MicroRNAs upregulated during HIV infection target peroxisome biogenesis factors: Implications for virus biology, disease mechanisms and neuropathology

Peroxisomes in brain development and function

(2016) Johannes Berger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

PEX2 is the E3 ubiquitin ligase required for pexophagy during starvation

(2016) Graeme Sargent et al.   JOURNAL OF CELL BIOLOGY

Hepatitis C virus NS3-4A inhibits the peroxisomal MAVS-dependent antiviral signalling response

(2016) Ana R. Ferreira et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The pro-inflammatory effects of miR-155 promote liver fibrosis and alcohol-induced steatohepatitis

(2016) Shashi Bala et al.   JOURNAL OF HEPATOLOGY

MiR-144-3p and Its Target Gene β-Amyloid Precursor Protein Regulate 1-Methyl-4-Phenyl-1,2-3,6-Tetrahydropyridine-Induced Mitochondrial Dysfunction

(2016) Kuo Li et al.   MOLECULES AND CELLS

HIV-associated neurocognitive disorder — pathogenesis and prospects for treatment

(2016) Deanna Saylor et al.   Nature Reviews Neurology

Peroxisomes are platforms for cytomegalovirus’ evasion from the cellular immune response

(2016) Ana Cristina Magalhães et al.   Scientific Reports

Cerebral white matter integrity during primary HIV infection

(2015) Patrick W. Wright et al.   AIDS

Functional microRNA high throughput screening reveals miR-9 as a central regulator of liver oncogenesis by affecting the PPARA-CDH1 pathway

(2015) Alexandra Drakaki et al.   BMC CANCER

Mutual induction of transcription factor PPARγ and microRNAs miR-145 and miR-329

(2015) Ashutosh Dharap et al.   JOURNAL OF NEUROCHEMISTRY

HIV-1 Tat Alters Neuronal Autophagy by Modulating Autophagosome Fusion to the Lysosome: Implications for HIV-Associated Neurocognitive Disorders

(2015) J. Fields et al.   JOURNAL OF NEUROSCIENCE

Flavivirus Infection Impairs Peroxisome Biogenesis and Early Antiviral Signaling

(2015) Jaehwan You et al.   JOURNAL OF VIROLOGY

Compartmentalized Replication of R5 T Cell-Tropic HIV-1 in the Central Nervous System Early in the Course of Infection

(2015) Christa Buckheit Sturdevant et al.   PLoS Pathogens

Activation of Type I and III Interferon Response by Mitochondrial and Peroxisomal MAVS and Inhibition by Hepatitis C Virus

(2015) Silke Bender et al.   PLoS Pathogens

Neuropathology of HAND With Suppressive Antiretroviral Therapy: Encephalitis and Neurodegeneration Reconsidered

(2015) Benjamin B. Gelman   Current HIV/AIDS Reports

Neurocognitive Change in the Era of HIV Combination Antiretroviral Therapy: The Longitudinal CHARTER Study

(2014) R. K. Heaton et al.   CLINICAL INFECTIOUS DISEASES

The Montreal Cognitive Assessment to Screen for Cognitive Impairment in HIV Patients Older Than 60 Years

(2014) Benedetta Milanini et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Astrocyte Elevated Gene-1 Is a Novel Modulator of HIV-1-associated Neuroinflammation via Regulation of Nuclear Factor-κB Signaling and Excitatory Amino Acid Transporter-2 Repression

(2014) Neha Vartak-Sharma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heme oxygenase-1 deficiency accompanies neuropathogenesis of HIV-associated neurocognitive disorders

(2014) Alexander J. Gill et al.   JOURNAL OF CLINICAL INVESTIGATION

Brain morphometric correlates of metabolic variables in HIV: the CHARTER study

(2014) S. L. Archibald et al.   JOURNAL OF NEUROVIROLOGY

Controversies in HIV-associated neurocognitive disorders

(2014) Sam Nightingale et al.   LANCET NEUROLOGY

Diverse intracellular pathogens activate type III interferon expression from peroxisomes

