In vitro-engineered non-antibody protein therapeutics

Engineered knottin peptides as diagnostics, therapeutics, and drug delivery vehicles

(2016) James R Kintzing et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Biodistribution and Radiation Dosimetry of the Anti-HER2 Affibody Molecule 68Ga-ABY-025 in Breast Cancer Patients

(2016) M. Sandstrom et al.   JOURNAL OF NUCLEAR MEDICINE

Antibodies to watch in 2017

(2016) Janice M. Reichert   mAbs

Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus

(2016) Wanwisa Dejnirattisai et al.   NATURE IMMUNOLOGY

BMS-986089 is a high affinity anti-myostatin adnectin that increases muscle volume in three preclinical species

(2016) M. Madireddi et al.   NEUROMUSCULAR DISORDERS

Oral activity of a nature-derived cyclic peptide for the treatment of multiple sclerosis

(2016) Kathrin Thell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Measuring HER2-Receptor Expression In Metastatic Breast Cancer Using [68Ga]ABY-025 Affibody PET/CT

(2016) Jens Sörensen et al.   Theranostics

Functional characterization of a VEGF-A-targeting Anticalin, prototype of a novel therapeutic human protein class

(2015) Hendrik Gille et al.   ANGIOGENESIS

Designed Ankyrin Repeat Proteins (DARPins): Binding Proteins for Research, Diagnostics, and Therapy

(2015) Andreas Plückthun   Annual Review of Pharmacology and Toxicology

A Cactus-Derived Toxin-Like Cystine Knot Peptide with Selective Antimicrobial Activity

(2015) Teshome L. Aboye et al.   CHEMBIOCHEM

Discovery and characterization of COVA322, a clinical-stage bispecific TNF/IL-17A inhibitor for the treatment of inflammatory diseases

(2015) Michela Silacci et al.   mAbs

Abstract B25: First-in-human Phase I study to evaluate MP0250, a DARPin blocking HGF and VEGF, in patients with advanced solid tumors

(2015) Jordi Rodon et al.   MOLECULAR CANCER THERAPEUTICS

CXCR4 Protein Epitope Mimetic Antagonist POL5551 Disrupts Metastasis and Enhances Chemotherapy Effect in Triple-Negative Breast Cancer

(2015) J. Xiang et al.   MOLECULAR CANCER THERAPEUTICS

Review article: linaclotide for the management of irritable bowel syndrome with constipation

(2014) P. Layer et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Engineered proteins with desired specificity: DARPins, other alternative scaffolds and bispecific IgGs

(2014) Christian Jost et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Phase 2 study of CT-322, a targeted biologic inhibitor of VEGFR-2 based on a domain of human fibronectin, in recurrent glioblastoma

(2014) David Schiff et al.   INVESTIGATIONAL NEW DRUGS

Linker Length Matters, Fynomer-Fc Fusion with an Optimized Linker Displaying Picomolar IL-17A Inhibition Potency

(2014) Michela Silacci et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Carotid Intima-Media Thickness and Cardiovascular Disease Risk Prediction

(2014) James H. Stein et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

9th Annual European Antibody Congress, November 11–13, 2013, Geneva, Switzerland

(2014) Janice M Reichert et al.   mAbs

The therapeutic monoclonal antibody market

(2014) Dawn M Ecker et al.   mAbs

From DARPins to LoopDARPins: Novel LoopDARPin Design Allows the Selection of Low Picomolar Binders in a Single Round of Ribosome Display

(2013) Johannes Schilling et al.   JOURNAL OF MOLECULAR BIOLOGY

The novel CXCR4 antagonist POL5551 mobilizes hematopoietic stem and progenitor cells with greater efficiency than Plerixafor

(2013) D Karpova et al.   LEUKEMIA

First-in-Human Phase I Study of PRS-050 (Angiocal), an Anticalin Targeting and Antagonizing VEGF-A, in Patients with Advanced Solid Tumors

(2013) Klaus Mross et al.   PLoS One

Linaclotide for Irritable Bowel Syndrome With Constipation: A 26-Week, Randomized, Double-blind, Placebo-Controlled Trial to Evaluate Efficacy and Safety

