps et al.   PPAR Research

Perinatal overnutrition and the programming of food preferences: pathways and mechanisms

(2012) Z. Y. Ong et al.   Journal of Developmental Origins of Health and Disease

Genome-Wide Association for Abdominal Subcutaneous and Visceral Adipose Reveals a Novel Locus for Visceral Fat in Women

(2012) Caroline S. Fox et al.   PLoS Genetics

EpiExplorer: live exploration and global analysis of large epigenomic datasets

(2012) Konstantin Halachev et al.   GENOME BIOLOGY

Urokinase-Type Plasminogen Activator Downregulates Paraoxonase 1 Expression in Hepatocytes by Stimulating Peroxisome Proliferator–Activated Receptor-γ Nuclear Export

(2011) Jasmin Khateeb et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Epigenetic Gene Promoter Methylation at Birth Is Associated With Child's Later Adiposity

(2011) K. M. Godfrey et al.   DIABETES

Environmental epigenomics and disease susceptibility

(2011) Michael K Skinner   EMBO REPORTS

Lower birth weight and increased body fat at school age in children prenatally exposed to modern pesticides: a prospective study

(2011) Christine Wohlfahrt-Veje et al.   Environmental Health

Widely Used Pesticides with Previously Unknown Endocrine Activity Revealed as in Vitro Antiandrogens

(2011) Frances Orton et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Timing is everything

(2011) Christopher Faulk et al.   Epigenetics

Deficiency of the GPR39 receptor is associated with obesity and altered adipocyte metabolism

(2011) Pia Steen Petersen et al.   FASEB JOURNAL

Perinatal undernutrition affects the methylation and expression of the leptin gene in adults: implication for the understanding of metabolic syndrome

(2011) Céline Jousse et al.   FASEB JOURNAL

Exposure to maternal consumption of cafeteria diet during the lactation period programmes feeding behaviour in the rat

(2011) Thomas M. Wright et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Organophosphates dysregulate dopamine signaling, glutamatergic neurotransmission, and induce neuronal injury markers in striatum

(2011) Melissa I. Torres-Altoro et al.   JOURNAL OF NEUROCHEMISTRY

GPR39, a Receptor of the Ghrelin Receptor Family, Plays a Role in the Regulation of Glucose Homeostasis in a Mouse Model of Early Onset Diet-Induced Obesity

(2011) P. J. Verhulst et al.   JOURNAL OF NEUROENDOCRINOLOGY

Prenatal environmental exposures, epigenetics, and disease

(2011) Frederica Perera et al.   REPRODUCTIVE TOXICOLOGY

Genetic variants inMTNR1Baffecting insulin secretion

(2010) Karsten Müssig et al.   ANNALS OF MEDICINE

Maternal High-Fat Diet Alters Methylation and Gene Expression of Dopamine and Opioid-Related Genes

(2010) Zivjena Vucetic et al.   ENDOCRINOLOGY

Combined exposure to endocrine disrupting pesticides impairs parturition, causes pup mortality and affects sexual differentiation in rats

(2010) P. R. Jacobsen et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

Orchestrated downregulation of genes involved in oxidative metabolic pathways in obese vs. lean high-fat young male consumers

(2010) M. Pilar Marrades et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Plasminogen activator inhibitor type-1 is an independent marker of metabolic disorders in young adults born small for gestational age

(2010) T. MEAS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes

(2010) Sabine Endele et al.   NATURE GENETICS

Early life protein restriction alters dopamine circuitry

(2010) Z. Vucetic et al.   NEUROSCIENCE

Cortical neurons from intrauterine growth retardation rats exhibit lower response to neurotrophin BDNF

(2010) Midori Ninomiya et al.   NEUROSCIENCE LETTERS

Fetal programming: link between early nutrition, DNA methylation, and complex diseases

(2010) Agata Chmurzynska   NUTRITION REVIEWS

Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity?

(2010) Theodore A. Slotkin   REPRODUCTIVE TOXICOLOGY

Reward, dopamine and the control of food intake: implications for obesity

(2010) Nora D. Volkow et al.   TRENDS IN COGNITIVE SCIENCES

Paraoxonase 1 (PON1) expression in hepatocytes is upregulated by pomegranate polyphenols: A role for PPAR-γ pathway

(2009) Jasmin Khateeb et al.   ATHEROSCLEROSIS

The paraoxonase gene family and atherosclerosis

(2009) David Seo et al.   Current Atherosclerosis Reports

DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific

(2009) Elmar W. Tobi et al.   HUMAN MOLECULAR GENETICS

Early life exposure to a high fat diet promotes long-term changes in dietary preferences and central reward signaling

(2009) S.L. Teegarden et al.   NEUROSCIENCE

Prenatal protein deprivation alters dopamine-mediated behaviors and dopaminergic and glutamatergic receptor binding

(2008) Abraham A. Palmer et al.   BRAIN RESEARCH

Leptin: Linking obesity, the metabolic syndrome, and cardiovascular disease

(2008) Sanjeev B. Patel et al.   CURRENT HYPERTENSION REPORTS

Potential developmental neurotoxicity of pesticides used in Europe

(2008) Marina Bjørling-Poulsen et al.   Environmental Health

Impaired Reproductive Development in Sons of Women Occupationally Exposed to Pesticides during Pregnancy

(2008) Helle R. Andersen et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Building a scientific framework for studying hormonal effects on behavior and on the development of the sexually dimorphic nervous system

(2008) Abby A. Li et al.   NEUROTOXICOLOGY

OPCML Is a Broad Tumor Suppressor for Multiple Carcinomas and Lymphomas with Frequently Epigenetic Inactivation

(2008) Yan Cui et al.   PLoS One