Enteric Pathogens and Their Toxin-Induced Disruption of the Intestinal Barrier through Alteration of Tight Junctions in Chickens

The CpAL system regulates changes of the trans-epithelial resistance of human enterocytes during Clostridium perfringens type C infection

(2016) Porfirio Nava et al.   ANAEROBE

NetB and necrotic enteritis: the hole movable story

(2016) Julian I. Rood et al.   AVIAN PATHOLOGY

Targeting and alteration of tight junctions by bacteria and their virulence factors such as Clostridium perfringens enterotoxin

(2016) Miriam Eichner et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Campylobacter jejunicolonization promotes the translocation ofEscherichia colito extra-intestinal organs and disturbs the short-chain fatty acids profiles in the chicken gut

(2016) W. A. Awad et al.   POULTRY SCIENCE

Impact of luminal and systemic endotoxin exposure on gut function, immune response and performance of chickens

(2016) K. GHAREEB et al.   WORLDS POULTRY SCIENCE JOURNAL

Age-Related Differences in the Luminal and Mucosa-Associated Gut Microbiome of Broiler Chickens and Shifts Associated with Campylobacter jejuni Infection

(2016) Wageha A. Awad et al.   Frontiers in Cellular and Infection Microbiology

Tight Junction Disruption Induced by Type 3 Secretion System Effectors Injected by Enteropathogenic and Enterohemorrhagic Escherichia coli

(2016) Paul Ugalde-Silva et al.   Frontiers in Cellular and Infection Microbiology

Novel perspectives on therapeutic modulation of the gut microbiota

(2016) Justin L. McCarville et al.   Therapeutic Advances in Gastroenterology

Increased intracellular calcium level and impaired nutrient absorption are important pathogenicity traits in the chicken intestinal epithelium during Campylobacter jejuni colonization

(2015) Wageha A. Awad et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Citrus nobiletin ameliorates experimental colitis by reducing inflammation and restoring impaired intestinal barrier function

(2015) Yongjian Xiong et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Poultry enteric inflammation model with dextran sodium sulfate mediated chemical induction and feed restriction in broilers

(2015) V. A. Kuttappan et al.   POULTRY SCIENCE

Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin

(2015) Y. Saitoh et al.   SCIENCE

Alternatives to Antibiotics to Prevent Necrotic Enteritis in Broiler Chickens: A Microbiologist's Perspective

(2015) Delphine L. Caly et al.   Frontiers in Microbiology

The feed contaminant deoxynivalenol affects the intestinal barrier permeability through inhibition of protein synthesis

(2014) Wageha A. Awad et al.   ARCHIVES OF TOXICOLOGY

Towards an understanding of the role of Clostridium perfringens toxins in human and animal disease

(2014) Francisco A Uzal et al.   Future Microbiology

Campylobacter infection in chickens modulates the intestinal epithelial barrier function

(2014) Wageha A Awad et al.   Innate Immunity

Composition of diet modifies colonization dynamics ofCampylobacter jejuniin broiler chickens

(2014) A. Molnár et al.   JOURNAL OF APPLIED MICROBIOLOGY

Impacts of the feed contaminant deoxynivalenol on the intestine of monogastric animals: poultry and swine

(2014) Khaled Ghareeb et al.   JOURNAL OF APPLIED TOXICOLOGY

In Vitro Exposure to Escherichia coli Decreases Ion Conductance in the Jejunal Epithelium of Broiler Chickens

(2014) Wageha A. Awad et al.   PLoS One

Mechanisms underlying the inhibitory effect of the feed contaminant deoxynivalenol on glucose absorption in broiler chickens

(2014) W.A. Awad et al.   VETERINARY JOURNAL

Campylobacter jejuni influences the expression of nutrient transporter genes in the intestine of chickens

(2014) Wageha A. Awad et al.   VETERINARY MICROBIOLOGY

Some aspects of control of salmonella infection in poultry for minimising contamination in the food chain

(2014) W.A. AWAD et al.   WORLDS POULTRY SCIENCE JOURNAL

Campylobacter jejuni Is Not Merely a Commensal in Commercial Broiler Chickens and Affects Bird Welfare

(2014) S. Humphrey et al.   mBio

Cello-oligosaccharide ameliorates heat stress-induced impairment of intestinal microflora, morphology and barrier integrity in broilers

(2013) J. Song et al.   ANIMAL FEED SCIENCE AND TECHNOLOGY

Strain-Dependent Augmentation of Tight-Junction Barrier Function in Human Primary Epidermal Keratinocytes by Lactobacillus and Bifidobacterium Lysates

