Article
Cell Biology
Ruimin Chang, Xiaoxiong Xiao, Yao Fu, Chunfang Zhang, Xiaoyan Zhu, Yang Gao
Summary: In this study, ITGB1-DT was identified as a prognosis-related and oncogenic lncRNA in LUAD through activating the ITGB1-DT/ITGB1/Wnt/beta-catenin/MYC positive feedback loop, implicating it as a potential prognostic biomarker and therapeutic target for LUAD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Stefan Stoiber, Faris F. Brkic, Tobias Maier, Julia Schnoell, Elisabeth Gurnhofer, Gregor Heiduschka, Lorenz Kadletz-Wanke, Lukas Kenner
Summary: This study evaluated the prognostic relevance of the Wnt/beta-CATENIN pathway in patients with HPV-positive HNSCC. High CTNNB1 expression was linked to better overall survival, and high beta-CATENIN expression was significantly associated with a better overall survival as well. Thus, beta-CATENIN expression may serve as a marker for better survival outcomes in patients with HPV-positive HNSCC.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Elisavet Lioulia, Panagiotis Mokos, Emmanuel Panteris, Dimitra Dafou
Summary: This study demonstrates the UBE2T/MAPK-ERK/beta-catenin axis as a critical regulator of cell state transition and EMT in HCC.
MOLECULAR ONCOLOGY
(2022)
Article
Cell Biology
Qianwen Wang, Chenxiang Qi, Pengxiang Min, Yueyuan Wang, Fengwen Ye, Tianxiang Xia, Yujie Zhang, Jun Du
Summary: By regulating MICAL2, the migratory ability of gastric cancer cells can be influenced, and it involves changes in the E-cadherin/beta-catenin signaling pathway.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Oncology
Gang Chen, Yi Wang, Xin Zhao, Xiao-zai Xie, Jun-gang Zhao, Tuo Deng, Zi-yan Chen, Han-bin Chen, Yi-fan Tong, Zhen Yang, Xi-wei Ding, Peng-yi Guo, Hai-tao Yu, Li-jun Wu, Si-na Zhang, Qian-dong Zhu, Jun-jian Li, Yun-feng Shan, Fu-xiang Yu, Zheng-ping Yu, Jing-lin Xia
Summary: The study revealed the crucial role of POSTN in generating LCSCs and maintaining their stemness in HCC, with the POSTN/TGF beta 1 positive feedback pathway regulating the expression of stemness factors and the malignant progression of HCC cells by controlling the transcriptional activation of AP-2 alpha. This pathway may serve as a new target for targeted gene therapy in HCC.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Ben Yang, Fengling Wang, Gang Zheng
Summary: This study investigated the role of TMEM119 in breast cancer progression and found that TMEM119 overexpression is associated with poor survival in patients. Knockdown of TMEM119 reduced stemness marker expression. RNA-sequencing and Co-IP experiments confirmed the relationship between TMEM119 and Wnt/beta-catenin signaling pathway.
Review
Oncology
Srishti Kotiyal, Kimberley Jane Evason
Summary: Mutations in TERT promoter and CTNNB1 gene are common in hepatocellular carcinoma (HCC), and their interaction plays a role in promoting hepatocarcinogenesis.