(2012) William D Chey et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Orally Active Peptidic Bradykinin B1 Receptor Antagonists Engineered from a Cyclotide Scaffold for Inflammatory Pain Treatment

(2012) Clarence T. T. Wong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemical Macrocyclization of Peptides Fused to Antibody Fc Fragments

(2012) Alessandro Angelini et al.   BIOCONJUGATE CHEMISTRY

Anti-inflammatory effects of DX-890, a human neutrophil elastase inhibitor

(2012) Fiona K. Dunlevy et al.   Journal of Cystic Fibrosis

Generation, characterization and structural data of chymase binding proteins based on the human Fyn kinase SH3 domain

(2012) Daniel Schlatter et al.   mAbs

Structures of Adnectin/Protein Complexes Reveal an Expanded Binding Footprint

(2012) Vidhyashankar Ramamurthy et al.   STRUCTURE

Phase I and Pharmacokinetic Study of CT-322 (BMS-844203), a Targeted Adnectin Inhibitor of VEGFR-2 Based on a Domain of Human Fibronectin

(2011) A. W. Tolcher et al.   CLINICAL CANCER RESEARCH

Strategies for extended serum half-life of protein therapeutics

(2011) Roland E Kontermann   CURRENT OPINION IN BIOTECHNOLOGY

Impact of albumin on drug delivery — New applications on the horizon

(2011) Bakheet Elsadek et al.   JOURNAL OF CONTROLLED RELEASE

Delivery of Molecular and Nanoscale Medicine to Tumors: Transport Barriers and Strategies

(2011) Vikash P. Chauhan et al.   Annual Review of Chemical and Biomolecular Engineering

EDEMA4: a phase 3, double-blind study of subcutaneous ecallantide treatment for acute attacks of hereditary angioedema

(2010) Robyn J. Levy et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Radionuclide Molecular Imaging Using Affibody Molecules

(2010) Sara Ahlgren et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Design of an Optimized Scaffold for Affibody Molecules

(2010) Joachim Feldwisch et al.   JOURNAL OF MOLECULAR BIOLOGY

Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract

(2010) Alexander P. Bryant et al.   LIFE SCIENCES

Industrialization of mAb production technology: The bioprocessing industry at a crossroads

(2010) Brian Kelley   mAbs

Ecallantide for the Treatment of Acute Attacks in Hereditary Angioedema

(2010) Marco Cicardi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Adnectins: engineered target-binding protein therapeutics

(2010) D. Lipovsek   PROTEIN ENGINEERING DESIGN & SELECTION

Safety and efficacy of intrathecal ziconotide in the management of severe chronic pain

(2010) Howard Howard Smith   Therapeutics and Clinical Risk Management

Cyclotides: macrocyclic peptides with applications in drug design and agriculture

(2009) David J. Craik et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Biological diversity and therapeutic potential of natural and engineered cystine knot miniproteins

(2009) Harald Kolmar   CURRENT OPINION IN PHARMACOLOGY

PEG-modified biopharmaceuticals

(2009) Pascal Bailon et al.   Expert Opinion on Drug Delivery

Guanylate cyclase C-mediated antinociceptive effects of linaclotide in rodent models of visceral pain

(2009) h. eutamene et al.   NEUROGASTROENTEROLOGY AND MOTILITY

The Adnectin CT-322 is a novel VEGF receptor 2 inhibitor that decreases tumor burden in an orthotopic mouse model of pancreatic cancer

(2008) Sean P Dineen et al.   BMC CANCER

Alternative binding proteins: Anticalins - harnessing the structural plasticity of the lipocalin ligand pocket to engineer novel binding activities

(2008) Arne Skerra   FEBS Journal

Alternative binding proteins: Affibody binding proteins developed from a small three-helix bundle scaffold

(2008) Per-Åke Nygren   FEBS Journal

Picomolar Affinity Fibronectin Domains Engineered Utilizing Loop Length Diversity, Recursive Mutagenesis, and Loop Shuffling

(2008) Benjamin J. Hackel et al.   JOURNAL OF MOLECULAR BIOLOGY

Anti-serum albumin domain antibodies for extending the half-lives of short lived drugs

(2008) L. J. Holt et al.   PROTEIN ENGINEERING DESIGN & SELECTION