Complete mapping of viral escape from neutralizing antibodies

Plasmid-based one-pot saturation mutagenesis

(2016) Emily E Wrenbeck et al.   NATURE METHODS

Cross-Neutralising Nanobodies Bind to a Conserved Pocket in the Hemagglutinin Stem Region Identified Using Yeast Display and Deep Mutational Scanning

(2016) Tiziano Gaiotto et al.   PLoS One

Global mapping of antibody recognition of the hepatitis C virus E2 glycoprotein: Implications for vaccine design

(2016) Brian G. Pierce et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accurate Measurement of the Effects of All Amino-Acid Mutations on Influenza Hemagglutinin

(2016) Michael Doud et al.   Viruses-Basel

Two Escape Mechanisms of Influenza A Virus to a Broadly Neutralizing Stalk-Binding Antibody

(2016) Ning Chai et al.   PLoS Pathogens

Experimental Estimation of the Effects of All Amino-Acid Mutations to HIV’s Envelope Protein on Viral Replication in Cell Culture

(2016) Hugh K. Haddox et al.   PLoS Pathogens

Measuring the sequence-affinity landscape of antibodies with massively parallel titration curves

(2016) Rhys M Adams et al.   eLife

Selection of antigenically advanced variants of seasonal influenza viruses

(2016) Chengjun Li et al.   Nature Microbiology

nextflu: real-time tracking of seasonal influenza virus evolution in humans

(2015) Richard A. Neher et al.   BIOINFORMATICS

Software for the analysis and visualization of deep mutational scanning data

(2015) Jesse D Bloom   BMC BIOINFORMATICS

Safety, pharmacokinetics and neutralization of the broadly neutralizing HIV-1 human monoclonal antibody VRC01 in healthy adults

(2015) J. E. Ledgerwood et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Rapid Fine Conformational Epitope Mapping Using Comprehensive Mutagenesis and Deep Sequencing

(2015) Caitlin A. Kowalsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Site-Specific Amino Acid Preferences Are Mostly Conserved in Two Closely Related Protein Homologs

(2015) Michael B. Doud et al.   MOLECULAR BIOLOGY AND EVOLUTION

Global circulation patterns of seasonal influenza viruses vary with antigenic drift

(2015) Trevor Bedford et al.   NATURE

Massively parallel single-amino-acid mutagenesis

(2015) Jacob O Kitzman et al.   NATURE METHODS

Advances in the development of influenza virus vaccines

(2015) Florian Krammer et al.   NATURE REVIEWS DRUG DISCOVERY

Microneutralization Assay Titres Correlate with Protection against Seasonal Influenza H1N1 and H3N2 in Children

(2015) Chris P. Verschoor et al.   PLoS One

An Experimentally Determined Evolutionary Model Dramatically Improves Phylogenetic Fit

(2014) Jesse D. Bloom   MOLECULAR BIOLOGY AND EVOLUTION

A predictive fitness model for influenza

(2014) Marta Łuksza et al.   NATURE

Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions

(2014) J. B. Munro et al.   SCIENCE

The inherent mutational tolerance and antigenic evolvability of influenza hemagglutinin

(2014) Bargavi Thyagarajan et al.   eLife

Defining Influenza A Virus Hemagglutinin Antigenic Drift by Sequential Monoclonal Antibody Selection

(2013) Suman R. Das et al.   Cell Host & Microbe

Influenza A Virus Hemagglutinin Trimerization Completes Monomer Folding and Antigenicity

(2013) J. G. Magadan et al.   JOURNAL OF VIROLOGY

A Mutant Influenza Virus That Uses an N1 Neuraminidase as the Receptor-Binding Protein

(2013) Kathryn A. Hooper et al.   JOURNAL OF VIROLOGY

Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution

(2013) B. F. Koel et al.   SCIENCE

PFunkel: Efficient, Expansive, User-Defined Mutagenesis

(2012) Elad Firnberg et al.   PLoS One

Antibody-based protection against HIV infection by vectored immunoprophylaxis

(2011) Alejandro B. Balazs et al.   NATURE

Permissive Secondary Mutations Enable the Evolution of Influenza Oseltamivir Resistance

(2010) J. D. Bloom et al.   SCIENCE

Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target

(2009) L. M. Walker et al.   SCIENCE

Hemagglutinin Receptor Binding Avidity Drives Influenza A Virus Antigenic Drift

(2009) S. E. Hensley et al.   SCIENCE

The challenges of eliciting neutralizing antibodies to HIV-1 and to influenza virus

(2008) Gunilla B. Karlsson Hedestam et al.   NATURE REVIEWS MICROBIOLOGY

Recent advances in the characterization of HIV-1 neutralization assays for standardized evaluation of the antibody response to infection and vaccination

(2008) Victoria R. Polonis et al.   VIROLOGY