Journal
DIABETES-METABOLISM RESEARCH AND REVIEWS
Volume 30, Issue 6, Pages 447-456Publisher
WILEY
DOI: 10.1002/dmrr.2493
Keywords
lipocalin-2; adipocyte fatty acid-binding protein; obesity; atherosclerosis
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Funding
- National 973 Project of China [2011CB504001]
- National Natural Science Foundation [81170379, 81220108006, 81200292]
- Shanghai Rising-Star Programme [13QA1402900]
- Shanghai Jiao Tong University School of Medicine
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Obesity is considered to be a chronic inflammatory state in which the dysfunction of adipose tissue plays a central role. The adipokines, which are cytokines secreted by adipose tissue, are key links between obesity and related diseases such as metabolic syndrome and atherosclerosis. LCN2 and A-FABP, both of which are major adipokines predominantly produced in adipose tissue, have recently been shown to be pivotal modulators of vascular function. However, different adipokines modulate the development of atherosclerosis in distinctive manners, which are partly attributable to their unique regulatory mechanisms and functions. This review highlights recent advances in the understanding of the role of two adipokines in mediating chronic inflammation and the pathogenesis of atherosclerosis. Copyright (c) 2013 John Wiley & Sons, Ltd.
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