(2014) Charlotte Odendall et al.   NATURE IMMUNOLOGY

Novel HIV-1 MiRNAs Stimulate TNFα Release in Human Macrophages via TLR8 Signaling Pathway

(2014) Mark A. Bernard et al.   PLoS One

Rapid inflammasome activation in microglia contributes to brain disease in HIV/AIDS

(2014) John G Walsh et al.   Retrovirology

High-throughput detection of miRNAs and gene-specific mRNA at the single-cell level by flow cytometry

(2014) Filippos Porichis et al.   Nature Communications

Peroxisome biogenesis in mammalian cells

(2014) Yukio Fujiki et al.   Frontiers in Physiology

Brain peroxisomes

(2013) D. Trompier et al.   BIOCHIMIE

PEX7 and EBP50 target iNOS to the peroxisome in hepatocytes

(2013) Patricia A. Loughran et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Peroxisome deficiency-induced ER stress and SREBP-2 pathway activation in the liver of newborn PEX2 knock-out mice

(2012) Werner J. Kovacs et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A parallel genome-wide mRNA and microRNA profiling of the frontal cortex of HIV patients with and without HIV-associated dementia shows the role of axon guidance and downstream pathways in HIV-mediated neurodegeneration

(2012) Li Zhou et al.   BMC GENOMICS

Neurovirological Correlation With HIV-Associated Neurocognitive Disorders and Encephalitis in a HAART-Era Cohort

(2012) Benjamin B. Gelman et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Cerebrospinal fluid miRNA profile in HIV-encephalitis

(2012) Marco Pacifici et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Genomic HIV RNA Induces Innate Immune Responses through RIG-I-Dependent Sensing of Secondary-Structured RNA

(2012) Randi K. Berg et al.   PLoS One

Fenofibrate Reduces Mortality and Precludes Neurological Deficits in Survivors in Murine Model of Japanese Encephalitis Viral Infection

(2012) Neha Sehgal et al.   PLoS One

The National NeuroAIDS Tissue Consortium Brain Gene Array: Two Types of HIV-Associated Neurocognitive Impairment

(2012) Benjamin B. Gelman et al.   PLoS One

Relationships of PBMC microRNA expression, plasma viral load, and CD4+ T-cell count in HIV-1-infected elite suppressors and viremic patients

(2012) Kenneth W Witwer et al.   Retrovirology

Evidence for post-transcriptional regulation of clustered microRNAs in Drosophila

(2011) Sergei S Ryazansky et al.   BMC GENOMICS

Impaired neurosteroid synthesis in multiple sclerosis

(2011) Farshid Noorbakhsh et al.   BRAIN

Deletion of a single allele of the Pex11  gene is sufficient to cause oxidative stress, delayed differentiation and neuronal death in mouse brain

(2011) B. Ahlemeyer et al.   Disease Models & Mechanisms

Central Nervous System Immune Activation Characterizes Primary Human Immunodeficiency Virus 1 Infection Even in Participants With Minimal Cerebrospinal Fluid Viral Burden

(2011) Serena Spudich et al.   JOURNAL OF INFECTIOUS DISEASES

A KLF4-miRNA-206 Autoregulatory Feedback Loop Can Promote or Inhibit Protein Translation Depending upon Cell Context

(2011) C.-C. Lin et al.   MOLECULAR AND CELLULAR BIOLOGY

Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus

(2011) S. M. Horner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

General Aspects and Neuropathology of X-Linked Adrenoleukodystrophy

(2010) Isidro Ferrer et al.   BRAIN PATHOLOGY

Peroxisomes Are Signaling Platforms for Antiviral Innate Immunity

(2010) Evelyn Dixit et al.   CELL

MicroRNA profiling reveals new aspects of HIV neurodegeneration: caspase-6 regulates astrocyte survival

(2010) Farshid Noorbakhsh et al.   FASEB JOURNAL

Mammalian microRNAs predominantly act to decrease target mRNA levels

(2010) Huili Guo et al.   NATURE

HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study

(2010) R. K. Heaton et al.   NEUROLOGY