Gankyrin: a novel promising therapeutic target for hepatocellular carcinoma

A Highly Durable RNAi Therapeutic Inhibitor of PCSK9

(2017) Kevin Fitzgerald et al.   NEW ENGLAND JOURNAL OF MEDICINE

Circulating microRNAs in Hepatocellular Carcinoma: Potential Diagnostic and Prognostic Biomarkers

(2016) Hamid Mirzaei et al.   CURRENT PHARMACEUTICAL DESIGN

Small molecules, big targets: drug discovery faces the protein–protein interaction challenge

(2016) Duncan E. Scott et al.   NATURE REVIEWS DRUG DISCOVERY

Gankyrin regulates cell signaling network

(2016) Xinxin Wang et al.   TUMOR BIOLOGY

Prognostic and clinicopathological significance of Gankyrin overexpression in cancers: evidence from a meta-analysis

(2016) Xiaotong Zhao et al.   OncoTargets and Therapy

Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell

(2016) Anasuya Chattopadhyay et al.   Scientific Reports

Synthetic Proteins Potently and Selectively Bind the Oncoprotein Gankyrin, Modulate Its Interaction with S6 ATPase, and Suppress Gankyrin/MDM2-Dependent Ubiquitination of p53

(2015) Alex M. Chapman et al.   ACS Chemical Biology

Interleukin-1β/Iinterleukin-1 receptor-associated kinase 1 inflammatory signaling contributes to persistent Gankyrin activation during hepatocarcinogenesis

(2015) Bo Su et al.   HEPATOLOGY

Clinicopathologic features and prognostic implications of Gankyrin protein expression in non-small cell lung cancer

(2015) Wu-ping Wang et al.   PATHOLOGY RESEARCH AND PRACTICE

Gankyrin drives malignant transformation of chronic liver damage-mediated fibrosis via the Rac1/JNK pathway

(2015) X Zhao et al.   Cell Death & Disease

YAP is a critical oncogene in human cholangiocarcinoma

(2015) Tiemin Pei et al.   Oncotarget

siRNA Versus miRNA as Therapeutics for Gene Silencing

(2015) Jenny K W Lam et al.   Molecular Therapy-Nucleic Acids

Gankyrin is a predictive and oncogenic factor in well-differentiated and dedifferentiated liposarcoma

(2015) Ju-Ae Hwang et al.   Oncotarget

Resurfaced Shape Complementary Proteins That Selectively Bind the Oncoprotein Gankyrin

(2014) Alex M. Chapman et al.   ACS Chemical Biology

The oncoprotein, gankyrin, is up-regulated in middle ear cholesteatoma

(2014) Ki Hyun Kim et al.   ACTA OTO-LARYNGOLOGICA

MiR-605 represses PSMD10/Gankyrin and inhibits intrahepatic cholangiocarcinoma cell progression

(2014) Jianwei Li et al.   FEBS LETTERS

Therapeutic potentials of gene silencing by RNA interference: Principles, challenges, and new strategies

(2014) Yan Deng et al.   GENE

Expression of the oncoprotein gankyrin and phosphorylated retinoblastoma protein in human testis and testicular germ cell tumor

(2014) Satoshi Ando et al.   INTERNATIONAL JOURNAL OF UROLOGY

First-in-Human Phase I Study of the Liposomal RNA Interference Therapeutic Atu027 in Patients With Advanced Solid Tumors

(2014) Beate Schultheis et al.   JOURNAL OF CLINICAL ONCOLOGY

miR-122 decreases HCV entry into hepatocytes through binding to the 3′ UTR of OCLN mRNA

(2014) Hossein Sendi et al.   LIVER INTERNATIONAL

p28GANK is a novel marker for prognosis and therapeutic target in gastric cancer

(2014) J. -Y. Zheng et al.   MOLECULAR BIOLOGY

Gankyrin Is Frequently Overexpressed in Cervical High Grade Disease and Is Associated with Cervical Carcinogenesis and Metastasis

(2014) Yuan Liu et al.   PLoS One

Molecular targeted therapy for hepatocellular carcinoma: Current and future

(2014) Jung Woo Shin   WORLD JOURNAL OF GASTROENTEROLOGY

Epigenetics in hepatocellular carcinoma: An update and future therapy perspectives