Article
Biochemistry & Molecular Biology
Mehran Erfani, Mozhdeh Zamani, Seyed Younes Hosseini, Zohreh Mostafavi-Pour, Sayed Mohammad Shafiee, Mohammadreza Saeidnia, Pooneh Mokarram
Summary: Our study reveals a close correlation between E-cadherin levels and ARID1A expression, suggesting that ARID1A downregulation may promote CRC metastasis through decreasing E-cadherin expression and enhancing epithelial cell movement. ARID1A could be a potential therapeutic target for CRC treatment.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Cell Biology
Hong-Xiang Shi, Chao Liang, Chao-Yan Yao, Zi-Xuan Gao, Jia Qin, Jin-Lan Cao, Ming-Zhu Zhang, Ying-Ying Li, Meng-Qing Wang, Hua Sun, Song-Qiang Xie, Dong Fang
Summary: This study reveals the immunosuppressive role of spermine in hepatocellular carcinoma by activating the CaSR pathway to promote the expression of PD-L1 and reducing the infiltration of CD8(+) T cells. This discovery highlights the crucial function of spermine in establishing immune privilege.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Oncology
Cen-Shan Lin, Yuyi Liang, Shu-Guang Su, Yin-Li Zheng, Neng Jiang, Jing Zhou, Ying Zhang, Ru Deng, Chun-Hua Wang, Shi-Xun Lu, Yu-Hua Huang, Li-Li Liu, Chao Zhang, Jing-Ping Yun
Summary: The study identified elevated Nup93 expression in HCC tissues, especially in cases with metastasis, and its association with poorer prognosis. Nup93 was found to promote HCC metastasis and proliferation by regulating beta-catenin translocation, while the interaction between Nup93 and beta-catenin, as well as a positive feedback loop involving LEF1 and beta-catenin, further facilitated metastasis and proliferation in HCC. The findings suggest potential therapeutic targets in the LEF1-Nup93-beta-catenin pathway for HCC treatment.
Article
Cell Biology
Risa Kanematsu, Mitsuyoshi Hirokawa, Aki Tanaka, Ayana Suzuki, Miyoko Higuchi, Seiji Kuma, Toshitetsu Hayashi, Akira Miyauchi
Summary: This study evaluated the expression of E-cadherin and beta-catenin in immunoreactivity to determine undifferentiated carcinoma cells in the diagnosis of ATC. The results showed that WDTC expressed TTF-1, PAX8, and E-cadherin positively, while ATC showed loss or reduced expression of these markers. Detection of beta-catenin nuclear expression without cell membranous expression may be a potential marker for ATC diagnosis.
Article
Biology
Ran Liu, Chuanzheng Yin, Peng Zhao, Bing Guo, Wenbo Ke, Xichuan Zheng, Dawei Xie, Yaofeng Wang, Gengqiao Wang, Yinzhao Jia, Yang Gao, Wenjun Hu, Gang Logan Liu, Zifang Song
Summary: This study reveals that NRF1 is overexpressed in hepatocellular carcinoma (HCC) and promotes HCC progression by activating the LPCAT1-ERK1/2-CREB axis. NRF1 may serve as a promising therapeutic target for HCC patients.
Article
Biochemistry & Molecular Biology
Li Han, Huaiqing Luo, Wenjie Huang, Jiang Zhang, Di Wu, Jinmei Wang, Jiao Pi, Chi Liu, Xiangping Qu, Huijun Liu, Xiaoqun Qin, Yang Xiang
Summary: Persistent injury and improper repair in bronchial epithelial cells contribute to airway inflammation and remodeling in asthma. E-cadherin plays a role in regulating the balance between EMT and MET during injury repair by inhibiting EMT features, enhancing MET features, and decreasing TGF-beta 1 secretion and Snail expression, ultimately facilitating epithelial repair.
Article
Medicine, Research & Experimental
Lili Zhu, Xiaobei Yang, Jingyu Feng, Jian Mao, Qidong Zhang, Mengru He, Yang Mi, Yingwu Mei, Ge Jin, Haifeng Zhang
Summary: The study reveals that CYP2E1 plays a role in hepatocarcinogenesis by manipulating the Wnt/Dvl2/beta-catenin pathway through inducing ROS accumulation, which leads to the inhibition of tumor growth and metastasis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Yuan Guo, Yan-Rong Zhao, Huan Liu, Yang Xin, Jian-Zhi Yu, Yun-Jin Zang, Qing-guo Xu
Summary: The study identified EHMT2 as a critical factor in the development of hepatocellular carcinoma, showing that elevated EHMT2 expression promotes tumorigenesis and activates the Wnt-beta-catenin signaling pathway. EHMT2 was found to epigenetically silence the APC promoter through methylation, and the specific inhibitor UNC0642 demonstrated anti-tumorigenesis effects in HCC, suggesting it as a potential candidate for targeted drug therapy.