(2013) R. Sultana et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Claudins and the Modulation of Tight Junction Permeability

(2013) Dorothee Günzel et al.   PHYSIOLOGICAL REVIEWS

Deoxynivalenol Impairs Hepatic and Intestinal Gene Expression of Selected Oxidative Stress, Tight Junction and Inflammation Proteins in Broiler Chickens, but Addition of an Adsorbing Agent Shifts the Effects to the Distal Parts of the Small Intestine

(2013) Ann Osselaere et al.   PLoS One

 -1,3/1,6-Glucan alleviated intestinal mucosal barrier impairment of broiler chickens challenged with Salmonella enterica serovar Typhimurium

(2013) Y. Shao et al.   POULTRY SCIENCE

Dietary inulin alters the intestinal absorptive and barrier function of piglet intestine after weaning

(2013) Wageha A. Awad et al.   RESEARCH IN VETERINARY SCIENCE

Control strategies for Campylobacter infection in poultry production

(2013) K. GHAREEB et al.   WORLDS POULTRY SCIENCE JOURNAL

Natural plant extracts and prebiotic compounds as alternatives to antibiotics in broiler chicken diets in a necrotic enteritis challenge model

(2013) J. K. Vidanarachchi et al.   Animal Production Science

Central Role of the Gut Epithelial Barrier in the Pathogenesis of Chronic Intestinal Inflammation: Lessons Learned from Animal Models and Human Genetics

(2013) Luca Pastorelli et al.   Frontiers in Immunology

Tight junctions on the move: molecular mechanisms for epithelial barrier regulation

(2012) Le Shen   Annals of the New York Academy of Sciences

Zinc preventsSalmonella entericaserovar Typhimurium-induced loss of intestinal mucosal barrier function in broiler chickens

(2012) Bingkun Zhang et al.   AVIAN PATHOLOGY

Intestinal epithelial responses to Salmonella enterica serovar Enteritidis: Effects on intestinal permeability and ion transport

(2012) W. A. Awad et al.   POULTRY SCIENCE

Evaluating the efficacy of an avian-specific probiotic to reduce the colonization of Campylobacter jejuni in broiler chickens

(2012) K. Ghareeb et al.   POULTRY SCIENCE

Comparative tight junction protein expressions in colonic Crohn’s disease, ulcerative colitis, and tuberculosis: a new perspective

(2012) Prasenjit Das et al.   VIRCHOWS ARCHIV

The toxicity of Fusarium mycotoxin deoxynivalenol in poultry feeding

(2012) W.A. AWAD et al.   WORLDS POULTRY SCIENCE JOURNAL

Tight Junction Pore and Leak Pathways: A Dynamic Duo

(2011) Le Shen et al.   Annual Review of Physiology

Epithelial Barriers in Intestinal Inflammation

(2011) Lena J. John et al.   ANTIOXIDANTS & REDOX SIGNALING

The Impact of the Fusarium Mycotoxin Deoxynivalenol on the Health and Performance of Broiler Chickens

(2011) Wageha A. Awad et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cytotoxicity and metabolic stress induced by deoxynivalenol in the porcine intestinal IPEC-J2 cell line

(2011) W. A. Awad et al.   JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION

Regulation of Tight Junction Permeability by Intestinal Bacteria and Dietary Components

(2011) Dulantha Ulluwishewa et al.   JOURNAL OF NUTRITION

A diet naturally contaminated with the Fusarium mycotoxin deoxynivalenol (DON) downregulates gene expression of glucose transporters in the intestine of broiler chickens

(2011) Wageha A. Awad et al.   Livestock Science

Effect of Lactobacilli on Paracellular Permeability in the Gut

(2011) Siv Ahrne et al.   Nutrients

ClC-2 regulates mucosal barrier function associated with structural changes to the villus and epithelial tight junction

(2010) Prashant K. Nighot et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Developmental Profile of Claudin-3, -5, and -16 Proteins in the Epithelium of Chick Intestine

(2010) Ozkan Ozden et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

An Economic Analysis of the Impact of Subclinical (Mild) Necrotic Enteritis in Broiler Chickens

(2010) James T. Skinner et al.   AVIAN DISEASES

Exogenous lysozyme influences Clostridium perfringens colonization and intestinal barrier function in broiler chickens

(2010) Dan Liu et al.   AVIAN PATHOLOGY

Anti-neuroinflammatory Activity of Nobiletin on Suppression of Microglial Activation