(2014) Li Ma   WORLD JOURNAL OF GASTROENTEROLOGY

Gankyrin Activates IL-8 to Promote Hepatic Metastasis of Colorectal Cancer

(2013) Z. Bai et al.   CANCER RESEARCH

Restoration of microRNA-214 expression reduces growth of myeloma cells through positive regulation of P53 and inhibition of DNA replication

(2013) I. Misiewicz-Krzeminska et al.   HAEMATOLOGICA

Gankyrin promotes tumor growth and metastasis through activation of IL-6/STAT3 signaling in human cholangiocarcinoma

(2013) Tongsen Zheng et al.   HEPATOLOGY

Epidemiology of Hepatocellular Carcinoma

(2013) Sahil Mittal et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

LBH589 Inhibits proliferation and metastasis of hepatocellular carcinoma via inhibition of gankyrin/stat3/akt pathway

(2013) Xuan Song et al.   Molecular Cancer

Gankyrin is essential for hypoxia enhanced metastatic potential in breast cancer cells

(2013) LIUCUN GAO et al.   Molecular Medicine Reports

First-in-Humans Trial of an RNA Interference Therapeutic Targeting VEGF and KSP in Cancer Patients with Liver Involvement

(2013) Josep Tabernero et al.   Cancer Discovery

Gankyrin plays an essential role in estrogen-driven and GPR30-mediated endometrial carcinoma cell proliferation via the PTEN/PI3K/AKT signaling pathway

(2012) Jiawen Zhang et al.   CANCER LETTERS

Developing MicroRNA Therapeutics

(2012) Eva van Rooij et al.   CIRCULATION RESEARCH

Gankyrin is frequently overexpressed in breast cancer and is associated with ErbB2 expression

(2012) Yeong Hwa Kim et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Inhibition of Hepatitis C Virus Replication by Intracellular Delivery of Multiple siRNAs by Nanosomes

(2012) Partha K Chandra et al.   MOLECULAR THERAPY

Gankyrin promotes breast cancer cell metastasis by regulating Rac1 activity

(2012) C Zhen et al.   ONCOGENE

Up-regulated oncoprotein P28GANK correlates with proliferation and poor prognosis of human glioma

(2012) Yang Yang et al.   World Journal of Surgical Oncology

Overexpression of gankyrin induces liver steatosis in zebrafish (Danio rerio)

(2011) Guor Mour Her et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The oncoprotein p28GANK establishes a positive feedback loop in β-catenin signaling

(2011) Li-wei Dong et al.   CELL RESEARCH

Developing therapeutic microRNAs for cancer

(2011) A G Bader et al.   GENE THERAPY

The reduction of SIRT1 in livers of old mice leads to impaired body homeostasis and to inhibition of liver proliferation

(2011) Jingling Jin et al.   HEPATOLOGY

Current prospects for RNA interference-based therapies

(2011) Beverly L. Davidson et al.   NATURE REVIEWS GENETICS

Overexpression of a novel gene gankyrin correlates with the malignant phenotype of colorectal cancer

(2010) Shanhong Tang et al.   CANCER BIOLOGY & THERAPY

Gankyrin promotes the proliferation of human pancreatic cancer

(2010) Yun Meng et al.   CANCER LETTERS

The Promise of MicroRNA Replacement Therapy

(2010) A. G. Bader et al.   CANCER RESEARCH

p28GANK overexpression accelerates hepatocellular carcinoma invasiveness and metastasis via phosphoinositol 3-kinase/AKT/hypoxia-inducible factor-1α pathways

(2010) Jing Fu et al.   HEPATOLOGY

Gankyrin plays an essential role in Ras-induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cells

(2010) Jiang-Hong Man et al.   JOURNAL OF CLINICAL INVESTIGATION

Deregulation of microRNA expression in the different genetic subtypes of multiple myeloma and correlation with gene expression profiling

(2010) N C Gutiérrez et al.   LEUKEMIA

A novel gene P28GANK confers multidrug resistance by modulating the expression of MDR-1, Bcl-2, and bax in osteosarcoma cells

(2010) Guowen Wang et al.   MOLECULAR BIOLOGY

A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus

(2010) J. DeVincenzo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatocellular carcinoma and the ubiquitin–proteasome system

(2008) Simon P. Dawson   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Retinoblastoma protein modulates gankyrin–MDM2 in regulation of p53 stability and chemosensitivity in cancer cells

(2008) W Qiu et al.   ONCOGENE

Primer: inflammasomes and interleukin 1β in inflammatory disorders

(2008) Leigh D Church et al.   Nature clinical practice. Rheumatology