CELL AND BIOSCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
Jian Zhang, Jingyi Sheng, Liwei Dong, Yinli Xu, Liming Yu, Yu Liu, Xiaoru Huang, Song Wan, Hui-Yao Lan, Huishan Wang
CARDIOVASCULAR RESEARCH
(2019)
Article
Gastroenterology & Hepatology
Zheng-Hua Wan, Yun-Han Ma, Tian-Yi Jiang, Yun-Kai Lin, Yuan-Yuan Shi, Ye-Xiong Tan, Li-Wei Dong, Hong-Yang Wang
HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL
(2019)
Article
Gastroenterology & Hepatology
Zheng-Hua Wan, Tian-Yi Jiang, Yuan-Yuan Shi, Yu-Fei Pan, Yun-Kai Lin, Yun-Han Ma, Chun Yang, Xiao-Fan Feng, Li-Feng Huang, Xiao-Ni Kong, Zhi-Wen Ding, Ye-Xiong Tan, Li-Wei Dong, Hong-Yang Wang
Article
Cell Biology
Wen Wen, Wenru Su, Hao Tang, Wenqing Le, Xiaopeng Zhang, Yingfeng Zheng, Xiuxing Liu, Lihui Xie, Jianmin Li, Jinguo Ye, Liwei Dong, Xiuliang Cui, Yushan Miao, Depeng Wang, Jiantao Dong, Chuanle Xiao, Wei Chen, Hongyang Wang
Article
Biochemical Research Methods
Qingqing Wang, Benzhe Su, Liwei Dong, Tianyi Jiang, Yexiong Tan, Xin Lu, Xinyu Liu, Xiaohui Lin, Guowang Xu
JOURNAL OF PROTEOME RESEARCH
(2020)
Article
Cell Biology
Tian-Yi Jiang, Yu-Fei Pan, Zheng-Hua Wan, Yun-Kai Lin, Bin Zhu, Zhen-gang Yuan, Yun-Han Ma, Yuan-Yuan Shi, Tian-Mei Zeng, Li-Wei Dong, Ye-Xiong Tan, Hong-Yang Wang
SCIENCE TRANSLATIONAL MEDICINE
(2020)
Article
Oncology
Tian-Yi Jiang, Xiao-Fan Feng, Zheng Fang, Xiao-Wen Cui, Yun-Kai Lin, Yu-Fei Pan, Chun Yang, Zhi-Wen Ding, Yong-Jie Zhang, Ye-Xiong Tan, Hong-Yang Wang, Li-Wei Dong
Summary: This study identified frequent alterations of PTEN in GBC, showing correlation with poor prognosis, and indicated proteasome inhibitor bortezomib as a promising therapeutic agent. Knockdown of PTEN increased bortezomib efficacy, and further evaluation using PDXs supported the utilization of bortezomib in PTEN-deficient GBC. Mechanistically, PTEN inhibited proteasome activity and bortezomib sensitivity through ARE-dependent transcriptional regulation, with involvement of the BACH1 transcriptional suppressor.
Review
Biochemistry & Molecular Biology
Shuang-Xi Li, Juan Li, Li-Wei Dong, Zhi-Yong Guo
Summary: CKAP4 plays a crucial role in stabilizing the structure of the endoplasmic reticulum and acting as an activated receptor at the cell surface. Despite its involvement in tumorigenesis, the exact role of CKAP4 in tumor biology remains controversial due to its interaction with different ligands and signal transduction pathways in various microenvironments.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Biochemical Research Methods
Chengnan Fang, Benzhe Su, Tianyi Jiang, Chao Li, Yexiong Tan, Qingqing Wang, Liwei Dong, Xinyu Liu, Xiaohui Lin, Guowang Xu
Summary: The study aimed to build prognostic models for hepatocellular carcinoma (HCC) patients based on serum metabolomics data, which demonstrated favorable ability to predict prognosis when combined with clinical staging system. Identified metabolic features were associated with mortality, recurrence, and metastasis, showing the power of metabolomics in screening HCC prognosis risk.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Cell Biology
Xiaofan Feng, Tianyi Jiang, Chun Yang, Shujie Pang, Zhiwen Ding, Heping Hu, Hui Wang, Liwei Dong, Ning Yang
Summary: This study reveals that RPRD1A is highly expressed in hepatocellular carcinoma (HCC) and is correlated with aggressive clinicopathological features. RPRD1A competitively interacts with TRIM21 to inhibit the ubiquitination of p62 and increase its sequestration for Keap1, thus enhancing the nuclear translocation of NRF2 and promoting HCC development. Additionally, genetic knockdown of RPRD1A disturbs the redox homeostasis of cancer cells and sensitizes them to platinum-induced cell death.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Chengnan Fang, Hui Wang, Zhikun Lin, Xinyu Liu, Liwei Dong, Tianyi Jiang, Yexiong Tan, Zhen Ning, Yaorui Ye, Guang Tan, Guowang Xu
Summary: This study analyzed the metabolic reprogramming of hepatocellular carcinoma (HCC) using metabolomics and developed a metabolite classifier for HCC prognostic risk evaluation. The results showed that HCC is characterized by active glycolysis, enhanced fatty acid metabolism, and inhibited tricarboxylic acid cycle. Risk stratification based on differential metabolites revealed that tumors with higher levels of free fatty acids have a worse prognosis.