(2010) Yanji Cui et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Evaluation of the chicory inulin efficacy on ameliorating the intestinal morphology and modulating the intestinal electrophysiological properties in broiler chickens

(2010) W. A. Awad et al.   JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION

Enterohemorrhagic E. coli alters murine intestinal epithelial tight junction protein expression and barrier function in a Shiga toxin independent manner

(2010) Jennifer L Roxas et al.   LABORATORY INVESTIGATION

Campylobacter jejuni induces transcytosis of commensal bacteria across the intestinal epithelium through M-like cells

(2010) Lisa D Kalischuk et al.   Gut Pathogens

NetB, a Pore-Forming Toxin from Necrotic Enteritis Strains of Clostridium perfringens

(2010) Anthony L. Keyburn et al.   Toxins

On the Interaction of Clostridium perfringens Enterotoxin with Claudins

(2010) Anna Veshnyakova et al.   Toxins

Vertebrate Animal Models Unravel Physiological Roles for Zonula Occludens Tight Junction Adaptor Proteins

(2009) Walter Hunziker et al.   Annals of the New York Academy of Sciences

Structure and Function of Extracellular Claudin Domains

(2009) Gerd Krause et al.   Annals of the New York Academy of Sciences

Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability

(2009) P. D. Cani et al.   GUT

Intestinal barrier function: Molecular regulation and disease pathogenesis

(2009) Katherine R. Groschwitz et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Effect of addition of a probiotic micro-organism to broiler diet on intestinal mucosal architecture and electrophysiological parameters

(2009) W. A. Awad et al.   JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION

Enteropathogenic Escherichia coli changes distribution of occludin and ZO-1 in tight junction membrane microdomains in vivo

(2009) Qiang Zhang et al.   MICROBIAL PATHOGENESIS

Campylobacter jejuni induces transcellular translocation of commensal bacteria via lipid rafts

(2009) Lisa D Kalischuk et al.   Gut Pathogens

Tight junctions as targets of infectious agents

(2008) Julian A. Guttman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Invasion of enteropathogenic Escherichia coli into host cells through epithelial tight junctions

(2008) Qiurong Li et al.   FEBS Journal

Structural and functional changes of the duodenum in human norovirus infection

(2008) H. Troeger et al.   GUT

Epidermal Growth Factor Inhibits Campylobacter jejuni-Induced Claudin-4 Disruption, Loss of Epithelial Barrier Function, and Escherichia coli Translocation

(2008) J. M. Lamb-Rosteski et al.   INFECTION AND IMMUNITY

Intestinal Structure and Function of Broiler Chickens on Diets Supplemented with a Synbiotic Containing Enterococcus faecium and Oligosaccharides

(2008) Wageha Awad et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state

(2008) Le Shen et al.   JOURNAL OF CELL BIOLOGY

The density of small tight junction pores varies among cell types and is increased by expression of claudin-2

(2008) C. M. Van Itallie et al.   JOURNAL OF CELL SCIENCE

Changes in growth performance, digestive enzyme activities and nutrient digestibility of cherry valley ducks in response to aflatoxin B1 levels

(2008) Xin-Yan Han et al.   Livestock Science

Tight junction-based epithelial microenvironment and cell proliferation

(2008) S Tsukita et al.   ONCOGENE

Campylobacter jejuni Mediated Disruption of Polarized Epithelial Monolayers is Cell-Type Specific, Time Dependent, and Correlates With Bacterial Invasion

(2008) Eytan Wine et al.   PEDIATRIC RESEARCH

NetB, a New Toxin That Is Associated with Avian Necrotic Enteritis Caused by Clostridium perfringens

(2008) Anthony L. Keyburn et al.   PLoS Pathogens

In vitro effects of alpha toxin from Clostridium perfringens on the electrophysiological parameters of jejunal tissues from laying hens preincubated with inulin and N-acetyl-L-cysteine

(2008) H. Rehman et al.   POULTRY SCIENCE

Effects of dietary inclusion of probiotic and synbiotic on growth performance, organ weights, and intestinal histomorphology of broiler chickens

(2008) W. A. Awad et al.   POULTRY SCIENCE

Intestinal Cytokine Response of Commercial Source Broiler Chicks to Salmonella Typhimurium Infection

(2008) Y. O. Fasina et al.   POULTRY SCIENCE

Structure and function of claudins

(2007) Gerd Krause et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Colonization strategy of Campylobacter jejuni results in persistent infection of the chicken gut

(2007) Kim Van Deun et al.   VETERINARY MICROBIOLOGY