Article
Cell Biology
Qingqing Wang, Yexiong Tan, Tianyi Jiang, Xiaolin Wang, Qi Li, Yanli Li, Liwei Dong, Xinyu Liu, Guowang Xu
Summary: This study comprehensively analyzed the metabolic reprogramming in hepatocellular carcinoma (HCC) using metabolomics and lipidomics. The findings revealed enhanced aerobic glycolysis and de novo lipogenesis in HCC tissue, as well as repression of the urea cycle. Additionally, a differential correlation network was constructed, identifying key molecules related to the disease, and a panel of biomarkers was generated for prognostic risk stratification of HCC patients.
Article
Oncology
Chun Yang, Xiao-Wen Cui, Zhi-Wen Ding, Tian-Yi Jiang, Xiao-Fan Feng, Yu-Fei Pan, Yun-Kai Lin, Tai-Yu Shang, Qing Wang, Jian Pan, Jian Wang, Hong-Yang Wang, Li-Wei Dong
Summary: This study focused on the impact of gankyrin, a relatively specific oncogene in hepatocellular carcinoma (HCC), on glycolysis and mitochondrial homeostasis. It was found that gankyrin regulated the pentose phosphate pathway (PPP), tricarboxylic acid (TCA) cycle, and mitochondrial function and homeostasis, which played crucial roles in tumor development. Mechanistically, gankyrin was found to modulate HCC metabolic reprogramming via TIGAR.
Article
Cell Biology
Yuanyuan Shi, Xiaowen Cui, Tianyi Jiang, Yufei Pan, Yunkai Lin, Xiaofan Feng, Zhiwen Ding, Chun Yang, Yexiong Tan, Hongyang Wang, Liwei Dong
Summary: In this study, several compound candidates were identified through a high-throughput drug screen as potential treatments for CCA. The KSP inhibitors showed significant cytotoxic effects on CCA cells, leading to mitotic arrest and cell death. Clinical data and the TCGA database also revealed that KIF11 expression was abundant in CCA tumor specimens and correlated with poor outcomes in CCA patients.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Tian-Yi Jiang, Xiao-Wen Cui, Tian-Mei Zeng, Yu-Fei Pan, Yun-Kai Lin, Xiao-fan Feng, Ye-Xiong Tan, Zhen-gang Yuan, Li-Wei Dong, Hong-Yang Wang
Summary: The deficiency of PTEN is correlated with the improved efficacy of gemcitabine-based chemotherapy in cholangiocarcinoma (CCA). PTEN deficiency or down-regulation enhances gemcitabine efficacy by directly binding to and dephosphorylating the catalytic subunit of protein phosphatase 2A (PP2Ac), leading to increased enzymatic activity and diminished phosphorylation of deoxycytidine kinase (DCK). Thus, PTEN deficiency and high phosphorylation of DCK can predict a better response to gemcitabine-based chemotherapy in CCA.
SCIENCE TRANSLATIONAL MEDICINE
(2023)